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| 1 | 黔西南卡林型金矿床与区域古油藏的关系:来自流体包裹体气相组成和沥青拉曼光谱特征的证据显示文摘黔西南地区是世界第二大卡林型金矿床集中区,同时也发育有大量古油藏,二者空间关系密切,但是否具有成因联系目前尚不清楚且存在较大争议。本文报道该区典型金矿床与成矿有关的热液矿物中流体包裹体的气相组成和高品位金矿石中沥青的激光拉曼光谱分析结果,以探讨含有机质流体与金成矿作用之间的关系。研究表明,虽然含砷富金黄铁矿、石英、方解石、萤石和雄黄等热液矿物形成于不同的成矿阶段,但其中流体包裹体的有机气相组分种类、含量及相对比例整体较为一致,表明成矿流体中的有机络离子团在成矿作用过程中没有发生明显的分解或重组,进而说明黔西南卡林型金矿成矿作用过程中有机质并未以有机络离子团的形式对金进行有效搬运或其搬运金的能力非常有限。在N2/Ar—CO2/CH4流体来源判别图解中,各蚀变矿物中的流体包裹体气相组成主要落在循环的大气降水区域,经大气水区域向岩浆流体区域延伸,整体上构成一条非常好的线性分布趋势,暗示成矿流体可能起源于深部岩浆但在演化过程中有大量循环大气水的加入。水银洞金矿床的1件石英样品偏离上述趋势线并向有机流体方向偏移,可能反映了流体迁移过程中有机质的加入。该区金矿床的矿石中均不同程度地发育浸染状沥青,不同矿床中沥青的激光拉曼光谱特征基本一致,说明该区金矿床中的沥青具有相同成因。根据沥青激光拉曼光谱特征地质温度计反演计算的成矿早阶段流体温度为317~336℃,明显高于区域古地温温度(160~250℃)以及区域古油藏的流体包裹体均一温度(73~175℃),说明该区卡林型金矿床的成矿热源与区域古地温无关。对区域地质及近年来地球物理与地球化学最新成果的综合分析表明,该区卡林型金矿床可能是叠加在区域古地温场之上的深部岩浆活动远端低温热液成矿作用的产物,与金矿床空间关系密切的有机质可能为来自先存古油藏并沿控矿构造发生逃逸的油气物质裂解产物,金成矿与区域古油藏之间不存在成因联系。 | 靳晓野 李建威 HOFSTRA Albert MARSH Erin 刘建中 杨梧 JIN XiaoYe LI JianWei LIU JianZhong YANG Wu | 2016 | 岩石学报2016，32，11： | 11 |
| 2 | Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial显示文摘 | Harold P. Adams Birgitte H. Bendixen L. Jaap Kappelle José Biller Betsy B. Love David Lee Gordon E. Eugene Marsh | 1993 | Stroke1993，，1： | 9 |
| 3 | Analysis of surgical and perioperative complications in seventy-five right hepatectomies for living donor liver transplantation显示文摘AIM: To present an analysis of the surgical and perioperative complications in a series of seventy- five right hepatectomies for living-donation (RHLD) performed in our center. METHODS: From January 2002 to September 2007, we performed 75 RHLD, defined as removal of a portion of the liver corresponding to Couinaud segments 5-8, in order to obtain a graft for adult to adult living-related liver transplantation (ALRLT). Surgical complications were stratified according to the most recent version of the Clavien classification of postoperative surgical complications. The perioperative period was defined as within 90 d of surgery. RESULTS: No living donor mortality was present in this series, no donor operation was aborted and no donors received any blood transfusion. Twenty- three (30.6%) living donors presented one or more episodes of complication in the perioperative period. Seven patients (9.33%) out of 75 developed biliary complications, which were the most common complications in our series.CONCLUSION: The need to define, categorize and record complications when healthy individuals, such as living donors, undergo a major surgical procedure, such as a right hepatectomy, reflects the need for prompt and detailed reports of complications arising in this particular category of patient. Perioperative complications and post resection liver regeneration are not influenced by anatomic variations or patient demographic. | Salvatore Gruttadauria James Wallis Marsh Giovan Battista Vizzini Fabrizio di Francesco Angelo Luca Riccardo Volpes Amadeo Marcos Bruno Gridelli | 2008 | World Journal of Gastroenterology2008，14，20： | 7 |
