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| 1 | “猪地方性肺炎及其防治控制”专栏二:有关猪肺炎支原体感染诊断方法和流行病学的最新观点显示文摘猪肺炎支原体是猪地方性肺炎(Enzoodc Pneumonia,EP)的主要病原体,本病是一种主要影响肥育猪的慢性呼吸道疾病。尽管人们在控制猪肺炎支原体感染及其带来的不利影响上花费了大量的精力,但是猪地方性肺炎仍继续给全球养猪生产造成重大的经济损失。猪肺炎支原体通常是通过引进亚临床型感染的动物而侵入猪群的,或通过短距离的空气传播发生感染,但后一种情况较少。一旦侵入猪群,猪肺炎支原体可通过与受感染的母猪直接接触而将病原体传给后代或在同圈猪只之间进行传播。用于诊断猪肺炎支原体感染的“黄金标准”技术——细菌学培养非常费劲,通常很少使用。酶联免疫吸附试验和聚合酶链式反应检测方法以及以屠宰场监测或田间剖解为形式的死后检查,是用于调查猪肺炎支原体是否参与了猪呼吸道疾病的最常用技术。这些技术已被用来监测受猪地方性肺炎影响的猪群猪肺炎支原体的临床型和亚临床型感染猪群、免疫猪群或非免疫猪群以及处于不同的生产条件和管理奈件下的猪群的发生情况。猪场水平上的猪地方性肺炎临床过程差异以及猪肺炎支原体疫苗接种效果的差异表明,猪肺炎支原体的不同田间分离株的传播和毒力特性存在差异。本文综述了猪肺炎支原体感染的流行病学最新知识,包括其传播、感染和血清转化动力学,并且还比较了用来监测猪地方性肺炎的各种流行病学方法。 | Marina Sibila Maria Pieters Thomas Molitor Dominiek Maes Freddy Haesebmuck Joaquim Segal e s 沈权(译) 邵嘉佳(校) | 2009 | 国外畜牧学(猪与禽)2009，，3： | 16 |
| 2 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 3 | Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome显示文摘Polycystic ovary syndrome(PCOS) is the most common endocrine disorder in reproductive-aged women. Women with PCOS frequently have metabolic complications including insulin resistance(IR), early diabetes, hypertension and dyslipidemia. Recent studies have demonstrated an association between PCOS and another metabolic complication: nonalcoholic fatty liver disease(NAFLD). NAFLD occurs as a result of abnormal lipid handling by the liver, which sensitizes the liver to injury and inflammation. It can progress to nonalcoholic steatohepatitis(NASH), which is characterized by hepatocyte injury and apoptosis. With time and further inflammation, NASH can progress to cirrhosis. Thus, given the young age at which NAFLD may occur in PCOS, these women may be at significant risk for progressive hepatic injury over the course of their lives. Many potential links between PCOS and NAFLD have been proposed, most notably IR and hyperandrogenemia. Further studies are needed to clarify the association between PCOS and NAFLD. In the interim, clinicians should be aware of this connection and consider screening for NAFLD in PCOS patients who have other metabolic risk factors. The optimal method of screening is unknown. However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered. First line treatment consists of lifestyle interventions and weight loss, with possible pharmacologic interventions in some cases. | Carly E Kelley Ann J Brown Anna Mae Diehl Tracy L Setji | 2014 | World Journal of Gastroenterology2014，20，39： | 11 |
| 4 | 浓料液中铜的溶剂萃取显示文摘用多种浓度的料液对现有铜萃取剂的适应性进行了考察.结果证明.经过改质的更强的乙醛后萃取剂同含有较弱的铜肟萃取剂的混合萃取剂相比,性能更加优越,尤其是经酯改质的ACORGAM5640萃取剂,在所有被考察的萃取剂中,最适合处理浓料液.在回收率、对铁的选择性及抗水解降解等方面ACORGAM5640显示出明显的优越性.为证实ACORGAM5640对浓料液的适应性,进行了实例研究. | Tony Moors Brian Townson Charles Maes 黄迪恭 | 2000 | 有色金属(冶炼部分)2000，，3： | 7 |
| 5 | Thalidomide for refractory gastrointestinal bleeding from vascular malformations in patients with significant comorbidities显示文摘BACKGROUND Refractory gastrointestinal bleeding(GIB)secondary to gastrointestinal vascular malformations(GIVM)such as gastrointestinal angiodysplasia(GIAD)and gastric antral vascular ectasia(GAVE)remains challenging to treat when endoscopic therapy fails.Recently thalidomide has been suggested as a treatment option for refractory GIB.AIM To determine the outcome of patients treated with thalidomide for refractory GIB due to GIVM.METHODS IRB approved,single center,retrospective review of electronic medical records from January 2012 to November 2018.Patients age>18 years old,who had>3 episodes of GIB refractory to medical or endoscopic therapy,and who had been treated with thalidomide for at least 3 mo were included.The primary