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| 1 | Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples显示文摘AIM:To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS:Twenty-two patients (15 men and 7 women; median age 68 years,range 56-81 years) underwent a liver tissue biopsy in order to make a diagnosis of HCC. Paraffin-embedded liver biopsy tissue samples from 22 patients were stained with anti-CD147 antibody,murine monoclonal antibody 12C3 (MAb12C3) for immunohistochemical analysis. An immunohistochemical analysis of CD147 was performed and the degree of staining compared between tumor and non-tumor tissue. In addition,the degree of staining within tumor tissue was compared according to a number of clinicopathological variables. RESULTS:The degree of staining of CD147 was significantly higher in tumor tissues than non-tumor tissues,even in tumors less than 15 mm in diameter.The expression of this protein was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and γ-GTP. | Satoshi Mamori Keisuke Nagatsuma Tomokazu Matsuura Kiyoshi Ohkawa Hiroshi Hano Masaharu Fukunaga Masato Matsushima Yoshifumi Masui Nao Fushiya Hiroshi Onoda Yasuyuki Searashi Ichiro Takagi Hisao Tajiri | 2007 | World Journal of Gastroenterology2007，13，21： | 20 |
| 2 | 悬吊技术在微血管减压术中的应用显示文摘BACKGROUND: The success of microvascular decompression (MVD) depends on the permanent and complete transposition of the offending vessels. This paper describes the stitched sling retraction techniques for treating trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia (GPN), focusing on the stitching point for slinging the offending artery in the appropriate direction. Between January 2007 and March 2009, 28 patients with TN, 5 patients with HFS, and 3 patients with GPN underwent MVD with a sling retraction technique. In cases of TN, MVD was performed using the infratentorial lateral supracerebellar approach, and the offending superior cerebellar artery was superomedially transposed with a sling stitched to the tentorium cerebelli. In cases of HFS, MVD was performed using the lateral suboccipital infrafloccular approach, and the offending vertebral artery was superolaterally transposed with a sling stitched to the petrous dura. In cases of GPN, MVD was performed using the transcondylar fossa approach, in which the posterior inferior cerebellar artery was inferolaterally mobilized with a sling secured to the jugular tubercle. No patient suffered recurrence in the follow-up period. For the sling retraction technique to be performed successfully, it is important for a stitch to be placed at a suitable site to sling the offending vessel in the intended direction. An appropriate surgical approach must be used to obtain a sufficient operative field for performing the stitching procedures safely. | Masuoka J Matsushima T Kawashima M Nakahara Y Funaki T Mineta T | 2011 | 中华神经外科疾病研究杂志2011，10，2： | 19 |
| 3 | Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy显示文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: 'intervascular background coloration'; 'proliferation of intrapapillary capillary loops(IPCL)'; and 'dilation', 'tortuosity', 'change in caliber', and 'various shapes(VS)' of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME. | Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 4 | Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study显示文摘AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) treatment.METHODS:One hundred patients with NERD were recruited and randomized to receive rabeprazole plus IM(group I) or rabeprazole plus placebo(group P).The efficacy of the treatment was assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG) and the short form(SF)-36 quality of life questionnaires after four weeks of treatment.We also assessed whether patients with NERD with minimal changes(grade M) had different responses to the therapies compared with patients who did not have minimal changes(grade N).RESULTS:Group I and group P showed significant improvements in their FSSG scores after the treatment(from 17.9 ± 7.9 to 9.0 ± 7.6, and from 17.7 ± 7.3 to 11.2 ± 7.9, respectively, P = 0.0001), but there was no statistically significant difference between the FSSG scores in group I and those in group P.Subgroup analysis showed that significant improvements in the FSSG scores occurred in the patients in group I who had NERD grade N(modified Los Angeles classification)(7.8 ± 7.4 vs 12.5 ± 9.8, P = 0.041).The SF-36 scores for patients with NERD grade N who had received IM and rabeprazole were significantly improved in relation to their vitality and mental health scores.CONCLUSION:The addition of IM to rabeprazole significantly improves gastroesophageal reflux diseasesymptoms and the quality of the lives of patients with NERD grade N. | Takayoshi Suzuki Masashi Matsushima Aya Masui Shingo Tsuda Jin Imai Jun Nakamura Yoko Tsukune Tetsufumi Uchida Hiroki Yuhara Muneki Igarashi Jun Koike Tetsuya Mine | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 5 | Pseudo-Dynamic Testing for Seismic Performance Assessment of Buildings with Seismic Isolation System Using Scrap Tire Rubber Pad Isolators显示文摘 | Huma Kanta Mishra Akira Igarashi Dang Ji Hiroshi Matsushima | 2014 | Journal of Civil Engineering and Architecture2014，8，1： | 6 |
