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| 1 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 2 | Land use change of Kitakyushu based on landscape ecology and Markov model显示文摘基于在 1990, 1995, 2000 和 2005 获得的 TM 图象的四个阶段,这篇论文作为案例研究在日本拿了 Kitakyushu 在风景生态学 theo | GUAN Dongjie GAO Weijun WATARI Kazuyuki FUKAHORI Hidetoshi | 2008 | Journal of Geographical Sciences2008，18，4： | 36 |
| 3 | Chemotherapy and molecular targeting therapy for recurrent cervical cancer显示文摘For patients with primary stage IVB, persistent, or recurrent cervical cancer, chemotherapy remains the standard treatment, although it is neither curative nor associated with long-term disease control. In this review, we summarized the history of treatment of recurrent cervical cancer, and the current recommendation for chemotherapy and molecular targeted therapy. Eligible articles were identified by a search of the MEDLINE bibliographical database for the period up to November 30, 2014. The search strategy included the following any or all of the keywords: 'uterine cervical cancer', 'chemotherapy', and 'targeted therapies'. Since cisplatin every 21 days was considered as the historical standard treatment for recurrent cervical cancer, subsequent trials have evaluated and demonstrated activity for other agents including paclitaxel, gemcitabine, topotecan and vinorelbine among others. Accordingly, promising agents were incorporated into phase III trials. To examine the best agent to combine with cisplatin, several landmark phase III clinical trials were conducted by Gynecologic Oncology Group(GOG) and Japan Clinical Oncology Group(JCOG). Through, GOG204 and JCOG0505, paclitaxel/cisplatin(TP) and paclitaxel/carboplatin(TC) are now considered to be the recommended therapies for recurrent cervical cancer patients. However, the prognosis of patients who are already resistant to chemotherapy, are very poor. Therefore new therapeutic strategies are urgently required. Molecular targeted therapy will be the most hopeful candidate of these strategies. From the results of GOG240, bevacizumab combined with TP reached its primary endpoint of improving overall survival(OS). Although, the prognosis for recurrent cervical cancer patients is still poor, the results of GOG240 shed light on the usefulness of molecular target agents to chemotherapy in cancer patients. Recurrent cervical cancer is generally considered incurable and current chemotherapy regiments offer only modest gains in OS, particularly for patients with multiple poor prognostic factors. Therefore, it is crucial to consider not only the survival benefit, but also the minimization of treatment toxicity, and maximization of quality of life(QOL). | Naotake Tsuda Hidemichi Watari Kimio Ushijima | 2016 | Chinese Journal of Cancer Research2016，28，2： | 24 |
| 4 | Neoadjuvant chemotherapy for locally advanced cervical cancer显示文摘Neoadjuvant chemotherapy followed by surgery(NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy(NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials(RCTs) have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy(CCRT) has markedly improved the outcome of radiotherapy(RT), and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT. | Takashi Iwata Azumi Miyauchi Yukako Suga Hiroshi Nishio Masaru Nakamura Akiko Ohno Nobumaru Hirao Tohru Morisada Kyoko Tanaka Hiroki Ueyama Hidemichi Watari Daisuke Aoki | 2016 | Chinese Journal of Cancer Research2016，28，2： | 20 |