endpoint was recurrence of GIB 6 mo after initiation of thalidomide.RESULTS Fifteen patients were included in the study,all with significant cardiac,hepatic,or renal comorbidities.The cause of GIB was GIAD in 10 patients and GAVE in 5 patients.Two patients were lost to follow up.Of the 13 patients followed,38.5%(n=5)had no recurrent GIB or transfusion requirement after treatment with thalidomide.Furthermore,84.6%(n=11)of patients had a reduction in transfusion requirements and hospitalizations for GIB.Thalidomide was discontinued in 2 patients due to cost(n=1)and medication interaction(n=1).Reported adverse reactions included fatigue(n=3),neuropathy(n=2),dizziness(n=1),and constipation(n=1).Six patients died during follow up due to unknown cause(n=4)and sepsis(n=2).CONCLUSION Thalidomide appears to be an effective treatment for refractory GIB due to GIAD or GAVE in a Western population with significant comorbidities. | Alexis Mae Bayudan Chien-Huan Chen | 2020 | World Journal of Clinical Cases2020，8，15： | 5 |
| 6 | Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease显示文摘 | Mark L. Palmeri Michael H. Wang Ned C. Rouze Manal F. Abdelmalek Cynthia D. Guy Barry Moser Anna Mae Diehl Kathryn R. Nightingale | 2011 | Journal of Hepatology2011，，3： | 5 |
| 7 | The diagnosis and management of non‐alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association显示文摘 | Naga Chalasani Zobair Younossi Joel E. Lavine Anna Mae Diehl Elizabeth M. Brunt Kenneth Cusi Michael Charlton Arun J. Sanyal | 2012 | Hepatology2012，，6： | 5 |
| 8 | Prophylactic lateral pelvic lymph node dissection in stage Ⅳ low rectal cancer显示文摘AIM To assess the clinical significance of prophylactic lateral pelvic lymph node dissection (LPLND) in stage Ⅳ low rectal cancer.METHODS We selected 71 consecutive stage Ⅳ low rectal cancer patients who underwent primary tumor resection,and enrolled 50 of these 71 patients without clinical LPLN metastasis.The patients had distant metastasis such as liver,lung,peritoneum,and paraaortic LN.Clinical LPLN metastasis was defined as LN with a maximum diameter of 10 mm or more on preoperative pelvic computed tomography scan.All patients underwent primary tumor resection,27 patients underwent total mesorectal excision(TME) with LPLND(LPLND group),and 23 patients underwent only TME(TME group).Bilateral LPLND was performed simultaneously with primary tumor resection in LPLND group.R0 resection of both primary and metastatic sites was achieved in 20 of 50 patients.We evaluated possible prognostic factors for 5-year overall survival (OS),and compared 5-year cumulative local recurrence between the LPLND and TME groups.RESULTS For OS,univariate analyses revealed no significant benefit in the LPLND compared with the TME group (28.7% vs 17.0%,P = 0.523); multivariate analysis revealed that R0 resection was an independent prognostic factor.Regarding cumulative local recurrence,the LPLND group showed no significant benefit compared with TME group (21.4% vs 14.8%,P = 0.833).CONCLUSION Prophylactic LPLND shows no oncological benefits in patients with Stage Ⅳ low rectal cancer without clinical LPLN metastasis. | Hiroshi Tamura Yoshifumi Shimada Hitoshi Kameyama Ryoma Yagi Yosuke Tajima Takuma Okamura Mae Nakano Masato Nakano Masayuki Nagahashi Jun Sakata Takashi Kobayashi Shin-ichi Kosugi Hitoshi Nogami Satoshi Maruyama Yasumasa Takii Toshifumi Wakai | 2017 | World Journal of Clinical Oncology2017，8，5： | 4 |
