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| 1 | Multipotent mesenchymal stromal cells:A promisingstrategy to manage alcoholic liver disease显示文摘Chronic alcohol consumption is a major cause of liver disease.The term alcoholic liver disease(ALD)refers to a spectrum of mild to severe disorders including steatosis,steatohepatitis,cirrhosis,and hepatocellular carcinoma.With limited therapeutic options,stem cell therapy offers significant potential for these patients.In this article,we review the pathophysiologic features of ALD and the therapeutic mechanisms of multipotent mesenchymal stromal cells,also referred to as mesenchymal stem cells(MSCs),based on their potential to differentiate into hepatocytes,their immunomodulatory properties,their potential to promote residual hepatocyte regeneration,and their capacity to inhibit hepatic stellate cells.The perfect match between ALD pathogenesis and MSC therapeutic mechanisms,together with encouraging,available preclinical data,allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage ALD onset and progression. | Fernando Ezquer Flavia Bruna Sebastián Calligaris Paulette Conget Marcelo Ezquer | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 2 | Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?显示文摘Multipotent mesenchymal stromal cells [also referred to as mesenchymal stem cells(MSCs)] are a heterogeneous subset of stromal cells. They can be isolated from bone marrow and many other types of tissue. MSCs are currently being tested for therapeutic purposes(i.e., improving hematopoietic stem cell engraftment, managing inflammatory diseases and regenerating damaged organs). Their tropism for tumors and inflamed sites and their context-dependent potential for producing trophic and immunomodulatory factors raises the question as to whether MSCs promote cancer and/or infection. Thisarticle reviews the effect of MSCs on tumor establishment, growth and metastasis and also susceptibility to infection and its progression. Data published to date shows a paradoxical effect regarding MSCs, which seems to depend on isolation and expansion, cells source and dose and the route and timing of administration. Cancer and infection may thus be adverse or therapeutic effects arising form MSC administration. | Martha L Arango-Rodriguez Fernando Ezquer Marcelo Ezquer Paulette Conget | 2015 | World Journal of Stem Cells2015，7，2： | 2 |
| 3 | Mensenchymal progenitor cells in human umbilical cord blood 显示文摘 | Erices A Conget P Minguell JJ | 2000 | Br J Haematol2000，109，： | 2 |
| 4 | Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells显示文摘 | Conget P Minguell JJ | 1999 | J Cell Physiol1999，181，： | 2 |
| 5 | Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells显示文摘 | Minguell JJ | 1999 | J Cell Physiol1999，181，1： | 1 |
| 6 | Short-term clinical outcome after acute symptomatic pulmonary embolism显示文摘 | Conget F Otero R Jiménez D | 2008 | Thromb Haemost2008，100，5： | 1 |
| 7 | Pbenotype and functional properties of human bone mesencbymal progenitor cells显示文摘 | Conget PA Minguell JJ | 1999 | J Cell Physiol1999，181，1： | 1 |
| 8 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conget P | 2001 | Exp Biol Med2001，226，6： | 1 |
| 9 | Mesenchymal progenitor cells in human umbilical cord blood 显示文摘 | Erices A Conget P Minguell JJ | 2000 | Br J Haematol2000，109，： | 1 |
| 10 | Phenotypical and functional properties ofhuman bone marrow mesenchymal progenitor cells显示文摘 | Conget PA Minguell JJ | 1999 | J CellPhysiol1999，181，1： | 1 |
| 11 | Mesenchymal progenitor cells in human umbilical cord blood显示文摘 | Erices A Conget P Minguell JJ | 2000 | Br J Haematol2000，109，1： | 1 |
| 12 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conget P | 2001 | Exp Biol Med(Maywod)2001，226，6： | 1 |
| 13 | Mesenchymal stem cells 显示文摘 | Minguell J Erices A Conget P | 2001 | Ezp Biol Med2001，，： | 1 |
| 14 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conget P | | 0，，： | 1 |
| 15 | Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells显示文摘 | Conget PA Minguell JJ | 1999 | J Cell Physiol1999，181，1： | 1 |
| 16 | Uric acid concentration in subjects at risk of type 2 diabetes mellitus: Relationship to components of the metabolic syndrome显示文摘 | A. Costa I. Igual J. Bedini L. Quint I. Conget | 2002 | Metabolism2002，，3： | 1 |
| 17 | Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells 显示文摘 | Conget PA Mingue JJ | 1999 | J Cell Physiol1999，181，1： | 1 |
| 18 | Mesenchymal Stem Cells显示文摘 | Minguell J Erices A Conget P | 2001 | Exp Biol Med2001，226，6： | 1 |
| 19 | Phenotypicaland functional properties of human bonemarrow mesenchymal progenitor cells显示文摘 | Conget PA Minguell JJ | 1999 | J Cell Physiol1999，181，1： | 1 |
| 20 | Mesenchymal stem cells 显示文摘 | Minguell JJ Erices A Conget P | 2003 | Hum Ce112003，16，1： | 1 |
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