| 5 | Clinical outcomes and risk factors for perforation in gastric endoscopic submucosal dissection: A prospective pilot study显示文摘AIM: To evaluate clinical outcomes and risk factors for endoscopic perforation during endoscopic submucosal dissection (ESD) in a prospective study. METHODS: We investigated the clinical outcomes and risk factors for the development of perforation in 98 consecutive gastric neoplasms undergoing ESD regarding. Demographic and clinical parameters including patient-, tumor-, and treatment-related factors, clinical parameters, and duration of hospital stay were analyzed for risk factors for perforation. In subgroup analysis, we also compared the clinical outcomes between perforation and 'silent' free air without endoscopically visible perforation detected only by computed tomography.RESULTS: Perforation was identified in 8.2% of patients. All patients were managed conservatively by the administration of antibiotics. The mean procedure time was significantly longer in patients with endoscopic perforation than in those without. According to the receiver-operating characteristic analysis, the resulting cutoff value of the procedure time for perforation was 115 min (87.5% sensitivity, 56.7% specificity). Prolonged procedure time (≥ 115 min) was associated with an increased risk of perforation (odds ratio 9.15; 95%CI: 1.08-77.54; P = 0.04). Following ESD, body temperature and C-reactive protein level were significantly higher in patients with perforation than in those without (P = 0.02), whereas there was no difference between these patient groups on the starting day of oral intake or of hospitalization. In subgroup analysis, the post-ESD clinical course was not different between endoscopic perforation and silent free air. CONCLUSION: Only prolonged procedure time (≥ 115 min) was significantly associated with perforation. The clinical outcomes of perforation are favorable and are comparable to those of patients with or without silent free air. | Jiro Watari Toshihiko Tomita Fumihiko Toyoshima Jun Sakurai Takashi Kondo Haruki Asano Takahisa Yamasaki Takuya Okugawa Hisatomo Ikehara Tadayuki Oshima Hirokazu Fukui Hiroto Miwa | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，6： | 17 |
| 6 | Adjuvant chemotherapy for early-stage cervical cancer显示文摘The aim of this review is to address the current status of adjuvant chemotherapy alone in early-stage cervical cancer treatments in the literature. At present, the therapeutic effect of adjuvant chemotherapy alone after radical surgery(RS) has not yet been established, and radiation therapy(RT) or concurrent chemoradiotherapy(CCRT) is recommended as the standard adjuvant therapy after RS for early-stage cervical cancer in various guidelines. The main purpose of adjuvant therapy after RS, however, should be to reduce extrapelvic recurrence rather than local recurrence, although adjuvant RT or CCRT has survival benefits for patients with intermediate- or high-risk factors for recurrence. Moreover, several studies reported that adjuvant therapies including RT were associated with a higher incidence of complications, such as lymphedema, bowel obstruction and urinary disturbance, and a lower grade of long-term quality of life(QOL) or sexual functioning than adjuvant chemotherapy alone. The effect of adjuvant chemotherapy alone for early-stage cervical cancer with intermediate- or high-risk factors for recurrence were not fully investigated in prospective studies, but several retrospective studies suggest that the adjuvant effects of chemotherapy alone are at least similar to that of RT or CCRT in terms of recurrence rate, disease-free survival, or overall survival(OS) with lower incidence of complications. Whereas cisplatin based combination regimens were used in these studies, paclitaxel/cisplatin(TP) regimen, which is currently recognized as a standard chemotherapy regimen for patients with metastatic, recurrent or persistent cervical cancer by Gynecologic Oncology Group(GOG), had also survival benefit as an adjuvant therapy. Therefore, it may be worth considering a prospective randomized controlled trial(RCT) of adjuvant chemotherapy alone using TP regimen versus adjuvant RT as an alternative adjuvant therapy. Because early-stage cervical cancer is a curable condition, it is necessary that the therapeutic strategies should be improved with considering adverse events and QOL for long-term survivors. | Hiroshi Asano Yukiharu Todo Hidemichi Watari | 2016 | Chinese Journal of Cancer Research2016，28，2： | 10 |
