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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | 以食物为基础的膳食模式与慢性疾病预防显示文摘Matthias B Schulze及其同事讨论了目前已知的膳食模式与癌症、冠心病、卒中及2型糖尿病的关联,重点在仍不确定的领域和未来的研究方向。 | Matthias B Schulze Miguel A Martínez-González Teresa T Fung Alice H Lichtenstein Nita G Forouhi 陈夏燕(译) 王燕芳(译) 武阳丰(校) | 2021 | 英国医学杂志中文版2021，24，3： | 3 |
| 3 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 4 | Leptospirosis: a zoonotic disease of global importance显示文摘 | Ajay R Bharti Jarlath E Nally Jessica N Ricaldi Michael A Matthias Monica M Diaz Michael A Lovett Paul N Levett Robert H Gilman Michael R Willig Eduardo Gotuzzo Joseph M Vinetz | 2003 | The Lancet Infectious Diseases2003，，12： | 2 |
| 5 | Do you want to participate in a clinical study as a healthy control?-Risk or benefit?显示文摘A healthy woman volunteered to participate as 'healthy control' in a study.An increased level of procalcitonin(PCT) was detected and remained elevated on follow-up measurements.As calcitonin levels were elevated as well,thyroid ultrasound was performed which revealed nodes in both thyroid lobes,one of them showing metabolic activity in positron emission tomography-computed tomography scan.To exclude a malignant thyroid cancer despite the negative findings in a fine needle aspiration the patient underwent thyroidectomy and a medullary thyroid carcinoma(MTC) was detected in the right lobe.MTC is a rare endocrine tumor with a poor prognosis once having spread,therefore early detection remains a priority for the outcome.Screening parameter is serum calcitonin,in absence of infection the pro-hormone PCT can be used as a screening parameter as well with high sensitivity. | Hanna Giessen Christian A Nebiker Matthias Bruehlmeier Stefan Spreitzer Beat Mueller Philipp Schuetz | 2017 | World Journal of Clinical Cases2017，5，12： | 2 |
| 6 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 7 | Folate deficiency increases postischemic brain injury显示文摘 | Matthias E Michael A Inna K | 2005 | Stroke2005，36，： | 1 |
| 8 | Introducing a partitioning mechanism for PAHs into the community multiscale air quality modeling system and its application to simulating the transport of benzo (a) pyrene over Europe显示文摘 | Aulinger A Matthias V Quante M | 2007 | Journal of Applied Meteorology and Climatology2007，46，11： | 1 |
| 9 | Expression of metallothionein Ⅱ in intestinal metaplasia,dysplasia,and gastric cancer显示文摘 | Matthias P A Ebert Thomas Günther Juliane Hoffmann | 2000 | Cancer Research2000，60，： | 1 |
| 10 | An extended Suzuki model for land mobile satellite channels and its statistical properties显示文摘 | Matthias P(a)tzold | 1998 | IEEE Trans Veh Technol1998，47，2： | 1 |
| 11 | Simulation of soil temperatures with sparse data 显示文摘 | Matthias A D Warrick A W | 1987 | Soil Science1987，144，6： | 1 |
| 12 | Growth of new technology - based firms: which factors matter 显示文摘 | MATTHIAS A E A NERLINGER | 1999 | Small Business Economics1999，，13： | 1 |
| 13 | Wall material and capping effects on microlysimeter temperatures and evaporation显示文摘 | Evett S R Warrick A W Matthias A D | 1995 | Soil Science Society of America Journal1995，59，2： | 1 |
| 14 | An Experimental and Numerical Crashworthiness Investigation of Thermoplastic Composite Crash Boxes显示文摘 | Hamidreza Z Matthias K Henrik A | 2008 | Composite Structure2008，85，3： | 1 |
| 15 | Bare soil evaporation near a surface point-source emitter显示文摘 | Matthias A D Salehi R Warrick A W | 1986 | Agricultural Water Management1986，11，34： | 1 |
| 16 | Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice显示文摘 | Takehiko U Matthias F Gavin E A | 2001 | Hepatology2001，34，： | 1 |
| 17 | Influence of preoperative skin sealing with cyanoacrylate on microbial contamination of surgical wounds following trauma surgery: a prospective ,blinded ,controlled observational study显示文摘 | Georg D Matthias N O jan A | 2014 | International Journal of Infectious Diseases2014，29，12： | 1 |
| 18 | Angiotensin - converting enzyme inhibition by enalapril : a novel approach to reduce ischemia/reperfusion damage after experimental liver transplantation显示文摘 | Matthias A Stefan F Markus R | 1997 | Hepatology1997，25，3： | 1 |
| 19 | Comparison of three nonlinear seizure prediction methods by means of the seizure prediction characteristic显示文摘 | Thomas M Matthias W Richard A | 2004 | Physica D: nonlinear phenomena2004，194，34： | 1 |
| 20 | Hdac6 knock-out increases tubulin aeetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease显示文摘 | Bobrowska A Paganetti P Matthias P | | 0，，06： | 1 |
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