|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor显示文摘Approximately 10% of patients with gastrointestinal stromal tumors (GIST) develop other neoplasms, either synchronously or metachronously. In this report we describe coexistence of a gastrointestinal stromal tumor and a hepatic perivascular epithelioid cell tumor (PEComa) in a 51-year-old woman with no evidence of tuberous sclerosis. A subcapsular hepatic nodule (0.8 cm in diameter) was found during surgery for symptomatic gastric neoplasm (15 cm in diameter) arising from the lesser curvature. Both tumors revealed histomorphological and immunohistochemical features confirming a diagnosis of a small incidental hepatic PEComa and a high risky extramural gastric GIST, respectively. The patient remained disease-free 25 mo after surgery with no evidence of tumor recurrence or new neoplasms. To our knowledge, this is the first report of PEComa in a patient with GIST. Hepatic lesions detected synchronously or metachronously in patients with GISTs may represent histogenetically distinct lesions and should be sampled to confirm or exclude metastatic GISTs. | Carlos Eduardo Paiva Francisco Alves Moraes Neto Abbas Agaimy Maria Aparecida Custódio Domingues Silvia Regina Rogatto | 2008 | World Journal of Gastroenterology2008，14，5： | 6 |
| 2 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 3 | MicroRNAs expression influence in ulcerative colitis and Crohn's disease:A pilot study for the identification of diagnostic biomarkers显示文摘BACKGROUND Inflammatory bowel disease(IBD)comprises two distinct diseases,Crohn’s disease(CD)and ulcerative colitis(UC),both of which are chronic,relapsing inflammatory disorders of the gastrointestinal tract with a mostly unknown etiology.The incidence and prevalence of IBD are continually increasing,indicating the need for further studies to investigate the genetic determinants of these diseases.Since microRNAs(miRNAs)regulate protein translation via complementary binding to mRNA,discovering differentially expressed miRNAs(DE)in UC or CD patients could be important for diagnostic biomarker identification,assisting in the appropriate disease differentiation progressing the understanding of IBD pathogenesis.AIM To determine the miRNA expression profile in UC and CD patients and the potential pathophysiological contributions of differentially expressed miRNA.METHODS A total of 20 formalin-fixed paraffin-embedded colonic samples were collected from the Pathology Department of Botucatu Medical School at São Paulo State University(Unesp).The diagnosis of UC or CD was based on clinical,endoscopic,radiologic,and histological criteria and confirmed by histopathological analysis at the time of selection.The TaqMan™Array Human MicroRNA A+B Cards Set v3.0(Applied Biosystems™)platform was used to analyze 754 miRNAs.Targets of DE-miRNAs were predicted using miRNA Data Integration Portal(mirDIP)and the miRNA Target Interaction database(MiRTarBase).All statistical analyses were conducted using GraphPad Prism software.Parametric and nonparametric data were analyzed using t-tests and Mann-Whitney U tests,respectively.RESULTS The results showed that of the 754 miRNAs that were initially evaluated,643 miRNAs were found to be expressed in at least five of the patients who were diagnosed with either CD or UC;the remaining 111 miRNAs were not considered to be expressed in these patients.The expression levels of 28 miRNAs were significantly different between the CD and UC patients(P≤0.05);13 miRNAs demonstrated a fold-change in expression level greater than 1.Five miRNAs with a downregulated expression were selected for enrichment analysis.The miRNAs whose expression levels were significantly lower in UC patients than in CD patients were enriched in certain signaling pathways that were mostly correlated with cancer-related processes and respective biomarkers.CONCLUSION MiRNAs could be used to differentiate UC from CD,and differently expressed miRNAs could help explain the distinct pathophysiology of each disease. | Ana Elisa Valencise Quaglio Felipe Jose Santaella Maria Aparecida Marchesan Rodrigues Ligia Yukie Sassaki Luiz Claudio Di Stasi | 2021 | World Journal of Gastroenterology2021，27，45： | 3 |
