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| 1 | Local longitudinal muscle shortening of the human esophagus from high-frequency ultrasonography显示文摘 | Nicosia MA Brasseur JG Liu JB | 2001 | Am J Physiol Gastrointest Liver Physiol2001，281，4： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia 显示文摘 | Hicks CA Ward MA Swettenham JB O'Neill MJ | 1999 | Eur J Pharmacol1999，381，23： | 2 |
| 4 | Updated population-based review of carcinoid tumors 显示文摘 | Maggard MA O' Connell JB Ko CY | 2004 | Ann Surg2004，240，1： | 1 |
| 5 | Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance显示文摘 | Tsukumo DM Carvalho-Filho MA Carvalheira JB | | 0，，08： | 1 |
| 6 | Infommtics methods to enable sharing of quantitative imaging research data 显示文摘 | Levy MA Freymann JB Kirby JS | 2012 | Magn Reson Imaging2012，30，9： | 1 |
| 7 | Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation显示文摘 | BedeU MA Hudson JB Golub TR | 1991 | J Viro 11991，65，5： | 1 |
| 8 | Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes显示文摘 | Green JB Bethel MA Armstrong PW | 2015 | N Engl J Med2015，373，3： | 1 |
| 9 | Caspases as treatment targets in stroke and neurodegenerative disease显示文摘 | Schulz JB Weller M Moskowitz MA | 1999 | Ann N eurol1999，45，4： | 1 |
| 10 | Apical entry channels in calci-um transporting epithelia显示文摘 | Peng JB Brown EM Hediger MA | 2003 | News Physiol Sci2003，18，： | 1 |
| 11 | Combined endov- enous ablation and transilluminated powered phlebectomy: is less invasive better? 显示文摘 | Passman MA Dattilo JB Guzman RJ | 2007 | Vasc Endovascular Surg2007，41，1： | 1 |
| 12 | Hyperinsulinemia, hy- perglycemia and impaired hemostasis: The Framingham Offspring Study显示文摘 | Meigs JB Mittleman MA Nathan DM | 2000 | JAMA2000，283，2： | 1 |
| 13 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 14 | Cancer stem cells: a review显示文摘 | Spillane JB Henderson MA | 2007 | ANZ J Surg2007，77，6： | 1 |
| 15 | Impaired temoralresolution of visual attion and dopamine beta-hydroxylase genotypein attention-deficit/hyperaltinity disorder显示文摘 | Bellgrove MA Mattingley JB Hawi Z | 2006 | Biol Psychiatry2006，60，： | 1 |
| 16 | Intraoperative radiation therapy in recurrent carcinoma of the uterine cervix:report of the French intraoperative group on 70 patients 显示文摘 | Mah MA Grard JP DUbois JB | 1996 | Int J Radiat Oneol Biol Phys1996，34，1： | 1 |
| 17 | Cognitive behavioral therapy for adolesccnt depression:meta analytic investigation of changes in effect size estimates显示文摘 | Klein JB Jacobs RH Reinecke MA | 2007 | J Am Acad Child Adolesc Psychiatry2007，46，11： | 1 |
| 18 | Amplification of the proinflammatory transcription factor cascade increases with severity of uncontrolled hemorrhage in swine显示文摘 | Brundage SI Schreiber MA Holcomb JB | 2003 | J Surg Res2003，113，1： | 1 |
| 19 | Hyperinsulinemia,hyperglycemia,and impaired hemostasis:the Framingham Offspring Study显示文摘 | Meigs JB Mittleman MA Nathan DM | 2000 | JAMA2000，283，2： | 1 |
| 20 | Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF,TNF-alpha and TGF-beta1显示文摘 | Araujo FA Rocha MA Mendes JB | | 0，，1： | 1 |
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