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| 1 | Performance of liver stiffness measurements by transient elastography in chronic hepatitis显示文摘AIM:To compare results of liver stiffness measurements by transient elastography(TE) obtained in our patients population with that used in a recently published meta-analysis.METHODS:This was a single center cross-sectional study.Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled.TE was carried out by using FibroScan(Echosens,Paris,France).Liver biopsy was performed on the same day as TE,as day case procedure.Fibrosis was staged according to the Metavir scoring system.The diagnostic performance of TE was assessed by using receiver operating characteristic(ROC) curves and the area under the ROC curve analysis.RESULTS:Two hundred and fifty-two patients met the inclusion criteria.Six(2%) patients were excluded due to unreliable TE measurements.Thus,246(171 men and 75 women) patients were analyzed.One hundred and ninety-five(79.3%) patients had chronic hepatitis C,41(16.7%) had chronic hepatitis B,and 10(4.0%) were coinfected with human immunodeficiency virus.ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa forF ≥ 2;7.9 kPa forF ≥ 3;9.6 kPa for F = 4 in all patients(n = 246),and as high as 6.9 kPa for F ≥ 2;7.3 kPa for F ≥ 3;9.3 kPa for F = 4 in patients with hepatitis C(n = 195).Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2;9.6 kPa for F ≥ 3;12.2 kPa for F = 4 in all patients(n = 246),and as high as 7.0 kPa forF ≥ 2;9.3 kPa forF ≥ 3;12.3 kPa forF = 4 in patients with hepatitis C(n = 195).CONCLUSION:The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies. | Giovanna Ferraioli Carmine Tinelli Barbara Dal Bello Mabel Zicchetti Raffaella Lissandrin Gaetano Filice Carlo Filice Elisabetta Above Giorgio Barbarini Enrico Brunetti Willy Calderon Marta Di Gregorio Roberto Gulminetti Paolo Lanzarini Serena Ludovisi Laura Maiocchi Antonello Malfitano Giuseppe Michelone Lorenzo Minoli Mario Mondelli Stefano Novati Savino FA Patruno Alessandro Perretti Gianluigi Poma Paolo Sacchi Domenico Zanaboni Marco Zaramella | 2013 | World Journal of Gastroenterology2013，19，1： | 18 |
| 2 | Point shear wave elastography method for assessing liver stiffness显示文摘AIM:To estimate the validity of the point shear-wave elastography method by evaluating its reproducibility and accuracy for assessing liver stiffness.METHODS:This was a single-center,cross-sectional study.Consecutive patients with chronic viral hepatitis scheduled for liver biopsy(LB)(Group 1)and healthy volunteers(Group 2)were studied.In each subject 10 consecutive point shear-wave elastography(PSWE)measurements were performed using the iU22 ultrasound system(Philips Medical Systems,Bothell,WA,United States).Patients in Group 1 underwent PSWE,transient elastography(TE)using FibroScan(Echosens,Paris,France)and ultrasound-assisted LB.For the assessment of PSWE reproducibility two expert raters(rater 1 and rater 2)independently performed the examinations.The performance of PSWE was compared to that of TE using LB as a reference standard.Fibrosis was staged according to the METAVIR scoring system.Receiver operating characteristic curve analyses were performed to calculate the area under the receiver operating characteristic curve(AUC)for F≥2,F≥3and F=4.The intraobserver and interobserver reproducibility of PSWE were assessed by calculating Lin’s concordance correlation coefficient.RESULTS:To assess the performance of PSWE,134consecutive patients in Group 1 were studied.The median values of PSWE and TE(in kilopascals)were 4.7(IQR=3.8-5.4)and 5.5(IQR=4.7-6.5),respectively,in patients at the F0-F1 stage and 3.5(IQR=3.2-4.0)and 4.4(IQR=3.5-4.9),respectively,in the healthy volunteers in Group 2(P<10-5).In the univariate analysis,the PSWE and TE values showed a high correlation with the fibrosis stage;low correlations with the degree of necroinflammation,aspartate