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| 1 | Risk factors associated with pancreatic fistula after distal pancreatectomy, which technique of pancreatic stump closure is more beneficial?显示文摘AIM: To identify risk factors related to pancreatic fistula in patients undergoing distal pancreatectomy (DP) and to determine the effectiveness of using a stapled and a sutured closed of pancreatic stump. METHODS: Sixty-four patients underwent DP during a 10-year period. Information regarding diagnosis, operative details, and perioperative morbidity or mortality was collected. Eight risk factors were examined. RESULTS: Indications for DP included primary pancreatic disease (n = 38, 59%) and non-pancreatic malignancy (n = 26, 41%). Postoperative mortality and morbidity rates were 1.5% and 37% respectively; one patient died due to sepsis and two patients required a reoperation due to postoperative bleeding. Pancreatic fistula was developed in 14 patients (22%); 4 of fistulas were classified as Grade A, 9 as Grade B and only 1 as Grade C. Incidence of pancreatic fistula rate was significantly associated with four risk factors: pathology, use of prophylactic octreotide therapy, concomitant splenectomy, and texture of pancreatic parenchyma. The role that technique (either stapler or suture) of pancreatic stump closure plays in the development of pancreatic leak remains unclear. CONCLUSION: The pancreatic fistula rate after DP is 22%. This is reduced for patients with non-pancreatic malignancy, fibrotic pancreatic tissue, postoperative prophylactic octreotide therapy and concomitant splenectomy. | Marco Pericoli Ridolfini Sergio Alfieri Stavros Gourgiotis Dario Di Miceli Fabio Rotondi Giuseppe Quero Roberta Manghi Giovanni Battista Doglietto | 2007 | World Journal of Gastroenterology2007，13，38： | 24 |
| 2 | Adjuvant chemotherapy for gastric cancer:Current evidence and future challenges显示文摘Gastric cancer still represents one of the major causes of cancer mortality worldwide.Patients survival is mainly related to stage,with a high proportion of patients with metastatic disease at presentation.Thus,the cure rate largely depend upon surgical resection.Despite the additional,albeit small,benefit of adjuvant chemotherapy has been clearly demonstrated,no general consensus has been reached on the best treatment option.Moreover,the narrow therapeutic index of adjuvant chemotherapy(i.e.,limited survival benefit with considerable toxicity)requires a careful assessment of expected risks and benefits for individual patients.Treatment choices vary widely based on the different geographic areas,with chemotherapy alone more often preferred in Europe or Asia and chemoradiotherapy in the United States.In the present review we discuss the current evidence and future challenges regarding adjuvant chemotherapy in curatively resected gastric cancer with particular emphasis on the recently completed landmark studies and meta-analyses.The most recent patient-level meta-analysis demonstrated the benefit of adjuvant chemotherapy over curative surgery;the same Authors also showed that disease free survival may be used as a surrogate end-point for overall survival.We finally discuss future research issues such as the need of economic evaluations,development of prognostic or predictive biomarkers,and the unmet clinical need of trials comparing perioperative chemotherapy with adjuvant treatment. | Rosalba Miceli Gianluca Tomasello Giacomo Bregni Maria Di Bartolomeo Filippo Pietrantonio | 2014 | World Journal of Gastroenterology2014，20，16： | 12 |
| 3 | Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis显示文摘 | Vincenzo Mazzaferro Josep M Llovet Rosalba Miceli Sherrie Bhoori Marcello Schiavo Luigi Mariani Tiziana Camerini Sasan Roayaie Myron E Schwartz Gian Luca Grazi René Adam Peter Neuhaus Mauro Salizzoni Jordi Bruix Alejandro Forner Luciano De Carlis Umberto | 2009 | Lancet Oncology2009，，1： | 4 |
