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| 1 | Pathogenesis of occult chronic hepatitis B virus infection显示文摘Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological patterns.Occult HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene expression.OBI is an entity with world-wide diffusion.The failure to detect HBsAg,despite the persistence of the viral DNA,is due in most cases to the strong suppression of viral replication and gene expression that characterizes this'occult'HBV infection;although the mechanisms responsible for suppression of HBV are not well understood.The majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV infection.Much evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma. | Rocio Aller de la Fuente María L Gutiérrez Javier Garcia-Samaniego Conrado Fernández-Rodriguez Jose Luis Lledó Gregorio Castellano | 2011 | World Journal of Gastroenterology2011，17，12： | 12 |
| 2 | A half century (1961-2011) of applying microsurgery to experimental liver research显示文摘The development of microsurgery has been dependent on experimental animals. Microsurgery could be a very valuable technique to improve experimental models of liver diseases. Microdissection and microsutures are the two main microsurgical techniques that can be considered for classifying the experimental models developed for liver research in the rat. Partial portal vein ligation, extrahepatic cholestasis and hepatectomies are all models based on microdissection. On the other hand, in portacaval shunts, orthotopic liver transplantation and partial heterotopic liver transplantation, the microsuture techniques stand out. By reducing surgical complications, these microsurgical techniques allow for improving the resulting experimental models. If good experimental models for liver research are successfully developed, the results obtained from their study might be particularly useful in patients with liver disease. Therefore experimental liver microsurgery could be an invaluable way to translate laboratory data on liver research into new clinical diagnostic and therapeutic strategies. | Maria-Angeles Aller Natalia Arias Isabel Prieto Salvador Agudo Carlos Gilsanz Laureano Lorente Jorge-Luis Arias Jaime Arias | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 3 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 4 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 5 | Study of gastrointestinal transit times with capsule endoscopy 显示文摘 | Velayos Jimenez B Fernandez Salazar L Aller de la Fuente R | 2005 | Gastroenterol Hepatol2005，28，6： | 1 |
| 6 | Sediment ammonium availability and eelgrass (Zostera marina ) growth显示文摘 | Dennison W C Aller R C Alberte R S | 1987 | Marine Biology1987，94，3： | 1 |
| 7 | 显示文摘 | Aller E Brown D S Cox G G | 1995 | J Org Chem1995，60，： | 1 |
| 8 | Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinasdmTOR inhibitor显示文摘 | Van Aller G S Carson J D Tang W | 2011 | Biochem Biophys Res Cornmun2011，406，2： | 1 |
| 9 | Partial hepatectomy, partial portal vein stenosis and mesenteric lymphadenectomy increase splanchnic mast cell infiltration in the rat显示文摘 | Luis M. Moquillaza María-Angeles Aller Maria-Paz Nava Luis Santamaría Patri Vergara Jaime Arias | 2009 | Acta Histochemica2009，，4： | 1 |
| 10 | Wind speed estimation based sensorless output maximization control for a wind turbine driving a DFIG 显示文摘 | QIAO W ZHOU W ALLER J M HARLEY R G | 2008 | IEEE Transactions on Industrial Electronics2008，23，3： | 1 |
| 11 | Effect of two different hypocaloric diets in transaminases and insulin resistance in nonalcoholic fatty liver disease and obese patients显示文摘 | de Luis DA Aller R Izaola O | 2010 | Nutr Hosp2010，25，5： | 1 |
| 12 | Optical and radio variability of the BL Lacertae object AO 0235 + 16: A possible5-6 year periodicity 显示文摘 | Raiteri C M Villata M Aller H D | 2001 | Astronomy and Astrophysics2001，377，： | 1 |
| 13 | Ammonium adsorption in marine sediments显示文摘 | MACKIN J E ALLER R C | 1984 | Limnology and Oceanography1984，29，2： | 1 |
| 14 | Ultrasound guided combined cryoablation and microencapsulated 5-Fluorouracil inhibits growth of human prostate tumors in xenogenic mouse model assessed by luminescence imaging显示文摘 | Le Pivert P Haddad RS Aller A | 2004 | Technol Cancer Res Treat2004，3，2： | 1 |
| 15 | Diffusion coefficients in nearshore marine sediments 显示文摘 | Ullman W S Aller R C | 1982 | Limnology and Oceanography1982，27，： | 1 |
| 16 | Effects of oxygen and redox oscillation on degradation of cell associated lipids in surficial marine sediments 显示文摘 | Sun M Y Aller R C Lee C | 2002 | Geochim Cosmoehim Acta2002，66，： | 1 |
| 17 | Bile duct ligation: step - by - step to cholangiocyte inflammatory tumorigenesis 显示文摘 | Aller MA Arias JL Prieto I | 2010 | Eur J Gastroenterol Hepatol2010，22，6： | 1 |
| 18 | Diffusion coefficients in nearshore marine sediments 显示文摘 | Ullman W J Aller R C | 1982 | Limnology and Oceanography1982，27，： | 1 |
| 19 | Spectra and linear polarizations of extragalactic variable sources at centimeter wavelengths显示文摘 | Aller H D Aller M F Latimer G E | 1985 | ApJS1985，59，： | 1 |
| 20 | Transport and transformation of dissolved and particulate materials on conti- nental margins influenced by major rivers: benthic boundary layer and seabed processes 显示文摘 | Mekee B A Aller R C Allison M A | 2004 | Continental Shelf Research2004，24，78： | 1 |
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