| 6 | CCR5 gene expression in fulminant hepatitis and DTH in mice显示文摘CCR5geneexpressioninfulminanthepatitisandDTHinmiceGUOBaoYu1,ZHANGSuYing2,NaofumiMukaida3,AkihisaHarada3,KoujiKuno3,WANGJian... | GUO Bao-Yu ZHANG Su-Ying Naofumi Mukaida Akihisa Harada Kouji Kuno WANG Jian-Bin SUN Shu-Han Kouji Matsushima | 1998 | World Journal of Gastroenterology1998，4，1： | 5 |
| 7 | Serum type Ⅳ collagen level is predictive for esophageal varices in patients with severe alcoholic disease显示文摘AIM: To determine factors predictive for esophageal varices in severe alcoholic disease (SAD). METHODS: Abdominal ultrasonography (US) was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal (UGI) endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables. RESULTS: Twenty-five patients (56.8%) had esophageal varices. A univariate analysis revealed a significant difference in age and type Ⅳ collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type Ⅳ collagen as the only independent variable predictive for esophageal varices (P = 0.017). The area under the curve (AUC) for type Ⅳ collagen as determined by the receiver operating characteristic (ROC) for predicting esophageal varices was 0.78. CONCLUSION: This study suggests that the level of type Ⅳ collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD. | Satoshi Mamori Yasuyuki Searashi Masato Matsushima Kenichi Hashimoto Shinichiro Uetake Hiroshi Matsudaira Shuji Ito Hisato Nakajima Hisao Tajiri | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 8 | 玉米大斑病菌(Exserohilum turcicum)原生质体的分离及转化显示文摘玉米大斑病是严重危害玉米生产的一个世界性真菌病害。由于玉米大斑病菌 (Exserohilumturcicum)在无性生长过程中迅速产生黑色素 ,致使原生质体难以分离。测试了包括Fungase、Funcelase、Novozyme、Glucanex、Driselase、Uskizyme、Kitalase在内的 7种细胞壁降解酶及其组合、病原菌菌株和培养基对原生质体分离效果的影响。结果表明菌株的培养形态和菌丝的生长状态显著影响原生质体的分离效率 ;酶组合Kitalase +Glucanex +Driselase ,Kitalase+Glucanex和Kitalase +Uskizyme能够有效地分离玉米大斑病菌的原生质体。初步的转化试验表明 ,质粒pAN71可以用于该病原菌的转化。这些结果将为E . | 周永力 TANAKA Chihiro MATSUSHIMA Satoshi TSUDA Mitsuya | 2003 | 生物工程学报2003，19，3： | 4 |
| 9 | Infrasound observations at Syowa Station,East Antarctica:Implications for detecting the surface environmental variations in the polar regions显示文摘Characteristic infrasound waves observed at Antarctic stations demonstrate physical interaction involving environmental changes in the Antarctic continent and the surrounding oceans.A Chaparraltype infrasound sensor was installed at Syowa Station(SYO;39°E,69°S),East Antarctica,as one of the projects of the International Polar Year(IPY2007—2008).Data continuously recorded during the three seasons in 2008—2010 clearly indicate a contamination of the background oceanic signals(microbaroms)with peaks between 4 and 10 s observed during a whole season.The peak amplitudes of the microbaroms have relatively lower values during austral winters,caused by a larger amount of sea-ice extending around the L(u|')tzow-Holm Bay near SYO,with decreasing ocean wave loading effects.Microbaroms measurements are useful tool for characterizing ocean wave climate,complementing other oceanographic and geophysical data.A continuous monitoring by infrasound sensors in the Antarctic firmly contributes to the Comprehensive Nuclear-Test-Ban Treaty(CTBT) in the southern high latitude,together with the Pan-Antarctic Observations System(PAntOS) under the Scientific Committee on Antarctic Research(SCAR).Detailed measurements of the infrasound waves in Antarctica,consequently,could be a new proxy for monitoring regional environmental change as well as the temporal climate variations in the polar regions. | Yoshiaki Ishihara Masaki Kanao Masa-yuki Yamamoto Shigeru Toda Takeshi Matsushima Takahiko Murayama | 2015 | Geoscience Frontiers2015，6，2： | 4 |
| 10 | High Th1/Th2 ratio in patients with multiple myeloma显示文摘 | Hatsue Ogawara Hiroshi Handa Tohru Yamazaki Takuma Toda Kensuke Yoshida Natsumi Nishimoto Wedad Hamdi Saleh Al-ma’Quol Yoriaki Kaneko Takafumi Matsushima Norifumi Tsukamoto Yoshihisa Nojima Morio Matsumoto Morio Sawamura Hirokazu Murakami | 2004 | Leukemia Research2004，，2： | 3 |
| 11 | Detecting emerging research fronts based on topological measures in citation networks of scientific publications显示文摘 | Naoki Shibata Yuya Kajikawa Yoshiyuki Takeda Katsumori Matsushima | 2008 | Technovation2008，，11： | 3 |
| 12 | Serum pepsinogens as a screening test of extensive chronic gastritis显示文摘 | Kazumasa Miki M.D. Masao Ichinose M.D. Akihiro Shimizu M.D. Shih Che Huang M.D. Hiroshi Oka M.D. Chie Furihata Ph.D. Taijiro Matsushima Ph.D. Kenji Takahashi Ph.D | 1987 | Gastroenterologia Japonica1987，，2： | 2 |