| 7 | What types of early gastric cancer are indicated for endoscopic ultrasonography staging of invasion depth?显示文摘AIM To clarify the diagnostic efficacy and limitations of endoscopic ultrasonography(EUS) and the characteristics of early gastric cancers(EGCs) that are indications for EUS-based assessment of cancer invasion depth.METHODS We retrospectively investigated the cases of 153 EGC patients who underwent conventional endoscopy(CE) and EUS(20 MHz) before treatment.RESULTS We found that 13.7% were 'inconclusive' cases with low-quality EUS images, including all nine of the cases with protruded(0-I)-type EGCs. There was no significant difference in the diagnostic accuracybetween CE and EUS. Two significant independent risk factors for misdiagnosis by EUS were identified-ulcer scarring [UL(+); odds ratio(OR) = 4.49, P = 0.003] and non-indication criteria for endoscopic resection(ER)(OR = 3.02, P = 0.03). In the subgroup analysis, 23.1% of the differentiated-type cancers exhibiting SM massive invasion(SM2) invasion(submucosal invasion ≥ 500 μm) by CE were correctly diagnosed by EUS, and 23.1% of the undifferentiated-type EGCs meeting the expanded-indication criteria for ER were correctly diagnosed by EUS.CONCLUSION There is no need to perform EUS for UL(+) EGCs or 0-I-type EGCs, but EUS may enhance the pretreatment staging of differentiated-type EGCs with SM2 invasion without UL or undifferentiated-type EGCs revealed by CE as meeting the expanded-indication criteria for ER. | Jiro Watari Shigemitsu Ueyama Toshihiko Tomita Hisatomo Ikehara Kazutoshi Hori Ken Hara Takahisa Yamasaki Takuya Okugawa Takashi Kondo Tomoaki Kono Katsuyuki Tozawa Tadayuki Oshima Hirokazu Fukui Hiroto Miwa | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，16： | 8 |
| 8 | Histological diagnosis of gastric submucosal tumors: A pilot study of endoscopic ultrasonography-guided fine-needle aspiration biopsy vs mucosal cutting biopsy显示文摘AIM: To compare the usefulness of endoscopic ultrasonography-guided fine-needle aspiration biopsy(EUS-FNAB) without cytology and mucosal cutting biopsy(MCB) in the histological diagnosis of gastric submucosal tumor(SMT).METHODS: We prospectively compared the diagnostic yield, feasibility, and safety of EUS-FNAB and those of MCB based on endoscopic submucosal dissection. The cases of 20 consecutive patients with gastric SMT ≥1 cm in diameter. who underwent both EUS-FNAB and MCB were investigated.RESULTS: The histological diagnoses were gastrointestinal stromal tumors(n = 7), leiomyoma(n =6), schwannoma(n = 2), aberrant pancreas(n = 2), and one case each of glomus tumor, metastatic hepatocellular carcinoma, and no-diagnosis. The tumors' mean size was 23.6 mm. Histological diagnosis was made in 65.0% of the EUS-FNABs and 60.0% of the MCBs, a nonsignificant difference. There were no significant differences in the diagnostic yield concerning the tumor location or tumor size between the two methods. However, diagnostic specimens were significantly more frequently obtained in lesions with intraluminal growth than in those with extraluminal growth by the MCB method(P = 0.01). All four SMTs with extraluminal growth were diagnosed only by EUSFNAB(P = 0.03). No complications were found in either method.CONCLUSION: MCB may be chosen as an alternative diagnostic modality in tumors showing the intraluminal growth pattern regardless of tumor size, whereas EUSFNAB should be performed for SMTs with extraluminal growth. | Hisatomo Ikehara Zhaoliang Li Jiro Watari Masato Taki Tomohiro Ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Toshihiko Tomita Tadayuki Oshima Hirokazu Fukui Ikuo Matsuda Seiichi Hirota Hiroto Miwa | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，14： | 7 |
