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| 1 | Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids显示文摘Hepatocellular carcinoma(HCC), with its high incidence and mortality rate, is one of the most common malignant tumors. Despite recent development of a diagnostic and treatment method, the prognosis of HCC remains poor. Therefore, to provide optimal treatment for each patient with HCC, more precise and effective biomarkers are urgently needed which could facilitate a more detailed individualized decision-making during HCC treatment, including the following; risk assessment, early cancer detection, prediction of treatment or prognostic outcome. In the blood of cancer patients, accumulating evidence about circulating tumor cells and cell-free nucleic acids has suggested their potent clinical utilities as novel biomarker. This concept, so-called 'liquid biopsy' is widely known as an alternative approach to cancer tissue biopsy. This method might facilitate a more sensitive diagnosis and better decision-making by obtaining genetic and epigenetic aberrations that are closely associated with cancer initiation and progression. In this article, we review recent developments based on the available literature on both circulating tumor cells and cell-free nucleic acids in cancer patients, especially focusing on Hepatocellular carcinoma. | wataru okajima shuhei komatsu daisuke ichikawa mahito miyamae takuma ohashi taisuke imamura jun kiuchi keiji nishibeppu tomohiro arita hirotaka konishi atsushi shiozaki ryo morimura hisashi ikoma kazuma okamoto eigo otsuji | 2017 | World Journal of Gastroenterology2017，23，31： | 22 |
| 2 | Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids显示文摘Despite recent advances in surgical techniques and perioperative management, the prognosis of pancreatic cancer(PCa) remains extremely poor. To provide optimal treatment for each patient with Pca, superior biomarkers are urgently needed in all phases of management from early detection to staging, treatment monitoring, and prognosis. In the blood of patients with cancer, circulating tumor cells(CTCs) and cell-free nucleic acids(cf NAs), such as DNA, m RNA, and noncoding RNA have been recognized. In the recent years, their presence in the blood has encouraged researchers to investigate their potential use as novel blood biomarkers, and numerous studies have demonstrated their potential clinical utility as a biomarker for certain types of cancer. This concept, called 'liquid biopsy' has been focused on as a less invasive, alternative approach to cancer tissue biopsy for obtaining genetic and epigenetic aberrations that contribute to oncogenesis and cancer progression. In this article, we review the available literature on CTCs and cfN As in patients with cancer, particularly focusing on PCa, and discuss future perspectives in this field. | Taisuke Imamura Shuhei Komatsu Daisuke Ichikawa Tsutomu Kawaguchi Mahito Miyamae Wataru Okajima Takuma Ohashi Tomohiro Arita Hirotaka Konishi Atsushi Shiozaki Ryo Morimura Hisashi Ikoma Kazuma Okamoto Eigo Otsuji | 2016 | World Journal of Gastroenterology2016，22，25： | 10 |
| 3 | Histological mixed-type as an independent prognostic factor in stageⅠgastric carcinoma显示文摘AIM: To evaluate the clinicopathological features of mixed-type gastric cancer and their influence on prognosis of mixed-type stageⅠgastric cancer.METHODS: We analyzed 446 patients who underwent curative gastrectomy for stageⅠgastric cancer between 1999 and 2009. The patients were divided into two groups: those with differentiated or undifferentiated cancer(non-mixed-type, n = 333) and those with a mixture of differentiated and undifferentiated cancers(mixed-type, n = 113).RESULTS: The overall prevalence of mixed-type gastric cancer was 25.3%(113/446). Compared with patients with non-mixed-type gastric cancer, those with mixedtype gastric cancer tended to be older at onset(P = 0.1252) and have a higher incidence of lymph node metastasis(P = 0.1476). They also had significantly larger tumors(P < 0.0001), more aggressive lymphatic invasion(P = 0.0011), and deeper tumor invasion(P < 0.0001). In addition, they exhibited significantly worse overall survival rates than did patients with non-mixedtype gastric cancer(P = 0.0026). Furthermore, mixedtype gastric cancer was independently associated with a worse outcome in multivariate analysis [P = 0.0300, hazard ratio = 11.4(1.265-102.7)].CONCLUSION: Histological mixed-type of gastric cancer contributes to malignant outcomes and highlight its usefulness as a prognostic indicator in stageⅠgastric cancer. | Shuhei Komatsu Daisuke Ichikawa Mahito Miyamae Hiroki Shimizu Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eigo Otsuji | 2015 | World Journal of Gastroenterology2015，21，2： | 6 |
| 4 | Combined assessment of T-wave alternans and late potentials used to predict arrhythmic events after myocardial infarction显示文摘 | Takanori Ikeda Takao Sakata Mitsuaki Takami Naoki Kondo Naoki Tezuka Takeshi Nakae Mahito Noro Yoshihisa Enjoji Ryoji Abe Kaoru Sugi Tetsu Yamaguchi | 2000 | Journal of the American College of Cardiology2000，，： | 2 |
