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| 1 | Long-term alpha interferon and lamivudine combination therapy in non-responder patients with anti-HBe-positive chronic hepatitis B:Results of an open,controlled trial显示文摘AIM: To investigate the safety and efficacy of long-term combination therapy with alpha interferon and lamivudine in non-responsive patients with anti-HBe-positive chronic hepatitis B.METHODS: 34 patients received combination treatment (1 month lamivudine, 12 month lamivudine+interferon, 6month lamivudine), 24 received lamivudine (12 months),24 received interferon (12 months). Interferon was administered at 6 MU tiw and lamivudine at 100 mg orally once daily. Patients were followed up for 6 months after treatment.RESULTS: At the end of treatment, HBV DNA negativity rates were 88 % with lamivudine+interferon, 99 % with lamivudine and 55 % with interferon, (P=0.004, combination therapy vs. interferon, and P=0.001 lamivudine vs.interferon), and serum transaminase normalization rates were 84 %, 91% and 53 % (P=0.01 combination therapy vs. interferon, and P=0.012 lamivudine vs. interferon). Six months later, HBV DNA negativity rates were 44 % with lamivudine+interferon, 33 % with lamivudine and 25 % with interferon, and serum transaminase normalization rates were 61%, 42 % and 45 %, respectively, without statistical significance. No YMDD variants were observed with lamivudine+interferon (vs. 12 % with lamivudine). The combination therapy appeared to be safe. CONCLUSION: Although viral clearance and transaminase normalization are slower with long-term lamivudine+interferon than that with lamivudine alone, the combination regimen seems to provide more lasting benefits and to protect against the appearance of YMDD variants. Studies with other regimens regarding sequence and duration are needed. | M. Francesca Jaboli Carlo Fabbri Stefania Liva Francesco Azzaroli Giovanni Nigro Silvia Giovanelli Francesco Ferrara Anna Miracolo Sabrina Marchetto Marco Montagnani Antonio Colecchia Davide Festi Letizia Bacchi Reggiani Enrico Roda Giuseppe Mazzella | 2003 | World Journal of Gastroenterology2003，9，7： | 10 |
| 2 | Microscale study of frictional properties of graphene in ultra high vacuum显示文摘We report on the frictional properties of epitaxial graphene on SiC in ultra high vacuum.Measurements have been performed using a microtribometer in the load regime of 0.5 to 1 mN.We observed that a ruby sphere sliding against graphene results in very low friction coefficients ranging from 0.02 to 0.05.The friction and also the stability of the graphene layer is higher than that under similar conditions in ambient conditions.The friction shows a load dependence.Finally it was found that graphene masks the frictional anisotropy which was observed on the SiC surface. | Diego MARCHETTO Tim FESER Martin DIENWIEBEL | 2015 | Friction2015，3，2： | 5 |
| 3 | Interference of iron as a coagulant on MIB removal by powdered activated carbon adsorption for low turbidity waters显示文摘Powered activated carbon (PAC) is widely used in water treatment plants to minimize odors in drinking water. This study investigated the removal of 2-methylisoborneol (MIB) by PAC adsorption, combined with coagulation using iron as a coagulant. The adsorption and coagulation process were studied through different case scenarios of jar tests. The analysis evaluated the effect of PAC dosing in the liquid phase immediately before or after the coagulant addition. Ferric sulphate was used as the coagulant with dosages from 10 to 30 mg/L, and PAC dosages varied from 10 to 40 mg/L. The highest MIB removal efficiency (about 70%) was achieved without the coagulant addition and with the highest PAC dosage (40 mg/L). Lower MIB removal efficiencies were observed in the presence of coagulant, showing