| 4 | Mechanisms involved in the therapeutic properties of mesenchymal stem cells显示文摘 | Lindolfo da Silva Meirelles Aparecida Maria Fontes Dimas Tadeu Covas Arnold I. Caplan | 2009 | Cytokine and Growth Factor Reviews2009，，5： | 3 |
| 5 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 6 | Low temperature induced changes in activity and protein levels of the enzymes associated to conversion of starch to sucrose in banana fruit显示文摘 | Roberta Ghedini Der Agopian Fernanda Helena Gon?alves Peroni-Okita Claudinéia Aparecida Soares Janaína Aparecida Mainardi Jo?o Roberto Oliveira do Nascimento Beatriz Rosana Cordenunsi Franco Maria Lajolo Eduardo Purgatto | 2011 | Postharvest Biology and Technology2011，，2： | 2 |
| 7 | Challenges in the diagnosis of intestinal neuronal dysplasia type B:A look beyond the number of ganglion cells显示文摘Intestinal neuronal dysplasia type B(IND-B)is a controversial condition among gastrointestinal neuromuscular disorders.Constipation is its most common clinical manifestation in patients.Despite intense scientific research,there are still knowledge gaps regarding the diagnostic criteria for IND-B in the histopathological analysis of rectal biopsies.The guidelines published in the past three decades have directed diagnostic criteria for quantifying the number of ganglion cells in the nervous plexus of the enteric nervous system.However,it is very complex to distinguish numerically what is pathological from what is normal,mainly because of the difficulty in determining a reliable control group composed of healthy children without intestinal symptoms.Thus,a series of immunohistochemical markers have been proposed to assist in the histopathological analysis of the enteric nervous system.Several of these markers facilitate the identification of other structures of the enteric nervous system,in addition to ganglion cells.These structures may be related to the etiopathogenesis of IND-B and represent new possibilities for the histopathological diagnosis of this disease,providing a view beyond the number of ganglion cells.This review critically discusses the aspects related to the disease definitions and diagnostic criteria of this organic cause of constipation. | Simone Antunes Terra Anderson Cesar Gonçalves Pedro Luiz Toledo de Arruda Lourenção Maria Aparecida Marchesan Rodrigues | 2021 | World Journal of Gastroenterology2021，27，44： | 2 |
| 8 | Clinical and hematological signs associated with dogs naturally infected by Hepatozoon sp. and with other hematozoa: A retrospective study in Uberlandia, Minas Gerais, Brazil显示文摘 | Antonio Vicente Mundim Iara Aparecida de Morais Marcelo Tavares Márcia Cristina Cury Maria José Santos Mundim | 2008 | Veterinary Parasitology2008，，1： | 2 |
| 9 | Mechanisms involved in the therapeutic properties of mesenchymal stem cells显示文摘 | Lindolfo da Silva Meirelles Aparecida Maria Fontes Dimas Tadeu Covas Arnold I. Caplan | 2009 | Cytokine and Growth Factor Reviews2009，，5： | 2 |
| 10 | Corrigendum to “PCR identification of Leishmania in diagnosis and control of canine leishmaniasis” [Vet. Parasitol. 144 (2007) 234–241]显示文摘 | Aparecida H.S. Gomes Isabelle M.R. Ferreira Maria L.S.R. Lima Elaine A. Cunha Andrea S. Garcia Maria F.L. Araújo Vera L. Pereira-Chioccola | 2007 | Veterinary Parasitology2007，，3： | 1 |
| 11 | Quantification of Listeria monocytogenes in minimally processed leafy vegetables using a combined method based on enrichment and 16S rRNA real-time PCR显示文摘 | Maria Aparecida de Oliveira Eliana Guimar?es Abeid Ribeiro Alzira Maria Morato Bergamini Elaine Cristina Pereira De Martinis | 2009 | Food Microbiology2009，，1： | 1 |