| 9 | Concurrent chemoradiotherapy for cervical cancer: background including evidence-based data, pitfalls of the data, limitation of treatment in certain groups显示文摘Concurrent chemoradiotherapy(CCRT) is regarded as the standard treatment for locally advanced uterine cervical cancer(LACC), including stage Ib2-IVa disease [International Federation of Gynecology and Obstetrics(FIGO) staging]. However, approximately a third of eligible patients in previous studies died of LACC despite receiving CCRT. The therapeutic significance of CCRT alone in stage III-IVa disease has not yet been confirmed. Effective treatment of some LACC is beyond the scope of CCRT. The objective of the present review is to highlight some challenging work aimed at overcoming this seemingly intractable disease. CCRT with increased peak concentrations of cisplatin(CDDP), surgery following CCRT, adjuvant chemotherapy(CT) following CCRT, and neoadjuvant CT followed by CCRT are strategies expected to enhance the therapeutic efficacy of CCRT. If patients with LACC were divided into those with low-risk or high-risk systemic disease or prognoses, novel strategies should be assessed in the group with high-risk disease. | Yukiharu Todo Hidemichi Watari | 2016 | Chinese Journal of Cancer Research2016，28，2： | 7 |
| 10 | EAST装置离子回旋加热液态阻抗匹配系统的研究显示文摘介绍了EAST装置离子回旋加热系统中的两种实现阻抗匹配的方式,用三支节液态调配器取代传统的滑竿式三支节调配器和用液态相移器与单支节液态调配器相结合组成液态阻抗匹配系统。通过对液态阻抗匹配系统的分析,表明这两种方式都能够较好地实现阻抗匹配。 | 王鹏 赵燕平 毛玉周 秦成明 T Watari R Kumazawa T Mutoh T Seki | 2005 | 核聚变与等离子体物理2005，25，4： | 4 |
| 11 | ICRF Heated Long-Pulse Plasma Discharges in LHD显示文摘A long-pulse plasma discharge for more than 30 min.was achieved on the LargeHelical Device(LHD).A plasma of n_e=0.8×10^(19)m^(-3)and T_(iO)=2.0 keV was sustained withP_(ICH)=0.52 MW,P_(ECH)=0.1 MW and averaged P_(NBI)=0.067 MW.Total injected heatingenergy was 1.3 GJ,which was a quarter of the prepared RF heating energy.One of the keys to thesuccess of the experiment was a dispersion of the local plasma heat load to divertors,accomplishedby shifting the magnetic axis inward and outward. | R. KUMAZAWA T. SEKI T. MUTOH K. SAITO T. WATARI Y. NAKAMURA M. SAKAMOTO T. WATANABE S. KUBO T. SHIMOZUMA Y. YOSHIMURA H. IGAMI Y. TAKEIRI Y. OKA K. TSUMORI M. OSAKABE K. IKEDA K. NAGAOKA O. KANEKO J. MIYAZAWA S. MORITA K. NARIHARA M. SHOJI S. MASUZAKI M. GOTO T. MORISAKI B. J. PETERSON K. SATO T. TOKUZAWA N. ASHIKAWA K. NISHIMURA H. FUNABA H. CHIKARAISHI T. NOTAKE Y. TORII H. OKADA M. ICHIMURA H. HIGAKI Y. TAKASE H. KASAHARA F. SHIMPO G.NOMURA C.TAKAHASHI M.YOKOTA A. KATO 赵燕平 J. S. YOON J. G. KWAK H. YAMADA K. KAWAHATA N. OHYABU K. IDA Y. NAGAYAMA N. NODA A. KOMORI S. SUDO O. MOTOJIMA | 2006 | Plasma Science and Technology2006，8，1： | 4 |
| 12 | Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study显示文摘AIM: To examine the efficacy of non-magnifying narrow-band imaging(NM-NBI) imaging for small signet ring cell carcinoma(SRC).METHODS: We retrospectively analyzed 14 consecutive small intramucosal SRCs that had been treated with endoscopic submucosal dissection(ESD) and 14 randomly selected whitish gastric ulcer scars(control). The strength and shape of the SRCs and whitish scars by NM-NBI and white-light imaging(WLI) were assessed with Image J(NIH, Bethesda).RESULTS: NM-NBI findings of SRC showed a clearly isolated whitish area amid the brown color of the surrounding normal mucosa. The NBI index, which indicates the potency of NBI for visualizing SRC, was significantly higher than the WLI index(P = 0.001), indicating SRC was more clearly identified by NM-NBI. Although the NBI index was not significantly different between SRCs and controls, the circle(C)-index, as an index of circularity of tumor shape, was significantly higher in SRCs(P = 0.001). According to the receiveroperating characteristic analysis, the resulting cut-off value of the circularity index(C-index) for SRC was 0.60(85.7% sensitivity, 85.7% specificity). Thus a lesion with a C-index ≥ 0.6 was significantly more likely to be an SRC than a gastric ulcer scar(OR = 36.0; 95%CI: 4.33-299.09; P = 0.0009).CONCLUSION: Small isolated whitish round area by NM-NBI endoscopy is a useful finding of SRCs which is the indication for ESD. | Jiro Watari Toshihiko Tomita Hisatomo Ikehara Masato Taki Tomohiro Ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Jun Sakurai Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Seiichi Hirota Hiroto Miwa | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，12： | 4 |
