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| 1 | Trends of foodborne diseases in China: lessons from laboratory- based surveillance since 2011显示文摘Foodborne 疾病是世界范围的最重要的公共健康问题之一。中国在食物链的所有方面面对各种各样、崭新的挑战。从从 2013 ~ 2016 的基于实验室的 foodborne 疾病监视系统的数据,以及不同区域和年龄,能在与多样的特征检测的病原体的模式与差别一起被发现。Vibrio parahaemolyticus 是在中国的传染腹泻的领先的原因,特别在在沿海的区域的成年人之中。沙门氏菌是为实质的社会经济的负担负责的严肃、广泛地分布式的病原体。Shigella 主要在 5 年下面在孩子之中与开发更少的区域在西北中国和内陆省(河南省) 被识别。从从 2011 ~ 2016 报导系统的 foodborne 疾病爆发的数据证明有毒的动物和为大多数死亡负责的植物因素在在西南区域的遥远的区域是有毒的蘑菇(54.7%) 。引起了报导的大多数案例(42.3%) 的生物危险被归因于 V。parahaemolyticus, foodborne 爆发的领先的原因。在这评论,我们在中国总结最近的监视途径到 foodborne 疾病并且在发达国家把结果与那些作比较。 | Jikai Liu Li Bai Weiwei Li Haihong Han Ping Fu Xiaochen Ma Zhenwang Bi Xiaorong Yang Xiuli Zhang Shiqi Zhen Xiaoling Deng Xiumei Liu Yunchang Guo | 2018 | Frontiers of Medicine2018，12，1： | 55 |
| 2 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 3 | Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response显示文摘Hypoxic-ischemic brain damage(HIBD)is a common cause of infant death.The purpose of our research was to explore the immunoregulatory mechanism of placenta-derived mesenchymal stem cells(PD-MSCs)in HIBD treatment.Seven-day-old rat pups were randomly divided into HIBD,PD-MSC,fibroblast,and control groups.Forty-eight hours after HIBD induction,cells at a density of 5×104 cells/10µl were injected into the cerebral tissue in the PD-MSC and fibroblast groups.The TNF-α,interleukin-17(IL-17),interferon-γ(IFN-γ),and IL-10 levels were detected through quantitative real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA).Regulatory T cell(Tregs)populations were detected through flow cytometry,and forkhead box P3(Foxp3)was measured through western blot analysis.Behavioral tests and gross and pathological examinations showed that PD-MSC treatment exerted significantly stronger neuroprotective effects than the other treatments.The expression levels of pro-inflammatory cytokines were substantially upregulated after HI injury.Compared with fibroblast treatment,PD-MSC treatment inhibited the production of pro-inflammatory cytokines and increased the production of IL-10 in the ischemic hemispheres and peripheral blood serum(all P<0.01).Flow cytometry results showed a notable increase in the number of Tregs within the spleen of the HIBD group.Moreover,the number of Tregs and the Foxp3 expression levels were higher in the PD-MSC treatment group than in the HIBD and fibroblast groups(all P<0.01).Our research suggests that the mechanism of PD-MSC treatment for HIBD partially involves inflammatory response suppression. | Hongfang Ding Hui Zhang Huifang Ding Dong Li Xinhao Yi Xiaoxu Ma Ruijuan Li Mei Huang Xiuli Ju | 2017 | Cellular & Molecular Immunology2017，14，8： | 10 |
| 4 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 5 | Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H^(+)-ATPase and Na^(+)/H^(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress显示文摘Plant metabolites are dynamically modified and distributed in response to environmental changes.How-ever,it is poorly understood how metabolic change functions in plant stress responses.Maintaining ion ho-meostasis under salt stress requires coordinated activation of two types of central regulators:plasma membrane(PM)H^(+)-ATPase and Na^(+)/H^(+) antiporter.In this study,we used a bioassay-guided isolation approach to identify endogenous small molecules that affect PM H^(+)-ATPase and Na^(+)/H^(+) antiporter activities and identified phosphatidylinositol(PI),which inhibits PM H^(+)-ATPase activity under non-stress conditions in Arabidopsis by directly binding to the C terminus of the PM H^(+)-ATPase AHA2.Under salt stress,the phosphatidylinositol 4-phosphate-to-phosphatidylinositol(PI4P-to-PI)ratio increased,and PI4P bound and activated the PM Na^(+)/H^(+) antiporter.PI prefers binding to the inactive form of PM H^(+)-ATPase,while PI4P tends to bind to the active form of the Na^(+)/H^(+) antiporter.Consistent