| 5 | Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partially Due to Peroxisome Proliferator-Activated Receptor-γ Activation in Mice With Chronic Cerebral Hypoperfusion显示文摘 | Kazuo Washida Masafumi Ihara Keiko Nishio Youshi Fujita Takakuni Maki Mahito Yamada Jun Takahashi Xiaofeng Wu Takeshi Kihara Hidefumi Ito Hidekazu Tomimoto Ryosuke Takahashi | 2010 | Stroke2010，，8： | 1 |
| 6 | Survival effect of para-aortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective cohort analysis显示文摘 | Yukiharu Todo Hidenori Kato Masanori Kaneuchi Hidemichi Watari Mahito Takeda Noriaki Sakuragi | 2010 | The Lancet2010，，9721： | 1 |
| 7 | Preparation of conducting polyaniline colloids under ultrasonication显示文摘 | Mahito Atobe Al-Nakib Chowdhury Toshio Fuchigami Tsutomu Nonaka | 2002 | Ultrasonics - Sonochemistry2002，，2： | 1 |
| 8 | Synthesis of multiple shapes of gold nanoparticles with controlled sizea in aqueous solution using ultrasound显示文摘 | Park J E Mahito Toshio F | 2006 | Ultrason Sonochem2006，13，3： | 1 |
| 9 | Paired elctrosynthesis of epoxides and dibromides from olefinic compounds显示文摘 | Mahito A M Li W | 2003 | Electrochimica Acta2003，48，： | 1 |
| 10 | Influence of cultural factors on landscapes of mountainous farm villages in western Japan显示文摘 | Mahito Kamada Nobukazu Nakagoshi | | 0，，： | 1 |
| 11 | Effective anti-tumor activity of oxaliplatin encapsulated in transferrin–PEG-liposome显示文摘 | Ryo Suzuki Tomoko Takizawa Yasuhiro Kuwata Mahito Mutoh Nobuyuki Ishiguro Naoki Utoguchi Atsuko Shinohara Masazumi Eriguchi Hironobu Yanagie Kazuo Maruyama | 2007 | International Journal of Pharmaceutics2007，，1： | 1 |
| 12 | Single Center Experience With a Low Volume Priming Cardiopulmonary Bypass Circuit for Preventing Blood Transfusion in Infants and Small Children显示文摘 | Yasuhiro Kotani Osami Honjo Mahito Nakakura Yasuhiro Fujii Shinya Ugaki Yu Oshima Ko Yoshizumi Shingo Kasahara Shunji Sano | 2009 | ASAIO Journal2009，，3： | 1 |
| 13 | 显示文摘 | Mahito Atobe Naohiro Yamada Toshio Fuchigami | 2003 | Electrochimica Acta2003，48，： | 1 |
| 14 | Cell cycle-dependent modulation of telomerase activity in humor cells 显示文摘 | ZhuXue li Rakesh K Mahitoal M | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 15 | Treatment of cervical cancer with adjuvant chemotherapy versus adjuvant radiotherapy after radical hysterectomy and systematic lymphadenectomy显示文摘 | Hosaka Masayoshi Watari Hidemichi Takeda Mahito | 2008 | J Obstet Gynaecol Res2008，34，4： | 1 |
| 16 | Effective anti-tumor activity of oxaliplatin encapsulated in transferrin–PEG-liposome显示文摘 | Ryo Suzuki Tomoko Takizawa Yasuhiro Kuwata Mahito Mutoh Nobuyuki Ishiguro Naoki Utoguchi Atsuko Shinohara Masazumi Eriguchi Hironobu Yanagie Kazuo Maruyama | 2007 | International Journal of Pharmaceutics2007，，1： | 1 |
| 17 | Gastric carcinoma originating from the heterotopic submucosal gastric gland treated by laparoscopy and endoscopy cooperative surgery显示文摘Gastric carcinoma is derived from epithelial cells in the gastric mucosa. We reported an extremely rare case of submucosal gastric carcinoma originating from the heterotopic submucosal gastric gland(HSG) that was safely diagnosed by laparoscopy and endoscopy cooperative surgery(LECS). A 66-year-old man underwent gastrointestinal endoscopy, which detected a submucosal tumor(SMT) of 1.5 cm in diameter on the lesser-anterior wall of the upper gastric body. The tumor could not be diagnosed histologically, even by endoscopic ultrasound-guided fine-needle aspiration biopsy. Local resection by LECS was performed to confirm a diagnosis. Pathologically, the tumor was an intra-submucosal well differentiated adenocarcinoma invading 5000 μm intothe submucosal layer. The resected tumor had negative lateral and vertical margins. Based on the Japanese treatment guidelines, additional laparoscopic proximal gastrectomy was curatively performed. LECS is a less invasive and safer approach for the diagnosis of SMT, even in submucosal gastric carcinoma originating from the HSG. | Taisuke Imamura Shuhei Komatsu Daisuke Ichikawa Hiroki Kobayashi Mahito Miyamae Shoji Hirajima Tsutomu Kawaguchi Takeshi Kubota Toshiyuki Kosuga Kazuma Okamoto Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kiyoshi Ogiso Nobuaki Yagi Akio Yanagisawa Takashi Ando Eigo Otsuji | 2015 | World Journal of Gastrointestinal Oncology2015，7，8： | 1 |
| 18 | Ecological and social evaluation of landscape in a rural area with terraced paddies in southwestern Japan显示文摘 | Naoki Liyama Mahito Kamada Nobukasu Nakagoshi | 2005 | Landscape and Urban Planning2005，73，1： | 1 |
| 19 | Malignant potential in pancreatic neoplasm; new insights provided by circulating miR-223 in plasma显示文摘 | Shuhei Komatsu Daisuke Ichikawa Mahito Miyamae Tsutomu Kawaguchi Ryo Morimura Shoji Hirajima Wataru Okajima Takuma Ohashi Taisuke Imamura Hirotaka Konishi Atsushi Shiozaki Hisashi Ikoma Kazuma Okamoto Hiroki Taniguchi Eigo Otsuji | 2015 | Expert Opinion on Biological Therapy2015，，6： | 1 |
| 20 | Treatment of cognitive impairment after poststroke Depression显示文摘 | Mahito Kimura Robert R James T | 2000 | Stroke2000，31，7： | 1 |
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