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| 1 | Efficacy of transcatheter embolization/chemoembolization (TAE/TACE) for the treatment of single hepatocellular carcinoma显示文摘AIM:To investigate the efficacy of transcatheter embolization/chemoembolization (TAE/TACE) in cirrhotic patients with single hepatocellular carcinoma (HCC) not suitable for surgical resection and percutaneous ablation therapy. METHODS:A cohort of 176 consecutive cirrhotic patients with single HCC undergoing TAE/TACE was reviewed; 162 patients had at least one image examination (helical CT scan or triphasic contrastenhanced MRI) after treatment and were included into the study. TAE was performed with Lipiodol followed by Gelfoam embolization; TACE was performed with Farmorubicin prepared in sterile drip at a dose of 50 mg/m2,infused over 30 min using a peristaltic pump,and followed by Lipiodol and Gelfoam embolization. RESULTS:Patients characteristics were:mean age,62 years; male/female 117/45; Child-Pugh score 6.2 ± 1.1; MELD 8.7 ± 2.3; mean HCC size,3.6 (range 1.0-12.0) cm. HCC size class was ≤ 2.0 cm,n = 51; 2.1-3.0 cm,n = 35; 3.1-4.0 cm,n = 29; 4.1-5.0 cm,n = 22; 5.1-6.0 cm,n = 11; and > 6.0 cm,n = 14. Patients received a total of 368 TAE/TACE (mean 2.4 ± 1.7). Complete tumor necrosis was obtained in 94 patients (58%),massive (90%-99%) necrosis in 16 patients (10%),partial (50%-89%) necrosis in 18 patients (11%) and poor (< 50%) necrosis in the remaining 34 patients (21%). The rate of complete necrosis according to the HCC size class was:69%,69%,52%,68%,50% and,13% for lesions of ≤ 2.0,2.1-3.0,3.1-4.0,4.1-5.0,5.1-6.0,and > 6.0 cm,respectively. Kaplan-Mayer survival at 24-mo was 88%,68%,59%,59%,45%,and 53% for lesions of ≤ 2.0,2.1-3.0,3.1-4.0,4.1-5.0,5.1-6.0,and > 6.0 cm,respectively. CONCLUSION:Our study showed that in cirrhotic patients with single HCC smaller than 6.0 cm,TAE/TACE produces complete local control of tumor in a significant proportion of patients. TAE/TACE is an effective therapeutic option in patients with single HCC not suitable for surgical resection or percutaneous ablation therapies. Further studies should investigate if the new available embolization agents or drug eluting beads may improve the effect on tumor necrosis. | Roberto Miraglia Giada Pietrosi Luigi Maruzzelli Ioannis Petridis Settimo Caruso Gianluca Marrone Giuseppe Mamone Giovanni Vizzini Angelo Luca Bruno Gridelli | 2007 | World Journal of Gastroenterology2007，13，21： | 38 |
| 2 | Interventional radiology procedures in adult patients who underwent liver transplantation显示文摘Interventional radiology has acquired a key role in every liver transplantation(LT)program by treating the majority of vascular and non-vascular post-transplant complications,improving graft and patient survival and avoiding,in the majority of cases,surgical revision and/or re-transplantation.The aim of this paper is to review indications,technical consideration,results achievable and potential complications of interventional radiology procedures after deceased donor LT and living related adult LT. | Roberto Miraglia Luigi Maruzzelli Settimo Caruso Mariapina Milazzo Gianluca Marrone Giuseppe Mamone Vincenzo Carollo Salvatore Gruttadauria Angelo Luca Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，6： | 11 |
| 3 | Multidisciplinary imaging of liver hydatidosis显示文摘Liver hydatidosis is a parasitic endemic disease affecting extensive areas in our planet,a significant stigma within medicine to manage because of its incidence,possible complications,and diagnostic involvements.The diagnosis of liver hydatidosis should be as fast as possible because of the relevant complications that may arise with disease progression,involving multiple organs and neighboring structures causing disruption,migration,contamination.The aim of this essay is to illustrate the role of imaging as ultrasonography(US),multi detector row computed tomography,and magnetic resonance imaging(MRI)in the evaluation of liver hydatidosis:the diagnosis,the assessment of extension,the identification of possible complications and the monitoring the response to therapy.US is the screening method of choice.Computed tomography(CT)is indicated in cases in which US is inadequate and has high sensitivity and specificity for calcified hydatid cysts.Magnetic resonance is the best imaging procedure to demonstrate a cystic component and to show a biliary tree involvement.Diagnostic tests such as CT and MRI are mandatory in liver hydatidosis because they allow thorough knowledge regarding lesion size,location,and relations to intrahepatic vascular and biliary structures,providing useful information for effective treatment and decrease in post-operative morbidity.Hydatid disease is classified into four types on the basis of their radiologic appearance. | Gianluca Marrone Francesca Crino' Settimo Caruso Giuseppe Mamone Vincenzo Carollo Mariapina Milazzo Salvatore Gruttadauria Angelo Luca Bruno Gridelli | 2012 | World Journal of Gastroenterology2012，18，13： | 10 |
