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| 1 | Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer显示文摘AIM:To evaluate the safety and clinical application of high-intensity focused ultrasound(HIFU)therapy for unresectable pancreatic cancer(PC).METHODS:Thirty PC patients(16 cases in stage III and 14 cases in stage IV)with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or chemoradiotherapy.Informed consent was obtained.This study began at the end of 2008 and was approved by the ethics committee of our hospital[Institutional Review Board(IRB):890].The HIFU device used was the FEP-BY02(Yuande Bio-Medical Engineering,Beijing,China).RESULTS:The mean tumor size after HIFU therapy changed to 30.9±1.7 mm from 31.7±1.7 mm at pre-therapy.There were no significant changes in tumor size,mean number of treatment sessions(2.7±0.1 mm),or mean total treatment time(2.4±0.1 h).The rate of symptom relief effect was 66.7%.The effectiveness of primary lesion treatment was as follows:complete response,0;partial response,4;stable disease,22;progressive disease,4.Treatment after HIFU therapy included 2 operations,24 chemotherapy treatments,and 4 best supportive care treatments.Adverse events occurred in 10%of cases,namely pseudocyst formation in 2 cases and mild pancreatitis development in 1.However,no severe adverse events occurred in this study.CONCLUSION:We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC. | Atsushi Sofuni Fuminori Moriyasu Takatomo Sano Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Mitsuru Fujita Takao Itoi | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 2 | Prognostic value of postoperative complication for early recurrence after curative resection of hepatocellular carcinoma显示文摘Background: Postoperative complications may adversely affect oncological outcomes. The aim of this study was to evaluate the impact of postoperative complications on early-phase recurrence after curative resection for hepatocellular carcinoma(HCC).Methods: We included 145 HCC patients who underwent initial and curative resection between January2004 and December 2013. Postoperative complications of grade III or higher based on Clavien–Dindo classification were defined as clinically relevant postoperative complications. Recurrence within two years after hepatectomy was defined as early-phase recurrence.Results: Thirty-eight patients(26%) developed postoperative complications. The only predictive factor for postoperative complication was longer operative duration(P = 0.037). The disease-specific survival rate of patients with complication was lower than that of patients without complications(P = 0.015). Earlyphase recurrence was observed in 20/38(53%) patients who suffered postoperative complications and36/107(34%) patients with no complications, which was statistically significant(P = 0.039). Multivariate analysis identified four factors contributing to early-phase recurrence: high serum AFP level(P = 0.042),multiple tumors(P < 0.001), poor differentiation(P = 0.036) and presence of postoperative complication(P = 0.039).Conclusions: Postoperative complication is an independent prognostic factor for early-phase recurrence after curative resection of HCC. Close observation of patients with postoperative complications may be a necessary treatment strategy for HCC. | Masataka Amisaki Hiroaki Saito Naruo Tokuyasu Teruhisa Sakamoto Soichiro Honjo Yoshiyuki Fujiwara | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 10 |
| 3 | Post-operative albumin-bilirubin grade predicts long-term outcomes among Child–Pugh grade A patients with hepatocellular carcinoma after curative resection显示文摘Background: Although Child–Pugh grade A patients with hepatocellular carcinoma(HCC) are candidates for curative resection, some may have a poor prognosis. The albumin-bilirubin(ALBI) grade, a measure of liver function based on albumin and bilirubin, has the potential to detect Child–Pugh grade A HCC patients with poor prognosis. Because components of the ALBI grade can be measured easily even after surgery, we explored the predictive values of ALBI in patient prognosis after HCC resection. Methods: In this retrospective case-control study, we included 136 HCC patients who underwent curative resection between January 2004 and December 2013 at our hospital. ALBI grade was calculated from laboratory data recorded the day before surgery and at post-operative day 5. Results: Pre-and post-operative ALBI grade predicted patients' long-term outcomes( P = 0.020 and P < 0.001, respectively, for overall survival, and P = 0.012 and P = 0.015, respectively, for recurrence-free survival). Post-operative ALBI grade was associated with patients' surgical factors of repeated hepatic resection( P = 0.012), intra-operative bleeding( P = 0.006), and surgery duration( P = 0.033). Furthermore, post-operative ALBI grade, rather than pre-operative ALBI grade, was an independent predictive factor of long-term outcome of Child–Pugh grade A patients with HCC. Conclusions: Post-operative ALBI grade is useful to predict the prognosis in patients after HCC resection. | Masataka Amisaki Ei Uchinaka Masaki Morimoto Naruo Tokuyasu Teruhisa Sakamoto Soichiro Honjo Hiroaki Saito Yoshiyuki Fujiwara | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，6： | 9 |