| 4 | 重组sCR1对大鼠急性脊髓损伤组织免疫炎症反应的影响显示文摘目的探讨重组可溶性补体受体Ⅰ型(sCR1)对大鼠急性脊髓损伤组织免疫炎症反应的影响及对脊髓损伤的保护作用。方法采用改良Allen重物打击法制成SD大鼠脊髓急性损伤模型,观察伤后12h、1d、3d、7d、14d时间点sCR1组与生理盐水(NS)组脊髓损伤组织中性粒细胞浸润程度及C3c的阳性表达,测定髓过氧化物酶(MPO)活性,并采用BBB评分法评定大鼠后肢运动功能。结果sCR1组在伤后各时间点C3c阳性表达均明显少于NS组,差异有极显著性意义(P<0.01);sCR1组在伤后各时间点损伤组织髓过氧化物酶(MPO)活性弱于NS组,差异有极显著性意义(P<0.01);sCR1组在伤后7、14d时间点大鼠后肢BBB评分明显优于NS组(P<0.05、P<0.01)。结论重组sCR1可通过抑制补体系统激活机制显著减轻急性脊髓损伤组织的免疫炎症反应,减轻继发性脊髓损伤。 | 李良满 朱悦 范广宇 Henry Marsh | 2005 | 中华创伤骨科杂志2005，7，6： | 7 |
| 5 | Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report显示文摘Hepatocellular carcinoma (HCC) recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemo- embolization (TACE), radiofrequency ablation (RFA), ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres (SIR-Spheres, Sirtex Medica Inc., Lake Forest, IL, USA). Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein (AFP) level. There were no adverse consequences of initial treatment. | Louis Rivera Huan Giap William Miller Jonathan Fisher Donald J Hillebrand Christopher Marsh Randolph L Schaffer | 2006 | World Journal of Gastroenterology2006，12，35： | 6 |
| 6 | Cadmium nanoclusters in a protein matrix: Synthesis, characterization, and application in targeted drug delivery and cellular imaging显示文摘Biotemplated 金属 nanoclusters 在 biosensing, bioimaging,催化作用,和 nanomedicine 由于他们潜在的应用的宽范围积累了许多注意。这里,我们报导马厩的合成, biocompatible,水溶性、高度荧光灯的牛的浆液白朊模板镉 nanoclusters (Cd 通过一个灵巧的一个壶绿色方法的 NC ) 。我们 covalently 结合了玻尿的酸(哈) 到 Cd 形成的 NC 一 pH 应答,有为 doxorubicin (纪录影片) 的持续版本侧面的 tumortargeting theranostic nanocarrier,模型 anticancer 药。nanocarrier 显示出大约 75.6% 的纪录影片封装效率。纪录影片版本侧面表明 74% 纪录影片在 pH 被释放 5.3,当不到 26% 纪录影片在 pH 被释放时 7.4 在一样的 24-h 时期以内。nanocarrier 有选择地认出了表示 CD44 的 MCF-7 乳癌房间,房间表面受体为哈,而没有如此的识别被观察与哈受体否定的 HEK293 房间。nanocarrier 的 Biocompatibility 与 HEK293 和 MCF-7 房间通过 cytotoxicity 试金被评估。展出的 nanocarrier 对没有 cytotoxicity 很低,而装载纪录影片的 nanocarrier 显示出可观的细胞的举起并且提高了 MCF-7 乳癌杀死房间的能力。我们也证实了使用的可行性高度荧光灯为 MCF-7 和 HeLa 房间的 bioimaging 的 nanoconjugate。优异的指向的药交货功效,细胞的成像能力,和低 cytotoxicity 用有希望的生物医学的应用作为令人激动的新 nanoplatform 放这 nanoconjugate。 | Morteza Sarparast Abolhassan Noori Hoda Ilkhani S. Zahra Bathaie Maher F. EI-Kady Lisa J. Wang Huong Pham Kristofer L. Marsh Richard B. Kaner Mir F. Mousavi | 2016 | Nano Research2016，9，11： | 5 |
| 7 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 8 | Microbial communities biostimulated by ethanol during uranium (VI) bioremediation in contaminated sediment as shown by stable isotope probing显示文摘(啜) 稳定的同位素探查被用来识别乙醇增加在包含在 US 能源部橡树理兹地点从 bioremediation 测试地区收集的二沉积的缩影刺激的微生物, TN,美国。一件样品是高度有乙醇的 bioreduced 当另外一个少些被减少时。有各自的沉积的缩影与标记乙醇并且为啜为 7 孵化了天的 13C 被修改。乙醇很快在伴有硝酸盐和硫酸盐的减小的 24 h 以内被变换成醋酸盐。醋酸盐的累积在远处坚持了 7 d 时期。水的 U 没由于 U 的解吸附作用与减少的沉积在缩影衰退,但是连续地在少些减少的样品衰退。微生物引起的生长和伴随物 < 啜 class= “ a-plus-plus ” > 13 C-DNA 生产被检测乙醇是否是精疲力尽的,丰富的醋酸盐在两个缩影积累了。这在少些减少的样品与 U (VI ) 减小与一致。< 啜 class= “ a-plus-plus ” > 13 从乙醇发源的 C 最终为生长被利用,直接或间接地,由在 7 天孵化以内的主导的微生物引起的社区成员。微生物引起的社区由包括 Desulfovibrio, Sphingomonas, Ferribacterium, Rhodanobacter, Geothrix, Thiobacillus 和其它减少细菌的已知的 denitrifiers,减少硫酸盐的细菌和铁(III ) 主要组成,包括减少细菌 Acidovorax, Anaeromyxobacter, Desulfovibrio, Geobacter 和 Desulfosporosinus 的已知的 U (VI ) 。调查结果建议那乙醇 biostimulates 由首先为硝酸盐,硫酸盐,铁( III )和 U ( VI )用作一个电子施主减少微生物引起的社区的 U ( VI )减小,并且然后为微生物引起的生长为 U ( VI )减小和碳来源作为电子施主工作的醋酸盐。 | Mary Beth LEIGH Wei-Min WU Erick CARDENAS Ondrej UHLIK Sue CARROLL Terry GENTRY Terence L. MARSH Jizhong ZHOU Philip JARDINE Craig S. CRIDDLE James M. TIEDJE | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 5 |
