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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | RF-superimposed DC and pulsed DC sputte- ring for deposition of transparent conductive ox- ides显示文摘 | MICHAEL S JOACHIM M MANFRED R | 2007 | Thin Solid Films2007，515，19： | 1 |
| 3 | Effect of CO2 and steam gasification reactions on the oxy- combustion of pulverized coal char显示文摘 | Ethan S H Christopher R S Manfred G | 2012 | Combustion and Flame2012，159，11： | 1 |
| 4 | Quantitative Assessment of Portal Vein Flow in sunbjects with Active Chronic Hepatitis:Comparison of Magnetic Resonance Angiography with Bolus Tracking with Color Doppler Ultrasonography显示文摘 | Manfred R Barbaro B Prudenzano R | 1999 | Radio Med1999，97，3： | 1 |
| 5 | HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘 | Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe | 2010 | Virchows Archiv2010，，3： | 1 |
| 6 | Measuring anterior chamber depth with the orbscan topography system显示文摘 | Manfred R Yaser B | 1997 | J Cataract Refract Surg1997，23，9： | 1 |
| 7 | Exp Soluble collagen Ⅵinduces tyrosine phosphorylation of paxillin and focal adhesion kinase and activaesthe MAP kinase erk2 in fibroblasts显示文摘 | Martin R Manfred J Jane A | 1999 | Cell Res1999，250，2： | 1 |
| 8 | Role of Kupffer cells in host defense and liver diseasep 显示文摘 | Manfred B Frigga R Alexander LG | 2006 | Liver Int2006，26，10： | 1 |
| 9 | Varicella-zoster virus does not signicantly induce the cell defence mechanism mediated by the 2- 5A/RNase L pathway during显示文摘 | Nathalie D Markus R Manfred H | 2005 | Med Microbiol Immunol2005，194，6： | 1 |
| 10 | Soluble collagen Ⅵ drives serumstarved fibroblasts through S phase and prevents apottosis via down-regulation of Bax显示文摘 | Martin R Ergun S Manfred J | 1999 | J Biol Chem1999，274，34： | 1 |
| 11 | Endoscopic ul- trasonography for diagnosis and staging of pancreatic adenocarci- noma: key messages for clinicians显示文摘 | DE ANGELIS C MANFRE SF PELLICANO R | 2014 | Minerva Medica2014，105，2： | 1 |
| 12 | An efficient multiplexgenotyping approach for detecting the major worldwide humanY-chromosome haplogroup显示文摘 | Mannis V O Arwin R Manfred K | 2011 | Int J Legal Med2011，125，： | 1 |
| 13 | HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘 | Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe | 2010 | Virchows Archiv2010，，3： | 1 |
| 14 | Free of water tanning using CO2 as process additive -An overview on the process development显示文摘 | Manfred R Eckhard W Bijoem J | 2012 | J- of Supercriti- cal Fluids2012，66，： | 1 |
| 15 | MR dacryocystography:comparison with dacryocystography and CT dacryocystography显示文摘 | Manfrè L de Maria M Todaro E Mangiameli A Ponte F Lagalla R | | 0，，06： | 1 |
| 16 | The paleozoic origin of eymatic lignin decomposition reconstructed from 31 fungal genomes显示文摘 | Dimitfios F Manfred B Robert R | 2012 | Science2012，338，29： | 1 |
| 17 | Poppy seed consumption and toxicological analysis of blood and urine samples显示文摘 | Manfred R Moeller Karin Hammer Oliver Engel | 2004 | Forensic Science International2004，，： | 1 |
| 18 | Prog Polm Sci显示文摘 | Manfred R Manfred A Eberhard B | 2002 | 27:11952002，27，： | 1 |
| 19 | Chromatin-remode- ling factors allow differentiation of bone marrow cells into insulin-producing cells 显示文摘 | Tayaramma T Bin M Manfred R | 2006 | Stem Cells2006，24，12： | 1 |
| 20 | P159 is a proteolytically processed,surface adhesin of Mycoplasma hyopneumoniae:defined domains of P159 bind heparin and promote adherence to eukaryote cells显示文摘 | TRACEY A KATRIN D MANFRED R | 2006 | Mol Microbiol2006，60，3： | 1 |
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