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| 1 | Age-related changes in the kinetics of human lenses:prevention of the cataract显示文摘The crystalline lens is a transparent,biconvex structure in the eye that,along with the cornea,helps to refract light to be focused on the retina and,by changing shape,it adjusts focal distance(accommodation).The three classes of structural proteins found in the lens areα,β,and γ crystallins.These proteins make up more than 90% of the total dry mass of the eye lens.Other components which can be found are sugars,lipids,water,several antioxidants and low weight molecules.When ageing changes occur in the lens,it causes a gradual reduction in transparency,presbyopia and an increase in the scattering and aberration of light waves as well as a degradation of the optical quality of the eye.The main changes that occur with aging are: 1) reduced diffusion of water from the outside to the inside of the lens and from its cortical to its nuclear zone; 2)crystalline change due to the accumulation of high molecular weight aggregates and insoluble proteins; 3)production of advanced glycation end products(AGEs),lipid accumulation,reduction of reduced glutathione content and destruction of ascorbic acid.Even if effective strategies in preventing cataract onset are not already known,good results have been reached in some cases with oral administration of antioxidant substances such as caffeine,pyruvic acid,epigallocatechin gallate(EGCG),α-lipoic acid and ascorbic acid.Furthermore,methionine sulfoxide reductase A(MSRA) over expression could protect lens cells both in presence and in absence of oxidative stress-induced damage.Nevertheless,promising results have been obtained by reducing ultraviolet-induced oxidative damage. | Nicola Pescosolido Andrea Barbato Rossella Giannotti Chiara Komaiha Fiammetta Lenarduzzi | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 13 |
| 2 | Chronic pancreatitis as presentation of Crohn's disease in a child显示文摘It is reported that a pancreatic disease may precede the diagnosis of inflammatory bowel disease(IBD) both in children and in adults.Idiopathic chronic pancreatitis,however,occasionally co-exists with the IBD,mainly at pediatric age.We report a case of a patient who progressively developed the features of a chronic pancreatitis,before the diagnosis of Crohn's Disease(CD).Ten months after the onset of the first episode of pancreatitis the patient developed bloody diarrhea,mucus stools and biochemical findings of inflammation.The colonoscopy revealed a diffuse colitis without involvement of the last loop and the gastroscopy showed inflammation of the iuxta-papillary area.The histological findings confirmed the diagnosis of CD that involved the colon and the duodenum.In conclusion,in children the idiopathic chronic pancreatitis may be an unusual presentation of CD.Thus,if other known cause of chronic pancreatitis are not found,a not invasive work up to exclude the IBD should be warranted.An early coincidental diagnosis of the IBD may delay the progression of the pancreatic disease. | Daniela Knafelz Fabio Panetta Lidia Monti Fiammetta Bracci Bronislava Papadatou Giuliano Torre Luigi Dall'Oglio Antonella Diamanti | 2013 | World Journal of Gastroenterology2013，19，31： | 2 |
| 3 | Incidence of umbilical vein catheter-associated thrombosis of the portal system: A systematic review and meta-analysis显示文摘BACKGROUND The use of umbilical venous catheters(UVCs)in the perinatal period may be associated with severe complications,including the occurrence of portal vein thrombosis(PVT).AIM To assess the incidence of UVC-related PVT in infants with postnatal age up to three months.METHODS A systematic and comprehensive database searching(PubMed,Cochrane Library,Scopus,Web of Science)was performed for studies from 1980 to 2020(the search was last updated on November 28,2020).We included in the final analyses all peer-reviewed prospective cohort studies,retrospective cohort studies and casecontrol studies.The reference lists of included articles were hand-searched to identify additional studies of interest.Studies were considered