aminotransferase and gamma-glutamyl transferase(GGT);and a moderate negative correlation with the platelet count.A multiple regression analysis confirmed the correlations of both PSWE and TE with fibrosis stage and GGT but not with any other variables.The following AUC values were found:0.80(0.71-0.87)for PSWE and 0.82(0.73-0.89)for TE(P=0.42);0.88(0.80-0.94)for PSWE and 0.95(0.88-0.98)for TE(P=0.06);and 0.95(0.89-0.99)for PSWE and 0.92(0.85-0.97)for TE(P=0.30)for F≥2,F≥3 and F=4,respectively.To assess PSWE reproducibility,116 subjects were studied,including 47consecutive patients scheduled for LB(Group 1)and 69 consecutive healthy volunteers(Group 2).The intraobserver agreement ranged from 0.83(95%CI:0.79-0.88)to 0.96(95%CI:0.95-0.97)for rater 1 and from 0.84(95%CI:0.79-0.88)to 0.96(95%CI:0.95-0.97)for rater 2.The interobserver agreement yielded values from0.83(95%CI:0.78-0.88)to 0.93(95%CI:0.91-0.95).CONCLUSION:PSWE is a reproducible method for assessing liver stiffness,and it compares with TE.Compared with patients with nonsignificant fibrosis,healthy volunteers showed significantly lower values. | Giovanna Ferraioli Carmine Tinelli Raffaella Lissandrin Mabel Zicchetti Barbara Dal Bello Gaetano Filice Carlo Filice | 2014 | World Journal of Gastroenterology2014，20，16： | 12 |
| 3 | Controlled attenuation parameter for evaluating liver steatosis in chronic viral hepatitis显示文摘AIM:To assess the performance of controlled attenuation parameter(CAP)in patients with chronic viral hepatitis.METHODS:CAP is a new technique that measures the attenuation in the liver of an ultrasound beam,which is directly related to lipid accumulation.Consecutive patients undergoing liver biopsy for chronic viral hepatitis were studied using the M probe of FibroScan device(Echosens,Paris,France).The device estimates liver st-eatosis in decibel per meter(dB/m).An expert operator performed all measurements.Steatosis was graded according to Kleiner’s classification.Pearson or Spearman rank coefficient was used to test correlation between two study variables.Linear regression was used for multivariate model to assess the association between CAP and other variables.Receiver operating characteristic curve analysis was performed to calculate area under the curve(AUROC)for S0 vs S1-S3 and S0-S1 vs S2-S3.RESULTS:115 subjects(85 males and 30 females)were prospectively studied.The mean values of CAP were 227.1±43.1 for S0;254.6±38.9 for S1;297.8±49.4 dB/m for S2-S3.In univariate analysis CAP showed a significant correlation with age,body mass index(BMI),degree of steatosis,and cholesterol.Multivariate regression analysis confirmed the correlation with the degree of steatosis[coefficient,1.2(0.60-1.83);P<10-5]and BMI[coefficient,4.1(0.5-7.8);P=0.03]but not with all other variables.Optimal cutoff values for S≥1 and S≥2 were 219 dB/m[AUROC,0.76(0.67-0.84);sensitivity,91.1%(78.8-97.5);specificity,51.6%(38.7-64.2);positive predictive value,56.9%(44.7-68.6);negative predictive value,89.2%(74.3-97.0);positive likelihood ratio,1.88(1.4-2.5);negative likelihood ratio,0.17(0.07-0.5)]and 296 dB/m[AUROC,0.82(0.74-0.89);sensitivity,60.0%(32.3-83.7);specificity,91.5%(83.9-96.3);positive predictive value,52.9%(27.8-77.0);negative predictive value,93.5%(86.3-97.6);positive likelihood ratio,7.05(3.2-15.4);negative likelihood ratio,0.44(0.2-0.8)],respectively.CONCLUSION:Controlled attenuation parameter could be a useful tool in the clinical management of patients with chronic viral hepatitis for detecting liver steatosis. | Giovanna Ferraioli Carmine Tinelli Raffaella Lissandrin Mabel Zicchetti Barbara Dal Bello Gaetano Filice Carlo Filice | 2014 | World Journal of Gastroenterology2014，20，21： | 7 |