| 4 | Radiologic-pathologic correlation of three-dimensional shear-wave elastographic findings in assessing the liver ablation volume after radiofrequency ablation显示文摘AIM: To evaluate the usefulness of three-dimensional(3D) shear-wave elastography(SWE) in assessing the liver ablation volume after radiofrequency(RF) ablation.METHODS: RF ablation was performed in vivo in 10 rat livers using a 15-gauge expandable RF needle. 3D SWE as well as B-mode ultrasound(US) were performed 15 min after ablation. The acquired 3D volume data were rendered as multislice images(interslice distance: 1.10 mm), and the estimated ablation volumes were calculated. The 3D SWE findings were compared against digitized photographs of gross pathological and histopathological specimens of the livers obtained in the same sectional planes as the 3D SWE multislice images. The ablation volumes were also estimated by gross pathological examination of the livers, and theresults were then compared with those obtained by 3D SWE.RESULTS: In B-mode US images, the ablation zone appeared as a hypoechoic area with a peripheral hyperechoic rim; however, the findings were too indistinct to be useful for estimating the ablation area. 3D SWE depicted the ablation area and volume more clearly. In the images showing the largest ablation area, the mean kPa values of the peripheral rim, central zone, and nonablated zone were 13.1 ± 1.5 kPa, 59.1 ± 21.9 kPa, and 4.3 ± 0.8 kPa, respectively. The ablation volumes depicted by 3D SWE correlated well with those estimated from gross pathological examination(r2 = 0.9305, P = 0.00001). The congestion and diapedesis of red blood cells observed in histopathological examination were greater in the peripheral rim of the ablation zone than in the central zone.CONCLUSION: 3D SWE outperforms B-mode US in delineating ablated areas in the liver and is therefore more reliable for spatially delineating thermal lesions created by RF ablation. | Katsutoshi Sugimoto Hisashi Oshiro Saori Ogawa Mitsuyoshi Honjo Takeshi Hara Fuminori Moriyasu | 2014 | World Journal of Gastroenterology2014，20，33： | 9 |
| 5 | Height growth, diameter-height relationships and branching architecture of Pinus massoniana and Cunninghamia lanceolata in early regeneration stages in Anhui Province, eastern China: effects of light intensity and regeneration mode显示文摘To determine the growth strategies during early regeneration stages of two major coniferous species (Pinus massoniana and Cunninghamia lanceolata) in a secondary mixed coniferous forest in the Huangshan region of Anhui Province, eastern China, we examined height growth, diameter-height relationship and the relationship between main stem and lateral branch elongation in saplings, with a particular focus on the effects of light intensity and regeneration mode (seedlings versus sprouts). When light intensity was sufficiently high, the extension growth of main stems was greater and more positively related to initial size for P. massoniana than for C. lanceolata. The slenderness of the stem form increased in the following order: C. lanceolata seedlings < P. massoniana seedlings < C. lanceolata sprouts. P. massoniana became less slender with increasing light intensity. P. massoniana had shorter branches than C. lanceolata given the same main stem elongation. Growth allocation depended more strongly on light intensity for P. massoniana than for C. lanceolata, with more growth allocated to the main stem under dark conditions. These results suggest that P. massoniana is a typical shade avoider; this species gives priority to extension growth of the main stem, especially when it is shaded. In contrast, C. lanceolata is a shade tolerator; this species allocates more biomass to radial growth of its main stems and to extension growth of branches. Based on these results, the ecological characteristics of P. massoniana and C. lanceolata and the roles of seedlings and sprouts are discussed in relation to stand dynamics of the mixed forests of P. massoniana and C. lanceolata in eastern China. | CHENG Xi-ping Umeki KIYOSH Honjo TSUYOSHI SHAO Peng-yue | 2011 | Forestry Studies in China2011，13，1： | 9 |
