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| 1 | Multipotent mesenchymal stromal cells:A promisingstrategy to manage alcoholic liver disease显示文摘Chronic alcohol consumption is a major cause of liver disease.The term alcoholic liver disease(ALD)refers to a spectrum of mild to severe disorders including steatosis,steatohepatitis,cirrhosis,and hepatocellular carcinoma.With limited therapeutic options,stem cell therapy offers significant potential for these patients.In this article,we review the pathophysiologic features of ALD and the therapeutic mechanisms of multipotent mesenchymal stromal cells,also referred to as mesenchymal stem cells(MSCs),based on their potential to differentiate into hepatocytes,their immunomodulatory properties,their potential to promote residual hepatocyte regeneration,and their capacity to inhibit hepatic stellate cells.The perfect match between ALD pathogenesis and MSC therapeutic mechanisms,together with encouraging,available preclinical data,allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage ALD onset and progression. | Fernando Ezquer Flavia Bruna Sebastián Calligaris Paulette Conget Marcelo Ezquer | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 2 | Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?显示文摘Multipotent mesenchymal stromal cells [also referred to as mesenchymal stem cells(MSCs)] are a heterogeneous subset of stromal cells. They can be isolated from bone marrow and many other types of tissue. MSCs are currently being tested for therapeutic purposes(i.e., improving hematopoietic stem cell engraftment, managing inflammatory diseases and regenerating damaged organs). Their tropism for tumors and inflamed sites and their context-dependent potential for producing trophic and immunomodulatory factors raises the question as to whether MSCs promote cancer and/or infection. Thisarticle reviews the effect of MSCs on tumor establishment, growth and metastasis and also susceptibility to infection and its progression. Data published to date shows a paradoxical effect regarding MSCs, which seems to depend on isolation and expansion, cells source and dose and the route and timing of administration. Cancer and infection may thus be adverse or therapeutic effects arising form MSC administration. | Martha L Arango-Rodriguez Fernando Ezquer Marcelo Ezquer Paulette Conget | 2015 | World Journal of Stem Cells2015，7，2： | 2 |
| 3 | Systemic Administration of Multipotent Mesenchymal Stromal Cells Reverts Hyperglycemia and Prevents Nephropathy in Type 1 Diabetic Mice显示文摘 | Fernando E. Ezquer Marcelo E. Ezquer Daniela B. Parrau Daniel Carpio Alejandro J. Ya?ez Paulette A. Conget | 2008 | Biology of Blood and Marrow Transplantation2008，，6： | 1 |
| 4 | Endovenous Administration of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells Prevents Renal Failure in Diabetic Mice显示文摘 | Fernando Ezquer Marcelo Ezquer Valeska Simon Fabian Pardo Alejandro Ya?ez Daniel Carpio Paulette Conget | 2009 | Biology of Blood and Marrow Transplantation2009，，11： | 1 |
| 5 | Systemic Administration of Multipotent Mesenchymal Stromal Cells Reverts Hyperglycemia and Prevents Nephropathy in Type 1 Diabetic Mice显示文摘 | Fernando E. Ezquer Marcelo E. Ezquer Daniela B. Parrau Daniel Carpio Alejandro J. Ya?ez Paulette A. Conget | 2008 | Biology of Blood and Marrow Transplantation2008，，6： | 1 |
| 6 | The Antidiabetic Effect of Mesenchymal Stem Cells Is Unrelated to Their Transdifferentiation Potential But to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment显示文摘 | Fernando Ezquer Marcelo Ezquer David Contador Micaela Ricca Valeska Simon Paulette Conget | 2012 | STEM CELLS2012，，8： | 1 |
| 7 | Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome显示文摘 | Marcelo Ezquer Fernando Ezquer Micaela Ricca Carolina Allers Paulette Conget | 2011 | Journal of Hepatology2011，，5： | 1 |
| 8 | The Antidiabetic Effect of Mesenchymal Stem Cells Is Unrelated to Their Transdifferentiation Potential But to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment显示文摘 | Fernando Ezquer Marcelo Ezquer David Contador Micaela Ricca Valeska Simon Paulette Conget | 2012 | STEM CELLS2012，，8： | 1 |
| 9 | Systemic Administration of Multipotent Mesenchymal Stromal Cells Reverts Hyperglycemia and Prevents Nephropathy in Type 1 Diabetic Mice显示文摘 | Fernando E. Ezquer Marcelo E. Ezquer Daniela B. Parrau Daniel Carpio Alejandro J. Ya?ez Paulette A. Conget | 2008 | Biology of Blood and Marrow Transplantation2008，，6： | 1 |
| 10 | Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus显示文摘A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy,but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the disease on both transporters in type 1 diabetes mellitus(T1DM).We used eight-week-old male C57BL/6 mice divided into two groups;one of them received the vehicle(control group),while the other received the vehicle+200 mg/kg streptozotocin(T1DM).Ten weeks after the injection,we evaluated plasma insulin,enzymuria,urinary vitamin D-binding protein(VDBP),tubulointerstitial fibrosis and proximal tubule histology,markers of autophagy,and megalin and cubilin levels.We found a reduction in tubular protein reabsorption(albumin and VDBP as specific substances carried by both transporters)with increased tubulointerstitial injury,development of fibrosis,thickening of tubular basement membrane,and an increase in tubular cell metalloproteases.This was associated with a decrease in the renal expression of megalin and cubilin.We also observed an increase in the amount of cellular vesicles of the phagocytic system in the tubules,which could be linked to an alteration of normal intracellular trafficking of both receptors,thus affecting the normal function of transporters in early stages of diabetic nephropathy.In diabetic animals,the added effects of tubulointerstitial injury,the decreases in megalin and cubilin expression,and an altered intracellular trafficking of these receptors,seriously affect protein reabsorption. | Maximiliano GIRAUD-BILLOUD Fernando EZQUER Javiera BAHAMONDE Marcelo EZQUER | 2017 | BIOCELL2017，41，1： | 0 |
| 11 | Diabetic nephropathy,autophagy and proximal tubule protein endocytic transport:A potentially harmful relationship显示文摘Diabetic nephropathy(DN)is the most frequent cause of chronic renal failure.Until now,the pathophysiological mechanisms that determine its development and progression have not yet been elucidated.In the present study,we evaluate the role of autophagy at early stages of DN,induced in type 2 diabetes mellitus(T2DM)mouse,and its association with proximal tubule membrane endocytic receptors,megalin and cubilin.In T2DM animals we observed a tubule-interstitial injury with significantly increased levels of urinary GGT and ALP,but an absence of tubulointerstitial fibrosis.Kidney proximal tubule cells of T2DM animals showed autophagic vesicles larger than those observed in the control group,and an increase in the number of these vesicles marked with LBPA by immunofluorescence.Furthermore,a significant decrease in the ratio of LC3II/LC3I isoforms and in p62 protein expression in DN affected animals is shown.Finally,we observed a marked increase in urinary albumin and vitamin D binding-protein levels in T2DM animals as well as a significant decrease in expression of megalin in the renal cortex.These results indicate an alteration of the tubular endocytic transporters in DN,which could be related to autophagic dysfunction,which would in turn result in impaired organelle recycling,thus contributing to the progression of this disease. | Maximiliano GIRAUD-BILLOUD Claudio M.FADER Rocío AGÜERO Fernando EZQUER Marcelo EZQUER | 2018 | BIOCELL2018，42，2： | 0 |
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