eligible when they included infants with postnatal age up to three months with UVC-associated PVT.Incidence estimates were pooled by using random effects meta-analyses.The quality of included studies was assessed using the Newcastle-Ottawa scale.The systematic review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis(PRISMA)guidelines.RESULTS Overall,16 studies were considered eligible and included in the final analyses.The data confirmed the relevant risk of UVC-related thrombosis.The mean pooled incidence of such condition was 12%,although it varied across studies(0%-49%).In 15/16 studies(94%),diagnosis of thrombosis was made accidentally during routine screening controls,whilst in 1/16 study(6%)targeted imaging assessments were carried out in neonates with clinical concerns for a thrombus.Tip position was investigated by abdominal ultrasound(US)alone in 1/16(6%)studies,by a combination of radiography and abdominal US in 14/16(88%)studies and by a combination of radiography,abdominal US and echocardiography in 1/16(6%)studies.CONCLUSION To the best of our knowledge,this is the first systematic review specifically investigating the incidence of UVC-related PVT.The use of UVCs requires a high index of suspicion,because its use is significantly associated with PVT.Well-designed prospective studies are required to assess the optimal approach to prevent UVCrelated thrombosis of the portal system. | Iliana Bersani Fiammetta Piersigilli Giulia Iacona Immacolata Savarese Francesca Campi Andrea Dotta Cinzia Auriti Enrico Di Stasio Matteo Garcovich | 2021 | World Journal of Hepatology2021，13，11： | 1 |
| 4 | Glycated fetal calf serum affects the viability of an insulin-secreting cell line in vitro显示文摘 | Giorgio Luciano Viviani Alessandra Puddu Gianni Sacchi Anna Garuti Daniela Storace Arianna Durante Fiammetta Monacelli Patrizio Odetti | 2008 | Metabolism2008，，2： | 1 |
| 5 | Effect of Nicotine on 35: CO2-Induced anxiety: a study in healthy volunteers显示文摘 | Fiammetta Cosci Kenneth Abrams Koen R J Schruers | 2006 | Nicotine and Tobacco Research2006，8，4： | 1 |
| 6 | Determinants of chil- dren's eating hehavior显示文摘 | Silvia S Chiara A Fiammetta V | 2011 | Am J Clin Nutr2011，，： | 1 |
| 7 | Plasma levels of insulin and amyloid β42 are correlated in patients with amnestic Mild Cognitive Impairment显示文摘 | Patrizio Odetti Alessandra Piccini Luca Giliberto Roberta Borghi Alessia Natale Fiammetta Monacelli Monica Marchese Andrea Assini Monica Colucci Sergio Cammarata Massimo Tabaton | 2005 | Journal of Alzheimer’s Disease2005，，3： | 1 |
| 8 | Crowd dynamics on a moving platform: Mathematical modelling and application to lively footbridges显示文摘 | Fiammetta Venuti Luca Bruno Nicola Bellomo | 2006 | Mathematical and Computer Modelling2006，，3： | 1 |
| 9 | Hereditary hemochromatosis type 1 phenotype modifiers in Italian patients. The controversial role of variants in HAMP , BMP2 , FTL and SLC40A1 genes显示文摘 | Francesca Clementina Radio Silvia Majore Caterina Aurizi Fiammetta Sorge Gianfranco Biolcati Sara Bernabini Irene Giotti Francesca Torricelli Diana Giannarelli Carmelilia De Bernardo Paola Grammatico | 2015 | Blood Cells, Molecules and Diseases2015，，1： | 1 |
| 10 | An interpretative model of the pedestrian fundamental relation显示文摘 | Fiammetta Venuti Luca Bruno | 2007 | Comptes rendus - Mécanique2007，，： | 1 |
| 11 | Olive fruits infested with olive fly larvae respond with an ethylene burst and the emission of specific volatiles显示文摘Olive fly(Bactrocera oleae R.) is the most harmful insect pest of olive(Olea europaea L.) which strongly affects fruits and oil production. Despite the expanding economic importance of olive cultivation, up to now, only limited information on plant responses to B. oleae is available. Here,we demonstrate that olive fruits respond to B. oleae attack by producing changes in an array of different defensive compounds including phytohormones, volatile organic compounds(VOCs), and defense proteins. Bactrocera oleaeinfested fruits induced a strong ethylene burst and transcript levels of several putative ethylene-responsive transcription factors became significantly