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| 1 | Molecular genetics and targeted therapeutics in biliary tractcarcinoma显示文摘The primary malignancies of the biliary tract, cholangio-carcinoma and gallbladder cancer, often present at an advanced stage and are marginally sensitive to radiation and chemotherapy. Accumulating evidence indicates that molecularly targeted agents may provide new hope for improving treatment response in biliary tract carcinoma(BTC). In this article, we provide a critical review of the pathogenesis and genetic abnormalities of biliary tract neoplasms, in addition to discussing the current and emerging targeted therapeutics in BTC. Genetic studies of biliary tumors have identified the growth factors and receptors as well as their downstream signaling pathways that control the growth and survival of biliary epithelia. Target-specific monoclonal antibodies and small molecules inhibitors directed against the signaling pathways that drive BTC growth and invasion have been developed. Numerous clinical trials designed to test these agents as either monotherapy or in combination with conventional chemotherapy have been completed or are currently underway. Research focusing on understanding the molecular basis of biliary tumorigenesis will continue to identify for targeted therapy the key mutations that drive growth and invasion of biliary neoplasms. Additional strategies that have emerged for treating this malignant disease include targeting the epigenetic alterations of BTC and immunotherapy. By integrating targeted therapy with molecular profiles of biliary tumor, we hope to provide precision treatment for patients with malignant diseases of the biliary tract. | Eric I Marks Nelson S Yee | 2016 | World Journal of Gastroenterology2016，22，4： | 13 |
| 2 | Immunotherapeutic approaches in biliary tract carcinoma:Current status and emerging strategies显示文摘For biliary tract carcinoma(BTC),complete surgical resection of tumor is only feasible in a minority of patients,and the treatment options for patients with unresectable or metastatic disease are limited.Advances in cancer immunology have led to identification of tumor-infiltrating immune cells as indicators of prognosis and response to treatment in BTC.This has also facilitated development of immunotherapy that focuses on enhancing the immune system against biliary tumors.This includes peptide- and dendritic cell-based vaccines that stimulate in-vivo immune responses against tumorspecific antigens.Adoptive immunotherapy,which entails the ex-vivo expansion of tumor-infiltrating immune cells for subsequent reintroduction,and cytokinebased therapies have been developed in BTC.Clinical studies indicate that this type of therapy is generally well tolerated.Combination therapy with dendritic cell-based vaccines and adoptive immunotherapy has shown particularly good potential.Emerging strategies through discovery of novel antigen targets and by reversal of tumor-associated immunosuppression are expected to improve the efficacy of immunotherapy in BTC.Collaborative efforts by integration of targeted immunotherapeutics with molecular profiling of biliary tumor will hopefully make a positive impact on advancing towards the goal of developing precision treatment of patients with this highly lethal disease. | Eric I Marks Nelson S Yee | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 11 |
| 3 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 4 | Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate显示文摘The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and albuminuria.This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury. | Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan Dominic SC Raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Methodology2017，7，3： | 7 |
| 5 | Reelin induces EphB activation显示文摘进功能的 neuronal 网络的新生的神经原的集成在 neuronal 进程和与另外的神经原的 synaptic 接触的形成的发展中的大脑,生长和树枝状要求房间的移植到他们的最后的位置。在协调区别事件的这个复杂序列的信号之中的一个中央播放器是分泌 glycoprotein Reelin,它也调制 synaptic 粘性,学习并且在成年大脑的记忆形成。到 ApoER2 和 VLDL 受体的 Reelin 有约束力, LDL 受体家庭的二个成员,开始包含细胞内部的细胞质的适配器蛋白质 Disabled-1 的酷氨酸 phosphorylation 的发信号的串联,它指向 neuronal 细胞骨架并且最终控制在整个发展中的大脑放神经原。然而, Reelin 信号与另外的调停受体的发信号串联交往调整大脑开发和粘性的不同方面,是可能的。EphB 酷氨酸 kinases 经由通过 ephrin B transmembrane 蛋白质的双向发信号调整房间粘附和排斥依赖者过程。这里,我们证明 Reelin 绑在 EphB transmembrane 蛋白质的细胞外的领域,导致受体聚类和向前在神经原发信号的 EphB 的激活,独立于“古典”的 Reelin 受体, ApoER2 和 VLDLR。因此,鼠标缺乏 EphB1 和 EphB2 显示 CA3 海马趾的金字塔形的神经原的一个放的缺点,类似于那在 Reelin 缺乏的鼠标,和这房间迁居,缺点取决于 EphB 蛋白质的 kinase 活动。一起,我们的数据为在向前发信号的 Reelin 和 EphB 之间的信号集成提供生物化学、功能的证据。 | Elisabeth Bouche Mario I Romero-Ortega Mark Henkemeyer Timothy Catchpole Jost Leemhuis Michael Frotscher Petra May Joachim Herz Hans H Bock | 2013 | Cell Research2013，23，4： | 5 |