| 12 | One-week dual therapy with ranitidine bismuth citrate and clarithromycin for the treatment of Helicobacter pylori infection in Brazilian patients with peptic ulcer显示文摘AIM: To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer.METHODS: One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1) 1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment.RESULTS: By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P>0.05). By per protocol analysis, the eradication rates were 80% and 83%,respectively, in patients treated for 1 or 2 wk (P>0.05). Nine patients (8.2%) reported minor side effects. CONCLUSION: One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for treatment of H pylori infection, andappears to be comparable to the 2-wk regimen in terms of efficacy. | Maria Aparecida Mesquita S(o|^)nia Letícia Silva Lorena Jazon Romilson Souza Almeida Ciro Garcia Montes Fábio Guerrazzi Luciana T Campos José Murilo Rubiota Zeitune | 2005 | World Journal of Gastroenterology2005，11，23： | 1 |
| 13 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 14 | Serum calprotectin levels correlate with biochemical and histological markers of disease activity in TNBS colitis显示文摘 | Didia Bismara Cury Sender Jankiel Mizsputen Clara Versolato Luciana Odashiro Miiji Edson Pereira Maria Aparecida Delboni Nestor Schor Alan C. Moss | 2013 | Cellular Immunology2013，，1： | 1 |
| 15 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010，，3： | 1 |
| 16 | Effects of progressive exercise during phase I cardiac rehabilitation on the heart rate variability of patients with acute myocardial infarction显示文摘 | Michele D. B. Santos-Hiss Ruth C. Melo Victor R. Neves Flávio C. Hiss Roberto M. M. Verzola Ester Silva Audrey Borghi-Silva Alberto Porta Nicola Montano Aparecida Maria Catai | 2011 | Disability and Rehabilitation2011，，10： | 1 |
| 17 | Expression of Heparanase Isoforms in Intervertebral Discs Classified According to Pfirrmann Grading System for Disc Degeneration显示文摘 | Luciano Miller Reis Rodrigues Lilian Zerbinatti de Oliveira Maria Aparecida da Silva Pinhal | 2013 | Spine2013，，13： | 1 |
| 18 | Comminution of silicon carbide powder in a planetary mill显示文摘 | MARIA Aparecida P dos Santos Ce LIO A Costa | 2006 | Powder Technology2006，169，： | 1 |
| 19 | Association of Changes in Bone Remodeling and Coronary Calcification in Hemodialysis Patients: A Prospective Study显示文摘 | Daniela Veit Barreto Fellype de Carvalho Barreto Aluízio Barbosa de Carvalho Lilian Cuppari Sérgio Antonio Draibe Maria Aparecida Dalboni Rosa Maria Affonso Moyses Kátia Rodrigues Neves Vanda Jorgetti Márcio Miname Raul D. Santos Maria Eugênia F. Canziani | 2008 | American Journal of Kidney Diseases2008，，6： | 1 |
| 20 | The Effects of Host Diversity in Anthracnose Management and Race Composition of Colletotrichum sublineolum in Sorghum Lineage Mixtures显示文摘Alternative strategies of management of sorghum diseases were implemented using field experiments conducted in Embrapa Maize and Sorghum Research Center,Brazil in 2001 until 2003 to evaluate the efficacy of lineage mixtures of Sorghum bicolor for the control of anthracnose(caused by Colletotrichum sublineolum).The calculated values for disease severity considered the area under the disease progress curve(AUDPC)observed for the nine susceptible and resistant elite strains of sorghum planted in 30 stands randomly.Each stand was drawn in mixtures of three genotypes each,in the same proportions per plant.This design was compared with the severity of the disease measured in AUDPC calculated for each of the same nine strains of sorghum in pure stands.In most of the cases,the disease severity on the susceptible cultivars was decreased;and in some cases,reached 85%of disease reduction compared with disease progress in pure stand of correspondent plant.The implication and effect of these sorghum mixtures on the populations of C.sublineolum on each treatment were evaluated and revealed that there was an increase of frequency of complex races in most of these mixtures and a highest phenotypic diversity for virulence to pathogen populations from pure stands,than the characterized on populations collected from the mixtures,despite of the effectiveness on decrease of the anthracnose severity. | Henrique Maia Valério Janete Maria Silva Alves Maria Aparecida Resende Elio Gomes Fernandes Carlos Roberto Casela | 2018 | Journal of Agricultural Science and Technology(B)2018，8，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员