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| 1 | Characterization of functional biliary pain and dyspeptic symptoms in patients with sphincter of Oddi dysfunction:Effect of papillotomy显示文摘AIM: To characterize functional biliary pain and other gastrointestinal (GI) symptoms in postcholecystectomy syndrome (PCS) patients with and without sphincter of Oddi dysfunction (SOD) proved by endoscopic sphincter of Oddi manometry (ESOM), and to assess the post- endoscopic sphincterotomy (EST) outcome. METHODS: We prospectively investigated 85 cholecystectomized patients referred for ERCP because of PCS and suspected SOD. On admission, all patients completed our questionnaire. Physical examination, laboratory tests, abdominal ultrasound, quantitative hepatobiliary scintigraphy (QHBS), and ERCP were performed in all patients. Based on clinical and ERCP findings 15 patients had unexpected bile duct stone disease and 15 patients had SOD biliary typeⅠ. ESOM demonstrated an elevated basal pressure in 25 patients with SOD biliary-type Ⅲ. In the remaining 30 cholecystectomized patients without SOD, the liver function tests, ERCP, QHBS and ESOM were all normal. As a control group, 30 ‘asymptomatic’ cholecystectomized volunteers (attended to our hospital for general cardiovascular screening) completed our questionnaire, which is consisted of 50 separate questions on GI symptoms and abdominal pain characteristics. Severity of the abdominal pain (frequency and intensity) was assessed with a visual analogue scale (VAS). In 40 of 80 patients having definite SOD (i.e. patients with SOD biliary typeⅠand those with elevated SO basal pressure on ESOM), an EST was performed just after ERCP. In these patients repeated questionnaires were filled at each follow-up visit (at 3 and 6 mo) and a second lookQHBS was performed 3 mo after the EST to assess the functional response to EST. RESULTS: The analysis of characteristics of the abdominal pain demonstrated that patients with common bile duct stone and definite SOD had a significantly higher score of symptomatic agreement with previously determined biliary-like pain features than patient groups of PCS without SOD and controls. In contrary, no significant differences were found when the pain severity scores were compared in different groups of PCS patients. In patients with definite SOD, EST induced a significant acceleration of the transpapillary bile flow; and based on the comparison of VASs obtained from the pre- and post-EST questionnaires, the severity scores of abdominal pain were significantly improved, however, only 15 of 35 (43%) patients became completely pain free. Post-EST severity of abdominal pain by VASs was significantly higher in patients with predominant dyspepsia at initial presentation as compared to those without dyspeptic symptoms. CONCLUSION: Persistent GI symptoms and general patient dissatisfaction is a rather common finding after EST in patients with SOD, and correlated with the presence of predominant dyspeptic symptoms at the initial presentation, but does not depend on the technical and functional success of EST. | László Madácsy Roland Fejes Gábor Kurucsai Ildikó Joó András Székely Viktória Bertalan Attila Szepes János Lonovics | 2006 | World Journal of Gastroenterology2006，12，42： | 33 |