| 4 | Clinical characteristics and prognostic impact of atrial fibrillation in patients with chronic heart failure显示文摘AIM To assess the prevalence, clinical characteristics and independent prognostic impact of atrial fibrillation(AF) in chronic heart failure(CHF) patients, and the potential protective effect of disease-modifying medications, particularly beta-blockers(BB). METHODS We retrospectively reviewed the charts of patients referred to our center since January 2004, and collected all clinical information available at their first visit. We assessed mortality to the end of June 2015. We compared patients with and without AF, and assessed the association between AF and all-cause mortality by multivariate Cox regression and Kaplan-Meyer analysis, particularly accounting for ongoing treatment with BB.RESULTS A total of 903 patients were evaluated(mean age 68 ± 12 years, 73% male). Prevalence of AF was 19%, ranging from 10% to 28% in patients ≤ 60 and ≥ 77 years, respectively. Besides the older age, patients with AF had more symptoms(New York Heart Association II-III 60% vs 44%), lower prevalence of dyslipidemia(23% vs 37%), coronary artery disease(28% vs 52%) and left bundle branch block(9% vs 16%). On the contrary, they more frequently presented with an idiopathic etiology(50% vs 24%), a history of valve surgery(13% vs 4%) and received overall more devices implantation(31% vs 21%). The use of disease-modifying medications(i.e., BB and ACE inhibitors/angiotensin receptor blockers) was lower in patients with AF(72% vs 80% and 71% vs 79%, respectively), who on the contrary were more frequently treated with symptomatic and antiarrhythmic drugs including diuretics(87% vs 69%) and digoxin(51% vs 11%). At a mean follow-up of about 5 years, all-cause mortality was significantly higher in patients with AF as compared to those in sinus rhythm(SR)(45% vs 34%, P value < 0.05 for all previous comparisons). However, in a multivariate analysis including the main significant predictors of allcause mortality, the univariate relationship between AF and death(HR = 1.49, 95%CI: 1.15-1.92) became not statistically significant(HR = 0.98, 95%CI: 0.73-1.32). Nonetheless, patients with AF not receiving BB treatment were found to have the worst prognosis, followed by patients with SR not receiving BB therapy and patients with AF receiving BB therapy, who both had similarly worse survival when compared to patients with SR receiving BB therapy.CONCLUSION AF was highly prevalent and associated with older age, worse clinical presentation and underutilization of disease-modifying medications such as BB in a population of elderly patients with CHF. AF had no independent impact on mortality, but the underutilization of BB in this group of patients was associated to a worse long-term prognosis. | Lorenzo Gigli Pietro Ameri Gianmarco Secco Gabriele De Blasi Roberta Miceli Alessandra Lorenzoni Francesco Torre Francesco Chiarella Claudio Brunelli Marco Canepa | 2016 | World Journal of Cardiology2016，8，11： | 4 |
| 5 | Radiofrequency Ablation of Small Hepatocellular Carcinoma in Cirrhotic Patients Awaiting Liver Transplantation: A Prospective Study显示文摘 | Vincenzo Mazzaferro Carlo Battiston Stefano Perrone Andrea Pulvirenti Enrico Regalia Raffaele Romito Dario Sarli Marcello Schiavo Francesco Garbagnati Alfonso Marchianò Carlo Spreafico Tiziana Camerini Luigi Mariani Rosalba Miceli Salvatore Andreola | 2004 | Annals of Surgery2004，，5： | 3 |
