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| 1 | Gut microbiome in acute pancreatitis:A review based on current literature显示文摘The gut microbiome is a complex microbial community,recognized for its potential role in physiology,health,and disease.The available evidence supports the role of gut dysbiosis in pancreatic disorders,including acute pancreatitis(AP).In AP,the presence of gut barrier damage resulting in increased mucosal permeability may lead to translocation of intestinal bacteria,necrosis of pancreatic and peripancreatic tissue,and infection,often accompanied by multiple organ dysfunction syndrome.Preserving gut microbial homeostasis may reduce the systemic effects of AP.A growing body of evidence suggests the possible involvement of the gut microbiome in various pancreatic diseases,including AP.This review discusses the possible role of the gut microbiome in AP.It highlights AP treatment and supplementation with prebiotics,synbiotics,and probiotics to maintain gastrointestinal microbial balance and effectively reduce hospitalization,morbidity and mortality in an early phase.It also addresses novel therapeutic areas in the gut microbiome,personalized treatment,and provides a roadmap of human microbial contributions to AP that have potential clinical benefit. | Bharati Kadamb Patel Kadamb H Patel Madhav Bhatia Shridhar Ganpati Iyer Krishnakumar Madhavan Shabbir M Moochhala | 2021 | World Journal of Gastroenterology2021，27，30： | 10 |
| 2 | Comparative study and systematic review of laparoscopic liver resection for hepatocellular carcinoma显示文摘AIM: To compare the surgical outcomes between laparoscopic liver resection(LLR) and open liver resection(OLR) as a curative treatment in patients with hepatocellular carcinoma(HCC). METHODS: A Pub Med database search was performed systematically to identify comparative studies of LLR vs OLR for HCC from 2000 to 2014. An extensive text word search was conducted, using combinations of search headings such as 'laparoscopy', 'hepatectomy', and 'hepatocellular carcinoma'. A comparative study was also performed in our institution where we analysed surgical outcomes of 152 patients who underwent liver resection between January 2005 to December 2012, of which 42 underwent laparoscopic or hand-assisted laparoscopic resection and 110 underwent open resection. RESULTS: Analysis of our own series and a review of 17 high-quality studies showed that LLR was superior to OLR in terms of short-term outcomes, as patients in the laparoscopic arm were found to have less intraoperative blood loss, less blood transfusions, and a shorter length of hospital stay. In our own series, both LLR and OLR groups were found to have similar overall survival(OS) rates, but disease-free survival(DFS) rates were higher in the laparoscopic arm. CONCLUSION: LLR is associated with better short-term outcomes compared to OLR as a curative treatment for HCC. Long-term oncologic outcomes with regards to OS and DFS rates were found to be comparable in both groups. LLR is hence a safe and viable option for curative resection of HCC. | Wei Qi Leong Iyer Shridhar Ganpathi Alfred Wei Chieh Kow Krishnakumar Madhavan Stephen Kin Yong Chang | 2015 | World Journal of Hepatology2015，7，27： | 7 |
| 3 | Atrial tachyarrhythmia in adult congenital heart disease显示文摘The adult congenital heart disease(ACHD) population continues to grow and most cardiologists, emergency room physicians and family doctors will intermittently come into contact with these patients. Oftentimes this may be in the setting of a presentation with atrial tachyarrhythmia; one of the commonest late complications of ACHD and problem with potentially serious implications. Providing appropriate initial care and ongoing management of atrial tachyarrhythmia in ACHD patients requires a degree of specialist knowledge and an awareness of certain key issues. In ACHD, atrial tachyarrhythmia is usual y related to the abnormal anatomy of the underlying heart defect and often occurs as a result of surgical scar or a consequence of residual hemodynamic or electrical disturbances. Arrhythmias significantly increase mortality and morbidity in ACHD and are the most frequent reason for ACHD hospitalization. Intra-atrial reentrant tachycardia and atrial fibrillation are the most prevalent type of arrhythmia in this patient group. In hemodynamically unstable patients, urgent cardioversion is required. Acute management of the stable patient includes anticoagulation, rate control, and electrical or pharmacological