| 9 | Amphibians and Reptiles of Luzon Island,V:The Herpetofauna of Angat Dam Watershed,Bulacan Province,Luzon Island,Philippines显示文摘We report amphibian and reptile distribution records based on recent biodiversity surveys conducted at the Angat Watershed Reservation,Bulacan Province,Luzon Island,Philippines.This watershed constitutes the principal water source for Manila,the Philippines’largest metropolitan area.As virtually nothing is known of the herpetological diversity of the immediate area and the surrounding Bulacan Province,all species recorded as part of our surveys constitute major geographical records and/or significant range extensions.Our data result in a total of 63 new records of amphibian(19 frogs)and reptile(22 lizards,2 turtles,and 20 snakes)species for this protected area(and immediate vicinity)that serves as a watershed for the major metropolitan area of Manila and surrounding cities.Together with the few previous literature records,our new records bring the total number of amphibian and reptile species for Bulacan Province to 68.We discuss several strategies for future survey work(focusing on habitat type,seasonal variation,and elevational variability)that we anticipate will result in increased knowledge of diversity within the Angat Watershed Reserve.The impressive level of herpetological diversity within such a small area,so close to Metro Manila,emphasizes that the diversity and distribution patterns of amphibians and reptiles from Luzon are still poorly known and in need of further study. | David S.MCLEOD Cameron D.SILER Arvin C.DIESMOS Mae L.DIESMOS Vhon S.GARCIA Angela O.ARKONCEO Kelvin L.BALAQUIT Charlene C.UY Mariden M.VILLASERAN Earle C.YARRA Rafe M.BROWN | 2011 | Asian Herpetological Research2011，2，4： | 4 |
| 10 | Safety and effectiveness of the SUPRACOR presbyopic LASIK algorithm on hyperopic patients显示文摘Background:To evaluate the safety and effectiveness of the Supracor excimer laser algorithm to treat hyperopic presbyopic patients using laser in-situ keratomileusis(LASIK).Methods:This is a retrospective case review of patients diagnosed with hyperopia(Sphere≥+0.0 D and presbyopia reading add≥1.0 D)who underwent Supracor excimer laser treatment on at least one eye for presbyopia correction from year May 2011 to May 2013.Binocular vision was further analyzed after patients were subdivided into three groups:Group A(n=22 eyes,11 patients)had Supracor on both eyes;Group B(n=18 eyes,18 patients)had Supracor in one eye and hyperopic LASIK on fellow eye;and Group C(n=29 eyes,29 patients)had Supracor in one eye and no treatment on the fellow eye.Results:This study evaluated 58 patients wherein 69 eyes underwent Supracor presbyopic LASIK.Preoperatively,mean manifest refraction spherical equivalent(MRSE)of all eyes that underwent Supracor was+1.37±0.72 D with mean uncorrected distance visual acuity(UDVA),uncorrected intermediate visual acuity(UIVA),and uncorrected near visual acuity(UNVA)of 20/50(0.35 logMAR),20/50(0.35 logMAR),and J9(0.61 logMAR),respectively.At 6 months postoperatively,mean MRSE was−0.43±0.59 D with mean UDVA,UIVA and UNVA of 20/25(0.13 logMAR),20/20(0.01 logMAR),and J1(0.05 logMAR),respectively.Loss of two lines of best-corrected distance visual acuity(BCDVA)was seen in 6%of eyes.Mean corneal steepening of 1.0 D at the 3 mm zone and 0.7 D in the 5 mm zone was observed.Mean vertical coma increased from−0.02 to+0.10 while mean 4th order spherical aberration became more negative from 0.20 to−0.14.Mean binocular UDVA,UIVA,and UNVA are 20/20,20/20 and J1,respectively,in all treatment groups at the 6 month postoperative follow-up.No significant differences in binocular UDVA(p≥0.36),UIVA(p≥0.19)and UNVA(p≥0.56)among groups were seen.Conclusions:Supracor excimer laser algorithm is safe and effective for the treatment of presbyopia in hyperopes.Monolateral and bilateral Supracor treatments yielded similarly good binocular vision outcomes. | Robert Edward T.Ang Emerson M.Cruz Alex U.Pisig Maria Luisa Patricia C.Solis Rosalie Mae M.Reyes Gerhard Youssefi | 2016 | Eye and Vision2016，3，1： | 3 |
