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| 1 | Hepatic encephalopathy:An approach to its multiple pathophysiological features显示文摘Hepatic encephalopathy(HE)is a neuropsychiatric complex syndrome,ranging from subtle behavioral abnormalities to deep coma and death.Hepatic encephalopathy emerges as the major complication of acute or chronic liver failure.Multiplicity of factors are involved in its pathophysiology,such as central and neuromuscular neurotransmission disorder,alterations in sleep patterns and cognition,changes in energy metabolism leading to cell injury,an oxidative/nitrosative state and a neuroinflammatory condition.Moreover,in acute HE,a condition of imminent threat of death is present due to a deleterious astrocyte swelling.In chronic HE,changes in calcium signaling,mitochondrial membrane potential and long term potential expression,N-methyl-D-aspartate-cGMP and peripheral benzodiazepine receptors alterations,and changes in the mRNA and protein expression and redistribution in the cerebral blood flow can be observed.The main molecule indicated as responsible for all these changes in HE is ammonia.There is no doubt that ammonia,a neurotoxic molecule,triggers or at least facilitates most of these changes.Ammonia plasma levels are increased two-to three-fold in patients with mild to moderate cirrhotic HE and up to ten-fold in patients with acute liver failure. Hepatic and inter-organ trafficking of ammonia and its metabolite,glutamine(GLN),lead to hyperammonemic conditions.Removal of hepatic ammonia is a differentiated work that includes the hepatocyte,through the urea cycle,converting ammonia into GLN via glutamine synthetase.Under pathological conditions,such as liver damage or liver blood bypass,the ammonia plasma level starts to rise and the risk of HE developing is high. Knowledge of the pathophysiology of HE is rapidly expanding and identification of focally localized triggers has led the development of new possibilities for HE to be considered.This editorial will focus on issues where, to the best of our knowledge,more research is needed in order to clarify,at least partially,controversial topics. | Juan Carlos Perazzo Silvina Tallis Amalia Delfante Pablo Andrés Souto Abraham Lemberg Francisco Xavier Eizayaga Salvador Romay | 2012 | World Journal of Hepatology2012，4，3： | 16 |
| 2 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 3 | Antioxidant role of heme oxygenase-1 in prehepatic portal hypertensive rats显示文摘瞄准:在氧化的肝地位和这项活动和表示上学习胆红素的效果他我在老鼠肝损伤的 oxygenase-1 (HO-1 ) 由 prehepatic 门静脉高血压导致了。方法:Wistar 雄的老鼠,称 200-250 g,在随机被划分成二个组:有调整 prehepatic 门静脉结扎(PPVL ) 导致的 prehepatic 门静脉高血压(PH ) 的一个组和另外的组对应于假冒的操作老鼠。门压力,氧化压力参数,抗氧化剂酶, HO-1 活动和表示和肝的正弦曲线血管舒张被测量。结果:在 PPVL 老鼠,氧化应力被在减少的谷胱甘肽(GSH ) 的反应物质(TBARS ) 内容和减少铺平的 thiobarbituric 酸的显著增加证实。当 HO-1 的活动和表示被提高时,肝抗氧化剂酶,超级氧化物歧化酶(草皮) ,过氧化氢酶(猫) 和谷胱甘肽过氧化物酶(GSH-Px ) 的活动也被减少。胆红素(5 mumol/kg 体重) 的管理在实验的结束前的 24 h 完全阻止了所有这些效果。有 Sn-protoporphyrin IX (Sn-PPIX ) 的预告的处理(100 mug/kg 体重, i.p ) ,一个有势力禁止者惊讶,完全废除了氧化压力并且每氧化象类脂化合物的增加一样在肝 GSH 层次挑起了细微减少。而且,一氧化碳,另一他我分解代谢的产品,在在 PPVL 的肝的区域组织的正弦曲线导致了重要增加。有 Sn-PPIX 的 PPVL 老鼠的预告的处理完全阻止了这效果。结论:这些结果在 prehepatic 门 hypertensive 老鼠在表示上建议 HO-1 的一个有益的角色。 | Soledad Gonzales María Julia Pérez Juan C Perazzo María Luján Tomaro | 2006 | World Journal of Gastroenterology2006，12，26： | 6 |
| 4 | Prognostic value of liver fibrosis and steatosis biomarkers in type‐2 diabetes and dyslipidaemia显示文摘 | H. Perazzo M. Munteanu Y. Ngo P. Lebray N. Seurat F. Rutka M. Couteau S. Jacqueminet P. Giral D. Monneret F. Imbert‐Bismut V. Ratziu A. Hartemann‐Huertier C. Housset T. Poynard | 2014 | Aliment Pharmacol Ther2014，，9： | 3 |
