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| 1 | Multipotent mesenchymal stromal cells:A promisingstrategy to manage alcoholic liver disease显示文摘Chronic alcohol consumption is a major cause of liver disease.The term alcoholic liver disease(ALD)refers to a spectrum of mild to severe disorders including steatosis,steatohepatitis,cirrhosis,and hepatocellular carcinoma.With limited therapeutic options,stem cell therapy offers significant potential for these patients.In this article,we review the pathophysiologic features of ALD and the therapeutic mechanisms of multipotent mesenchymal stromal cells,also referred to as mesenchymal stem cells(MSCs),based on their potential to differentiate into hepatocytes,their immunomodulatory properties,their potential to promote residual hepatocyte regeneration,and their capacity to inhibit hepatic stellate cells.The perfect match between ALD pathogenesis and MSC therapeutic mechanisms,together with encouraging,available preclinical data,allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage ALD onset and progression. | Fernando Ezquer Flavia Bruna Sebastián Calligaris Paulette Conget Marcelo Ezquer | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 2 | Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?显示文摘Multipotent mesenchymal stromal cells [also referred to as mesenchymal stem cells(MSCs)] are a heterogeneous subset of stromal cells. They can be isolated from bone marrow and many other types of tissue. MSCs are currently being tested for therapeutic purposes(i.e., improving hematopoietic stem cell engraftment, managing inflammatory diseases and regenerating damaged organs). Their tropism for tumors and inflamed sites and their context-dependent potential for producing trophic and immunomodulatory factors raises the question as to whether MSCs promote cancer and/or infection. Thisarticle reviews the effect of MSCs on tumor establishment, growth and metastasis and also susceptibility to infection and its progression. Data published to date shows a paradoxical effect regarding MSCs, which seems to depend on isolation and expansion, cells source and dose and the route and timing of administration. Cancer and infection may thus be adverse or therapeutic effects arising form MSC administration. | Martha L Arango-Rodriguez Fernando Ezquer Marcelo Ezquer Paulette Conget | 2015 | World Journal of Stem Cells2015，7，2： | 2 |
| 3 | MSC transplanta-tion :a promising therapeutic strategy to manage the onsetand progression of diabetic nephropathy 显示文摘 | Ezquer ME Ezquer FE Martha L | 2012 | Biol Res2012，45，： | 1 |
| 4 | The antidiabetic effect of mesenchymal stem ceils is unrelated to their transdifferentiation po- tential but to their capability to restore Th1/Th2 balance and to modify the pancreatic microenvironment显示文摘 | Ezquer F Ezquer M Contador D | 2012 | Stem Cells2012，30，8： | 1 |
| 5 | Predicted and Measured Total Electron Content at Both Peaks of the Equatorial Anomaly 显示文摘 | Ezquer R G | 1994 | Radio Sci1994，29，4： | 1 |
| 6 | Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice显示文摘 | Ezquer FE Ezquer ME Parrau DB | 2008 | Biol Blood Marrow Transplant2008，14，6： | 1 |
| 7 | VTEC Be-haviour in the American Sector During High Solar Activity显示文摘 | EZQUER R G BRUNINI C MEZA A | 2004 | Advances in Space Research2004，33，： | 1 |
| 8 | The antidiabetic effect of MSCs is not impaired by insulin prophylaxis and is not improved by a second dose of cells显示文摘 | Ezquer F Ezquer M Simon V | | 0，，01： | 1 |
| 9 | Endovenous administration of bone-marrow-derived multipotent mesenchymal stromal cells prevents renal failure in diabetic mice显示文摘 | Ezquer F Ezquer M Simon V | 2009 | Biol Blood Marrow Transplant2009，15，11： | 1 |
| 10 | On the IRI 2007performance as a TEC predictor for the South American sector显示文摘 | SCIDA L A EZQUER R G CABRERA M A | 2012 | Journal of Atmospheric and Solar-Terrestrial Physics2012，81，： | 1 |
| 11 | Behaviour of ionospheric magnitudes of F2region over Tucuman during a deep solar minimum and comparison with the IRI 2012model predictions显示文摘 | EZQUER R G LOPEZ J L SCIDA L A | 2014 | Journal of Atmospheric and SolarTerrestrial Physics2014，107，： | 1 |
| 12 | The antidiabetie effect of mesenchymal stem cells is unrelated to their transdifferentiation potential but to their capability to restore Thl/Th2 balance and to modify the pancreatic 显示文摘 | Ezquer F Ezquer M Contador D | 2012 | Stem Cells2012，30，8： | 1 |
| 13 | The antidiabetic effect of mesenchymal stem cells is unrelated to their transdifferentiation potential but to their capability to restore Th1/Th2 balance and to modify the pancreatic microenvironment显示文摘 | Ezquer F Ezquer M Contador D | | 0，，08： | 1 |
| 14 | Systemic administration of multipotent mesenchymal stromal ceils hyperglycemia and prevents nephropathy in type I diabetic mice 显示文摘 | Ezquer FE Ezquer ME Parrau DB | 2008 | Biol Blood Marrow Transplant2008，14，6： | 1 |
| 15 | Advancement of reproductive senescence and changes in the early expression of estrogen, progesterone and micro-opioid receptors induced by neonatal hypoxia in the female rat显示文摘 | Ezquer ME Valdez SR Seltzer AM | 2008 | Brain Res2008，1214，6： | 1 |
| 16 | Preductaland post-duc- tal Oz satm'ation in healthy term neonates after birth 显示文摘 | Mariani G Dik PB Ezquer A | 2007 | J Pe- diatr2007，150，4： | 1 |
| 17 | The antidiabeticeffect of mesenchymal stem cells is unrelated to their transdifferentiation potential but to their capability to restoreThl/Th2 balance and to modify the pancreatic microenviron-ment 显示文摘 | Ezquer F Ezquer M Contador D | 2012 | Stem Cell2012，30，8： | 1 |
| 18 | Hypothyroidism prolongs corpus luteum function in the pregnant rat显示文摘 | Hapon MB Mottal AB Ezquer Ama | 2007 | Reproduction2007，133，1： | 1 |
| 19 | Predicted and measured total electron content at both peaks of the equa- torial anomaly 显示文摘 | Ezquer R G de Adler N O Heredia T | 1994 | Radio Science1994，29，4： | 1 |
| 20 | MSC transplanta-tion:a promising therapeutic strategy to manage the onset and progres-sion of diabetic nephropathy显示文摘 | Ezquer ME Ezquer FE Arango-Rodriquez ML | | 0，，： | 1 |
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