| 6 | Structural insights into SUN-KASH complexes across the nuclear envelope显示文摘nucleoskeleton 和细胞骨架(LINC ) 的连接器建筑群由阳光和 KASH 包含域的蛋白质组成并且衔接原子信封的内部、外部的膜。LINC 建筑群在原子放,房间极化和细胞的僵硬起关键作用。以前,我们报导了人的 SUN2 的 homotrimeric 结构。我们现在决定了人的 SUN2-KASH 建筑群的水晶结构。在复杂结构, SUN 领域 homotrimer 绑在三独立 “ hook”相似 KASH 肽。在建筑群的 SUN 领域的全面符合构造非常处于它的 apo 状态类似于 SUN 领域。一个主要 conformational 变化包含 KASH 固定的阳光领域的 AA'-loop,它重排形成微型 β与 KASH 肽交往的表。KASH 领域的磅主题在 SUN 领域的 homotrimeric 接口上紧适合进一个恐水病的衣袋,我们它称为双性人衣袋。而且, SUN 领域 homotrimer 三明治的二邻近的 protomers 由结合的恐水病的相互作用和氢的 KASH 领域。这些有约束力的地点的变化在 vitro 破坏或减少在 SUN 和 KASH 域之间的协会。另外, transfection 野类型,然而并非变异, SUN2 在 Ovcar-3 房间支持房间移植。这些结果提供 LINC 建筑群的一个结构的模型,它为另外的学习是必要的物理、功能在细胞质和核质之间联合。 | Wenjia Wang Zhubing Shi Shi Jiao Cuicui Chen Huizhen Wang Guoguang Liu Qiang Wang Yun Zhao Mark I Greene Zhaocai Zhou | 2012 | Cell Research2012，22，10： | 3 |
| 7 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 8 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 9 | Nanoscopy reveals surface-metallic black phosphorus显示文摘Black phosphorus(BP)is an emerging two-dimensional material with intriguing physical properties.It is highly anisotropic and highly tunable by means of both the number of monolayers and surface doping.Here,we experimentally investigate and theoretically interpret the near-field properties of a-few-atomic-monolayer nanoflakes of BP.We discover near-field patterns of bright outside fringes and a high surface polarizability of nanofilm BP consistent with its surface-metallic,plasmonic behavior at mid-infrared frequencies o1176 cm−1.We conclude that these fringes are caused by the formation of a highly polarizable layer at the BP surface.This layer has a thickness of~1 nm and exhibits plasmonic behavior.We estimate that it contains free carriers in a concentration of n≈1.1×10^(20) cm^(−3).Surface plasmonic behavior is observed for 10–40 nm BP thicknesses but absent for a 4-nm BP thickness.This discovery opens up a new field of research and potential applications in nanoelectronics,plasmonics and optoelectronics. | Yohannes Abate Sampath Gamage Zhen Li Viktoriia Babicheva Mohammad H Javani Han Wang Stephen B Cronin Mark I Stockman | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 10 | Hypertonicity:Clinical entities,manifestations and treatment显示文摘Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and longterm neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia.Hypernatremia results from relative excess of body sodium over body water. Loss of water in excess of intake,gain of sodium salts in excess of losses or a combination of the two are the main mechanisms of hypernatremia.Hypernatremia can be hypervolemic,euvolemic or hypovolemic. The management of hypernatremia addresses both a quantitative replacement of water and,if present,sodium deficit,and correction of the underlying pathophysiologic process that led to hypernatremia.Hypertonicity in hyperglycemia has two components,solute gain secondary to glucose accumulation in the extracellular compartment and water loss through hyperglycemic osmotic diuresis in excess of the losses of sodium and potassium. Differentiating between these two components of hypertonicity has major therapeutic implications because the first component will be reversed simply by normalization of serum glucose concentration while the second component will require hypotonic fluid replacement. An estimate of the magnitude of the relative water deficit secondary to osmotic diuresis is obtained by the corrected sodium concentration,which represents a calculated value of the serum sodium concentration that would result from reduction of the serum glucose concentration to a normal level. | Helbert Rondon-Berrios Christos Argyropoulos Todd S Ing Dominic S Raj Deepak Malhotra Emmanuel I Agaba Mark Rohrscheib Zeid J Khitan Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，1： | 2 |