with this,pis1 mutants,with reduced levels of PI,displayed increased PM H^(+)-ATPase activity and salt stress toler-ance,while the pi4kβ1 mutant,with reduced levels of PI4P,displayed reduced PM Na^(+)/H^(+) antiporter activity and salt stress tolerance.Collectively,our results reveal that the dynamic change between PI and PI4P in response to salt stress in Arabidopsis is crucial for maintaining ion homeostasis to protect plants from un-favorable environmental conditions. | Yongqing Yang Xiuli Han Liang Ma Yujiao Wu Xiao Liu Haiqi Fu Guoyong Liu Xiaoguang Lei Yan Guo | 2021 | Molecular Plant2021，14，12： | 4 |
| 6 | Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir,Its Parent Nucleoside and β-D-N^(4)-hydroxycytidine显示文摘Porcine epidemic diarrhea(PED)caused by porcine epidemic diarrhea virus(PEDV)is widespread in the world.In recent years,the increased virulence of the virus due to viral variations,has caused great economic losses to the pig industry in many countries.It is always worthy to find effective therapeutic methods for PED.As an important class of antivirals,nucleoside drugs which target viral polymerases have been applied in treating human viral infections for half a century.Herein,we evaluated the anti-PEDV potential of three broad-spectrum antiviral nucleoside analogs,remdesivir(RDV),its parent nucleoside(RDV-N)andβ-D-N^(4)-hydroxycytidine(NHC).Among them,RDV-N was the most active agent in Vero E6 cells with EC_(50) of 0.31μmol/L,and more potent than RDV(EC_(50)=0.74μmol/L)and NHC(EC_(50)=1.17μmol/L).The activity of RDV-N was further confirmed using an indirect immuno-fluorescence assay.Moreover,RDV-N exhibited a good safety profile in cells and in mice.The high sequence similarity of the polymerase functional domains of PEDV with other five porcine coronaviruses indicated a broader antiviral spectrum for the three compounds.Generally,RDV-N is a promising broad-spectrum antiviral nucleoside,and it would be worthy to make some structural modifications to increse its oral bioavailability. | Yuanchao Xie Xiaozhen Guo Tianwen Hu Daibao Wei Xiuli Ma Jiaqiang Wu Bing Huang Jingshan Shen | 2021 | Virologica Sinica2021，36，5： | 3 |
| 7 | Nodal Promotes mir206 Expression to Control Convergence and Extension Movements During Zebrafish Gastrulation显示文摘Nodal,a member of the transforming growth factor b(TGF-b)superfamily,has been shown to play a role in mesendoderm induction and gastrulation movements.The activity of Nodal signaling can be modulated by microRNAs(miRNAs)as previously reported,but little is known about which miRNAs are regulated by Nodal during gastrulation.In the present study,we found that the expression of mir206,one of the most abundant miRNAs during zebrafish early embryo development,is regulated by Nodal signaling.Abrogation of Nodal signal activity results in defective convergence and extension(CE)movements,and these cell migration defects can be rescued by supplying an excess of mir206,suggesting that mir206 acts downstream of Nodal signaling to regulate CE movements.Furthermore,in mir206 morphants,the expression of cell adhesion molecule E-cadherin is significantly increased,while the key transcriptional repressor of E-cadherin,snail1a,is depressed.Our study uncovers a novel mechanism by which Nodal-regulated mir206 modulates gastrulation movements in connection with the Snail/E-cadherin pathway. | Xiuli Liu Yuanqing Ma Congwei Zhang Shi Wei Yu Cao Qiang Wang | 2013 | Journal of Genetics and Genomics2013，40，10： | 2 |