| 2 | 美国临床生化科学院检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物的应用显示文摘经美国临床生化科学院(NCAB)授权,由鄢盛恺教授组织学者、专家翻译审定2009年NCAB检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的应用单行本(Catharine M.Sturgeon教授和Eleftherios P.Diaman-dis教授编辑)。该指南包含第1至6章共6部分内容,参加指南制订的专家阵容强大,分别从临床及检验角度对睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的检测与临床应用方面的问题进行了详细阐述与说明,是目前国内外在肿瘤实验诊断方面的纲领性应用文件。不仅适合广大检验人员、临床医护人员学习使用,也非常适合相关仪器试剂生产厂商研发应用。本指南由刘洋、薛丽、林文涛、李江、梁红艳、顾兵、潘世扬、郑磊等翻译,姜晓峰、沈文梅、田亚平、鄢盛恺审校,最后由鄢盛恺统稿审定。本指南的翻译出版,不仅有助于我国检验人员和医护人员合理的检测和应用睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物,对我国检验医学指南的编写与应用也有一定的借鉴作用。本刊特在本期刊发,以飨广大读者。 | 鄢盛恺 Ulf-Hkan Stenman Rolf Lamerz Leendert H.Looijenga Nils Brünner Michael J.Duffy Caj Haglund Mads Holten-Andersen Hans JФrgen Nielsen Francisco J.Esteva Nadia Harbeck Daniel F.Hayes Rafael Molina Daniel W.Chan Robert C.Bast Jr Ie-Ming Shih Lori J.Sokoll Gyrgy Slétormos 刘洋 梁红艳 姜晓峰 田亚平 薛丽 林文涛 顾兵 潘世扬 沈文梅 郑磊 李江 | 2012 | 临床检验杂志2012，30，2： | 32 |
| 3 | New Algorithm for CBR-RBR Fusion with Robust Thresholds显示文摘The case-based reasoning(CBR) and rule-based reasoning(RBR) fusion systems include a diverse range of fusion methods and their tasks are characterized by interleaving combination of the reasoning procedures. Existing approaches cannot clarify the complex relationships between data from the knowledge sources nor uniformly represent the heterogeneous case and rule knowledge in one fusion space. As a result, existing approaches fail to solve system fragility due to knowledge uncertainty and reasoning unreliability. For the purpose of addressing the difficulties, a novel algorithm for CBR-RBR fusion with robust thresholds(CRFRT) is proposed. Heterogeneous case and rule knowledge are uniformly represented in one defined fusion unitary space. The robust thresholds have been achieved to distinguish the complex relationships between meta-knowledge in the fusion space and to enhance system capacity of knowledge identification. Furthermore, fusion reasoning strategies are constructed for CRFRT and its procedure based on which robust solution of the fusion reasoning problem is obtained. Finally, CRFRT is validated by benchmark problems in machine learning. Compared with other CBR and RBR approaches, the reasoning efficiency and accuracy are increased by 5% and 2.2% respectively. The variations of system accuracy are decreased by 2% to 3.8%. The above results show that the CRFRT algorithm boosts the system's effectiveness and robustness. The proposed CRFRT can solve the fragility of complex intelligence decision system and give quality performance for fault diagnosis. | XU Mad YU Haiyan SHEN Jiang | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 12 |
| 4 | 近红外激发荧光光谱与拉曼光谱快速鉴别马铃薯品种显示文摘马铃薯是世界上最重要的食物之一,快速无损的进行马铃薯品种鉴别对其在应用中更好的发挥品种优势具有重要作用。研究了以近红外荧光光谱和近红外拉曼光谱的土豆品种鉴别,并对两者进行了比较。实验采用3个品种共98个土豆样本,随机将其分成校正集(74个)和预测集(24个)。首先使用785nm近红外激光激发,采集所有样本的荧光和拉曼混合光谱,然后从混合光谱中分别提取荧光光谱和拉曼光谱,最后对荧光光谱和拉曼光谱进行偏最小二乘判别分析(PLS-DA),PLS-DA模型采用留一法和全交互验证。结果显示,荧光光谱与拉曼光谱都能够对三个马铃薯品种进行鉴别,其中荧光光谱的PLS-DA模型预测Favorita品种效果较好(灵敏度为1,特异性0.86,准确性0.92),但Diamant品种(灵敏度为0.75,特异性0.75,准确性0.75)和Granola品种(灵敏度为0.16,特异性0.89,准确性0.71)预测的效果较差,而拉曼光谱图很好的解释了马铃薯中的主要营养成分,基于拉曼光谱的PLSDA模型的预测效果(三个品种预测灵敏度,特异性,准确性均为1)比荧光光谱判别效果显著提高。 | 代芬 Mads Sylvest Bergholt Arnold Julian Vinoj Benjamin 洪添胜 Zhiwei Huang | 2014 | 光谱学与光谱分析2014，34，3： | 10 |