| 6 | Combined preoperative platelet-to-lymphocyte ratio and serum carbohydrate antigen 19–9 level as a prognostic factor in patients with resected pancreatic cancer显示文摘Background: Carbohydrate antigen 19–9(CA19-9) is the most frequently used tumor marker and serves as a prognostic indicator in patients with pancreatic cancer(PC). The platelet-to-lymphocyte ratio(PLR) is thought to be an inflammation-related serum marker. An elevated PLR represents increased inflammatory status and is associated with poor prognosis in patients with various cancers including PC. Methods: This study involved 103 patients with a histopathological diagnosis of pancreatic ductal adenocarcinoma who underwent pancreatectomy. The patients were assessed to determine the prognostic significance of the combination of the PLR and CA19-9 level. Results: Based on the receiver operating characteristic analysis results, the patients were divided into PLR H igh(PLR ≥ 129.1) andPLRLow(PLR < 129.1) groups and into CA19-9High(CA19-9 ≥ 74.0 U/mL) and CA19-9Low(CA19-9 < 74.0 U/mL) groups. The cumulative 5-year overall survival(OS) and disease-specific survival(DSS) rates significantly differed by both the PLR(PLR H igh group: 19.5% and 22.9%;PLRLow group: 39.1% and 45.9%) and CA19-9(CA19-9 H igh group: 19.1% and 25.6%;CA19-9Low group: 41.0% and 41.0%). We then divided the patients into Groups A(PLR L ow/CA19-9Low), B(PLR Low/CA19-9High or PLRHigh/CA19-9Low), and C(PLR H igh/CA19-9High). The cumulative 5-year OS rates in Groups A, B, and C were 44.0%, 31.9%, and 11.9%, respectively( P = 0.002). The cumulative 5-year DSS rates in Groups A, B, and C were 47.7%, 36.4%, and 16.8%, respectively( P = 0.002). Multivariate analysis revealed that the combination of the PLR and CA19-9 was an independent prognostic factor in patients with resected PC. Conclusions: The combination of the PLR and CA19-9 is useful for predicting the prognosis of patients with resected PC. | Teruhisa Sakamoto Hiroaki Saito Masataka Amisaki Naruo Tokuyasu Soichiro Honjo Yoshiyuki Fujiwara | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，3： | 3 |
| 7 | The PD-1–PD-L pathway in immunological tolerance显示文摘 | Taku Okazaki Tasuku Honjo | 2006 | Trends in Immunology2006，，4： | 2 |
| 8 | Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells显示文摘 | Derk Amsen J.Magarian Blander Gap Ryol Lee Kenji Tanigaki Tasuku Honjo Richard A Flavell | 2004 | Cell2004，，4： | 2 |
| 9 | Anti-red blood cell autoantibody transgenic mice: murine model of autoimmune hemolytic anemia显示文摘 | Murakami M Honjo T | 1996 | Semin Immunol1996，8，： | 1 |
| 10 | Expression of cyto-plasmie galectin-3 as a prognostic marker in tongue carcinoma显示文摘 | Honjo Y Inohara H Akahaui S | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 11 | Thyroid hormones aad lipid metabolism 显示文摘 | Sasaki S Kawai K Honjo Y | 2006 | Nippon Rinsho2006，64，12： | 1 |
| 12 | Galectin-3 induces endothelial cell morphogenesis and angiogenesis显示文摘 | Nangia-Makker P Honjo Y Sarvis R | 2000 | American Journal of Pathology2000，156，： | 1 |
| 13 | Galectin-3 phosphorylation is required for its antiapoptotic function and cell cycle arrest显示文摘 | Yoshii T Fukumori T Honjo Y | 2002 | J Biol Chem2002，277，： | 1 |
| 14 | Estrogen protects neuronal cells from amyloid β-induced apoptotic cell death显示文摘 | Hosoda T Nakajima H Honjo H | 2001 | Neuroreport2001，12，90： | 1 |
| 15 | Biogenic barium fluxes to the deep sea:implications for paleoproductivity reconstruction显示文摘 | FRANCOIS R HONJO S MANGANINI S J | 1995 | Global Biogeochemical Cycles1995，9，2： | 1 |
| 16 | Effects of market liberalization on smoking in Japan显示文摘 | Honjo T Lawachi I | 2009 | Tobacco Control2009，9，： | 1 |
| 17 | Detection of cyprinid herpesvirus 3 DNA in river water during and after an outbreak 显示文摘 | MINAMOTO T HONJO M N UCHII K | 2009 | Vet Microbiol2009，135，34： | 1 |
| 18 | Moderate hypothermia increases the chance of spiral wave collision in favor of self-termination of ventricular tachycardia/fibrillation显示文摘 | Harada M Honjo H Yamazaki M | 2008 | Am J Physiol Heart Circ Physiol2008，294，4： | 1 |
| 19 | Remodeling of gap junctional cou- pling in hypertrophied right ventricles of rats with monocrotaline-induced pulmo- nary hypertension显示文摘 | Uzzaman M Honjo H Takagishi Y | 2000 | Circ Res2000，86，8： | 1 |
| 20 | Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization 显示文摘 | Tugues S Honjo S Konig C | 2012 | Cancer Research2012，72，8： | 1 |
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