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| 1 | MicroRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled显示文摘Primary liver cancer is a global disease that is on the increase.Hepatocellular carcinoma(HCC)accounts for most primary liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatment,tumour recurrence and metastasis.MicroRNAs(miRNAs/miRs)are regulatory RNAs that modulate protein synthesis.miRNAs are involved in several biological and pathological processes including the development and progression of HCC.Given the poor outcomes with current HCC treatments,miRNAs represent an important new target for therapeutic intervention.Several studies have demonstrated their role in HCC development and progression.While many risk factors underlie the development of HCC,one process commonly altered is iron homeostasis.Iron overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well characterised.Aberrant miRNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated miRNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and metastasis.In2009,miR-26a delivery was shown to prevent HCC progression,highlighting its therapeutic potential.Several studies have since investigated the clinical potential of other miRNAs with one drug,Miravirsen,currently in phaseⅡclinical trials.miRNAs also have potential as biomarkers for the diagnosis of HCC and to evaluate treatment efficacy.Ongoing studies and clinical trials suggest miRNA-based treatments and diagnostic methods will have novel clinical applications for HCC in the coming years,yielding improved HCC survival rates and patient outcomes. | Catherine M Greene Robert B Varley Matthew W Lawless | 2013 | World Journal of Gastroenterology2013，19，32： | 5 |
| 2 | Cloning and mapping of variety-speeific rice genomic DNA sequences:amplifled fragment length polymorphisms(AFLP)from silver-stained Polyaerylamide gels显示文摘 | Yong G C MattheW w B OliVier P et a1 | 1996 | Genome1996，39，： | 1 |
| 3 | Microwave Land Surface Em- issivities Estimated from SSM/I Observations 显示文摘 | Prigent C Rossow W B Matthews E | 1997 | ] Geophys Res1997，102，21： | 1 |
| 4 | Recent advances of laser-spectroscopy based techniques for applications in breath analysis 显示文摘 | Matthew R M Yury B Gerard W | 2007 | J Breath Res2007，1，1： | 1 |
| 5 | Algal growth control by a barley straw extract 显示文摘 | Andrew S B Matthew W David V | 2001 | Bioresource Technology2001，77，2： | 1 |
| 6 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 7 | Modeling and Simulation of Induction Machine Vector Control with Rotor Resistance Identification显示文摘 | Wade S Matthew Dunnigan W Williams B W | 1997 | IEEE Transactions on Power Electronics1997，12，3： | 1 |
| 8 | Algal growth control by a barley straw Extract显示文摘 | Andrew S B Matthew W David V | 2001 | Bioresource Technology2001，77，2： | 1 |
| 9 | Rapid evolution of animal mitochondrial DNA显示文摘 | Wesley M B Matthew G JR Allen C W | 1979 | Proc Natl Acad Sci USA1979，76，4： | 1 |
| 10 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme显示文摘 | Matthews B W | 1975 | Biochimica et Biophysica Acta1975，405，2： | 1 |
| 11 | Vitamin a deficiency impairs fetal islet development and causes subsequent glucose intolerance in adult rats 显示文摘 | MATTHEWS K A RHOTEN W B DRISCOLL H K | 2004 | The Journal of Nutrition2004，134，8： | 1 |
| 12 | The layered and historical nature of ecological systems and the risk assessment ofpesticides显示文摘 | Landis W G Matthews R A Matthews G B | 1996 | Environ Toxicol Chem1996，15，： | 1 |
| 13 | The community conditioning hypothesis and its application to environmentaltoxicology显示文摘 | Matthews R A Landis W G Matthews G B | 1996 | Environ Toxicol Chem1996，15，： | 1 |
| 14 | Prediction of mammalian microRNA targets显示文摘 | Lewis B P Shih I H Matthew W J | 2003 | Cell2003，115，： | 1 |
| 15 | Efficacy of SSH PCR in isolating differentially expressed genes显示文摘 | WAN J MATTHEW B W LI C | 2002 | BMC Genomics2002，3，1： | 1 |
| 16 | SGMD:the soybean genomics and microarry database显示文摘 | ALKHAROUF N W MATTHEWS B F | 2004 | Nucleic Acids Research2004，32，： | 1 |
| 17 | Muhiple simuhaneous tumors in patients with head and neek cancer 显示文摘 | Mcguirt W Matthews B Koufman J | 1982 | Cancer1982，50，6： | 1 |
| 18 | Global Maps of Micro-wave Land Surface Emissivities:Potential for Land SurfaceCharacterization显示文摘 | Prigent C Rossow W B Matthews E | 1998 | Radio Science1998，33，： | 1 |
| 19 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 20 | Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human显示文摘 | CHRISTIAN W SPENCER G MATTHEW B | 1999 | Rev Physiol1999，79，： | 1 |
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