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| 1 | Comparative study and systematic review of laparoscopic liver resection for hepatocellular carcinoma显示文摘AIM: To compare the surgical outcomes between laparoscopic liver resection(LLR) and open liver resection(OLR) as a curative treatment in patients with hepatocellular carcinoma(HCC). METHODS: A Pub Med database search was performed systematically to identify comparative studies of LLR vs OLR for HCC from 2000 to 2014. An extensive text word search was conducted, using combinations of search headings such as 'laparoscopy', 'hepatectomy', and 'hepatocellular carcinoma'. A comparative study was also performed in our institution where we analysed surgical outcomes of 152 patients who underwent liver resection between January 2005 to December 2012, of which 42 underwent laparoscopic or hand-assisted laparoscopic resection and 110 underwent open resection. RESULTS: Analysis of our own series and a review of 17 high-quality studies showed that LLR was superior to OLR in terms of short-term outcomes, as patients in the laparoscopic arm were found to have less intraoperative blood loss, less blood transfusions, and a shorter length of hospital stay. In our own series, both LLR and OLR groups were found to have similar overall survival(OS) rates, but disease-free survival(DFS) rates were higher in the laparoscopic arm. CONCLUSION: LLR is associated with better short-term outcomes compared to OLR as a curative treatment for HCC. Long-term oncologic outcomes with regards to OS and DFS rates were found to be comparable in both groups. LLR is hence a safe and viable option for curative resection of HCC. | Wei Qi Leong Iyer Shridhar Ganpathi Alfred Wei Chieh Kow Krishnakumar Madhavan Stephen Kin Yong Chang | 2015 | World Journal of Hepatology2015，7，27： | 7 |
| 2 | Laparoendoscopic single-site minor hepatectomy for liver tumors显示文摘 | Ek Tan Victor Lee Stephen Chang Iyer Ganpathi Krishnakumar Madhavan Davide Lomanto | 2012 | Surgical Endoscopy2012，，7： | 2 |
| 3 | Endoscopic uhrasonography for gastric cancer:does it influence treatment?显示文摘 | Ganpathi IS So JB HO KY | 2006 | Surg Endosc2006，20，： | 1 |
| 4 | Acute acalculous cholecystitis:challenging the myths显示文摘 | Ganpathi IS Diddapur RK Eugene H | 2007 | HPB (Oxford)2007，9，2： | 1 |
| 5 | Interim report: A randomized controlled trial comparing postoperative pain in single‐incision laparoscopic cholecystectomy and conventional laparoscopic cholecystectomy显示文摘 | Stephen Kin Yong Chang Yi Liang Wang Liang Shen Shridhar Ganpathi Iyer Ahmad Bin Syed Buhari Shaik Davide Lomanto | 2012 | Asian J Endosc Surg2012，，1： | 1 |
| 6 | Evaluation of efficacy and safety of gabapentin,duloxetine,and pregabalin in patients w ith painful diabetic peripheral neuropathy显示文摘 | Devi P Madhu K Ganpathy B | 2012 | Indian J Pharmacol2012，44，： | 1 |
| 7 | Small cell gall- bladder carcinoma complicated by paraneoplastic hyponatremia: a case report and literature review 显示文摘 | Ng ES Venkateswaran K Ganpathi SI | 2010 | J Gastrointest Cancer2010，41，4： | 1 |
| 8 | Laparoscopic-assisted management of small bowel obstruction due to phytobezoar显示文摘 | Ganpathi IS Cheah WK | 2005 | Surg Laparosc En-dosc Percutan Tech2005，15，1： | 1 |
| 9 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 10 | Transgenic banana plants overexpressing a native plasma membrane aquaporin MusaPIP1;2 display high tolerance levels to different abiotic stresses显示文摘 | Sreedharan S Upendra K S S Ganpathi T | 2013 | Plant Biotechnology Journal2013，11，3： | 1 |
| 11 | Acute acalculous chole- cystitis:challenging the myths显示文摘 | Ganpathi IS Diddapur RK Eugene H | 2007 | HPB(Oxford)2007，9，3： | 1 |
| 12 | Endoscopic ultrasonography for grastric cancer:does it influence treatment显示文摘 | Ganpathi IS So JB Ho KY | 2006 | Surg Endosc2006，20，4： | 1 |
| 13 | Endoscopic ultrasonography for gastric cancer显示文摘 | I. S. Ganpathi J. B.-Y. So K.-Y. Ho | 2006 | Surgical Endoscopy2006，，4： | 1 |
| 14 | Endoscopic uhrasonography for gastric cancer: does it influence treatment? 显示文摘 | Ganpathi IS So JB Ho KY | 2006 | Surg Endosc2006，20，4： | 1 |
| 15 | Evaluation of efficacy and safety of gabapentin, duloxetine, and pregabalin in patients with painful diabetic peripheral neuropathy 显示文摘 | Devi P Madhu K Ganpathy B | 2012 | Indian J Pharmacol2012，44，1： | 1 |
| 16 | Endoscopic ultrasonography for gastric cancer:does it influence treatment显示文摘 | Ganpathi IS So JB Ho KY | 2006 | Surg Endosc2006，20，4： | 1 |
| 17 | Endoscopic ultrasonography for gastric cancer:Does it influence treatment?显示文摘 | Ganpathi IS So JB Ho KY | 2006 | Surg Endosc2006，20，4： | 1 |
| 18 | Endoscopic ultrasonography for gastric cancer显示文摘 | I. S. Ganpathi J. B.-Y. So K.-Y. Ho | 2006 | Surgical Endoscopy2006，，4： | 1 |
| 19 | Acute acalculous cholecystitis: Challenging the myths显示文摘 | Ganpathi IS Diddapur RK EugeneH | 2007 | HPB: The Official Journal of the International Hepato Pancreato Biliary Association2007，9，2： | 1 |
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