| 9 | Balloon kyphoplasty compared to vertebroplasty and nonsurgical management in patients hospitalised with acute osteoporotic vertebral compression fracture: a UK cost-effectiveness analysis显示文摘 | A. Svedbom L. Alvares C. Cooper D. Marsh O. Str?m | 2013 | Osteoporosis International2013，，1： | 5 |
| 10 | Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design显示文摘 | Matthew H. G. Katz Robert Marsh Joseph M. Herman Qian Shi Eric Collison Alan P. Venook Hedy L. Kindler Steven R. Alberts Philip Philip Andrew M. Lowy Peter W. T. Pisters Mitchell C. Posner Jordan D. Berlin Syed A. Ahmad | 2013 | Annals of Surgical Oncology2013，，8： | 4 |
| 11 | 学习者满意度建模与管理:利用学习者反馈提升混合学习和在线学习的体验显示文摘对于大多数学校和教师而言,最关心的事情莫过于学习者对其学习过程是否满意。在混合课程与在线课程领域,最新的相关研究也已经揭示出学生满意度的核心驱动力。利用逻辑回归方程建模,对涉及401门本科混合与在线课程的62 986名学习者学习满意度数据进行分析。这些数据包括超过200个基于学习者和课程学习设计特点的潜在解释变量。研究表明,学习设计在整体满意度方面对新学员和老学员均有显著影响,对教材、评价策略和工作量越满意的学习者,其整体学习体验也会越满意。此外,学习者的长期学习目标是学习者满意度重要的预测指标,而学习者的个体特点则不具备显著影响,这表明尽管在英国开放大学的学习者有广泛差异性,但是其根本的学习体验是相似的。未来的研究应该聚焦于如何改进学习设计以提高学生的学习体验。 | Nai Li Vicky Marsh Bart Rienties 叶青(译) 王炜(校) | 2018 | 当代职业教育2018，，6： | 4 |
| 12 | Neuroendocrine carcinoma of the extrahepatic bile duct: Case report and literature review显示文摘Neuroendocrine carcinoma (NEC) of the extrahepatic bile duct is rare, and only 22 cases have been reported. Only two of these were large-cell NEC (LCNEC); the vast majority were small-cell NEC. Here, we report a third case of LCNEC of the extrahepatic bile duct. A 76-year-old male presented to a local hospital with painless jaundice. Imaging studies revealed a tumor at the hepatic hilum. The patient underwent right hepatic lobectomy, bile duct resection, and cholecystectomy. The resection specimen showed a 5.0-cm invasive neoplasm involving the hilar bile ducts and surrounding soft tissue. Histologically, the tumor consisted of nests of medium to large cells with little intervening stroma. The tumor invaded a large portal vein branch. All four excised lymph nodes were positive for metastasis, and metastatic deposits were also present in the gallbladder wall. The tumor was diffusely positive for synaptophysin and focally positive for chromogranin A. Approximately 70%-80% of the tumor cells were positive for Ki-67, indicating strong proliferative activity. A diagnosis of LCNEC was made. A few bile ducts within and adjacent to the invasive tumor showed dysplasia of the intestinal phenotype and were focally positive for synaptophysin and chromogranin A, suggesting that the dysplastic intestinal-type epithelium played a precursor role in this case. A postoperative computer tomography scan revealed rapid enlargement of the abdominal and retroperitoneal lymph nodes. The patient died 21 d after the operation. NEC of the bile duct is an aggressive neoplasm, and its biological characteristics remain to be better defined. | Eizaburo Sasatomi Michael A Nalesnik J Wallis Marsh | 2013 | World Journal of Gastroenterology2013，19，28： | 4 |
