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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 3 | Leptospirosis: a zoonotic disease of global importance显示文摘 | Ajay R Bharti Jarlath E Nally Jessica N Ricaldi Michael A Matthias Monica M Diaz Michael A Lovett Paul N Levett Robert H Gilman Michael R Willig Eduardo Gotuzzo Joseph M Vinetz | 2003 | The Lancet Infectious Diseases2003，，12： | 2 |
| 4 | Introducing a partitioning mechanism for PAHs into the community multiscale air quality modeling system and its application to simulating the transport of benzo (a) pyrene over Europe显示文摘 | Aulinger A Matthias V Quante M | 2007 | Journal of Applied Meteorology and Climatology2007，46，11： | 1 |
| 5 | Comparison of three nonlinear seizure prediction methods by means of the seizure prediction characteristic显示文摘 | Thomas M Matthias W Richard A | 2004 | Physica D: nonlinear phenomena2004，194，34： | 1 |
| 6 | Global versus local ferromagnetism in a model for diluted magnetic semiconductors studied with Monte Carlo techniques显示文摘 | Matthias M Gonzalo A Elbio D | 2002 | Phys Rev B2002，65，24： | 1 |
| 7 | Rapid assessment of linear transport infrastructure in relation to the impact on landscape continuity for large ranging mammals 显示文摘 | THOMAS A M MATTHIAS D DIANA Z | 2013 | Biodiversity and Conservation2013，22，1： | 1 |
| 8 | Going beyond landscape change description: quantifying the im- portance of driving forces of landscape change in a central Europe case study显示文摘 | HERSPERGER A M MATTHIAS B | 2009 | Land Use Policy2009，26，3： | 1 |
| 9 | Nanoparticle-based monitoring of cell therapy显示文摘 | Chenjie Xu Luye Mu Isaac Roes David Miranda-Nieves Matthias Nahrendorf James A Ankrum Weian Zhao Jeffrey M Karp | 2011 | Nanotechnology2011，，49： | 1 |
| 10 | Global versus local ferromagnetism in a model for diluted magnetic semiconductors studied with Monte Carlo techniques 显示文摘 | MATTHIAS M GONZALO A ELBIO D | 2002 | Phys Rev B2002，65，24： | 1 |
| 11 | Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells 显示文摘 | ALTAMAN A M MATTHIAS N YAN Y | 2008 | Biomaterials2008，29，10： | 1 |
| 12 | Effective retention of litter derived dissolved organic carbon in organic layers显示文摘 | Matthias M Christine A Frank H | 2009 | Soil Biology and Biochemistry2009，41，： | 1 |
| 13 | Economic model predictive control with self-tuning terminal cost显示文摘 | Müller Matthias A Angeli David Allgower Frank | 2013 | European J of Control2013，19，5： | 1 |
| 14 | Austenite Formation in Plain Low - Carbon Steels 显示文摘 | Hamid A A Matthias M Warren J P | 2011 | Metallurgical and Materials Transactions A2011，42，6： | 1 |
| 15 | Alcohlic ingredients in skin disinfectants increase biofilm expression of Staphylococcus epidermidis显示文摘 | Jnhannes K M Knobloch Matthias A | | 0，，49： | 1 |
| 16 | Single-molecule biomechanics with optical methods显示文摘 | Matthias R James A | 1999 | Science1999，283，3： | 1 |
| 17 | Improving the stem heat balance method for determining sap flow in wheat显示文摘 | MATTHIAS L KUPISCH M GRAF A | 2014 | Agricul- tural and Forest Meteorology2014，186，： | 1 |
| 18 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 1 |
| 19 | IF ATS collection : Humanadipose-derived stem cells seeded on a silkfibroin-chitosan scaffoldenhance wound repair in a murine soft tissue injury model 显示文摘 | Altman A M Yan Y Matthias N | 2009 | Stem Cells2009，，： | 1 |
| 20 | Thermogenic responses in brown fat cells are fully UCP1 - dependent 显示文摘 | Matthias A Ohlson K B E Fredriksson J M | 2000 | Journal of Biological Chem- istry2000，275，25： | 1 |
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