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| 1 | Support for the predictions of the pollinator-mediated stabilizing selection hypothesis显示文摘Aims Floral traits are frequently used in traditional plant systematics because of their assumed constancy.One potential reason for the apparent constancy of flower size is that effective pollen transfer between flowers depends on the accuracy of the physical fit between the flower and pollinator.Therefore,flowers are likely to be under stronger stabilizing selection for uniform size than vegetative plant parts.Moreover,as predicted by the pollinator-mediated stabilizing selection(PMSS)hypothesis,an accurate fit between flowers and their pollinators is likely to be more important for specialized pollination systems as found in many species with bilaterally symmetric(zygomorphic)flowers than for species with radially symmetric(actinomorphic)flowers.Methods In a comparative study of 15 zygomorphic and 13 actinomorphic species in Switzerland,we tested whether variation in flower size,among and within individuals,is smaller than variation in leaf size and whether variation in flower size is smaller in zygomorphic compared to actinomorphic species.Important findings Indeed,variation in leaf length was significantly larger than variation in flower length and width.Within-individual variation in flower and leaf sizes did not differ significantly between zygomorphic and actinomorphic species.In line with the predictions of the PMSS,among-individual variation in flower length and flower width was significantly smaller for zygomorphic species than for actinomorphic species,while the two groups did not differ in leaf length variation.This suggests that plants with zygomorphic flowers have undergone stronger selection for uniform flowers than plants with actinomorphic flowers.This supports that the relative uniformity of flowers compared to vegetative structures within species,as already observed in traditional plant systematics,is,at least in part,a consequence of the requirement for effective pollination. | Mark van Kleunen Anna Meier Moritz Saxenhofer Markus Fischer | 2008 | Journal of Plant Ecology2008，1，3： | 2 |
| 2 | Modeling Arctic Ocean heat transport and warming episodes in the 20th century caused by the intruding Atlantic Water显示文摘This study investigates the Arctic Ocean warming episodes in the 20th century using both a high-resolution coupled global climate model and historical observations .The model,with no flux adjustment,reproduces well the Atlantic Water core temperature(AWCT) in the Arctic Ocean and shows that four largest decadal-scale warming episodes occurred in the 1930s,70s,80s,and 90s,in agreement with the hydrographic observational data.The difference is that there was no pre-warming prior to the 1930s episode,while there were two pre-warming episodes in the 1970s and 80s prior to the 1990s,leading the 1990s into the largest and prolonged warming in the 20th century.Over the last century,the simulated heat transport via Fram Strait and the Barents Sea was estimated to be,on average,31.32 TW and 14.82 TW,respectively,while the Bering Strait also provides 15.94 TW heat into the western Arctic Ocean.Heat transport into the Arctic Ocean by the Atlantic Water via Fram Strait and the Barents Sea correlates significantly with AWCT(C=0.75 ) at 0- lag.The modeled North Atlantic Oscillation(NAO) index has a significant correlation with the heat transport(C=0.37).The observed AWCT has a significant correlation with both the modeled AWCT(C=0.49) and the heat transport(C=0.41). However,the modeled NAO index does not significantly correlate with either the observed AWCT(C=0.03) or modeled AWCT(C=0.16) at a zero-lag,indicating that the Arctic climate system is far more complex than expected. | Wang Jia Jin Meibing Jun Takahashi Tatsuo Suzuki Igor V Polyakov Kohei Mizobata Moto Ikeda Fancois J. Saucier Markus Meier | 2008 | Chinese Journal of Polar Science2008，19，2： | 2 |
| 3 | Structural insight into mutations of cystathionine β-synthase显示文摘 | Markus Meier Jana Oliveriusova Kraus JP | 2003 | Biochimica et Biophysica Acta2003，，： | 1 |