| 11 | Redox regulation of the immune response显示文摘The immune-inflammatory response is associated with increased nitro-oxidative stress.The aim of this mechanistic review is to examine:(a)the role of redox-sensitive transcription factors and enzymes,ROS/RNS production,and the activity of cellular antioxidants in the activation and performance of macrophages,dendritic cells,neutrophils,T-cells,B-cells,and natural killer cells;(b)the involvement of high-density lipoprotein(HDL),apolipoprotein A1(ApoA1),paraoxonase-1(PON1),and oxidized phospholipids in regulating the immune response;and(c)the detrimental effects of hypernitrosylation and chronic nitro-oxidative stress on the immune response.The redox changes during immune-inflammatory responses are orchestrated by the actions of nuclear factor-κB,HIF1α,the mechanistic target of rapamycin,the phosphatidylinositol 3-kinase/protein kinase B signaling pathway,mitogen-activated protein kinases,5'AMP-activated protein kinase,and peroxisome proliferator-activated receptor.The performance and survival of individual immune cells is under redox control and depends on intracellular and extracellular levels of ROS/RNS.They are heavily influenced by cellular antioxidants including the glutathione and thioredoxin systems,nuclear factor erythroid 2-related factor 2,and the HDL/ApoA1/PON1 complex.Chronic nitro-oxidative stress and hypernitrosylation inhibit the activity of those antioxidant systems,the tricarboxylic acid cycle,mitochondrial functions,and the metabolism of immune cells.In conclusion,redox-associated mechanisms modulate metabolic reprogramming of immune cells,macrophage and T helper cell polarization,phagocytosis,production of pro-versus anti-inflammatory cytokines,immune training and tolerance,chemotaxis,pathogen sensing,antiviral and antibacterial effects,Toll-like receptor activity,and endotoxin tolerance. | Gerwyn Morris Maria Gevezova Victoria Sarafian Michael Maes | 2022 | Cellular & Molecular Immunology2022，19，10： | 3 |
| 12 | Mechanisms of Disease Progression in NASH显示文摘 | Brittany N. Bohinc Anna Mae Diehl | 2012 | Clinics in Liver Disease2012，，3： | 3 |
| 13 | Anti-porcine circovirus type 2(PCV2) antibody placental barrier leakage from sow to fetus: impact on the diagnosis of intra-uterine PCV2 infection显示文摘Dear Editor,Fetuses develop antibodies when they are infectedwith porcine circovirus type 2(PCV2).At abortion orbirth,both PCV2 and/or anti-PCV2 antibodies can thenbe detected.Finding anti-PCV2 antibodies in aborted fe-tuses or stillborn piglets is generally used as evidence ofan intra-uterine PCV2 infection.However,a recent anal-ysis of fetuses sent in for PCV2 diagnosis and caesare-an-derived,colostrum-deprived pigs revealed that | Dipongkor Saha Rubén Del Pozo Sacristán Nicolaas Van Renne Liping Huang Ruben Decaluwe Annelies Michiels Alfonso Lopez Rodriguez Maria José Rodrí-guez Margarita García Durán Ilse Declerk Dominiek Maes Hans J. Nauwynck | 2014 | Virologica Sinica2014，29，2： | 3 |
| 14 | 清洗和消毒对猪病控制的重要性显示文摘很多养猪生产者都熟悉猪舍的现代清洗和消毒规程。但是,这些规程常常没有被正确地应用。由比利时佛兰德动物保健中心(Animal Health Care Flanders,DGZ)完成的研究发现,已经在养禽业中使用了很长一段时间的微生物监测法也可以在猪舍中使用,以检查猪舍清洗和消毒措施的效率。 | 张佳 Wout Maes | 2008 | 国外畜牧学(猪与禽)2008，28，4： | 3 |
