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| 1 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Leader behaviors and the work environment for creativity: Perceived leader support显示文摘 | Teresa M Amabile Elizabeth A Schatzel Giovanni B Moneta Steven J Kramer | 2004 | The Leadership Quarterly2004，，1： | 2 |
| 4 | Selenium:an essential element for immune function显示文摘 | Roderick C M Teresa S R Geoffrey J B | 1998 | Immunology today1998，19，8： | 1 |
| 5 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 6 | Preparation, characterization and reactivity of V-and/or co-containing AlPO- 18 materials (VCoAPO-18) in the oxidative dehydrogenation of ethane 显示文摘 | PATRICIA C TERESA B JOSE M L N | 2004 | Micropor Mesopor Mater2004，67，23： | 1 |
| 7 | Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice显示文摘 | Mattia M Silvia B Teresa R | 2011 | Neurotherapeutics2011，8，2： | 1 |
| 8 | Effects of surface chemistry on the reactive adsorption of hydrogen cyanide on activated carbons显示文摘 | MYKOLA S MARTIN V M TERESA J B | | 0，，10： | 1 |
| 9 | Enzymatic assays for xylanase and β-glucanase feed enzymes 显示文摘 | Cossona T Vendrellb A M Teresa B G | 1999 | Animal Feed Science and Technology1999，77，： | 1 |
| 10 | Low cost adsorbents for low temperature clean- ing of flue gases显示文摘 | Rubio B Teresa M | 1998 | Fuel1998，77，6： | 1 |
| 11 | Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice显示文摘 | Mattia M Silvia B Teresa R | 2011 | Neurotherapeutics2011，8，2： | 1 |
| 12 | Ethylene oxide sterilization of medical devices: A review显示文摘 | GISELA C C MENDES M D TERESA R S B | 2007 | American Journal of Infection Control2007，35，9： | 1 |
| 13 | Room temperature chemical vapor deposition of co - axis ZnO 显示文摘 | TERESA M B JACQUELYN L CASSANDRA F | 2005 | J Cryst Growth2005，274，： | 1 |
| 14 | The multifarious,multireplicon Burkholderia cepacia complex显示文摘 | Eshwar M Teresa A Joanna B | 2005 | Nature Review Microbiology2005，3，： | 1 |
| 15 | Mechanism of Low--Temperature Selective Catalytic Reduction of NO with NH3 over Carbon - Supported Mn3O4 显示文摘 | Gregorio M Teresa V S Fuertes A B | 2004 | Journal of Catal2004，226，1： | 1 |
| 16 | Limitations of conventional methods of self-monitoring of blood glucose 显示文摘 | Elizabeth B Teresa M Maria D | 2001 | Diabetes Care2001，24，11： | 1 |
| 17 | Investigating the use of ahernative topologies on performance of the PSO- ELM显示文摘 | ELLIACKIN M N F TERESA B | 2014 | Neuroeomputing2014，127，3： | 1 |
| 18 | You can' t manage right what you can' t measure well: technological innovation efficlency显示文摘 | Claudio C C Cristina B S Teresa G M | 2013 | Research Policy2013，，42： | 1 |
| 19 | Spatial and seasonal variations of the macrobenthic community and metal contamination in the Douro estuary (Portugal) 显示文摘 | Ana P M Teresa S D V Adriano A B | 2005 | Marine Environmental Research2005，60，5： | 1 |
| 20 | Characterization of Bacillus probiotics available for human use显示文摘 | DUC L H HUYNH A H TERESA M B | 2004 | App Environm Microbiol2004，4，70： | 1 |
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