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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 3 | Phytosterols: physiologic and metabolic aspects related to cholesteol - lowering properties 显示文摘 | Gemma B Miguel A C Magda R | 2008 | Nutrition Research2008，，28： | 1 |
| 4 | Potential cellular and molecular causes of hypertrophic scar formation 显示文摘 | Willem M Monica B Magda U | 2009 | Bums2009，35，： | 1 |
| 5 | Tuning of metal work function with self-assembled monolayers显示文摘 | Bert de B Afshin H Magda M M | | 0，，05： | 1 |
| 6 | BMI-lgene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas显示文摘 | Frederic T Magda P | 2001 | Cancer Res2001，61，6： | 1 |
| 7 | Ambulatory monitoring derived blood pressure variability and cardiovascular risk factors in elderly hypertensive patients显示文摘 | Magdas A Szilagyi L Belenyi B | 2014 | Bio-medical Materials and Engineering2014，24，6： | 1 |
| 8 | Interleukin-1-Beta and Dyslipidemic Syndrome as Major Risk Factors for Thrombotic Complications in Type 2 Diabetes Mellitus显示文摘 | Oana B?dulescu Codru?a B?descu Manuela Ciocoiu Magda B?descu Fabrizio Montecucco | 2013 | Mediators of Inflammation2013，，： | 1 |
| 9 | Financial systems across ' developed economies':convergence or path de- pendenee显示文摘 | MAGDA B GERALI A MASSARO R | 1997 | Research in Economics1997，51，3： | 1 |
| 10 | NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients显示文摘AIM:To investigate the small bowel of seronegative spondyloarthropathy(SpA) patients in order to ascertain the presence of mucosal lesions.METHODS:Between January 2008 and June 2010,54 consecutive patients were enrolled and submitted to avideo capsule endoscopy(VCE) examination.Historyand demographic data were taken,as well as the history of non-steroidal anti-inflammatory drug(NSAID) consumption.After reading each VCE recording,a capsule endoscopy scoring index for small bowel mucosal inflammatory change(Lewis score) was calculated.Statistical analysis of the data was performed.RESULTS:The Lewis score for the whole cohort was 397.73.It was higher in the NSAID consumption subgroup(P = 0.036).The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel,but not for its distal third(P values of 0.036,0.001 and 0.18,respectively).There was no statistical significant difference between the groups with regard to age or sex of the patients.CONCLUSION:The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel,but not for its distal part. | Mihai Rimba■ Mǎdǎlina Marinescu Mihail Radu Voiosu Cristian Rǎsvan Bǎicu■ Simona Caraiola Adriana Nicolau Doina Ni■escu Georgeta Camelia Badea Magda Ileana Parvu | 2011 | World Journal of Gastroenterology2011，17，8： | 1 |
| 11 | Financial Systems Across 'Developed Economies': Convergence or Path Dependence? 显示文摘 | Magda B Gerali A Massaro R | 1997 | Research in Economics1997，51，3： | 1 |
| 12 | Amoebicidal activity of milk, apo-lactoferrin, slgA and lysozyme 显示文摘 | Nidia L S D Fernando L S M Magda R L B | 2004 | Clinical Medicine & Research2004，4，2： | 1 |
| 13 | The effects of gammair radiation on the vitamin E content and sensory qualities of pecan nuts(Caryaillinoensis)显示文摘 | Magda S Taipina LedaC A Lamardo Maria A B Rodas | 2009 | Radiation lhysics and Chemistry2009，，78： | 1 |
| 14 | Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma显示文摘 | Staquicini Fernanda I Ozawa Michael G Moya Catherine A Driessen Wouter H P Barbu E Magda Nishimori Hiroyuki Soghomonyan Suren Flores Leo G Liang Xiaowen Paolillo Vincenzo Alauddin Mian M Basilion James P Furnari Frank B Bogler Oliver Lang F | 2011 | Journal of Clinical Investigation2011，，1： | 1 |
| 15 | The structure-specific endonuclease Erccl-Xpf is required to resolve DNA interstrand crosslink-induced double-strand breaks 显示文摘 | Laura JN Hanny O Magda B | 2004 | Mol Cell Biol2004，24，13： | 1 |
| 16 | Courts and Banks:Effects of Judicial Enforcement on Credit Markets显示文摘 | Jappelli T Marco P Magda B | 2005 | Journal of Money Credit and Banking2005，37，2： | 1 |
| 17 | Phytosterols:Physiologic and metabolic aspects related tocholesterol-lowering properties显示文摘 | Gemma B Miguel I A C Magda R | 2008 | Nutrition Research2008，28，： | 1 |
| 18 | Maternal synthesis of abscisic acid controls seed development and yield in Nicotiana plumbaginifolia显示文摘 | Anne Frey Béatrice Godin Magda Bonnet Bruno Sotta Annie Marion-Poll | 2004 | Planta2004，，6： | 1 |
| 19 | Ocular surface inflammatory changes induced by topical antiglaucoma drugs显示文摘 | Christophe Baudouin Pierre-Jean Pisella Kathleen Fillacier Marie Goldschild Frank Becquet Magda De Saint Jean Alain Béchetoille | 1999 | Ophthalmology1999，，3： | 1 |
| 20 | Intractable seizures in tuberous sclerosis complex:from molecular pathogenesis to the rationale for treatment显示文摘 | Paolo C Roberta B Magda V | 2005 | J Child Neurol2005，20，4： | 1 |
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