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32篇 您的检索式：作者名="Madhankumar"

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	题名	作者	年代	出处	被引量
1	High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma显示文摘Glioblastoma(GBM),the deadliest form of brain cancer,presents long-standing problems due to its localization.Chimeric antigen receptor(CAR)T cell immunotherapy has emerged as a powerful strategy to treat cancer.IL-13-receptor-α2(IL13Rα2),present in over 75%of GBMs,has been recognized as an attractive candidate for antiglioblastoma therapy.Here,we propose a novel multidisciplinary approach to target brain tumors using a combination of fluorescent,therapeutic nanoparticles and CAR T cells modified with a targeted-quadruplemutant of IL13(TQM-13)shown to have high binding affinity to IL13Rα2-expressing glioblastoma cells with low off-target toxicity.Azide-alkyne cycloaddition conjugation of nanoparticles to the surface of T cells allowed a facile,selective,and high-yielding clicking of the nanoparticles.Nanoparticles clicked onto T cells were retained for at least 8 days showing that the linkage is stable and promising a suitable time window for in vivo delivery.T cells clicked with doxorubicin-loaded nanoparticles showed a higher cytotoxic effect in vitro compared to bare T cells.In vitro and in vivo T cells expressing TQM-13 served as delivery shuttles for nanoparticles and significantly increased the number of nanoparticles reaching brain tumors compared to nanoparticles alone.This work represents a new platform to allow the delivery of therapeutic nanoparticles and T cells to solid tumors.	Gloria B.Kim Virginia Aragon-Sanabria Lauren Randolph Hali Jiang Joshua A.Reynolds Becky S.Webb Achuthamangalam Madhankumar Xiaojun Lian James R.Connor Jian Yang Cheng Dong	2020	Bioactive Materials2020，5，3：	6
2	Laparoscopic Pancreaticoduodenectomy: Technique and Outcomes显示文摘	Chinnasamy Palanivelu Kalpesh Jani Palanisamy Senthilnathan Ramasamy Parthasarathi Subbaiah Rajapandian Madathupalayam Velusamy Madhankumar	2007	Journal of the American College of Surgeons2007，，2：	2
3	Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme显示文摘	Madhankumar AB Slagle-Webb B Mintz A	2006	Mol Cancer Ther2006，5，12：	1
4	Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model显示文摘	Madhankumar AB Slagle-Webb B Wang X	2009	Mol Cancer Ther2009，8，3：	1
5	Management of pancreatic pseudocyst in the era of laparoscopic surgery Experience from a tertiary centre显示文摘	Palanvelu C Senthilkumar K Madhankumar MV	2007	Surg Endosc2007，22，2：	1
6	PPAR dual agonists: Are they opening Pandora’s Box?显示文摘	Pitchai Balakumar Madhankumar Rose Subrahmanya S. Ganti Pawan Krishan Manjeet Singh	2007	Pharmacological Research2007，，2：	1
7	Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the in- tracranial brain tumor model 显示文摘	Madhankumar AB Slagle-Webb B Wang X	2009	Mol Cancer Ther2009，8，3：	1
8	Interleukin- 13 receptor-targeted nanovesicles are a potential therapy for glio- blastoma muhiforme 显示文摘	Madhankumar AB Slagle-Webb B Mintz A	2006	Mol Cancer Ther2006，5，12：	1
9	Influence of Si nanoparticles on the electrochemical behavior of organic coatings on carbon steel in chloride environment 显示文摘	Madhankumar A Rajendran N Nishimura T	2012	Jour-nal of Coatings Technology and Research2012，9，：	1
10	Management of pancreatic pseudocyst in the era of la-paroscopic surgery-experience from atertiary centre显示文摘	PALANIVELU C SENTHILKUMAR K MADHANKUMAR MV	2007	Surg En-dosc2007，21，12：	1
11	Management of pancreatic pseudocyst in the era of la-paroseopie surgery-experience from a tertiary centre显示文摘	PALANIVELU C SENTHILKUMAR K MADHANKUMAR MV	2007	Surg En-dosc2007，21，：	1
12	Biomimetic synthesis of silver nanoparticles by aqueous extract of Syzygium aromaticum显示文摘	K. Vijayaraghavan S.P. Kamala Nalini N. Udaya Prakash D. Madhankumar	2012	Materials Letters2012，，：	1
13	Laparoscopic Pancreaticoduodenectomy: Technique and Outcomes显示文摘	Chinnasamy Palanivelu Kalpesh Jani Palanisamy Senthilnathan Ramasamy Parthasarathi Subbaiah Rajapandian Madathupalayam Velusamy Madhankumar	2007	Journal of the American College of Surgeons2007，，2：	1
14	Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents 显示文摘	Liu X Madhankumar AB Slagle-Webb B	2011	Cancer Res2011，71，6：	1
15	Management of pancreatic pseudocyst in the era of laparoscopic surgery experience from a tertiary centre显示文摘	Palanivelu C Senthilkumar K Madhankumar MV	2007	Surg Endosc2007，21，12：	1
16	Protein- and DNA- based active immunotherapy targeting interleukin-13 receptor alpha2显示文摘	Mintz A Gibo DM Madhankumar AB	2008	Cancer Biother Radiopharm2008，23，5：	1
17	Laparoscopic sutured closure with mesh reinforcement of incisional hernias显示文摘	C. Palanivelu K. V. Jani P. Senthilnathan R. Parthasarathi M. V. Madhankumar V. K. Malladi	2007	Hernia2007，，3：	1
18	Management of pancreatic pseudocyst in the era of lapareseopic surgery experience from a tertiary centre显示文摘	Palanivelu C Senthilkumar K Madhankumar MV	2007	Surg Endosc2007，21，12：	1
19	Management of pancreatic pseudocyst in the era of laparoscopicsurgery experience from a tertiary centre显示文摘	Palanivelu C senth Ilkumar K Madhankumar MV	2007	Surg Endosc2007，21，12：	1
20	Management of pancreatic pseudocyst in the era of laparoscopic surgery – Experience from a tertiary centre显示文摘	Chinnusamy Palanivelu Karuppuswamy Senthilkumar Madathupalayam Velusamy Madhankumar Pidigu Seshiyar Rajan Alangar Roshan Shetty Kalpesh Jani Muthukumaran Rangarajan Gobi Shanmugam Maheshkumaar	2007	Surgical Endoscopy2007，，12：	1

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