| 4 | International validation of the Chinese University Prognostic Index for staging of hepatocellular carcinoma: a joint United Kingdom and Hong Kong study显示文摘The outcome of hepatocellular carcinoma(HCC) patients significantly differs between western and eastern population centers. Our group previously developed and validated the Chinese University Prognostic Index(CUPI) for the prognostication of HCC among the Asian HCC patient population. In the current study, we aimed to validate the CUPI using an international cohort of patients with HCC and to compare the CUPI to two widely used staging systems, the Barcelona Clinic Liver Cancer(BCLC) classification and the Cancer of the Liver Italian Program(CLIP). To accomplish this goal, two cohorts of patients were enrolled in the United Kingdom(UK; n = 567; 2006-2011) and Hong Kong(HK; n = 517; 2007-2012). The baseline clinical data were recorded. The performances of the CUPI, BCLC, and CLIP were compared in terms of a concordance index(C-index) and were evaluated in subgroups of patients according to treatment intent. The results revealed that the median follow-up durations of the UK and HK cohorts were 27.9 and 29.8 months, respectively. The median overall survival of the UK and HK cohorts were 22.9 and 8.6 months, respectively. The CUPI stratified the patients in both cohorts into three risk subgroups corresponding to distinct outcomes. The median overall survival of the CUPI low-, intermediate-, and high-risk subgroups were 3.15, 1.24, and 0.29 years, respectively, in the UK cohort and were 2.07, 0.32, and 0.10 years, respectively, in the HK cohort. For the patients who underwent curative treatment, the prognostic performance did not differ between the three staging systems, and all were suboptimal. For those who underwent palliative treatment, the CUPI displayed the highest C-index, indicating that this staging system was the most informative for both cohorts. In conclusion, the CUPI is applicable to both western and eastern HCC patient populations. The performances of the three staging systems differed according to treatment intent, and the CUPI was demonstrated to be optimal for those undergoing palliative treatment. A more precise staging system for early-stage disease patients is required. | Stephen L.Chan Philip J.Johnson Frankie Mo Sarah Berhane Mabel Teng Anthony W.H.Chan Ming C.Poon Paul B.S.Lai Simon Yu Anthony T.C.Chan Winnie Yeo | 2014 | Chinese Journal of Cancer2014，33，10： | 4 |
| 5 | Priorities and needs for research on urban interventions targeting vector-borne diseases: rapid review of scoping and systematic reviews显示文摘This paper highlights the critical importance of evidence on vector-borne diseases(VBD)prevention and control interventions in urban settings when assessing current and future needs,with a view to setting policy priorities that promote inclusive and equitable urban health services.Research should produce knowledge about policies and interventions that are intended to control and prevent VBDs at the population level and to reduce inequities.Such interventions include policy,program,and resource distribution approaches that address the social determinants of health and exert influence at organizational and system levels. | Clara Bermudez-Tamayo Olive Mukamana Mabel Carabali Lyda Osorio Florence Fournet Kounbobr Roch Dabiré Celina Turchi Marteli Adolfo Contreras Valéry Ridde | 2016 | Infectious Diseases of Poverty2016，5，1： | 3 |
| 6 | Probabilistic Seismic Risk Assessment in Manizales,Colombia: Quantifying Losses for Insurance Purposes显示文摘A fully probabilistic seismic risk assessment was developed in Manizales, Colombia, considering assets of different types. The first type includes elements that are part of the water and sewage network, and the second type includes public and private buildings. This assessment required the development of a probabilistic seismic hazard analysis that accounts for the dynamic soil response,assembling high resolution exposure databases, and the development of damage models for different types of elements. The economic appraisal