| 6 | Hepatocellular carcinoma,hepatitis C virus infection and miRNA involvement:Perspectives for new therapeutic approaches显示文摘Chronic hepatitis C virus(HCV)infection is the principal etiology of cirrhosis and,ultimately,hepatocellular carcinoma(HCC).At present,approximately 71 million people are chronically infected with HCV,and 10%–20%of these are expected to develop severe liver complications throughout their lifetime.Scientific evidence has clearly shown the causal association between miRNAs,HCV infection and HCC.Although it is not completely clear whether miRNA dysregulation in HCC is the cause or the consequence of its development,variations in miRNA patterns have been described in different liver diseases,including HCC.Many studies have analyzed the importance of circulating miRNAs and their effect on cell proliferation and apoptosis.In this Review,we aim to summarize current knowledge on the association between miRNA,HCV and HCC from a diagnostic point of view,and also the potential implications for therapeutic approaches. | Ester Badami Rosalia Busà Bruno Douradinha Giovanna Russelli Vitale Miceli Alessia Gallo Giovanni Zito Pier Giulio Conaldi Gioacchin Iannolo | 2022 | World Journal of Gastroenterology2022，28，22： | 2 |
| 7 | Subtotal Versus Total Gastrectomy for Gastric Cancer: Five-Year Survival Rates in a Multicenter Randomized Italian Trial显示文摘 | Federico Bozzetti Ettore Marubini Giuliano Bonfanti Rosalba Miceli Chiara Piano Leandro Gennari | 1999 | Annals of Surgery1999，，： | 2 |
| 8 | Dermatofibrosarcoma protuberans treated at a single institution:a surgical disease with a high cure rate显示文摘 | Fiore M Miceli R Mussi C | 2005 | J Clin Oncol2005，23，30： | 1 |
| 9 | Clinical relevance of vascular endothelial growth factor and thymidine phosphorylase in patients with node-positive breast cancer treated with either adjuvant chemotherapy or hormone therapy显示文摘 | Gasparini G Toi M Miceli R | 1999 | Cancer J Sci Am1999，5，2： | 1 |
| 10 | LEFTY2 expression andlocalization in rat oviduct during early pregnancy 显示文摘 | Argafiaraz ME Apichela SA Miceli DC | 2010 | Zygote2010，12，21： | 1 |
| 11 | Ghrelin in vitro mod- ulates vasoactive factors in human umbilical vein endothe- lial cells 显示文摘 | Minici F Miceli F Tiberi F | 2007 | Fertil Steril2007，88，4： | 1 |
| 12 | Far infrared emitting piaster in knee osteoarthritis: a single blinded, randomised cli- nicaltrial 显示文摘 | Bagnato GL Miceli G Atteritano M | 2012 | Reumatismo2012，64，6： | 1 |
| 13 | Maternal satis- faction as an outcome criterion in research on labor anal- gesia data analysis from the recent literature显示文摘 | Abraham N Miceli MC Parnes JR | 2015 | Clinical Journal of Pain2015，31，3： | 1 |
| 14 | Patients with headache and functionaldyspepsia present meal–inducedhypersensitivity of the stomach显示文摘 | E. Pucci M. Stefano E. Miceli G. R. Corazza G. Sandrini G. Nappi | 2005 | The Journal of Headache and Pain2005，，4： | 1 |
| 15 | In vitro analyses of the combination of high-dose doxycycline and antifungal agents against Candida albicans biofilms 显示文摘 | Miceli MH Bernardo SM Lee SA | 2009 | Int J Antimicrob Agents2009，34，4： | 1 |
| 16 | Perioperative total parenteral nutrition in malnourished,gastrointestinal cancer patients:a randomized,clinical trial显示文摘 | Bozzetti F Gavazzi C Miceli R | 2000 | JPEN2000，24，1： | 1 |
| 17 | Pharmacodynamics of ziprasidone in children and adolescents: impact on dopamine transmission 显示文摘 | Sallee FR Gilbert DL Vinks AA Miceli JJ Robarge L Wilner K | 2003 | J Am Acad Child Adolesc Psychiatry2003，42，8： | 1 |
| 18 | An exploration of the meaning and consequences of workaholism显示文摘 | Scott K S Moore K S Miceli M P | 1997 | Human Rela- tions1997，50，： | 1 |
| 19 | Diffraction-free beams显示文摘 | Durnin J Miceli J J Eberly J H | 1987 | Phys Rev Lett1987，58，15： | 1 |
| 20 | Voluntary Environmental Agreements: Good or Bad News for Environmental Protection?显示文摘 | Kathleen Segerson Thomas J. Miceli | 1998 | Journal of Environmental Economics and Management1998，，2： | 1 |
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