| 8 | Cyclic Shearing Deformation Behavior of Saturated Clays显示文摘The apparatus for static and dynamic universal triaxial and torsional shear soil testing is employed to perform stress-controlled cyclic single-direction torsional shear tests and two-direction coupled shear tests under unconsolidated-undrained conditions. Through a series of tests on saturated clay, the effects of initial shear stress and stress reversal on the clay’s strain-stress behavior are examined, and the behavior of pore water pressure is studied. The experimental results indicate that the patterns of stress-strain relations are distinctly influenced by the initial shear stress in the cyclic single-direction shear tests. When the initial shear stress is large and no stress reversal occurs, the predominant deformation behavior is characterized by an accumulative effect. When the initial shear stress is zero and symmetrical cyclic stress occurs, the predominant deformation behavior is characterized by a cyclic effect. The pore water pressure fluctuates around the confining pressure with the increase of cycle number. It seems that the fluctuating amplitude increases with the increase of the cyclic stress. But a buildup of pore water pressure does not occur. The de- formations of clay samples under the complex initial and the cyclic coupled stress conditions include the normal deviatoric deforma- tion and horizontal shear deformation, the average deformation and cyclic deformation. A general strain failure criterion taking into account these deformations is recommended and is proved more stable and suitable compared to the strain failure criteria currently used. | QI Jianfeng LUAN Maotian FENG Xiuli MA Tailei NIE Ying | 2007 | Journal of Ocean University of China2007，6，4： | 2 |
| 9 | Molecular characterization of the genome of duck enteritis virus显示文摘 | Yufeng Li Bing Huang Xiuli Ma Jing Wu Feng Li Wu Ai Minxun Song Hanchun Yang | 2009 | Virology2009，，2： | 2 |
| 10 | Review of Semantic Web Service Composition Based on OWL-S显示文摘By analyzing of the existing Web services,an ontology based on OWL is presented,which has rich semantic information,and the service description language OWL-S based on OWL is put forward. OWL-S through IOPE can describe services,can also combine the service,but the method of combination service is not automatic. So a method is presented by using Situation Calculus for automatic service composition based on the OWL-S model. Finally through the example analysis,the method of automatic service combination was validated. | MA Xiuli DING Yingying WANG Hongxia | 2014 | 沈阳理工大学学报2014，33，3： | 2 |
| 11 | Parkin dosage mutations in patients with early-onset sporadic and familial Parkinson’s disease in Chinese: An independent pathogenic role显示文摘 | Chaodong Wang Huili Ma Xiuli Feng Shu Xie Piu Chan | 2010 | Brain Research2010，，： | 2 |
| 12 | Evolution of H9N2 influenza viruses isolated in Shandong Province显示文摘Dear Editor,The low-pathogenic avian influenza subtype of the H9N2virus circulates in domestic poultry and wild birds throughout the world,causing severe morbidity and mortality in commercial chickens during coinfection with other pathogens,resulting in enormous losses.This kind of virus has been prevalent since the H9N2 virus was first identified | ZHANG Wei XU HuaiYing MENG Fang MA XiuLi LIU Xia HUANG DiHai QIN ZhuoMing LIU JinHua ZHAO Peng | 2015 | Science China(Life Sciences)2015，58，2： | 2 |
| 13 | Study on Synthesis of Mesoporous M-MCM-48(M=Zr,Mg) and Its Activity for Isomerization of n-Heptane显示文摘The mesoporous materials supported zirconium(Zr-MCM-48) and magnesium(Mg-MCM-48) with three-dimensional pore structures and different Zr or Mg contents were prepared via the hydrothermal method, respectively. The prepared samples were characterized by means of X-ray diffraction(XRD), scanning electron microscope(SEM), transmission electron microscope(TEM), Fourier transform infrared spectroscopy(FT-IR), NH_3 temperature programmed desorption(NH_3-TPD) and N_2 adsorption-desorption. The XRD, TEM and N_2 adsorption-desorption results suggested that M-MCM-48(where M = Zr, Mg) samples still maintained typical cubic mesoporous framework of MCM-48, with slight decrease of specific surface areas and mesopore orders. The isomerization of n-heptane was carried out as a probe reaction at various factors including the zirconium or magnesium content, reaction