| 13 | Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule显示文摘Malignant peritoneal mesothelioma is a rare aggres-sive tumor of the peritoneum. An increasing number of malignant mesothelioma cases have been reported in recent years. We report here a very rare case of malignant peritoneal mesothelioma with both umbilical hernia and umbilical metastasis which is also called Sister Mary Joseph's nodule. We performed laparoscopy which showed specific laparoscopic findings, and the pathological findings of the biopsy specimen led to the diagnosis. This case was associated with umbilical her-nia which could be induced by massive ascites. A newly developed abdominal hernia should be noted as a primary symptom of malignant peritoneal mesothelioma, as shown in the present case. | Kota Tsuruya Masashi Matsushima Takayuki Nakajima Mia Fujisawa Katsuya Shirakura Muneki Igarashi Jun Koike Takayoshi Suzuki Tetsuya Mine | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 2 |
| 14 | Image-based autonomous navigation of Hayabusa2 using artificial landmarks: The design and brief in-flight results of the first landing on asteroid Ryugu显示文摘Hayabusa2 is an asteroid sample return mission carried out by the Japan Aerospace Exploration Agency.The spacecraft was launched in 2014 and arrived at the target asteroid Ryugu on June 27,2018.During the 1.5-year proximity phase,several critical operations(including two landing/sampling operations)were successfully performed.They were based on autonomous image-based descent and landing techniques.This paper describes an imagebased autonomous navigation scheme of the Hayabusa2 mission using artificial landmarks named target markers(TMs).Its basic algorithm,and the in-flight results of the first touchdown and its rehearsal,are shown. | Naoko Ogawa Fuyuto Terui Yuya Mimasu Kent Yoshikawa Go Ono Seiji Yasuda Kota Matsushima Tetsuya Masuda Hiroki Hihara Junpei Sano Takashi Matsuhisa Satoshi Danno Manabu Yamada Yasuhiro Yokota Yuto Takei Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，2： | 2 |
| 15 | Feature-aware regularization for sparse online learning显示文摘Learning a compact predictive model in an online setting has recently gained a great deal of attention.The combination of online learning with sparsity-inducing regularization enables faster learning with a smaller memory space than the previous learning frameworks.Many optimization methods and learning algorithms have been developed on the basis of online learning with L1-regularization.L1-regularization tends to truncate some types of parameters,such as those that rarely occur or have a small range of values,unless they are emphasized in advance.However,the inclusion of a pre-processing step would make it very difficult to preserve the advantages of online learning.We propose a new regularization framework for sparse online learning.We focus on regularization terms,and we enhance the state-of-the-art regularization approach by integrating information on all previous subgradients of the loss function into a regularization term.The resulting algorithms enable online learning to adjust the intensity of each feature’s truncations without pre-processing and eventually eliminate the bias of L1-regularization.We show theoretical properties of our framework,the computational complexity and upper bound of regret.Experiments demonstrated that our algorithms outperformed previous methods in many classification tasks. | OIWA Hidekazu MATSUSHIMA Shin NAKAGAWA Hiroshi | 2014 | Science China(Information Sciences)2014，57，5： | 2 |
| 16 | Postoperative urinary retention after surgery for benign anorectal disease: potential risk factors and strategy for prevention显示文摘 | Takayuki Toyonaga Makoto Matsushima Nobuhito Sogawa Song Feng Jiang Naomi Matsumura Yasuhiro Shimojima Yoshiaki Tanaka Kazunori Suzuki Junnichi Masuda Masao Tanaka | 2006 | International Journal of Colorectal Disease2006，，7： | 2 |
| 17 | EFFICACY OF PROCALCITONIN IN THE EARLY DIAGNOSIS OF BACTERIAL INFECTIONS IN A CRITICAL CARE UNIT显示文摘 | Akiko Nakamura Hideo Wada Makoto Ikejiri Tsuyoshi Hatada Hiroyuki Sakurai Yoshiko Matsushima Junji Nishioka Kazuo Maruyama Shuji Isaji Taichi Takeda Tsutomu Nobori | 2009 | Shock2009，，6： | 2 |
| 18 | Texture, sensory and swallowing characteristics of high-pressure-heat-treated pork meat gel as a dysphagia diet显示文摘 | Ai Tokifuji Yasuyuki Matsushima Kenji Hachisuka Keiko Yoshioka | 2012 | Meat Science2012，，： | 2 |
| 19 | Novel dry-desulfurization process using Ca(OH)2/fly ash sorbent in a circulating fluidized bed 显示文摘 | Matsushima N Li Y Nishioka M | 2004 | Eviron Sci Technol2004，38，24： | 1 |
| 20 | Microvascular decompression for treatment of trigeminal neuralgia,hemifacial spasm,and glossopharyngeal neuralgia:three surgical approach variations:technical note显示文摘 | Hitotsumatsu T Matsushima T Inoue T | 2003 | Neurosurgery2003，53，6： | 1 |
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