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| 1 | Current trends in management of hepatitis B virus reactivation in the biologic therapy era显示文摘Hepatitis B virus (HBV) reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents. In particular, the risk ofHBV reactivation is heightened by the use monoclonalantibodies, such as rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and longlasting immunosuppression. Emerging data indicatethat HBV reactivation could also develop following theuse of other biologic agents, such as tumor necrosis factor (TNF)-α inhibitors. When HBV reactivation is di-agnosed, it is mandatory to suspend biologic treatmentand start antiviral agents immediately. However, preemptive antiviral therapy prior to monoclonal antibodyadministration is crucial in preventing HBV reactivationand its clinical consequences. Several lines of evidencehave shown that risk of HBV reactivation is greatlyreduced by the identifi cation of high-risk patients andthe use of prophylactic antiviral therapy. In this article, we discuss current trends in the management of HBV reactivation in immunosuppressed patients receiving biologic therapy, such as rituximab, alemtuzumab and TNF-α antagonists. | Claudio M Mastroianni Miriam Lichtner Rita Citton Cosmo Del Borgo Angela Rago Helene Martini Giuseppe Cimino Vincenzo Vullo | 2011 | World Journal of Gastroenterology2011，17，34： | 12 |
| 2 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 3 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 4 | Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials显示文摘 | Guglielmo Ronco Joakim Dillner K Miriam Elfstr?m Sara Tunesi Peter J F Snijders Marc Arbyn Henry Kitchener Nereo Segnan Clare Gilham Paolo Giorgi-Rossi Johannes Berkhof Julian Peto Chris J L M Meijer | 2013 | The Lancet2013，，： | 3 |
| 5 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 6 | Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis显示文摘 | Simon IR Noble Mike D Shelley Bernadette Coles Susan M Williams Andrew Wilcock Miriam J Johnson | 2008 | Lancet Oncology2008，，6： | 2 |
| 7 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 8 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 9 | Array biosensor for detection of oehratoxin A in cereals and beverages 显示文摘 | Miriam M N Lias C S Martin H M | 2005 | Analytical Chemistry2005，77，1： | 1 |
| 10 | A cyanogluceside,sarmentosin,from the Magpie Moth,Abraxas grossulariata,Geometridae:Lepidoptera显示文摘 | Ritsuo N Miriam R Rosemary M | 1994 | Phytochemistry1994，36，： | 1 |
| 11 | Does the presence of hepatitis virus B and C influence the evolution of diffuse large B-cell lymphoma?显示文摘 | Judit Rubio Fernando Franco Antonio Sá nchez Blanca Cantos Miriam Mé ndez Virginia Calvo Constanza Maximiano David Perez Isabel Millá n Margarita Sá nchez-Beato Mariano Provencio | 2015 | Leukemia & Lymphoma2015，，6： | 1 |
| 12 | Differences in the pheno- lic composition and sensory profile between red wines aged in oak barrels and wines aged with oak chips显示文摘 | Miriam O H Silvia P M Estela C M | 2010 | LWT-Food Science and Technology2010，，43： | 1 |
| 13 | Can virtual reality re- duce reality distortion Impact of performance feedback on symptom change in schizophrenia patients 显示文摘 | Steffen M Miriam V Ulf K | 2014 | Journal of Behavior Therapy and Experimental Psychiatry2014，45，2： | 1 |
| 14 | New molecular targeted therapies for advanced non-small-cell lung cancer显示文摘 | Miriam M Ana C Mariano P | | 0，，03： | 1 |
| 15 | Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4显示文摘 | Miriam E. Jaax Krystin Krauel Thomas Marschall Sven Brandt Julia Gansler Birgitt Fürll Bettina Appel Silvia Fischer Stephan Block Christiane A. Helm Sabine Müller Klaus T. Preissner Andreas Greinacher | 2013 | Blood2013，，： | 1 |
| 16 | Occurrence and Specific Congener Profile of 40 polybrominated diphenyl Ethers in River and Coastal Sediments from Portugal 显示文摘 | Silvia L Miriam G Elena M | 2003 | Environmental Science Technology2003，37，5： | 1 |
| 17 | The Influence of Maternal Quality on Brood Sex Allocation in the Small Carpenter Bee, Ceratina calcarata显示文摘 | Rehan Sandra M Richards Miriam H | 2010 | Ethology2010，116，9： | 1 |
| 18 | Road Extraction from Aerial Images Using a Region Competition Algorithm显示文摘 | Miriam A Femando M Margarita T | 2006 | IEEE Transaction on Image Processing2006，15，5： | 1 |
| 19 | Molecular epidemiology of 'Norwalk-like viruses' associated with gast roenteritis outbreaks in New Zealand显示文摘 | Greening GE Miriams M Berke T | 2001 | J Med Virol2001，64，1： | 1 |
| 20 | Determination of menthol in plasma and urine of rats and humans by headspace solid phase microextraction and gas chromatography-mass spectrometry显示文摘 | Miriam Spichiger Roman C Mühlbauer | 2004 | J of Chromatogr B2004，799，： | 1 |
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