| 15 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 16 | How to construct neuroscience-informed psychiatric classification?Towards nomothetic networks psychiatry显示文摘Psychiatry remains in a permanent state of crisis,which fragmented psychiatry from the field of medicine.The crisis in psychiatry is evidenced by the many different competing approaches to psychiatric illness including psychodynamic,biological,molecular,pan-omics,precision,cognitive and phenomenological psychiatry,folk psychology,mind-brain dualism,descriptive psychopathology,and postpsychiatry.The current“gold standard”Diagnostic and Statistical Manual of Mental Disorders/International Classification of Diseases taxonomies of mood disorders and schizophrenia are unreliable and preclude to employ a deductive reasoning approach.Therefore,it is not surprising that mood disorders and schizophrenia research was unable to revise the conventional classifications and did not provide more adequate therapeutic approaches.The aim of this paper is to explain the new nomothetic network psychiatry(NNP)approach,which uses machine learning methods to build data-driven causal models of mental illness by assembling risk-resilience,adverse outcome pathways(AOP),cognitome,brainome,staging,symptomatome,and phenomenome latent scores in a causal model.The latter may be trained,tested and validated with Partial Least Squares analysis.This approach not only allows to compute pathway-phenotypes or biosignatures,but also to construct reliable and replicable nomothetic networks,which are,therefore,generalizable as disease models.After integrating the validated feature vectors into a well-fitting nomothetic network,clustering analysis may be applied on the latent variable scores of the R/R,AOP,cognitome,brainome,and phenome latent vectors.This pattern recognition method may expose new(transdiagnostic)classes of patients which if cross-validated in independent samples may constitute new(transdiagnostic)nosological categories. | Drozdstoy Stoyanov Michael HJ Maes | 2021 | World Journal of Psychiatry2021，11，1： | 3 |
| 17 | Chronic exposure to elevated levels of manganese and nickel is not harmful to a cosmopolitan detritivore, Megaselia scalaris (Diptera: Phoridae)显示文摘有象锰(Mn ) 和镍(Ni ) 那样的金属的环境污染经常在植物纸巾导致这些金属的提高的集中。在高集中,这些金属被知道在某些昆虫草食动物上有有害效果。用实验室生物鉴定和人工的饮食,我们调查了大都会的昆虫 detritivore 的发展和幸存, Megaselia 数量(双翅目:Phoridae ) ,暴露了到到达 2600 mg Mn/kg 和 5200 mg Ni/kg 的 Mn 和 Ni 的集中在人工的饮食的干燥质量(dm ) 。令人惊讶地,在测试的集中的 Ni 和 Mn 没伤害这个苍蝇。从显著地更短的幼虫的开发时间,成年出现的全面时间,和 pupariation 和蛹的羽化与一个控制组相比预定的有 260 2600 mg Mn/kg dm 和 Ni/kg dm 有的 1300 5200 mg 的食谱的处理组。女性的翅膀长度,成年健康的相互关联,在金属处理组也是更大的。包括的另外的措施鸡蛋开口,雌的新兴的苍蝇的百分比,和雄的苍蝇的翅膀长度评价,不在金属处理组是显著地不同的。我们断定那 Megaselia 数量是是容忍的 Mn 和 Ni 特别高级。 | Mary A. Sorensen C. Mae Chase-Dunn John T. Trumble | 2009 | Insect Science2009，16，1： | 3 |
| 18 | Dietary Composition and Nonalcoholic Fatty Liver Disease显示文摘 | Steven Solga Amir R. Alkhuraishe Jeanne M. Clark Mike Torbenson Ashli Greenwald Anna Mae Diehl Thomas Magnuson | 2004 | Digestive Diseases and Sciences2004，，10： | 2 |
| 19 | Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism显示文摘 | Yuping Chen Steve S. Choi Gregory A. Michelotti Isaac S. Chan Marzena Swiderska-Syn Gamze F. Karaca Guanhua Xie Cynthia A. Moylan Francesca Garibaldi Richard Premont Hagir B. Suliman Claude A. Piantadosi Anna Mae Diehl | 2012 | Gastroenterology2012，，5： | 2 |
| 20 | The prevalence and etiology of elevated aminotransferase levels in the United States显示文摘 | Jeanne M Clark Frederick L Brancati Anna Mae Diehl | 2003 | The American Journal of Gastroenterology2003，，5： | 2 |
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