| 13 | Synaptic dysfunction in Alzheimer's disease:the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention显示文摘The most prevalent form of dementia in the elderly is Alzheimer's disease.A significant contributing factor to the progression of the disease appears to be the progressive accumulation of amyloid-β42(Aβ42),a small hydrophobic peptide.Unfortunately,attempts to develop therapies targeting the accumulation of Aβ42 have not been successful to treat or even slow down the disease.It is possible that this failure is an indication that targeting downstream effects rather than the accumulation of the peptide itself might be a more effective approach.The accumulation of Aβ42 seems to affect various aspects of physiological cell functions.In this review,we provide an overview of the evidence that implicates Aβ42 in synaptic dysfunction,with a focus on how it contributes to defects in synaptic vesicle dynamics and neurotransmitter release.We discuss data that provide new insights on the Aβ42 induced pathology of Alzheimer's disease and a more detailed understanding of its contribution to the synaptic deficiencies that are associated with the early stages of the disease.Although the precise mechanisms that trigger synaptic dysfunction are still under investigation,the available data so far has enabled us to put forward a model that could be used as a guide to generate new therapeutic targets for pharmaceutical intervention. | Jade Marsh Pavlos Alifragis | 2018 | Neural Regeneration Research2018，13，4： | 4 |
| 14 | Embedding hollow Co3O4 nanoboxes into a three- dimensional macroporous graphene framework for high-performance energy storage devices显示文摘 | Mengping Li Maher F. EI-Kady Jee Y. Hwang Matthew D. Kowal Kristofer Marsh Haosen Wang Zhijuan Zhao Richard B. Kaner | 2018 | Nano Research2018，11，5： | 3 |
| 15 | Comparative analysis of de novo transcriptome assembly显示文摘The fast development of next-generation sequencing technology presents a major computational challenge for data processing and analysis.A fast algorithm,de Bruijn graph has been successfully used for genome DNA de novo assembly;nevertheless,its performance for transcriptome assembly is unclear.In this study,we used both simulated and real RNA-Seq data,from either artificial RNA templates or human transcripts,to evaluate five de novo assemblers,ABySS,Mira,Trinity,Velvet and Oases.Of these assemblers,ABySS,Trinity,Velvet and Oases are all based on de Bruijn graph,and Mira uses an overlap graph algorithm.Various numbers of RNA short reads were selected from the External RNA Control Consortium(ERCC) data and human chromosome 22.A number of statistics were