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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-Like Receptor-2显示文摘 | Thimoteus Speer Lucia Rohrer Przemyslaw Blyszczuk Rukshana Shroff Kira Kuschnerus Nicolle Kr?nkel Gabriela Kania Stephen Zewinger Alexander Akhmedov Yi Shi Tina Martin Damir Perisa Stephan Winnik Maja F. Müller Urban Sester Gabriel Wernicke Andreas Jung U | 2013 | Immunity2013，，： | 2 |
| 3 | Application of a novel recombinant plasminogen activator in acute myocardial infarction patients: pharmacokinetics and effects on the hemostatic system 显示文摘 | Seifried E Muller MM Martin U | 1992 | Ann N Y Acad Sci1992，667，12： | 2 |
| 4 | Non-fusion instrumentation of the lumbar spine with a hinged pedicle screw rod system:an in vitro experiment显示文摘 | Schmoelz W Onder U Martin A | 2009 | Eur Spine J2009，18，10： | 1 |
| 5 | Liver hemostasis using high-intensity focused ultrasound显示文摘 | Vaezy S Martin R Schmiedl U | 1997 | Ultrasound in Med and Biol1997，23，： | 1 |
| 6 | Mentalhealth, depression, and anxiety in patients on maintaindialysis显示文摘 | Feroze U Martin D Reina - Patton A | 2010 | IranJ Kidney Dis2010，4，3： | 1 |
| 7 | Agro- industrial residues as low-price feedstock for diesel- like fuel production by thermal cracking显示文摘 | Santos A L F Martins D U Iha O K | 2010 | Bioresource Technology2010，101，： | 1 |
| 8 | Microstructure and room temperature hardening of ultra-fine-grained oxide-dispersion strengthened copper prepared by cryomilling 显示文摘 | Kudashov D V Baum H Martin U | 2004 | Materials Sci-enceandEngineeringA2004，387，： | 1 |
| 9 | Comparative study of the protective effect against Salmonella colonisation in newly hatched SPF chickens using live, attenuated Salmonella vaccine strains, wild- type Salmonella strains or a competitive exclusion product 显示文摘 | METHNER U BARROW P A MARTIN G | 1997 | Int J Food Microbiol1997，35，3： | 1 |
| 10 | Learning lessons from past mistakes:how can health in all policies fulfill its promises 显示文摘 | Bacigalupe A Esnaola S Martin U | 2010 | Journal of Epidemiology and Community Health2010，64，： | 1 |
| 11 | Effect of CPAPtherapy on daytime function in patients with mild sleep apnoea/hypopnoea syndrome显示文摘 | Engleman HM Martin SE Deaiy U | 1997 | Thorax1997，52，2： | 1 |
| 12 | Effect of ageing of HZSM-5 zeolite during coupled methanol hydrocarbon cracking (CMHC) 显示文摘 | MARTIN A PETER S WOLF U | 1991 | Reaction Kinetic Catalysis Letter1991，44，1： | 1 |
| 13 | Relative effectiveness of clinic and home blood pressure monitoring compared with ambulatory blood pressure monitoring in diagnosis of hypertension : systematic review 显示文摘 | Hodgkinson J Mant J Martin U | 2011 | BMJ2011，342，： | 1 |
| 14 | Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori显示文摘 | Céu Figueiredo Wim G.V Quint Ricardo Sanna Erwin Sablon John P Donahue Qing Xu Geraldine G Miller Richard M Peek Martin J Blaser Leen-Jan van Doorn | 2000 | Gene2000，，1： | 1 |
| 15 | Mutation spectrum in the nephrin gene ( NPHS1 ) in congenital nephrotic syn- drome显示文摘 | Beltcheva O Martin P Lenkkeri U | 2001 | Hum Mutat2001，17，5： | 1 |
| 16 | Hardening mechanisms and tecrystallization behaviour of several molybdenum alloys显示文摘 | HOFFMANN A MARTIN U | 2006 | International Journal of Refractory Metals & Hard Materials2006，24，4： | 1 |
| 17 | Heme oxygenase 1 ameliorates ischemia/reper fusion injury by targeting dendritic cell maturation and migra tion显示文摘 | Kotsch K Martins P N Klemz R Janssen U Gerstmayer B Dernier A | 2007 | Antioxid Redox Signal2007，9，： | 1 |
| 18 | Dehydration of glycerol in gas phase using heteropolyacid catalysts as active compounds显示文摘 | ATIA H ARMBRUSTER U MARTIN A | 2008 | J Catal2008，258，： | 1 |
| 19 | Hardening mecha- nisms and recrystallization behaviour of several molybde- num alloys显示文摘 | Mntzek T Hoffmann A Martin U | 2006 | International Journal of Refractory Metals & Hard Materials2006，24，4： | 1 |
| 20 | Effect of pressure on the luminescence properties of Nd^(3+) doped SrWO4 laser crystal显示文摘 | Errandonea D Tu Chaoyang Jia Guohua Martin I R Rodrlguez-Mendoza U R Lahoz F Tortes M E Lavin V | 2008 | Journal of Alloys and Compounds2008，451，： | 1 |
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