of the exposed assets was developed together with specialists of the water utilities company of Manizales and the city administration. The risk assessment was performed using several Comprehensive Approach to Probabilistic Risk Assessment modules as well as the R-System, obtaining results in terms of traditional metrics such as loss exceedance curve, average annual loss, and probable maximum loss. For the case of pipelines, repair rates were also estimated. The results for the water and sewage network were used in activities related to the expansion and maintenance strategies, as well as for the exploration of financial retention and transfer alternatives using insurance schemes based on technical,probabilistic, and prospective damage and loss estimations.In the case of the buildings, the results were used in the update of the technical premium values of the existing collective insurance scheme. | Mario A. Salgado-Gálvez Gabriel A. Bernal Daniela Zuloaga Mabel C. Marulanda Omar-Darío Cardona Sebastián Henao | 2017 | International Journal of Disaster Risk Science2017，8，3： | 2 |
| 7 | phytochemical analysis and in vitro antioxidant acitivity of hydroalcoholic seed extract of Nymphaea nouchali Burm.f.显示文摘Objective:To evaluate the phytochemical constituents and the antioxidant activity of hydroalcoholic extract of Nymphaea nouchali seed locally prescribed as a diet for diabetes mellitus.Methods:The antioxidant and free radical scavenging activity of hydroalcoholic extract of the plant was assessed against 1,1 diphenyl-2-picryl hydrazyl(DPPH),nitric oxide and lipid peroxidation using standard protocols.Total phenolics,flavonoids and tannins were also determined.Results:Phytochemical analysis revealed the presence of phenols,flavones,tannins,protein,reducing sugars,glycosides,saponins,alkaloids and steroids.The activities of plant extract against DPPH,nitric oxide and lipid peroxidation was concentration dependent with IG_(50)value of42.82,23.58 and 54.65μg/mL respectively.The total antioxidant capacity was high with 577.73 mg vitamin E/g of the extract and showed a moderately high vitamin C content of 197.22 mg/g.The total tannin content of hydroalcoholic seed extract was high(195.84 GE/g),followed by phenolics(179.56 GE/g)and flavonoids(23.55 QE/g).Conclusion:Our findings provide evidence that the crude extract of Nymphaea nouchali is a potential source of natural antioxidants and this justifies its use in folkloric medicine. | Mabel Parimala Francis Gricilda Shoba | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，11： | 2 |
| 8 | Presence of three dengue serotypes in Ouagadougou(Burkina Faso):research and public health implications显示文摘Background:The significant malaria burden in Africa has often eclipsed other febrile illnesses.Burkina Faso’s first dengue epidemic occurred in 1925 and the most recent in 2013.Yet there is still very little known about dengue prevalence,its vector proliferation,and its poverty and equity impacts.Methods:An exploratory cross-sectional survey was performed from December 2013 to January 2014.Six primary healthcare centers in Ouagadougou were selected based on previously reported presence of Flavivirus.All patients consulting with fever or having had fever within the previous week and with a negative rapid diagnostic test(RDT)for malaria were invited to participate.Sociodemographic data,healthcare use and expenses,mobility,health-related status,and vector control practices were captured using a questionnaire.Blood samples of every eligible subject were obtained through finger pricks during the survey for dengue RDT using SD BIOLINE Dengue Duo(NS1Ag and IgG/IgM)®and to obtain blood spots for reverse transcription polymerase chain reaction(RT-PCR)analysis.In a sample of randomly selected yards and those of patients,potential Aedes breeding sites were found and described.Larvae were collected and brought to the