then calculated for the resulting contigs from each assembler.Each experiment was repeated multiple times to obtain the mean statistics and standard error estimate.Trinity had relative good performance for both ERCC and human data,but it may not consistently generate full length transcripts.ABySS was the fastest method but its assembly quality was low.Mira gave a good rate for mapping its contigs onto human chromosome 22,but its computational speed is not satisfactory.Our results suggest that transcript assembly remains a challenge problem for bioinformatics society.Therefore,a novel assembler is in need for assembling transcriptome data generated by next generation sequencing technique. | CLARKE Kaitlin YANG Yi MARSH Ronald XIE LingLin ZHANG Ke K. | 2013 | Science China(Life Sciences)2013，56，2： | 3 |
| 16 | A rare cause of drug-induced hepatitis in an immunocompromised patient and the role of glutathione显示文摘The Food and Drug Administration (FDA) has issued a warning on numerous herbal drugs, including many popular products at General Nutrition Centers (GNC), regarding unstudied hepatotoxicity. There have been recent reports of GNC products such as hydroxycut and herbalife, causing drug-induced hepatitis. Herbal medications are over-the-counter products and are not investigated thoroughly by the FDA. Given that the mostcommon outpatient laboratory abnormality is elevated liver transaminases, a sign of hepatocellular toxicity; it is not surprising that some of these products end up causing hepatic dysfunction, especially when taken in large volume. There are numerous herbal supplements that are hepatotoxic, however, these medications have a much more significant effect in human immunodeficiency virus (HIV)/ acquired immune deficiency syndrome patients, which is secondary to depleted glutathione. We present a rare case of drug induced hepatitis secondary to herbal medications used to treat HIV and elucidate the role of glutathione depletion in immunocompromised patients. | Viplove Senadhi Deepika Arora Manish Arora Franklin Marsh | 2012 | World Journal of Hepatology2012，4，8： | 3 |
| 17 | Aplastic Anemia: Pathophysiology and Treatment显示文摘 | Neal S. Young Andrea Bacigalupo Judith C.W. Marsh | 2010 | Biology of Blood and Marrow Transplantation2010，，1： | 3 |
| 18 | Kinematic and Contact Stress Analysis of Posterior Malleolus Fractures of the Ankle显示文摘 | Daniel C. Fitzpatrick Jason K. Otto Todd O. McKinley J. Lawrence Marsh Thomas D. Brown | 2004 | Journal of Orthopaedic Trauma2004，，5： | 3 |
| 19 | Impurity induced disordering in InGaAs/InGaAlAs quantum wells using implanted fluorine and boron显示文摘 | Bryce A C Marsh J H Gwilliam R | 1991 | IEEE Proceeding-J1991，38，2： | 2 |
| 20 | MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer显示文摘 | Melissa Crawford Kara Batte Lianbo Yu Xin Wu Gerard J. Nuovo Clay B. Marsh Gregory A. Otterson Serge P. Nana-Sinkam | 2009 | Biochemical and Biophysical Research Communications2009，，3： | 2 |
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