a clear interference of the iron precipitate or coagulant in the adsorption process. The degree of interference of the coagulation process in the MIB removal was proportional to the ratio of ferric hydroxide mass to the PAC mass. For both cases of PAC dosing, upstream and downstream of the coagulant injection point, the MIB removal efficiency was similar. However, MIB removal efficiency was 15% lower when compared with experiments without the coagulant application. This interference in the MIB adsorption occurs potentially because the coagulant coats the surface of the carbon and interferes with the MIB coming in contact with the carbon's surface and pores. This constraint requires an increase of the PAC dosage to provide the same efficiency observed without coagulation. | Ferreira Filho SIDNEY SECKLER Marchetto MARGARIDA Alves Laganaro ROSEMEIRE | 2013 | Journal of Environmental Sciences2013，25，8： | 3 |
| 4 | Mechanisms Underlying Inflammation in Neurodegeneration显示文摘 | Christopher K. Glass Kaoru Saijo Beate Winner Maria Carolina Marchetto Fred H. Gage | 2010 | Cell2010，，6： | 3 |
| 5 | Assessment of the endoscopic semitendinosus/gracilis autograft procedure with interference screw fixation for reconstruction of the anterior cruciate ligament显示文摘 | Allen A D Sitler M R Marchetto P | 2001 | Orthopedics2001，24，4： | 1 |
| 6 | ERBIN:A basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor显示文摘 | Borg JP Marchetto S Le Bivic A | 2000 | Nature Cell Biol2000，2，： | 1 |
| 7 | Optimization based on bacterial chemotaxis显示文摘 | Muller SD Marchetto J Airaghi S | | 0，，01： | 1 |
| 8 | ERBIN: a basolateral PDZ protein that interacts with the mamma- lian ERBB2/HER2 receptor显示文摘 | Borg JP Marchetto S Le Bivic A | 2000 | Nat Cell Biol2000，2，7： | 1 |
| 9 | Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells显示文摘 | ROSNET O BUHRING HJ MARCHETTO S | 1996 | Leukemia1996，10，2： | 1 |
| 10 | Aggressive angiomyxoma:findings on CT and MR imaging显示文摘 | Outwater EK Marchetto BE Wagner ]3J el al | 1999 | AJR Am J Roentgenol1999，172，43： | 1 |
| 11 | Tribo- logical Effects of Surface Texturing on Nitriding Steel for High--performance Engine Applicationst显示文摘 | Borghi A Gualtieri E Marchetto D | 2008 | Wear2008，265，： | 1 |
| 12 | Optimization based on bacterial chemotaxis显示文摘 | Muller S D Marchetto J A S Koumoutsakos P | 2002 | IEEE Transaction of Evolutionary Computation2002，6，1： | 1 |
| 13 | A new coding technique for spectral shaping of data显示文摘 | Cavers J K Marchetto R F | 1992 | IEEE Transactions on Communications1992，40，9： | 1 |
| 14 | Aggressive angiomyxoma:findings on CT and MR imaging显示文摘 | Outwater EK Marchetto BE Wagner BJ | 1999 | AJR1999，172，2： | 1 |
| 15 | Optimization based on bacterial chemotaxis显示文摘 | MULLER S D MARCHETTO J A S KOUTMOUTSAKOS P | 2002 | IEEE Transaction of Evolutionary Computation2002，6，1： | 1 |
| 16 | A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells显示文摘 | Maria C.N. Marchetto Cassiano Carromeu Allan Acab Diana Yu Gene W. Yeo Yangling Mu Gong Chen Fred H. Gage Alysson R. Muotri | 2010 | Cell2010，，4： | 1 |
| 17 | Optimization Based on Bacterial Chemotaxis 显示文摘 | Muller S D J Airaghi Marchetto S Koumoutsakos P | 2002 | IEEE Transaction of Evolutionary Computation2002，6，1： | 1 |
| 18 | Aggressive angiomyx- oma:findings on CT and MR imaging 显示文摘 | Outwater K Marchetto E Wagner J | 1999 | Am J Roentgenol1999，172，： | 1 |
| 19 | Pluripotent stem cells in neu- rodegenerative and neurodevelopmental diseases 显示文摘 | Marchetto MC Winner B Gage FH | 2010 | Hum Mol Genet2010，19，： | 1 |
| 20 | Interaction with the phosphotyrosine binding domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosie kinase 显示文摘 | Fournier E Rosnet O Marchetto S | 1996 | J Biol Chem1996，271，12： | 1 |
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