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| 1 | Gene and cell therapy based treatment strategies for inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD)are a group of chronic inflammatory disorders most commonly affecting young adults.Currently available therapies can result in induction and maintenance of remission,but are not curative and have sometimes important side effects.Advances in basic research in IBD have provided new therapeutic opportunities to target the inflammatory process involved.Gene and cell therapy approaches are suitable to prevent inflammation in the gastrointestinal tract and show therefore potential in the treatment of IBD.In this review,we present the current progress in the field of both gene and cell therapy and future prospects in the context of IBD.Regarding gene therapy,we focus on viral vectors and their applications in preclinical models.The focus for cell therapy is on regulatory T lymphocytes and mesenchymal stromal cells,their potential for the treatment of IBD and the progress made in both preclinical models and clinical trials. | Sander van der Marel Anna Majowicz Sander van Deventer Harald Petry Daniel W Hommes Valerie Ferreira | 2011 | World Journal of Gastrointestinal Pathophysiology2011,2,6: | 3 |
| 2 | Taxonomy and pathogenicity of Ceratocystis species on Eucalyptus trees in South China, including C. chinaeucensis sp. nov.显示文摘Commercial plantations of Eucalyptus species have been established in South China,especially during the past 20 years,to meet the needs of a rapidly growing national economy.As part of a survey of fungal diseases affecting Eucalyptus species in South China,Ceratocystis species were collected from Eucalyptus plantations in the GuangDong Province.The aims of this study were to identify these Ceratocystis isolates and to test their pathogenicity to Eucalyptus.The most aggressive isolates were also used to screen different species and clones of Eucalyptus for susceptibility to infection under field conditions.The fungi were identified based on morphology and through comparisons of DNA sequence data of the ITS,partialβ-tubulin and TEF-1αgene regions.Morphological and DNA sequence comparisons showed that isolates collected from Chinese Eucalyptus plantations represent two species,C.acaciivora in the C.fimbriata s.l.species complex and a previously undescribed species belonging to the C.moniliformis s.l.species complex,for which the name C.chinaeucensis sp.nov.is provided.In pathogenicity trials,both C.acaciivora and C.chinaeucensis gave rise to lesions on wounded Eucalyptus trees,and the former fungus was most pathogenic.Differences were also observed in the responses of different Eucalyptus clones to inoculation and this could be useful in reducing disease,if C.acaciivora should emerge as a pathogen in the future. | ShuaiFei Chen Marelize Van Wyk Jolanda Roux Michael J.Wingfield YaoJian Xie XuDong Zhou | 2013 | Fungal Diversity2013,,1: | 2 |
| 3 | The Influence on GNSS Estimates of NWP-derived Mapping Functions显示文摘 | de Haan S van der Marel H | 2004 | Physicas and Chemistry of the Earth2004,29,: | 1 |
| 4 | Low dose powdered activated carbon addition at high sludge retention times to reduce fouling in membrane bioreactors显示文摘 | Remy M van der Marel P Zwijnenburg A | 2009 | Water Research2009,43,2: | 1 |
| 5 | Precise GPS positioning by applying ionospheric corrections from an active control network 显示文摘 | ODIJK D MAREL H VAN DER SONG I | 1999 | GPS Solutions1999,3,3: | 1 |
| 6 | Green consumer behav- ior: determinants of curtailment and eco- innovation adoption 显示文摘 | JANSSON J MARELL A NORDLUND A | 2010 | Journal of consumer marketing2010,27,4: | 1 |
| 7 | Isolation of biologically active components from rabies and other envelope viruses显示文摘 | Van Wezel A L | 1979 | Dev Biol Stand1979,42,: | 1 |
| 8 | Interaction effects of mood induction and nominal representation of price on consumer choice显示文摘 | AMELIE GAMBLE TOMMY GA' RLING DANIEL VA'STFJA' LL AGNETA MARELL | | 0,,: | 1 |
| 9 | The incidence of pleural effusion in a well-defined region:epidemiologic study in central bohemia显示文摘 | Marel M Zrustova M Stasny B | 1993 | Chest1993,104,: | 1 |
| 10 | Terahertz polarization imaging显示文摘 | Van der Valk N C Van der Marel W A Planken P | 2005 | Optics Letters2005,30,20: | 1 |
| 11 | Short and zero baseline analysis of GPS L1 C/A, L5Q, GIOVE E1B, and FSaQ signals显示文摘 | DEBAKKERPF TIBERIUS C C J M VAN DER MAREL H | 2012 | GPS solutions2012,16,1: | 1 |
| 12 | The phase diagram of the system lithium-silicon显示文摘 | Van der Marel C Vinke G J B Van der Lugt W | 1985 | Solid State Communications1985,54,11: | 1 |
| 13 | Interaction effects of mood induction and nominal representation of price on consumer choice显示文摘 | Gamble A G(a)ding T V(a)tfj(a)l D Marell A | | 0,,: | 1 |
| 14 | Diagnosis of pleural effusions: experience with clinical studies, 1986 to 1990显示文摘 | Marel M Stasmy B Melinora L | 1995 | Chest1995,107,6: | 1 |
| 15 | Gene and cell therapy based treatment strategies for inflammatory bowel diseases 显示文摘 | VAN DER MAREL S MAJOWICZ A VAN DEVENTER S | 2011 | World J Gastrointest Pathophysiol2011,2,6: | 1 |
| 16 | The value of endocervical curettage in addition to biopsies in women referred to colposcopy显示文摘 | Van der Marel J Rodriguez A Del Pino M | 2015 | J Low Genit Tract Dis2015,19,4: | 1 |
| 17 | Terahertz polarization imaging显示文摘 | van der VALK N C van der MAREL W A PLANKEN P C | 2005 | Optics Letters2005,30,20: | 1 |
| 18 | Pattern evoked potentials in awake rhesus monkeys显示文摘 | Dagnelie G Spekreijse H | 1981 | Invest Ophthalmol Vis Sci1981,21,3: | 1 |
| 19 | Peptidomimetic glutathione analogues as novel gamma GT stable GST inhibitors显示文摘 | Burg D Filippov DV Hermanns R van der Marel GA van Boom JH Mulder GJ | 2002 | Bioorg Med Chem2002,10,: | 1 |
| 20 | Combining Water Vapor Data from GPS and MERIS显示文摘 | LINDENBERGH R KESHIN M VANDER MAREL H | 2006 | Remote Sensing2006,,7: | 1 |