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1Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels 2010World Journal of Gastroenterology2010,16,6:11
2Environmentally decoupled sds-wave Josephson junctions for quantum computing显示文摘Ioffe L B Geshkenbein V B Feigel'man M V 1999Nature(London)1999,398,:1
3Analysis of raw meats and fats of pigs using polymerase chain reaction for Halal authentication 显示文摘Aida A A Che Man Y B Wong C M V L 2005Meat Science2005,69,:1
4Crop salt tolerance-current assessment显示文摘Maas E V Hof man G J 0,,02:1
5Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses显示文摘Manning A Russell V Eastick K 2006J Infect Dis2006,194,9:1
6Coal Char Thermal Deactivation Under Pulverized Fuel Combustion Conditions显示文摘Russell N V Gibbins J R Man C K 2000Energy Fuels2000,14,4:1
7Theory of collective flux creep显示文摘Feigel’man M V Geshkenbein V B Larkin A I 1989Phys Rev Lett1989,63,:1
8The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M 2010Science2010,330,6010:1
9Conjugated linoleic acid inhibits differentiation of pre- and post-confluent 3T3- L1 preadipocytes but inhibits cell proliferation only in preconfluent cells显示文摘Brodie A E Manning V A Ferguson K R 1999J Nutr1999,129,:1
10Work Group Diversity and Group Per?formance: An Integrative Model and Research Agenda显示文摘V AN KNIPPENBERG D DE DREU C K W HO?MAN A C 2004Journal of Applied Psychology2004,89,6:1
11the problem of 45 degree embrittlement of low-alloy sheet molybdenum显示文摘Mil'man Y V Rachek A P Kurdyumov G G 1979Fiz Metal MetaUoved1979,48,2:1
12Proximity-induced Superconductivity in Graphene显示文摘Feigel' man M V Skvortsov M A Tikhonov K S 2008JETP Lett2008,88,11:1
13Role of marine reserves in recruitment to reef fisheries: a metapopulation model显示文摘Man A Law R Polunin N V C 1995Biol Conserv1995,71,:1
14Epidemiological profile and clinical associa- tions of human Bocavirus and other human parvoviruses显示文摘Manning A Russell V Eastick K Leadbetter GH Hallam N Templeton K 2006J In- fect Dis2006,194,9:1
15Conjugated linoleic acid inhibits differentiation of pre-and post-confluent 3T3-L1 preadipocytes but inhibits cell proliferation only preconfluent cells显示文摘Brodie A E Manning V A Ferguson K R 1999J Nutr1999,129,:1
16Obesity,sleep apnea,and hypertension显示文摘WOLK R SHAMSUZZfi MAN A S SOMERS V K 2003Hyperten- sion2003,42,:1
17A Cross-Category Model of Households' Incidence and Quantity Decisions显示文摘NIRAJ R PADMANABHAN V SEETHARA MAN P B 2008Marketing Sci- ence2008,27,2:1
18Phase-stabilizwd two-dimensional electronic spectroscopy显示文摘Brixner T Man?al T Stiopkin I V Fleming G R 0,,09:1
19Detection of endog- enous tissue factor levels in plasma using the calibra- ted automated thrombogram assay显示文摘Ollivier V Wang J Manly I) 2010Thromb Res2010,125,:1
20Elevated temperature aluminum alloys produced by water atomization 显示文摘Neikov O D Mil'man Yu V Sirko A I 2008Mterrials Science and Engineering2008,477,:1
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