| 5 | Endoscopic transluminal pancreatic necrosectomy using a self-expanding metal stent and high-flow water-jet system显示文摘Walled-off pancreatic necrosis and a pancreatic abscess are the most severe complications of acute pancreatitis. Surgery in such critically ill patients is often associated with significant morbidity and mortality within the first few weeks after the onset of symptoms. Minimal invasive approaches with high success and low mortality rates are therefore of considerable interest. Endoscopic therapy has the potential to offer safe and effective alternative treatment. We report here on 3 consecutive patients with infected walled-off pancreatic necrosis and 1 patient with a pancreatic abscess who underwent direct endoscopic necrosectomy 19-21 d after the onset of acute pancreatitis. The infected pancreatic necrosis or abscess was punctured transluminally with a cystostome and, after balloon dilatation, a non-covered self-expanding biliary metal stent was placed into the necrotic cavity. Following stent deployment, a nasobiliary pigtail catheter was placed into the cavity to ensure continuous irrigation. After 5-7 d, the metal stent was removed endoscopically and the necrotic cavity was entered with a therapeutic gastroscope. Endoscopic debridement was performed via the simultaneous application of a high-flow water-jet system; using a flush knife, a Dormia basket, and hot biopsy forceps. The transluminal endotherapy was repeated 2-5 times daily during the next 10 d. Supportive care included parenteral antibiotics and jejunal feeding. All patients improved dramatically and with resolution of their septic conditions; 3 patients were completely cured without any further complications or the need for surgery. One patient died from a complication of prolonged ventilation severe bilateral pneumonia, not related to the endoscopic procedure. No procedure related complications were observed. Transluminal endoscopic necrosectomy with temporary application of a self-expanding metal stent and a high-flow water-jet system shows promise for enhancing the potential of this endoscopic approach in patients with walled-off pancreatic necrosis and/or a pancreatic abscess. | István Hritz Roland Fejes András Székely Iván Székely László Horváth gnes Sárkány ron Altorjay László Madácsy | 2013 | World Journal of Gastroenterology2013，19，23： | 10 |
| 6 | Abnormal ground reaction forces lead to a general decline in gait speed in knee osteoarthritis patients显示文摘AIM To analyse ground reaction forces at higher speeds using another method to be more sensitive in assessing significant gait abnormalities. METHODS A total of 44 subjects, consisting of 24 knee osteoarthritis(OA) patients and 20 healthy controls were analysed. The knee OA patients were recruited from an orthopaedic clinic that were awaiting knee replacement. All subjects had their gait patterns during stance phase at top walking speed assessed on a validated treadmill instrumented with tandem force plates. Temporal measurements and ground reaction forces(GRFs) along with a novel impulse technique were collected for both limbs and a symmetry ratio was applied to all variables to assess inter-limb asymmetry. All continuous variables for each group were compared using a student t-test and χ2 analysis for categorical variables with significance set at α = 0.05. Receiver operator characteristics curves were utilised to determine best discriminating ability.RESULTS The knee OA patients were older(66 ± 7 years vs 53 ± 9 years, P = 0.01) and heavier(body mass index: 31 ± 6 vs 23 ± 7, P < 0.001) but had a similar gender ratio when compared to the control group. Knee OA patients were predictably slower at top walking speed(1.37 ± 0.23 m/s vs 2.00 ± 0.20 m/s, P < 