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您的检索式：作者名="XIE LingLin"
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| 1 | Application of in vitro and in vivo models in the study of food allergy显示文摘Food allergy is one of the most important food safety problems that has attracted increasing attention.The food allergy experimental models provide not only the accurate allergen detection and evaluation methods but also the powerful approaches for mechanism investigations.In this paper,we reviewed the common food allergy cell models including mast cell,basophil granulocyte and basophil,as well as the animal models of BALB/c mouse,C3H/HeJ mouse,and BN rat.We also introduced zebrafish,a promising model organism for investigating immunity though lacking direct applications in food allergy to date,and focused on traumatic inflammation,bacterial infection and viral infection models.In addition,we also summarized the clinical diagnostic research methods for food allergy.The elucidation of these topics will help researchers to understand the characteristics and mechanisms of various models and thus select the proper models for particular study,so as to support further investigations of food allergy. | Jianjian Huang Changjun Liu Yanbo Wang Chong Wang Menghua Xie Yi Qian Linglin Fu | 2018 | Food Science and Human Wellness2018，7，4： | 7 |
| 2 | Comparative analysis of de novo transcriptome assembly显示文摘The fast development of next-generation sequencing technology presents a major computational challenge for data processing and analysis.A fast algorithm,de Bruijn graph has been successfully used for genome DNA de novo assembly;nevertheless,its performance for transcriptome assembly is unclear.In this study,we used both simulated and real RNA-Seq data,from either artificial RNA templates or human transcripts,to evaluate five de novo assemblers,ABySS,Mira,Trinity,Velvet and Oases.Of these assemblers,ABySS,Trinity,Velvet and Oases are all based on de Bruijn graph,and Mira uses an overlap graph algorithm.Various numbers of RNA short reads were selected from the External RNA Control Consortium(ERCC) data and human chromosome 22.A number of statistics were then calculated for the resulting contigs from each assembler.Each experiment was repeated multiple times to obtain the mean statistics and standard error estimate.Trinity had relative good performance for both ERCC and human data,but it may not consistently generate full length transcripts.ABySS was the fastest method but its assembly quality was low.Mira gave a good rate for mapping its contigs onto human chromosome 22,but its computational speed is not satisfactory.Our results suggest that transcript assembly remains a challenge problem for bioinformatics society.Therefore,a novel assembler is in need for assembling transcriptome data generated by next generation sequencing technique. | CLARKE Kaitlin YANG Yi MARSH Ronald XIE LingLin ZHANG Ke K. | 2013 | Science China(Life Sciences)2013，56，2： | 3 |
| 3 | Rheology and microstructure effects of waste spent coffee grounds in modifying asphalt binder显示文摘本文将咖啡萃取后得到的固体废弃物咖啡渣(Spent coffee grounds,SCGs)应用于沥青材料改性中,旨在实现生物基固废材料处理和沥青路面性能提升的双重目的。通过傅里叶红外光谱(FTIR)、差示扫描量热仪(DSC)、动态剪切流变仪(DSR)和布氏黏度计等技术,证实了咖啡渣在路面材料可持续化发展中具有潜在的应用与推广前景。试验结果表明,咖啡渣改性过程主要基于物理增强作用;与基质沥青相比,合理掺量的咖啡渣改性沥青具有理想的高温稳定性和良好的抗永久变形能力;同时1%和3%掺量的咖啡渣引入有利于增强基质沥青的低温性能。然而,过多咖啡渣的加入可能会对改性沥青的流变性能产生负面影响,这表明改性时应选择合理掺量的咖啡渣改性剂以满足实际性能提升需求。 | Mingjun Xie Linglin Xu Kai Wu Yutong Wen Hongmi Jiang Zhengwu Jiang | 2023 | Low-carbon Materials and Green Construction2023，1，1： | 0 |
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