time, reaction temperature and weight hourly space velocity(WHSV). Preliminary results demonstrated that the Mg-MCM-48 catalyst exhibited a higher catalytic activity with a maximum heptane conversion of 91.5% and a corresponding isomerization selectivity of 72.3% as compared to that of ZrMCM-48. However, the catalytic stability of Mg-MCM-48 for n-heptane isomerization was poorer than Zr-MCM-48, because the Mg-MCM-48 catalyst could maintain a relatively high catalytic activity for only 130 min, while the Zr-MCM-48 catalyst could maintain a relatively high catalytic activity for more than 190 min without any obvious decrease in performance. | Wang Yingjun Dong Xiuli Ma Shoutao Wang Jian Li Xiaoqing Suo Yanhua Zhang Wei | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，3： | 2 |
| 14 | High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair显示文摘 | Bing Pan Baoqi Yu Hui Ren Belinda Willard Ling Pan Lingyun Zu Xiaoli Shen Yijing Ma Xiuli Li Chenguang Niu Jinge Kong Siyu Kang Y. Eugene Chen Subramaniam Pennathur Lemin Zheng | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 15 | A meso-scale analysis method for the simulation of nonlinear damage and failure behavior of RC members显示文摘 | Du Xiuli Jin Liu Ma Guowei | 2012 | Internatonal Journal of Damage Mechanics2012，22，61： | 1 |
| 16 | The Study of Visible Implant Elastomer(VIE)Tag on Small-sized Chinese Shrimp(Fenneropenaeus chinensis)显示文摘[Objective] The paper was to prove the feasibility of using visible implant elastomer( VIE) tags to mark Chinese shrimp of about 1 cm in length.[Method]In June 2014,2 856 Chinese shrimps with an average length of 1. 14 cm were tagged with red VIE. After temporary rearing for one day,2 321 tagged shrimps were cultured in the same pond with 60 000 untagged shrimps in this experiment. In predation test,spottedtail gobies( Synechogobius ommaturus) were selected as the predator,and the predation rate of spottedtail gobies on small-sized Chinese shrimps was measured. [Result]On September 21,2014,206 kg of Chinese shrimp was harvested in the pond. There were 389 tagged shrimps,with an average body weight of 16. 84 g,and an average length of 11. 15 cm. The untagged shrimps had an average body weight of 17. 08 g,and average length of 11. 23 cm. The results indicated that there was no significant difference in growth between the tagged and untagged shrimps. The survival rate of the tagged shrimps was 2. 7% lower than the untagged ones. Although the fluorescent tag dispersed and the position changed,the tag was still distinct both under ultraviolet light and to the naked eye. The predation test revealed that the fluorescent tag of shrimps did not increase the predation rate by spottedtail gobies. [Conclusion]Red VIE tagging is feasible in Chinese shrimps. There was no significant difference in predation rate between untagged and VIE tagged shrimps. | Hao Xiaopeng Liu Haiying Zhang Guosheng Liu Qing Yin Zengqiang Wang Xiuli Xing Kun Liu Qi Ma Jun Chen Lei | 2017 | Animal Husbandry and Feed Science2017，9，1： | 1 |
| 17 | Adsorption characteristics of methylene blue on polar leaf in batch mode:Equilibrium,kinetics and thermodynamics显示文摘 | HAN Xiuli NIU Xiaona MA Xiaojian | 2012 | Korean J Chem Eng2012，29，4： | 1 |
| 18 | A meso-scale numerical method for the simulation of chloride diffusivity in concrete 显示文摘 | DU Xiuli JIN Liu MA Guowei | 2014 | Finite Elements in Analysis and Design2014，85，： | 1 |
| 19 | Synthesis, Characterization and Crystal Structure of a New Cobalt Phosphomolybdate that Contains [(Mo16O32)Co16(H2O)18(PO4)6(HPO4)18] Wheels显示文摘 | Ying Ma Yangguang Li Enbo Wang Ying Lu Xinxin Xu Xiuli Bai | 2006 | Transition Metal Chemistry2006，，2： | 1 |
| 20 | High-temperature phase transition and the activity of tobermorite显示文摘 | Xiuli Yang Chong Cui Xiaoyu Cui Guodong Tang Hailong Ma | 2014 | Journal of Wuhan University of Technology-Mater Sci Ed2014，，2： | 1 |
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