| 4 | Complete spontaneous regression of giant focal nodular hyperplasia of the liver: Magnetic resonance imaging evaluation with hepatobiliary contrast media显示文摘Focal nodular hyperplasia(FNH) of the liver is a benign lesion occurring in 0.6%-3% of the general population that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Most lesions are diagnosed incidentally and the natural history of the disease remains largely unknown. It has been shown that most FNH remain stable, or even regress, over a long follow-up period. We present a patient with FNH of the liver who was followed up for 7 years. A 26-yearold woman with a 5-year history of oral contraceptive use was referred to our hospital in February 2005 for further examination of a liver tumour. The diagnosis of FNH was made using magnetic resonance(MR) imaging with hepatospecific contrast media; this technique allows a correct diagnosis, in particular distinguishing FNH from hepatic adenoma, avoiding an invasive procedure such as the lesion biopsy. After 7-year from the diagnosis, we observed the complete spontaneous regression of the lesion by enhanced MR scanning. In this patient, discontinuation of oral contraceptive use and two childbirths may have influenced the natural history of FNH. To our knowledge, in the English literature there is no report illustrating a complete regression of giant FNH but only studies of decreasing in size. The present case suggests that a young patient with giant FNH should be managed conservatively rather than by resection, because FNH has the potential for spontaneous regression. | Giuseppe Mamone Settimo Caruso Kelvin Cortis Roberto Miraglia | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 5 | Phase I study of neoadjuvant accelerated short course radiation therapy with photons and capecitabine for resectable pancreatic cancer显示文摘 | Jennifer Y. Wo Harvey J. Mamon Cristina R. Ferrone David P. Ryan Lawrence S. Blaszkowsky Eunice L. Kwak Yolanda D. Tseng Brian N. Napolitano Marek Ancukiewicz Richard S. Swanson Keith D. Lillemoe Carlos Fernandez-del Castillo Theodore S. Hong | 2013 | Radiotherapy and Oncology2013，，： | 2 |
| 6 | Intestinal Tcell responses to gluten peptides are largely heterogeneous :implications for a peptide-based therapy in celiac disease 显示文摘 | Camarca A Anderson R P Mamone G | 2009 | The Journal of Immunology2009，182，7： | 1 |
| 7 | The frontiers of mass spectrometry-based techniques in food allergenomics显示文摘 | Pieariello G Mamone G Addeo F | 2011 | J Chromatogr A2011，1218，42： | 1 |
| 8 | Whole genome amplification of plasma-circulating DNA enables expanded screening for allelic imbalance in plasma显示文摘 | LI J HARRIS L MAMON H | 2006 | J Mol Diagn2006，8，1： | 1 |
| 9 | Identification of apeptide from a-gliadin resistant to digestive enzymes : Implicationsfor celiac disease显示文摘 | Mamone G Ferranti P Rossi M | 2007 | Journal of Chromatography B2007，855，2： | 1 |
| 10 | High risk of brain metastases in surgically staged ⅢA non small-cell lung cancer patients treated with surgery ,chemotherapy ,and radiationJ显示文摘 | Mamon HJ Yeap BY Janne PA | 2005 | Clin Oncol2005，23，7： | 1 |
| 11 | Adjuvant treatment of colorectal cancer显示文摘 | Wolpin BM Meyerhardt JA Mamon HJ | | 0，，： | 1 |
| 12 | Analysis of food proteins and peptides by mass spectrometry- based techniques 显示文摘 | Mamone G Picariello G Caira S | 2009 | Journal of Chromatography A2009，1216，43： | 1 |
| 13 | Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing显示文摘 | Li J Wang L Mamon H | 2008 | Nat Med2008，14，5： | 1 |
| 14 | Adjuvant treatment ofcolorectal cancer显示文摘 | Wolpin BM Meyerhardt JA Mamon HJ | 2007 | CA Cancer J Clin2007，57，3： | 1 |
| 15 | Explicit solutions to European options in a regime-switching economy显示文摘 | Rogemar S Mamon Marianito R Rodrigo | 2005 | Operations Research Letters2005，33，： | 1 |
| 16 | Identification of N–linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry显示文摘 | Picariello G Ferranti P Mamone G | 2008 | Proteomics2008，8，38： | 1 |
| 17 | Protein digestomics:Integrated platforms to study food-protein digestion and derived functional and active peptides显示文摘 | PICARIELLO G MAMONE G NITRIDE C | 2013 | Tr AC Trends in Analytical Chemistry2013，52，： | 1 |
| 18 | Adjuvanttreatment of colorectal cancer显示文摘 | Wolpin B M Meyerhardt J A Mamon H J | 2007 | CA Cancer J Clin2007，57，3： | 1 |
| 19 | Prote- omic analysis in allergy and intolerance to wheat products 显示文摘 | Mamone G Picariello G Addeo F | 2011 | Expert Review of Proteo- mics2011，8，1： | 1 |
| 20 | Chara- cterization of wheat gliadin proteins by comb- ined two-dimensional gel electrophoresis and tandem mass spectrometry 显示文摘 | Mamone G Addeo F Chianese L | 2005 | Proteomics2005，5，11： | 1 |
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