| 13 | Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis显示文摘AIM: To compare previously reported randomized controlled studies(RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse events.METHODS: A meta-analysis was conducted to evaluate the predominance of cold and hot polypectomy for removing colon polyps. Published articles and abstracts from worldwide conferences were searched using the keywords 'cold polypectomy'. RCTs that compared either or both the effects or adverse events of cold polypectomy with those of hot polypectomy were collected. The patients' demographics, endoscopic procedures, No. of examined lesions, lesion size, macroscopic and histologic findings, rates of incomplete resection, bleeding amount, perforation, and length of procedure were extracted from each study. A forest plot analysis was used to verify the relative strength of the effects and adverse events of each procedure. A funnel plot was generated to assess the possibility of publication bias.RESULTS: Ultimately, six RCTs were selected. No significant differences were noted in the average lesion size(less than 10 mm) between the cold and hot polypectomy groups in each study. Further, the rates of complete resection and adverse events, including delayed bleeding, did not differ markedly between cold and hot polypectomy. The average procedural time in the cold polypectomy group was significantly shorter than in the hot polypectomy group.CONCLUSION: Cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy. | Mikihiro Fujiya Hiroki Sato Nobuhiro Ueno Aki Sakatani Kazuyuki Tanaka Tatsuya Dokoshi Shugo Fujibayashi Yoshiki Nomura Shin Kashima Takuma Gotoh Junpei Sasajima Kentaro Moriichi Jiro Watari Yutaka Kohgo | 2016 | World Journal of Gastroenterology2016，22，23： | 3 |
| 14 | Integrated experiments of fast ignition targets by Gekko-XII and LFEX lasers显示文摘 | H. Shiraga S. Fujioka M. Nakai T. Watari H. Nakamura Y. Arikawa H. Hosoda T. Nagai M. Koga H. Kikuchi Y. Ishii T. Sogo K. Shigemori H. Nishimura Z. Zhang M. Tanabe S. Ohira Y. Fujii T. Namimoto Y. Sakawa O. Maegawa T. Ozaki K.A. Tanaka H. Habara T. Iwawak | 2012 | High Energy Density Physics2012，，3： | 2 |
| 15 | Apoptosis and Molecular Targeting Therapy in Cancer显示文摘 | Mohamed Hassan Hidemichi Watari Ali AbuAlmaaty Yusuke Ohba Noriaki Sakuragi Elena Orlova | 2014 | BioMed Research International2014，，： | 2 |
| 16 | 用仿生自组装法制备的新型生物复合材料及表征显示文摘通过仿生自组装法在室温下制备了纳米碳酸化羟基磷灰石/胶原(nCHAC)复合材料,并采用X射线衍射(XRD)、热分析(TGA)和透射电镜(TEM)进行了观察和分析.结果表明,该材料具有与天然骨相同的纳米尺度和胶原蛋白无机相,含有(2.8~14.7)w%的碳酸化HA成分;其显微结构是矿化的胶原纤维束,类似于天然骨的分级结构.揭示了碳酸化HA和胶原含量不同的复合材料中,具有微小差别的自组装单元.碳酸的百分含量影响矿物的晶体尺寸和胶原纤维的组装.因此,nCHAC复合材料是有前途的硬组织修复用材料,其所具有的特殊性能要归功于生物仿生制备出的nCHAC材料有与天然骨类似的成分和类似的微观结构. | 徐国富 牟申周 廖素三 Fumio Watari | 2006 | 稀有金属快报2006，25，5： | 2 |
| 17 | Dielectric and thermal properties of AlN ceramics显示文摘 | Shoichi Kume Masaki Yasuoka Sang-Kee Lee Akinori Kan Hirotaka Ogawa Koji Watari | 2006 | Journal of the European Ceramic Society2006，，8： | 2 |
| 18 | Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-kappaB activation 显示文摘 | Watari K Nakao S Fotovali A | 2008 | Bioehem Biophys Res Commun2008，377，3： | 1 |
| 19 | Synthesis andproperties of highly sulfonated proton conductingpolyimides from bis(3-sulfopropoxy)benzidine diam-ines显示文摘 | Yin Y Fang J H Watari T | 2004 | Journal of Material Chemistry2004，14，： | 1 |
| 20 | Transplantation of mature adipocyte-derived dedifferentiated fat cells promotes locomotor functional recovery by remyelination and glial scar reduction after spinal cord injury in mice显示文摘 | Hiromi Yamada Daisuke Ito Yoshinao Oki Masato Kitagawa Taro Matsumoto Tosihiro Watari Koichiro Kano | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
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