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| 1 | Intratumoral dendritic cell vaccin ation elicits potent tumoricidal im munity against malignant glioma in rats显示文摘Dendritic cells(DC)are attractive candidates for innovative cancer immunotherapy by virtu e of their ability to function as powe rful antigen presenting cells and elicit potent antitumor cytotoxic immune r esponses.With the aim of generating antitumor immunity,the authors sought to enhance in vivo tum or antigen presentation by using an i ntratumoral DC vaccination strateg y in the setting of partially irradiated intracranial brain tumo rs.Fisher rats,implanted with 9L gliomas in the right corpus striatum,w ere treated with freshly cultured,unpulsed syngeneic DC inoculated directly into the tumor bed.Intracranially inoculated DCs were found to drain to ipsilateral deep cervical lymph nodes.This was a ssociated with increased local and s ystemic antitumor cytoxicity,as evidenced by robust infiltration of treated tumors with CD4and CD8T ce lls as well as by increased IFN-gamma protein and message levels in in vitr o restimulated splenic lymphocytes.DC therapy resulted in prolonged survival and immunity to s ubsequent intracranial tumor re-ch allenge.These results demonstrate the viability of intratumoral DC vaccination as an effectiv e therapeutic strategy for intracra nial glioma. | Ehtesham M Kabos P Gutierrez MA Samoto K Black KL Yu JS | 2003 | 癌症2003，22，7： | 8 |
| 2 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Preservative toleranceand resistance显示文摘 | Chapman JS Diehl MA Fearnside KB | 1998 | International Journal of Cosmetic Science1998，20，： | 1 |
| 5 | Implantation of scleral expansion band segments for the treatment of presbyopia显示文摘 | Qazi MA Pepose JS Shuster JJ | 2002 | Am J Ophthalmol2002，134，： | 1 |
| 6 | Investigation of the presence of OH radicals in electrolyzed NaCl solution by electron spin resonance spectroscopy显示文摘 | Stan SD Woods JS Daeschel MA | 2005 | Journal of Agricultural and Food Chemistry2005，53，： | 1 |
| 7 | Detection of single bacterial pathogens with semiconductor quantum dots显示文摘 | Hahn MA Tabb JS Kranss TD | 2005 | Anal Chem2005，77，15： | 1 |
| 8 | Use of allogeneic NK cells for cancer immu-notherapy显示文摘 | Geller MA Miller JS | 2011 | Immunotherapy2011，3，12： | 1 |
| 9 | Decision making about mode of delivery among pregnant women who have previously had a caesarean section:a qualitive study显示文摘 | Moffat MA Bell JS Porter MA | | 0，，： | 1 |
| 10 | Chronic obstructive pulmonary disease,asthma,and risk of type 2 diabetes in women显示文摘 | Rana JS Mittleman MA Sheikh J | | 0，，10： | 1 |
| 11 | Infommtics methods to enable sharing of quantitative imaging research data 显示文摘 | Levy MA Freymann JB Kirby JS | 2012 | Magn Reson Imaging2012，30，9： | 1 |
| 12 | Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1显示文摘 | Nakamura S Whitsitt JS | 2000 | Kidney Int2000，58，6： | 1 |
| 13 | Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics显示文摘 | Lampertico P Malter JS Gerber MA | 1991 | Hepatology1991，13，3： | 1 |
| 14 | Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics显示文摘 | Pertico P Malter JS Gerber MA | 1991 | Hepatology1991，13，3： | 1 |
| 15 | Trau- matic brain injury of the forelimb and hindlimb sensorimotor areas in thi rat: physiological, histological and behavioral corre- lates显示文摘 | SOBLOSKY JS MATFHEWS MA DAVIDSON JF | 1996 | Behav Brain Res1996，79，12： | 1 |
| 16 | Guidelines for the measurement of glomerular filtration rate using plasma sampling显示文摘 | Fleming JS Zivanovic MA Blake GM | 2004 | Nucl Med Commun2004，25，8： | 1 |
| 17 | Long-term survival after Cisplatin-based induction chemotherapy and radiotherapy for nasopharyngealcarcinoma: A pooled data analysis of two phase Ⅲ trials显示文摘 | Chua DT Ma J Sham JS | 2005 | J Clin Oncol2005，23，6： | 1 |
| 18 | Influence of antenatal magnesium sulfate application on cord blood levels of brainderived neurotrophic factor in premature infants显示文摘 | Bachnas MA Mose JC Effendi JS | 2014 | J Perinat Med2014，42，1： | 1 |
| 19 | Cytotoxicity compar- ison of mineral trioxide aggregates and bndosequence bioceramic root repair materidal显示文摘 | Damas BA Wheater MA Bringas JS | 2011 | J Ended2011，37，3： | 1 |
| 20 | Rotavirus disease and its prevention显示文摘 | Widdowson MA Bresee JS Gentsch JR | 2005 | Curr Opin Gastroenterol2005，21，1： | 1 |
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