upregulated. Moreover, infested fruits induced significant changes in the levels of 12-oxophytodienoic acid and C12 derivatives of the hydroperoxide lyase. The emission of VOCs was also changed quantitatively and qualitatively in insect-damaged fruits, indicating that B.oleae larval feeding can specifically affect the volatile blend offruits. Finally, we show that larval infestation maintained high levels of trypsin protease inhibitors in ripe fruits, probably by affecting post-transcriptional mechanisms. Our results provide novel and important information to understand the response of the olive fruit to B. oleae attack; information that can shed light onto potential new strategies to combat this pest. | Fiammetta Alagna Mario Kallenbach Andrea Pompa Francesca De Marchis Rosa Rao Ian T.Baldwin Gustavo Bonaventure Luciana Baldoni | 2016 | Journal of Integrative Plant Biology2016，58，4： | 1 |
| 12 | The outflow from Hudson Strait and its contribution to the Labrador Current显示文摘 | Fiammetta S Francois | 2008 | Deep Sea Research Part1 : Oceanographic Research Papers2008，8，55： | 1 |
| 13 | Determinants of chil- dren's eating behavior 显示文摘 | Silvia S Chiara A Fiammetta V | 2011 | Am J Clin Nutr2011，，： | 1 |
| 14 | Disseminated intravascular coagulation after splenic artery aneurysm coils embolization:an unexpected surprise显示文摘Introduction The Society for Vascular Surgery recommends treating nonruptured splenic artery aneurysms(SAAs)of>3 cm with a demonstrable increase in size or with associated symptoms[1].Percutaneous intervention with embolization coils or covered stents has become popular due to its high technical success rates and low morbidity[2,3]. | Marco Biolato Alessandro D’Errico Fiammetta Maria Rognoni Giuseppe Marrone Luca Laurenti Alessandro Cina Antonio Grieco | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 15 | Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape显示文摘Scaffold proteins are crucial regulators of signaling networks,and their abnormal expression may favor the development of tumors.Among the scaffold proteins,immunophilin covers a unique role as‘protein-philin’(Greek‘philin’=friend)that interacts with proteins to guide their proper assembly.The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties.Among the members of the immunophilin family,the FKBP5 gene was the only one identified to have a splicing variant.Cancer cells impose unique demands on the splicing machinery,thus acquiring a particular susceptibility to splicing inhibitors.This review article aims to overview the current knowledge of the FKBP5 gene functions in human cancer,illustrating how cancer cells exploit the scaffolding function of canonical FKBP51 to foster signaling networks that support their intrinsic tumor properties and the spliced FKBP51s to gain the capacity to evade the immune system. | LAURA MARRONE MASSIMO D’AGOSTINO CAROLINA GIORDANO VALERIA DI GIACOMO SIMONA URZINI CHIARA MALASOMMA MARIA PAOLA GAMMELLA MARTINA TUFANO SIMONA ROMANO MARIA FIAMMETTA ROMANO | 2023 | Oncology Research2023，31，4： | 0 |
| 16 | Pleomorphic cutaneous xanthomas disclosing homozygous familial hypercholesterolemia显示文摘Homoxygous Familial Hypercholesterolemia is characterized by a presence of several types of cutaneous xanthomas with an abnormal lipid profile. Some of these could be pathognomonic. Although these could be initially interpreted as isolated and localized benign disorders and offered surgical treatment, it has become increasingly clear that they could be a part of a systemic pathology. Here we describe a case of this rare disorder in a 19 years old non-obese young man who presented multiple, intertriginous, tuberous and tendinous xanthomas and had an associated abnormal lipid profile with elevated lowdensity lipoprotein cholesterol levels. A detailed history with clinical assessment in the differential diagnosis and laboratory investigations led to a precise diagnosis. | Antonio Mastrolorenzo Antonietta D'Errico Piera Pierotti Margherita Vannucchi Stefano Giannini Fiammetta Fossi | 2017 | World Journal of Dermatology2017，6，4： | 0 |
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