| 4 | Slowing the progression of chronic allograft nephropathy by conversion from cyclosporine to tacrolimus:A randomized controlled trial显示文摘 | Markus Meier Martin Nitschke | 2006 | Transplantation2006，7，81： | 1 |
| 5 | Assessment of right ventricular systolic function: Comparison between cardiac magnetic resonance derived ejection fraction and pulsed-wave tissue Doppler imaging of the tricuspid annulus显示文摘 | Andreas Wahl Fabien Praz Markus Schwerzmann Harald Bonel Simon C. Koestner Roger Hullin Jean-Paul Schmid Thomas Stuber Etienne Delacrétaz Otto M. Hess Bernhard Meier Christian Seiler | 2010 | International Journal of Cardiology2010，，1： | 1 |
| 6 | Improved Response to Cardiac Resynchronization Therapy Through Optimization of Atrioventricular and Interventricular Delays Using Acoustic Cardiography: A Pilot Study显示文摘 | Stefan Toggweiler Michel Zuber Richard Kobza Markus Roos Peiman Jamshidi Rolf Meier Paul Erne | 2007 | Journal of Cardiac Failure2007，，8： | 1 |
| 7 | Seizures in patients with Alzheimer’s disease or vascular dementia: A population‐based nested case–control analysis显示文摘 | Patrick Imfeld Michael Bodmer Markus Schuerch Susan S. Jick Christoph R. Meier | 2012 | Epilepsia2012，，： | 1 |
| 8 | Compartment Pressure of the Rectus Sheath Accurately Reflects Intra-Abdominal Pressure in a Porcine Model显示文摘 | Emanuel Benninger Matthias W. Laschke Markus Cardell Joerg H. Holstein Burkhardt Seifert Marius Keel Otmar Trentz Michael D. Menger Christoph Meier | 2010 | Journal of Surgical Research2010，，2： | 1 |
| 9 | Late Results After Percutaneous Closure of Patent Foramen Ovale for Secondary Prevention of Paradoxical Embolism Using the Amplatzer PFO Occluder Without Intraprocedural Echocardiography显示文摘 | Andreas Wahl Tony Tai Fabien Praz Markus Schwerzmann Christian Seiler Krassen Nedeltchev Stephan Windecker Heinrich P. Mattle Bernhard Meier | 2009 | JACC: Cardiovascular Interventions2009，，2： | 1 |
| 10 | Patent Foramen Ovale Screening by Ear Oximetry in Divers显示文摘 | Michael Billinger Markus Schwerzmann Wilhelm Rutishauser Andreas Wahl Stephan Windecker Bernhard Meier Christian Seiler | 2013 | The American Journal of Cardiology2013，，2： | 1 |
| 11 | Purification and characterization of the wild type and truncated human cystathionine β-synthase enzymes expressed in E. coli显示文摘 | Nina Frank Jana O. Kent Markus Meier Jan P. Kraus | 2007 | Archives of Biochemistry and Biophysics2007，，1： | 1 |
| 12 | 确定预焙阳极生产中沥青加入量的方法显示文摘介绍了一种预焙阳极生产工艺全过程优化的系统方法,包括把糊料中沥青加入量作为一个决定关键设备选型和使用的参数进行研究。通过精心设计阳极高度和阳极的加热时间实现优化目的。 | Raymond Perruchoud Markus Meier Julien Wyss 闫修瑾 | 2020 | 炭素技术2020，，3： | 0 |
| 13 | Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma:results from a retrospective multicenter trial显示文摘Metastases of uveal melanoma(UM)spread predominantly to the liver.Due to low response rates to systemic therapies,liver-directed therapies(LDT)are commonly used for tumor control.The impact of LDT on the response to systemic treatment is unknown.A total of 182 patients with metastatic UM treated with immune checkpoint blockade(ICB)were included in this analysis.Patients were recruited from prospective skin cancer centers and the German national skin cancer registry(ADOReg)of the German Dermatologic Cooperative Oncology Group(DeCOG).Two cohorts were compared:patients with LDT(cohort A,n=78)versus those without LDT(cohort B,n=104).Data were analyzed for response to treatment,progression-free survival(PFS),and overall survival(OS).The median OS was significantly longer in cohort A than in cohort B(20.1 vs.13.8 months;P=0.0016)and a trend towards improved PFS was observed for cohort A(3.0 vs.2.5 months;P=0.054).The objective response rate to any ICB(16.7%vs.3.8%,P=0.0073)and combined ICB(14.1%vs.4.5%,P=0.017)was more favorable in cohort A.Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM. | Elias A.T.Koch Anne Petzold Anja Wessely Edgar Dippel Markus Eckstein Anja Gesierich Ralf Gutzmer Jessica C.Hassel Harald Knorr Nicole Kreuzberg Ulrike Leiter Carmen Loquai Friedegund Meier Markus Meissner Peter Mohr Claudia Pföhler Farnaz Rahimi Dirk Schadendorf Max Schlaak Kai-Martin Thoms Selma Ugurel Jochen Utikal Michael Weichenthal Beatrice Schuler-Thurner Carola Berking Markus V.Heppt | 2023 | Frontiers of Medicine2023，17，5： | 0 |
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