0.0001) with shorter mean step length(79 ± 12 cm vs 99 ± 8 cm, P < 0.0001) and broader gait width(14 ± 5 cm vs 11 ± 3 cm, P = 0.015) than controls without any known lower-limb joint disease. At a matched mean speed(1.37 ± 0.23 vs 1.34 ± 0.07), ground reaction results revealed that pushoff forces and impulse were significantly(P < 0.0001) worse(18% and 12% respectively) for the knee OA patients when compared to the controls. Receiver operating characteristic curves analysis demonstrated total impulse to be the best discriminator of asymmetry, with an area under the curve of 0.902, with a cut-off of-3% and a specificity of 95% and sensitivity of 88%.CONCLUSION Abnormal GRFs in knee osteoarthritis are clearly evident at higher speeds. Analysing GRFs with another method may explain the general decline in knee OA patient's gait. | Anatole Vilhelm Wiik Adeel Aqil Mads Brevadt Gareth Jones Justin Cobb | 2017 | World Journal of Orthopedics2017，8，4： | 7 |
| 7 | Evaluation of the biliary tract in patients with functional biliary symptoms显示文摘这篇论文的目的是在这些病人为胆道的评估描述功能的胆汁的症候群和方法。没有可论证的器官的底层,功能的胆汁的症状能被定义为胆汁的症状。二主要症候群存在:胆囊机能障碍和 Oddi 机能障碍的括约肌。最重要的研究工具是 cholescintigraphy 和 Oddi 测压法的内视镜的括约肌。在胆囊机能障碍 scintigraphic 胆囊喷射部分在下面 35% 能选择将得益于胆囊炎的病人。Oddi 测压法的内视镜的括约肌在 Oddi 机能障碍的括约肌被认为标准答案,但是在 scintigraphic 方法的最近的开发就要改变这。因此, hilum-to-duodenum 运输时间的计算和 cholescintigraphy 上的十二指肠的外观时间在这些病人证明了有用。在结论,周围的方法能诊断功能的胆汁的症候群。然而,仍然有很多个问题,知识进一步被需要。可能,下一个向前走将在感觉测试和阻抗 planimetric 方法的区域。 | Peter Funch-Jensen Asbjφrn Mohr Drewes László Madácsy | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 8 | A Lesion-Mimic Syntaxin Double Mutant in Arabidopsis Reveals Novel Complexity of Pathogen Defense Signaling显示文摘损害模仿 Arabidopsis 异种, syp121 syp122,组成地表示表明小径的水杨酸酸(SA ) 并且有低穿入抵抗到粉的霉真菌。损害模仿显型的基因分析在植物扩展了我们规划房间死亡(PCD ) 的理解。在 syp121 syp122 表明基因的 SA 的 Inactivation 仅仅部分救损害模仿显型,显示另外的防卫贡献 PCD。整个染色体 transcriptome 分析证实了那知道的导致 SA 的抄本,以及众多的其它病原体反应抄本,在 syntaxin 基因的 inactivation 以后是起来调整的。syp121 syp122 的 suppressor 异种分析表明 FMO1, ALD1,和 PAD4 为损害开发是重要的。EDS1, NDR1, RAR1,和 SGT1b 的变异的等位基因部分也救了损害模仿显型,建议那变异的 syntaxin 基因刺激 TIR-NB-LRR 和 CC-NB-LRR-type 电阻。syntaxin 两倍大美人加强了粉的导致霉的象 HR 一样回答。发信号的这要求的功能的 PAD4 然而并非功能的 SA。然而,发信号的 SA 加强了 PAD4 依赖的象 HR 一样反应。四倍的异种的分析建议 EDS5 和 SID2 授与分开的 SA 独立的发信号功能,并且那 FMO1 和 ALD1 调停 NPR1 依赖的 SA 独立的信号。这些研究加亮多重小径的贡献到防卫和点到他们的相互作用的复杂性。 | Ziguo Zhang Andrea Lenk Mats X. Andersson Torben Gjetting Carsten Pedersen Mads E. Nielsen Mari-Anne Newman Bi-Huei Hou Shauna C. Somerville Hans Thordal-Christensen | 2008 | Molecular Plant2008，1，3： | 3 |
| 9 | MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors显示文摘 | Liu Xi Sempere Lorenzo F Ouyang Haoxu Memoli Vincent A Andrew Angeline S Luo Yue Demidenko Eugene Korc Murray Shi Wei Preis Meir Dragnev Konstantin H Li Hua DiRenzo James Bak Mads Freemantle Sarah J Kauppinen Sakari Dmitrovsky Ethan | 2010 | Journal of Clinical Investigation2010，，4： | 3 |
| 10 | Development and predictive validity of the cirrhosis-associated ascites symptom scale: A cohort study of 103 patients显示文摘AIM To develop a scale of domains associated with the health-related quality-of-life(HRQOL) in patients with cirrhosis-related ascites.METHODS We initially undertook literature searches and a qualitative study in order to design a cirrhosis-associated ascites symptom(CAS) scale describing symptoms with a potential detrimental impact on health related quality of life(HRQL)(the higher the score, the worse the symptoms). Discriminatory validity was assessed in