| 5 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 6 | Characterization of goat whey proteins and their bioactivity and toxicity assay显示文摘Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s physiology.Therefore,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute toxicity.Concentrated proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE methods.Antibacterial activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for L.monocytogenes growth.Antiproliferative activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of exposure.The highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical oxidation.The acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout exposure.Thus,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without toxicity.The present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry. | Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha | 2022 | Food Bioscience2022，46，2： | 2 |
| 7 | Liver fibrosis evaluation using real-time shear wave elastography: Applicability and diagnostic performance using methods without a gold standard显示文摘 | Thierry Poynard Mona Munteanu Elena Luckina Hugo Perazzo Yen Ngo Luca Royer Larysa Fedchuk Florence Sattonnet Raluca Pais Pascal Lebray Marika Rudler Dominique Thabut Vlad Ratziu | 2013 | Journal of Hepatology2013，，5： | 2 |
| 8 | Role of ammonia and nitric oxide in the decrease in plasmaprolactin levels in prehepatic portal hypertensive male rats 显示文摘 | Camila C Scorticati Juan C Perazzo Valeria Rettori | 2006 | Neuroimmunomodulation2006，13，3： | 1 |
| 9 | Blood management and transfusion strategies in 600 patients undergoing total joint arthroplasty: an analysis of pre-operative autologous blood donation 显示文摘 | Perazzo P Viganb M De Girolamo L | 2013 | Blood Transfus2013，11，3： | 1 |
| 10 | Prognostic value of liver fibrosis biomarkers:a meta-analysis显示文摘 | Poynard T Ngo Y Perazzo H | | 0，，： | 1 |
| 11 | A finite point method for elastic- ity problems 显示文摘 | Ofiate E Perazzo F Miquel J | 2001 | Computers and Structures2001，79，： | 1 |
| 12 | Natural Products and Biological Activity of the Pharmacologically Active Cauliflower Mushroom Sparassis crispa显示文摘 | Takashi Kimura Fabio Ferreira Perazzo | 2013 | BioMed Research International2013，，： | 1 |
| 13 | Phase inversion emulsification:current understanding and applications 显示文摘 | PERAZZO A PREZIOSI V GUIDO S | 2015 | Advances in Colloid and Interface Science2015，222，： | 1 |
| 14 | Adaptive methodology for meshless finite point method显示文摘 | Perazzo F Lohner R Perez-Pozo L | 2008 | Advances in Engineering Software2008，39，： | 1 |
| 15 | Optimization and Performance of High-resolution Micro-optomechanical Thermal Sensors 显示文摘 | Lai J Perazzo T Shi Z Majumdar A | 1997 | Sensors and Actuators A1997，58，： | 1 |
| 16 | Urinary biomarkers of kidney diseases in HIV-infected chil- dren 显示文摘 | Perazzo S Soler-Garcla 6A Hathout Y etal | 2015 | Proteomics ClinAppl2015，9，56： | 1 |
| 17 | A finite point method for elasticity problems显示文摘 | ONATE E PERAZZO F MIQUEL J | 2001 | Computers and Structures2001，79，2225： | 1 |
| 18 | Blood management and transfusion strategies in 600 patients undergoing total joint arthroplasty: an analysis of pre-operative autologous blood donation 显示文摘 | Perazzo P Viganb M De Girolamo L | 2013 | Blood Transfus2013，11，3： | 1 |
| 19 | Cetuximab plus irino- tecan in pretreated metastatic colorectal cancer progressing on iri- noteean: the LABEL study 显示文摘 | Buzaid AC Mathias Cde C Perazzo F | 2010 | Clin Coloreetal Cancer2010，9，5： | 1 |
| 20 | A finite point method for elasticity problems显示文摘 | ONATE E PERAZZO F MIQUEL J | 2001 | Computers&Structures2001，79，2225： | 1 |
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