cardioversion. In ACHD, rhythm control is the preferred management strategy and can often be achieved. However, in the long-term, medication side-effects can prove problematic. Electrophysiology studies and catheter ablation are important treatments modalities and in certain cases, surgical or percutaneous treatment of the underlying cardiac defect has a role. ACHD patients, especially those with complex CHD, are at increased risk of thromboembolic events and anticoagulation is usually required. Female ACHD patients of child bearing age may wish to pursue pregnancies. The risk of atrial arrhythmias is increased during pregnancy and management of atrial tachyarrhythmia during pregnancy needs specific consideration. | Arsha Karbassi Krishnakumar Nair Louise Harris Rachel M Wald S Lucy Roche | 2017 | World Journal of Cardiology2017，9，6： | 3 |
| 4 | Solar active fire clay based hetero-Fenton catalyst over a wide pH range for degradation of Acid Violet 7显示文摘Fe(III) immobilized fire clay (Fe-FC) was prepared using ferric nitrate by solid state dispersion method and this hetero-Fenton catalyst was applied for the degradation of Acid Violet 7 (AV 7) under natural sunlight. The 26% ferric nitrate loaded fire clay was found to be most efficient. The experimental conditions such as solution pH, H2O2 concentration for efficient degradation of AV 7 have been determined. Unlike Fenton catalyst, Fe-FC is photoactive over a wide pH range of 3-7. This catalyst was found to be stable and reusable. The GC-MS analysis of experimental solutions during irradiation revealed the formation of 2,8-diaminonaphthalene-1,3,6- triol, 8-aminonaphthalene-1,2,3,6-tetrol, 2-aminonaphthalene-1,3,6,8-tetrol and 2-aminobenzene-1,3-diol/5-aminonbenzene-1,3-diol/ 2-aminobenzene-1,4-diol as intermediates. The 26% ferric nitrate loaded fire clay was characterized by XRD, ICP-AES, BET surface area, FT-IR, SEM-EDS and UV-DRS studies. | Inbasekaran Muthuvel Balu Krishnakumar Meenakshisundaram Swaminathan | 2012 | Journal of Environmental Sciences2012，24，3： | 3 |
| 5 | The utility of laparoscopic assessment in the preoperative staging of suspected hilar cholangiocarcinoma显示文摘 | Saxon Connor F.R.A.C.S. Emma Barron B.Sc. Stephen J. Wigmore M.D. F.R.C.S. Krishnakumar K. Madhavan M.S. F.R.C.S. Rowan W. Parks M.D. F.R.C.S. O. James Garden M.D. F.R.C.S | 2005 | Journal of Gastrointestinal Surgery2005，，4： | 3 |
| 6 | Molt and reproduction enhancement together with hemolymph ecdysteroid elevation under eyestalk ablation in the female fiddler crab,Uca triangularis(Brachyura:Decapoda)显示文摘We present the results of eyestalk extirpation experiments performed on the fiddler crab, Uca triangularis at seasons of molting and reproduction, with a view to have a better understanding of the regulatory mechanisms of these two highly energy-demanding processes. Bilateral eyestalk ablation resulted in precocious acceleration of both molting and reproduction, irrespective of the season at which each experiment was conducted. The rate of accelerated ovarian growth, however, was maximum if the eyestalk ablation was conducted during August–January, the breeding season in the wild, or in February–May(molting-reproductive season), wherein a section of the wild population would be engaged in molting and another section in breeding. The highest degree of precocious molt acceleration, on the other hand, was obtained during June–July when the population was primarily engaged in molting, but with no reproductive activity. The precocious oocyte maturation(due to de-eyestalking) was minimal in June–July. Significantly, the eyestalk ablation also resulted in a dramatic increase in the hemolymph ecdysteroid titer, revealing that a high ecdysteroid titer would have no restraining influence on vitellogenesis. No spawning was, however, observed among de-eyestalked females, even though their final oocyte size surpassed the size of the normal mature oocytes, implying that spawning is not exclusively under the control of eyestalk hormones. A comparative study performed on the vitelline components of the experimentals and the controls revealed that the precociously incorporated yolk under eyestalk ablation was biochemically impoverished. These results indicate that throughout the annual cycle, both the somatic and the reproductive growth of U. triangularis are under the influence of inhibitory principles from the eyestalks. It is also revealing that mere deprival of the inhibitory principles does not culminate into successful vitellogenesis. Arguably, the inhibitory influence from the eyestalks could be a prerequisite for normal healthy maturation of the oocytes and spawning. | SUPRIYA Nagathinkal T SUDHA Kappalli KRISHNAKUMAR Velayudhannair ANILKUMAR Gopinathan | 2017 | Chinese Journal of Oceanology and Limnology2017，35，3： | 3 |
