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| 1 | Langerhans cell histiocytosis masquerading as acute appendicitis: Case report and review显示文摘Langerhans cell histiocytosis(LCH) is a rare syndrome characterized by unifocal,multifocal unisystem,or disseminated/multi-system disease that commonly involves the bone,skin,lymph nodes,pituitary,or sometimes lung(almost exclusively in smokers) causing a variety of symptoms from rashes and bone lesions to diabetes insipidus or pulmonary infiltrates.We present a previously unreported case of gastrointestinal LCH as well as a novel characteristic lesion affecting the colon of a young woman who presented with signs and symptoms mimicking acute on chronic appendicitis.Immunohistochemical analysis of appendectomy specimen and nodular specimens on colonoscopy demonstrated S-100,CD1a,and langerin reactivity.The patient underwent systemic chemotherapy with cytarabine and demonstrated excellent response to therapy. | Mohammad M Karimzada Michele N Matthews Samuel W French Daniel De Ugarte Dennis Y Kim | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，3： | 3 |
| 2 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 3 | Categorization of Scope 3 Emissions for Streamlined Enterprise Carbon Footprinting 显示文摘 | Huang Y A Weber C L Matthews H S | 2009 | Environmental Science & Technology2009，43，22： | 1 |
| 4 | The Texas method of preliminary instream flow determination显示文摘 | Matthews R C Bao Y | 1991 | Rivers1991，2，4： | 1 |
| 5 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 6 | High-throughput solution processing of large-scale graphene显示文摘 | Vincent C T Matthew J A Yang Y | 2009 | Nature Nano technology2009，4，： | 1 |
| 7 | Minimum domain of the Shiga A subunit required for enzymatic activity显示文摘 | Haddad JE AL-Jaufy Y Matthew P | 1992 | Baeteriol1992，175，： | 1 |
| 8 | SCL-90-R and 16PF Profiles of senior high school students with excessive internet use显示文摘 | Chang-Kong Y Byeong-Moo C Matthew B | 2005 | Canada J Psychiatry2005，50，： | 1 |
| 9 | Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial显示文摘 | George L Bakris Pantelis A Sarafidis Matthew R Weir Bj?rn Dahl?f Bertram Pitt Kenneth Jamerson Eric J Velazquez Linda Staikos-Byrne Roxzana Y Kelly Victor Shi Yann-Tong Chiang Michael A Weber | 2010 | The Lancet2010，，9721： | 1 |
| 10 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 11 | Calcium channel alpha2delta subunit mediates spinal hyperexcitability in pain modulation 显示文摘 | Li C Y Zhang X L Matthews E A | 2006 | Pain2006，125，12： | 1 |
| 12 | Rainfall profiling u- sing atmospheric radiation measurement program vertically pointing 8 - mm wavelength radars 显示文摘 | Matrosov S Y Peter T M Matthew D Shupe | 2010 | Atmospheric and Oceanic2010，23，： | 1 |
| 13 | Latest-generation CVD-grown synthetic diamonds from Apollo Diamond Inc显示文摘 | WANG W Y MATTHEW S H KYAW S M | 2007 | Gems&Gemology2007，43，4： | 1 |
| 14 | Investigation into etching mechanism of polyethylene terephthalate (PET) fillms treated in helium and oxygenated-helium atmospheric plasmas显示文摘 | MATTHEWS S R HWANG Y J MCCORD M G | 2004 | J Appl Polym Sci2004，94，： | 1 |
| 15 | The Texas method of preliminary instream flow determination显示文摘 | Matthews R C Bao Y | 1991 | Rivers1991，2，4： | 1 |
| 16 | Mechanical behaviour of cp- magnesium with duplex hydroxyapatite and PEO coatings 显示文摘 | Gao Y Yerokhin A Matthews A | 2015 | Mater Sci Eng C Mater Biol Appl2015，49，： | 1 |
| 17 | Worsening severity of vitamin D deficiency is associated with increased length of stay, surgical intensive care unit cost, and mortality rate in surgical in- tensive care unit patients显示文摘 | Matthews LR Ahmed Y Wilson KL | 2012 | Am J Surg2012，204，1： | 1 |
| 18 | Calcium channel alpha2deltal subunit mediates spinal hyperexcitability in pain modulation显示文摘 | Li C Y Zhang X L Matthews E A | | 0，，1： | 1 |
| 19 | Mar- ket Structure and Competitive Conditions in the Arab GCC Banking System 显示文摘 | A1 - Muharrami S Matthews K Khabari Y | 2006 | Journal of Banking and Finance2006，30，12： | 1 |
| 20 | Does combined open and arthroscopic synovectomy for diffuse PVNS of the knee improve recurrence rates显示文摘 | Matthew WC Jason Y Kurt RW | 2013 | Clin Orthop Rel Res2013，471，3： | 1 |
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