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| 1 | Comparison of the use of wireless capsule endoscopy with magnetic resonance enterography in children with inflammatory bowel disease显示文摘BACKGROUND Magnetic resonance enterography (MRE) and wireless capsule endoscopy (WCE) are equally accepted modalities for noninvasive screening of small bowel involvement (SBI) in children with Crohn’s disease (CD) and indeterminate colitis (IC) albeit there is a paucity of data comparing the two and thereby guiding the clinician in selecting the ideal diagnostic approach. Therefore, the goal of this study is to provide additional evidence for capsule endoscopy role in the evaluation of established Crohn’s disease exacerbation compared to MRE in relation to Pediatric Crohn's Disease Activity Index (PCDAI), and histological indices. AIM To prospectively compare the findings of MRE and WCE and their agreement with PCDAI or histology in children with CD or IC. METHODS Consecutive patients diagnosed with CD and IC were screened for inclusion. After informed consent, patient’s demographic and clinical data was abstracted. The current pediatric disease activity index (PCDAI) and endoscopic findings were included. Patients underwent MRE and WCE including preprocedural patency capsule within a maximum of 7 d of each other. Pathological presence of active small bowel disease in ileal and duodenal biopsies were collected if the endoscopy was performed within 2 mo of the WCE study. Patients who failed to pass the PC were excluded from the study. WCE was read by two different experienced gastroenterologists (Attard TM and Colombo JM) blinded to each other's findings and to the findings on MRE (Mardis NJ). Agreement between WCE reviewers, WCE and MRE findings and concordance between positive PCDAI and SBI based on MRE compared with WCE was computed. RESULTS Forty-five patients were included in the study, 18 withdrew and 27 (20 males and 20 CD), mean age (standard deviation) 13.46 (2.4) years, completed the study protocol. There were no instances of capsule retention. Concordance between gastroenterologist reviewers was excellent for the diagnosis of small intestinal CD with good correlation between the two Lewis scores (r=0.875, P<0.001). Concordance between WCE and MRE was poor (69%). In CD patients, when both MRE and WCE were compared using PCDAI>10 as the standard reference reflecting active small intestinal CD, the sensitivity of MRE and WCE were 100% and 83% respectively and the specificity of MRE and WCE were 57.14% and 78.6%, respectively. If the histology in ileum or/and duodenum was used as the reference for active small bowel involvement, WCE had a higher specificity as compared to MRE (83.3% vs 50%). In patients with Crohn’s disease, those with a positive PCDAI (>10) were more likely to have a positive WCE as compared to those with a negative PCDAI (83% vs 21%;P=0.018). CONCLUSION We suggest that MRE and WCE have a complementary role in the assessment of SBI in CD. WCE detected SBI with a much higher specificity while MRE had a higher sensitivity. | Nadia Mazen Hijaz Thomas Mario Attard Jennifer Marie Colombo Neil Joseph Mardis Craig Alan Friesen | 2019 | World Journal of Gastroenterology2019，25，28： | 3 |
| 2 | The impact of next-generation sequencing technology on genetics显示文摘 | Elaine R. Mardis | 2007 | Trends in Genetics2007，，： | 2 |
| 3 | Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)显示文摘 | Raymond L. Benza Dave P. Miller Mardi Gomberg-Maitland Robert P. Frantz Aimee J. Foreman Christopher S. Coffey Adaani Frost Robyn J. Barst David B. Badesch C. Gregory Elliott Theodore G. Liou Michael D. McGoon | 2010 | Circulation2010，，2： | 2 |
| 4 | The effects of human-generated sound on fish显示文摘There is growing international concern about the effects of human-generated sound on fish and other aquatic or-ganisms.However,because of a striking paucity of well-designed and controlled experimental data,very little is actually known about the effects of these sounds on fish.Findings suggest that human-generated sounds,even from very high intensity sources,might have no effect in some cases or might result in effects that range from small and temporary shifts in behavior all the way to immediate death.At this point,however,it is nearly impossible to ex-trapolate from results with one sound source,one fish species,or even fish of one size to other sources,species,or fish sizes.The present paper briefly discusses the potential effects of sound on fish,describes some of the more recent well-controlled experimental studies,and points out areas for future study that will be needed before a real understanding of the effects of sound on fish can be developed. | Arthur N.POPPER Mardi C.HASTINGS | 2009 | Integrative Zoology2009，4，1： | 2 |
| 5 | The impact of next-generation sequencing technology on genetics 显示文摘 | Mardis ER | 2008 | Trends Genet2008，24，3： | 1 |
| 6 | The impact of next-generation sequencing technologyon genetics显示文摘 | Mardis ER | 2008 | Trends Genet2008，24，1： | 1 |
| 7 | DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome显示文摘 | Ley TJ Mardis ER Ding L | 2008 | Nature2008，456，7218： | 1 |
| 8 | Clinical and laboratory characteristics of patients with atherothrombotic risk factors presenting with low concentrations of highly sensitive C-reactive protein显示文摘 | ZELTSER D ROGOWSKI O MARDI T | 2004 | Atherosclerosis2004，176，2： | 1 |
| 9 | Congenital insensitivity topain with anhidrosis; novel mutations in the TRKA (NTRK1)gene encoding a high-affinity receptor for nerve growth factor显示文摘 | Mardy S Miura Y Endo F | 1999 | Am J Hum Genet1999，64，： | 1 |
| 10 | Recurring mutations found by sequencing an acute myeloid leukemia genome显示文摘 | Mardis ER Ding L Dooling DJ] | 2009 | N Engl J Med2009，361，11： | 1 |
| 11 | The impact of next-generation sequen- cing technology on genetics 显示文摘 | MARDIS E R | 2008 | Trends in Genetics2008，24，3： | 1 |
| 12 | A decade's perspective on DNA sequencing technology显示文摘 | Mardis E R | 2011 | Nature2011，470，7333： | 1 |
| 13 | Next-generation DNA sequencing methods显示文摘 | Mardis ER | 2008 | AnnuRev Genomics Hum Genet2008，9，6： | 1 |
| 14 | Recurring mutations found by sequencing an acute myeloid leukemia genome显示文摘 | Mardis ER Ding L Dooling DJ | 2009 | N EnglJ Med2009，361，11： | 1 |
| 15 | Healthy Nature Healthy People:“Contact with Nature”as an Upstream Health Promotion Intervention for Populations显示文摘 | Maller Cecily Townsend Mardie Pryor Anita | 2005 | Health Promotion International2005，21，1： | 1 |
| 16 | Ureteral stents: materials 显示文摘 | Kroeger RM | 1988 | Urol Clin Nor Amer1988，15，3： | 1 |
| 17 | Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)显示文摘 | Raymond L. Benza Dave P. Miller Mardi Gomberg-Maitland Robert P. Frantz Aimee J. Foreman Christopher S. Coffey Adaani Frost Robyn J. Barst David B. Badesch C. Gregory Elliott Theodore G. Liou Michael D. McGoon | 2010 | Circulation2010，，2： | 1 |
| 18 | DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome显示文摘 | Ley TJ Mardis EB Ding L | 2008 | Nature2008，456，6： | 1 |
| 19 | The impact of next-generation sequencing tech nology on genetics 显示文摘 | Mardis E R | 2008 | Trends G-enet2008，24，3： | 1 |
| 20 | The impact of next-generation sequencing technologyon genetjcs显示文摘 | Mardis ER | 2008 | Trends Genet2008，24，3： | 1 |
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