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| 1 | Cell-block procedure in endoscopic ultrasound-guided-fine-needle-aspiration of gastrointestinal solid neoplastic lesions显示文摘In the present review we have analyzed the clinical applications of endoscopic ultrasound-guided-fineneedle-aspiration(EUS-FNA) and the methodological aspects obtained by cell-block procedure(CBP) in the diagnostic approach to the gastrointestinal neoplastic pathology. CBP showed numerous advantages in comparison to the cytologic routine smears; in particular, better preservation of cell architecture, achievement of routine haematoxylin-eosin staining equivalent to histological slides and possibility to perform immunohistochemistry or molecular analyses represented the most evident reasons to choose this method. Moreover, by this approach, the differential diagnosis of solid gastrointestinal neoplasias may be more easily achieved and the background of contaminant nonneoplastic gastrointestinal avoided. Finally, biological samples collected by EUS-FNA CBP-assisted should be investigated in order to identify and quantify further potential molecular markers. | Antonio Ieni Valeria Barresi Paolo Todaro Rosario Alberto Caruso Giovanni Tuccari | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，11： | 6 |
| 2 | Endoscopic ultrasound-guided fine-needle aspiration cytology in pancreaticobiliary carcinomas:diagnostic efficacy of cell-block immunocyto-chemistry显示文摘BACKGROUND:Endoscopic ultrasound-guided fine-needle aspiration cytology was demonstrated to be a useful tool for the diagnosis and staging of pancreaticobiliary neoplastic lesions.Nonetheless,the diagnostic value of this procedure may be limited by low cellularity of the specimen,contamination of intestinal cells and unfeasibility of ancillary immunocytochemical procedures.The present study was to evaluate its usefulness in the diagnosis of neoplastic lesions.METHODS:A series of 46 pancreaticobiliary carcinomas with available cell block preparations was submitted to immunocytochemistry against cytokeratins,carcinoembryonic antigen,E-cadherin,CD10 and p53.The sensitivity,specificity,positive and negative predictive values of the cytological smear in the discrimination of malignant lesions were calculated and compared with those of cell block preparation with the immunocytochemical stains against p53 and CD10.RESULTS:According to our findings,the use of cell block preparations together with immunostains against p53 and CD10allowed to discriminate malignant versus benign specimens with higher sensitivity than the only cytological examination.In detail,CD10 immunostaining was of significant help for the discrimination between cytological contaminants,such as benign gastrointestinal cells,and the neoplastic elements of pancreaticobiliary well differentiated adenocarcinomas.Also,intense nuclear immunoreactivity for p53 was encountered in about 2/3 of the cases and identified pancreatic malignancy with high sensitivity.CONCLUSIONS:We suggest that immunocytochemistry against both CD10 and p53 could be applied case by case,mainly to differentiate gastrointestinal and pancreatic benign cellular contaminants showing hyperplasia or reactive changes from differentiated pancreaticobiliary adenocarcinomas. | Antonio Ieni Paolo Todaro Stefano Francesco Crinò Valeria Barresi Giovanni Tuccari | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，3： | 4 |