| 7 | Identification, characterization and utilization of EST-derived genic microsatellite markers for genome analyses of coffee and related species显示文摘 | Ramesh K. Aggarwal Prasad S. Hendre Rajeev K. Varshney Prasanna R. Bhat V. Krishnakumar Lalji Singh | 2007 | Theoretical and Applied Genetics2007，，2： | 2 |
| 8 | Laparoendoscopic single-site minor hepatectomy for liver tumors显示文摘 | Ek Tan Victor Lee Stephen Chang Iyer Ganpathi Krishnakumar Madhavan Davide Lomanto | 2012 | Surgical Endoscopy2012，，7： | 2 |
| 9 | New approaches to water purification for resource- constrained settings: Production of activated biochar by chemical activation with diammonium hydrogenphosphate显示文摘 | Mohit Nahata Chang Y. Seo Pradeep Krishnakumar Johannes Schwank | 2018 | Frontiers of Chemical Science and Engineering2018，12，1： | 2 |
| 10 | Phantom bite syndrome:Revelation from clinically focused review显示文摘Phantom bite syndrome(PBS),also called occlusal dysesthesia,is characterized by persistent non-verifiable occlusal discrepancies.Such erroneous and unshakable belief of a“wrong bite”might impel patients to visit multiple dental clinics to meet their requirements to their satisfaction.Subsequently,it takes a toll on their quality of life causing,career disruption,financial loss and suicidal thoughts.In general,patients with PBS are quite rare but distinguishable if ever encountered.Since Marbach reported the first two cases in 1976,there have been dozens of published cases regarding this phenomenon,but only a few original studies were conducted.Despite the lack of official classification and guidelines,many authors agreed on the existence of a PBS“consistent pattern”that clinicians should be made aware.Nevertheless,the treatment approach has been solely based on incomplete knowledge of etiology,in which none of the proposed theories are fully explained in all the available cases.In this review,we have discussed the critical role of enhancing dental professionals’awareness of this phenomenon and suggested a comprehensive approach for PBS,provided by a multidisciplinary team of dentists,psychiatrists and exclusive psychotherapists. | Trang Thi Huyen Tu Motoko Watanabe Gayatri Krishnakumar Nayanar Yojiro Umezaki Haruhiko Motomura Yusuke Sato Akira Toyofuku | 2021 | World Journal of Psychiatry2021，11，11： | 2 |
| 11 | Powder dispersion and aqueous tape casting of YSZ-NiO composite 显示文摘 | RAMANATHAN S KRISHNAKUMAR K P DE P K | 2004 | J Mater Sci2004，39，： | 1 |
| 12 | Permea- bility of dense(homogeneous) cellulose acetate membranes to methane, carbon dioxide, and their mixtures at elevated pressures显示文摘 | Houde A Y Krishnakumar B Charati S G | 1996 | Journal of Applied Polymer Science1996，62，： | 1 |
| 13 | Modeling of slag eye formation over a metal bath due to gas bubbling显示文摘 | Krishnakumar Krishnapisharody Gordon A. Irons | 2006 | Metallurgical and Materials Transactions B2006，，5： | 1 |
| 14 | A Comprehensive Model to Study the Dynamic Motion of Piston and Friction and Lubrication in IC Engine显示文摘 | Ravindra R Malagi Shivakant N Kurbet R Krishnakumar | 2008 | SAE2008，28，： | 1 |
| 15 | Bacterial oxidation of sulphide under denitrifying conditions 显示文摘 | KRISHNAKUMAR B MANILAL V B | 1999 | Biotechnology Letters1999，21，： | 1 |
| 16 | Process and temperature compensation in a 7 MHz CMOS clock oscillator显示文摘 | Krishnakumar Sundaresan Phillip E Allen Farrokh Ayazi | | 0，，02： | 1 |
| 17 | Lifetimes of polypropylene films under combined high electric fields and thermal stresses显示文摘 | Cygan P Krishnakumar B | 1989 | IEEE Transactions on Electrical Insulation1989，24，4： | 1 |
| 18 | New methods to identify and rank high pedestrian crash zones: an illustration显示文摘 | Pulugurtha S S Krishnakumar V K Nambisan S S | 2007 | Accident Analysis and Prevention2007，39，4： | 1 |
| 19 | Flight dynamics and hybrid adaptive control of damaged aircraft显示文摘 | Nguyen N Krishnakumar K Kaneshige J | 2008 | Journal of Guidance Control and Dynamics2008，31，3： | 1 |
| 20 | Multiple mRNAs from the Punch locus of Drosophila melanogaster encode isoforms of GTP cyclohydrolaseⅠwith distinct N-terminal domains显示文摘 | MCLEAN J R KRISHNAKUMAR S O’DONNELL J M | 1993 | J Biol Chem1993，268，27： | 1 |
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