a validation cohort including cirrhotic patients with(1) tense/severe;(2) moderate/mild; or(3) no ascites(controls). Patients also completed chronic liver disease questionnaire(CLDQ) and the Euro QoL 5-Dimensions 5-Level(EQ-5D-5L) questionnaire evaluating HRQL. The relation between scale scores was analysed using Spearman correlations. RESULTS The final CAS scale included 14 items. The equivalent reliability was high(Chronbach's alpha 0.88). The validation cohort included 103 patients(72% men, mean age 62.4 years). The mean scores for each question in the CAS scale were higher for patients with severe/tense ascites than for mild/moderate ascites and controls. Compared with controls(mean = 9.9 points), the total CAS scale score was higher for severe/tense ascites(mean = 23.8 points) as well as moderate/mild ascites(mean = 18.6 points)(P < 0.001 both groups). We found a strong correlation between the total CAS and CLDQ score(rho = 0.82, P < 0.001) and a moderate correlation between the CAS and the EQ-5D-5L score(0.67, P < 0.001). CONCLUSION The CAS is a valid tool, which reflects HRQOL in patients with ascites. | Agnete Nordheim Riedel Nina Kimer Anne-Sofie Houlberg Jensen Emilie Kristine Dahl Mads Israelsen Luise Aamann Lise Lotte Gluud | 2018 | World Journal of Gastroenterology2018，24，15： | 3 |
| 11 | 基-塘概念:中国的持续农业与营养循环显示文摘随着中国工业化进程的迅速推进,一些传统的综合农业技术在对它们的潜力作出合理评价之前就消失了。粤南基-塘系统的有机在业和废料循环已实践了数百年,至今仍为当地人民提供了稳定的收入和多种收获。就单位面积的产值而言,这种系统是世界最高产的。在基-塘系统内,营养物的流失和化学品的使用降到了最低点。对基-塘概念进行研究,有助于发现简便的方法以减少食物生产对环境的有害影响。 | Mads Korn 吴持政 | 1996 | 人类环境杂志1996，25，1： | 3 |
| 12 | Spillovers in the development of new pollution abatement technology: A new look at the Porter-hypothesis显示文摘 | Mads Greaker | 2006 | Journal of Environmental Economics and Management2006，，1： | 2 |
| 13 | High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer显示文摘 | Mads H. Rasmussen Niels F. Jensen Line S. Tarpgaard Camilla Qvortrup Maria U. R?mer Jan Stenvang Tine P. Hansen Lise L. Christensen Jan Lindebjerg Flemming Hansen Benny V. Jensen Torben F. Hansen Per Pfeiffer Nils Brünner Torben F. ?rntoft Claus L. Anders | 2013 | Molecular Oncology2013，，3： | 2 |
| 14 | 哈尔滨大剧院显示文摘哈尔滨大剧院坐落在松花江北岸江畔,以环绕周围的湿地自然风光与北国冰封的地貌特征为设计灵感,从湿地中破冰而出.建筑的白色表皮仿佛是会呼吸的细胞,在北国阳光的照耀下发生“光合作用”.大剧院顶部的玻璃天窗最大限度地将室外的自然光纳入室内.自然光洒落在剧场中庭的水曲柳墙面上,凸显了当地材料手工打造的匠心独运,也使人无论走到哪里,都能感受到日光倾泻的通透与空灵.小剧场的后台设计为透明的隔音玻璃,使得室外的自然环境成为舞台的延伸和背景. | MAD Architects | 2016 | 建筑学报2016，，6： | 2 |
| 15 | 我们应该怎样利用新抗凝剂治疗急性肺栓塞?显示文摘由于大多数的治疗都增加了出血并发症的风险,因此急性肺栓塞(pulmonary embolism,PE)患者的治疗成为临床医生面临的一大挑战。80%的PE患者具有可识别的诱发因素, | Jens Eckardt Mads Nybo 章仲恒 何建行 | 2013 | 国际病理科学与临床杂志2013，33，3： | 2 |
| 16 | Denaturing High-performance Liquid Chromatography mutation analysis in patients with reduced Protein S levels 显示文摘 | Lise Bathum Anna-Marie Mtl nster Mads Nybo | 2008 | Clinica Chimica Acta 20082008，7681，： | 1 |
| 17 | Influence of microemulsions on cutaneous drug deliwery 显示文摘 | Mads K | 2002 | Advanced Drug Delivery Reviews2002，54，： | 1 |
| 18 | A centralized energy-efficient routing protocol for wireless sensor networks 显示文摘 | MURUGANATHAN S D MAD C F BHASIN R I | 2005 | IEEE Radio Communication2005，43，3： | 1 |
| 19 | Enhancing endosomal escape for nanoparticle mediated siRNA delivery显示文摘 | MAD | 2014 | Nanoscale2014，6，12： | 1 |
| 20 | Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia 显示文摘 | Scherbaum W A Schweizer A Mad A | 2008 | Diabetes Obes Metab2008，10，11： | 1 |
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