| 11 | Respiratory failure in diabetic ketoacidosis显示文摘Respiratory failure complicating the course of diabetic ketoacidosis(DKA)is a source of increased morbidity and mortality.Detection of respiratory failure in DKA requires focused clinical monitoring,careful interpretation of arterial blood gases,and investigation for conditions that can affect adversely the respiration.Conditions that compromise respiratory function caused by DKA can be detected at presentation but are usually more prevalent during treatment.These conditions include deficits of potassium,magnesium and phosphate and hydrostatic or non-hydrostatic pulmonary edema.Conditions not caused by DKA that can worsen respiratory function under the added stress of DKA include infections of the respiratory system,pre-existing respiratory or neuromuscular disease and miscellaneous other conditions.Prompt recognition and management of the conditions that can lead to respiratory failure in DKA may prevent respiratory failure and improve mortality from DKA. | Nikifor K Konstantinov Mark Rohrscheib Emmanuel I Agaba Richard I Dorin Glen H Murata Antonios H Tzamaloukas | 2015 | World Journal of Diabetes2015，6，8： | 2 |
| 12 | Direct observation of localized surface plasmon field enhancement by Kelvin probe force microscopy显示文摘A surface plasmon(SP)is a fundamental excitation state that exists in metal nanostructures.Over the past several years,the performance of optoelectronic devices has been improved greatly via the SP enhancement effect.In our previous work,the responsivity of GaN ultraviolet detectors was increased by over 30 times when using Ag nanoparticles.However,the physics of the SP enhancement effect has not been established definitely because of the lack of experimental evidence.To reveal the physical origin of this enhancement,Kelvin probe force microscopy(KPFM)was used to observe the SP-induced surface potential reduction in the vicinity of Ag nanoparticles on a GaN epilayer.Under ultraviolet illumination,the localized field enhancement induced by the SP forces the photogenerated electrons to drift close to the Ag nanoparticles,leading to a reduction of the surface potential around the Ag nanoparticles on the GaN epilayer.For an isolated Ag nanoparticle with a diameter of~200 nm,the distribution of the SP localized field is located within 60 nm of the boundary of the Ag nanoparticle.For a dimer of Ag nanoparticles,the localized field enhancement between the nanoparticles was the strongest.The results presented here provide direct experimental proof of the localized field enhancement.These results not only explain the high performance of GaN detectors observed with the use of Ag nanoparticles but also reveal the physical mechanism of SP enhancement in optoelectronic devices,which will help us further understand and improve the performance of SP-based optoelectronic devices in the future. | Da-Bing Li Xiao-Juan Sun Yu-Ping Jia Mark I Stockman Hari P Paudel Hang Song Hong Jiang Zhi-Ming Li | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 13 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 14 | Dynamic habitat selection by two wading bird species with divergent foraging strategies in a seasonally fluctuating wetland显示文摘 | Beerens James M Gawlik Dale E Herring Garth Cook Mark I | 2011 | EN2011，，4： | 2 |
| 15 | Large Molecular Hyperpolarizabilities. Quantitative Analysis of Aromaticity and Auxiliary Donor-Acceptor Effects显示文摘 | Albert I D L Marks T J Ratner M A | | 0，，： | 2 |
| 16 | Opal and inverse opal photonic crystals: Fabrication and characterization 显示文摘 | Geoffrey I N Waterhouse Mark R Waterland | 2007 | Polyhedron2007，26，： | 1 |
| 17 | Coral decline threatens fish biodiversity in marine reserves显示文摘 | GEOFFREY P J MARK I M MAYA S | 2004 | Proceedings of the National Academy of Sciences of the USA2004，101，： | 1 |
| 18 | The relationship between multiple scratch tests and wear behavior of hot-pressed sili- con nitride ceramics with various rare-earth additive systems 显示文摘 | Hideki Hyuga Mark I J | 2008 | J Am Ceram SOc2008，91，1： | 1 |
| 19 | The Grotesque and the Taboo in Roald Dahl's Humorous Writings for Children显示文摘 | West Mark I | 1990 | Children''s Literature Association Quarterly1990，15，3： | 1 |
| 20 | Selenium assimilation and volatilization from selenocyanate-treated Indian Mustard and Muskgrass显示文摘 | Mark P S Pickering I J Michael W | 2002 | Plant Physiol2002，128，： | 1 |
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