| 3 | CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis显示文摘 | Matilde Todaro Miriam Gaggianesi Veronica Catalano Antonina Benfante Flora Iovino Mauro Biffoni Tiziana Apuzzo Isabella Sperduti Silvia Volpe Gianfranco Cocorullo Gaspare Gulotta Francesco Dieli Ruggero De Maria Giorgio Stassi | 2014 | Cell Stem Cell2014，，3： | 3 |
| 4 | Mechanisms underlying lineage commitment and plasticity of human yo T cells显示文摘Phenotypic 和功能的异质是受动器和记忆 T 房间的特点。在抗原刺激之上, γ δT 房间区分进记忆 T 房间的二种主要类型:中央记忆房间,它巡逻血和第二等的淋巴的机关,和受动器记忆房间,它移居到外部纸巾。γ δT 房间在他们在常规 CD4 T 房间被观察的使人想起那的函数在 vitro 显示粘性的某个度。类似于 CD4 T 房间,在哪个专业化子集的过多影响主人反应, γ δT 房间可以乐意地并且很快假定不同 Th1- , Th2- , Th17- , T FH 和 T 象规章一样受动器功能,建议他们深刻地影响调停房间、体液的有免疫力的回答。除了在 cytokine 全部剧目的差别, γ δT 房间在 homing 展出差异,例如到淋巴节点滤泡的移植,到到煽动的纸巾的帮助 B 房间对移植。这里,我们考察我们 γ 的当前的理解; δT 房间系异质和灵活性与人的系统上的一个重音,并且建议受动器 γ 的一个分类; δT 房间基于不同功能的显型。 | Nadia Caccamo Matilde Todaro Guido Sireci Serena Meraviglia Giorgio Stassi Francesco Dieli | 2013 | Cellular & Molecular Immunology2013，10，1： | 2 |
| 5 | NF-kappaB protects Behcet's disease T cells against CD95-induced apoptosls up-regulating antlapoptotic proteins显示文摘 | Todaro M Zerilli M Triolo G | 2005 | Arthrit Rheum2005，52，7： | 1 |
| 6 | Fas/FasL-driven T cell apoptosis as a consequence of ineffective thyroid immunoprivillege in Hashimoto's thyroidits显示文摘 | Stassl G Todaro M Bucchierl F | 1996 | J Immunol1996，162，： | 1 |
| 7 | “Migration,Unemployment and Development:A Two-Sectors Analysis”显示文摘 | Harris J Todaro M. P | | 0，，： | 1 |
| 8 | Tumorigenic and metastatic activity of human thyroid cancer stem cells显示文摘 | Todaro M Iovino F Eterno V | | 0，，21： | 1 |
| 9 | Laserpulse heating of gun bore coatings显示文摘 | COTE P J KENDALL G TODARO M E | 2001 | Surface CoatingTechnology2001，，： | 1 |
| 10 | Migration,unemployment and development:a two sector analysis显示文摘 | HARRIST J R TODARO M P | 1970 | American Economic Review1970，，1： | 1 |
| 11 | Acute exposure to vanadium containing dusts: the health effects and biological monitoring in a group of workers employed in bouler maintenance 显示文摘 | Todaro A | 1991 | Med Lay1991，82，2： | 1 |
| 12 | A Model of Labor Migration and Urban Unemployment in Less Developed Countries 显示文摘 | Michael Todaro P | 1969 | The American Economic Review1969，，1： | 1 |
| 13 | Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity显示文摘 | Verneulen L Todaro M de Sousa Mello F | | 0，，： | 1 |
| 14 | Gun boreerosion mechanisms revisited with laser pulse heating显示文摘 | COTE P J TODARO M E KENDALL G | 2003 | Surface and Coatings Technology2003，163，： | 1 |
| 15 | Migration, unemployment and development : a two-sector analysis 显示文摘 | HARRIS J TODARO M P | 1970 | American Economic Review1970，60，1： | 1 |
| 16 | A Model of Labor Migration and Urban Unemploy- ment in Less Developed Countries显示文摘 | Todaro M P | 1969 | The American Economic Re- view1969，59，1： | 1 |
| 17 | “A Model of Labor Migration and urban unemployment in Less Developed Countries”显示文摘 | Todaro M. P | | 0，，01： | 1 |
| 18 | Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4显示文摘 | Todaro M Alea MP Di Stefano AB | | 0，，04： | 1 |
| 19 | A Model of Labor Migration and Urban Unem- ployment in Less Developed Countries 显示文摘 | Todaro M P | 2002 | American Eco- nomic Review2002，59，1： | 1 |
| 20 | Migration, unemployment and development: a two - sector analysis 显示文摘 | Harris J R Todaro M P | 1970 | American Economic Review1970，60，： | 1 |
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