laboratory to monitor the emergence of adults and identify the species.Results:Of the 379 subjects,8.7%(33/379)had positive RDTs for dengue.Following the 2009 WHO classification,38.3%(145/379)had presumptive,probable,or confirmed dengue,based on either clinical symptoms or laboratory testing.Of 60 samples tested by RT-PCR(33 from the positive tests and 27 from the subsample of negatives),15 were positive.The serotypes observed were DENV2,DENV3,and DENV4.Odds of dengue infection in 15-to-20-year-olds and persons over 50 years were 4.0(CI 95%:1.0–15.6)and 7.7(CI 95%:1.6–37.1)times higher,respectively,than in children under five.Average total spending for a dengue episode was 13771 FCFA[1300–67300 FCFA](1$US=478 FCFA).On average,2.6 breeding sites were found per yard.Potential Aedes breeding sites were found near 71.4%(21/28)of patients,but no adult Aedes were found.The most frequently identified potential breeding sites were water storage containers(45.2%).Most specimens collected in yards were Culex(97.9%).Conclusions:The scientific community,public health authorities,and health workers should consider dengue as a possible cause of febrile illness in Burkina Faso. | Valéry Ridde Isabelle Agier Emmanuel Bonnet Mabel Carabali Kounbobr Roch Dabiré Florence Fournet Antarou Ly Ivlabèhiré Bertrand Meda Beatriz Parra | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 9 | Lewis acid metal ion-exchanged MAPO-5 molecular sieves for solvent free synthesis of coumarin derivative显示文摘 | GOPALAKRISHNAN S VISWANATHAN K R PRIYA S V MABEL J H PALANICHAMY M MURUGESAN V | 2008 | Catalysis Communications2008，10，10： | 1 |
| 10 | Analysis of wind power generation andprediction using ANN :a case study 显示文摘 | Mabel M C Fernandez E | 2008 | Renewable Energy2008，，33： | 1 |
| 11 | Metaraminol Infusion for Maintenance of Arterial Blood Pressure During Spinal Anesthesia for Cesarean Delivery: The Effect of a Crystalloid Bolus显示文摘 | Warwick D. Ngan Kee Kim S. Khaw Bee B. Lee Mabel M.S . Wong Floria F. Ng | 2001 | Anesthesia & Analgesia2001，，3： | 1 |
| 12 | Eigenvalue Problems for the P - laplaeian with Indefinite Weights 显示文摘 | MABEL CUESTA | 2001 | Journal of Differential Equations2001，33，： | 1 |
| 13 | The Synergism of Exper- tise in Clinical Teaching: An Integrative Model for Nursing Education显示文摘 | Mabel H Andrea B Janie L | 2000 | J Nurs Edu2000，39，6： | 1 |
| 14 | Effect of hydrophobic and hydrophilic properties of solid acid catalysts on the esterification of mateic anhydride with ethanol显示文摘 | Bhagiyalakshmi M Priya S V Mabel J H | 2008 | Catalysis Communications2008，9，10： | 1 |
| 15 | Salivary carriage of periodontal pathogens in generalized aggressive perlodontitls families显示文摘 | Mabelle FM Mareio ZC Tiago T | 2012 | Interna- tional Journal of Paediatric Dentistry2012，24，2： | 1 |
| 16 | An Input - Output Analysis of Public and Private Secondary Schools in Lagos显示文摘 | Olasunkanmi A A Mabel MOO | 2012 | Nigeria2012，，7： | 1 |
| 17 | Physicochemical characterization of fructooligosaccharides and evaluation of their suitability as a potential sweetener for diabetics显示文摘 | Mabel M J Sangeetha P T Platel K | 2008 | Carbohyd Res2008，343，： | 1 |
| 18 | The relationship between WRB soil units and heavy metals content in soils of Catamarca (Argentina)显示文摘 | Núria Roca Mabel Susana Pazos Jaume Bech | 2007 | Journal of Geochemical Exploration2007，，2： | 1 |
| 19 | Reproducibility of real-time shear wave elastography in the evaluation of liver elasticity显示文摘 | Giovanna Ferraioli Carmine Tinelli Mabel Zicchetti Elisabetta Above Gianluigi Poma Marta Di Gregorio Carlo Filice | 2012 | European Journal of Radiology2012，，11： | 1 |
| 20 | Disulfiram Is a Potent in Vitro Inhibitor of DNA Topoisomerases显示文摘 | J.Sebastian Yakisich ?ke Sidén Peter Eneroth Mabel Cruz | 2001 | Biochemical and Biophysical Research Communications2001，，2： | 1 |
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