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| 1 | Evolution of transanal total mesorectal excision for rectal cancer:From top to bottom显示文摘The gold standard for curative treatment of locally advanced rectal cancer involves radical resection with a total mesorectal excision(TME). TME is the most effective treatment strategy to reduce local recurrence and improve survival outcomes regardless of the surgical platform used. However, there are associated morbidities, functional consequences, and quality of life(QoL) issues associated with TME; these risks must be considered during the modern-day multidisciplinary treatment for rectal cancer. This has led to the development of new surgical techniques to improve patient, oncologic, and QoL outcomes. In this work, we review the evolution of TME to the transanal total mesorectal excision(TaTME) through more traditional minimally invasive platforms. The review the development, safety and feasibility, proposed benefits and risks of the procedure, implementation and education models, and future direction for research and implementation of the TaTME in colorectal surgery. While satisfactory short-term results have been reported, the procedure is in its infancy, and long term outcomes and definitive results from controlled trials are pending.As evidence for safety and feasibility accumulates,structured training programs to standardize teaching,training, and safe expansion will aid the safe spread of the TaTME. | Sameh Hany Emile F Borja de Lacy Deborah Susan Keller Beatriz Martin-Perez Sadir Alrawi Antonio M Lacy Manish Chand | 2018 | World Journal of Gastrointestinal Surgery2018，10，3： | 18 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | A striking local esophageal cytokine expression profile in eosinophilic esophagitis显示文摘 | Carine Blanchard Emily M. Stucke Beatriz Rodriguez-Jimenez Karen Burwinkel Margaret H. Collins Annette Ahrens Eileen S. Alexander Bridget K. Buckmeier Butz Sean C. Jameson Ajay Kaul James P. Franciosi Jonathan P. Kushner Philip E. Putnam J. Pablo Abonia M | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 3 |
| 4 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 5 | Determination of 23 pesticide residues in leafy vegetables using gas chromatography–ion trap mass spectrometry and analyte protectants显示文摘 | Rosa M a . González-Rodríguez Raquel Rial-Otero Beatriz Cancho-Grande Jesús Simal-Gándara | 2008 | Journal of Chromatography A2008，，： | 2 |
| 6 | Production and release of yessotoxins by the dinoflagellates Protoceratium reticulatum and Lingulodinium polyedrum in culture显示文摘 | Beatriz P Pilar Riobo'a M Luisa Ferna'ndezb | 2004 | Toxicon2004，44，： | 1 |
| 7 | Building dynamic capabilities in product de- velopment: How do contextual antecedents matter? 显示文摘 | Isabel M Prieto Elena Revilla Beatriz Rodr?' guez- Prado | 2009 | Scandinavian Journal of Management2009，25，： | 1 |
| 8 | Marking of otoliths, age validation and growth of Argyrosomus regiu-sjuveniles (Sciaenidae) 显示文摘 | Beatriz M Nin Amalia G S Pérez M ea al | 2010 | Fish Res2010，106，： | 1 |
| 9 | Optical UWB pulse generator using an N tap microwave photonic filter and phase inversion adaptable to different pulse modulation formats 显示文摘 | MARIO B JOSE M BEATRIZ O | 2009 | Optics Express2009，17，7： | 1 |
| 10 | Copper-catalyzed enantioselective conjugate addition of Grignard reagents to acyclic enones using monodentate phosphoramidite ligands显示文摘 | Beatriz Macia M Angeles Fernandez-Ibanez Natasa Mrsic | 2008 | Tetrahedron Letters2008，49，： | 1 |
| 11 | Cell cycle arrest and proapoptotic effects of the anticancer cyclodep-sipeptide serratamolide(AT514)are independent of p53 status in breast cancer cells显示文摘 | Vanessa S C Beatriz M Marc M | 2005 | Biochemical pharmacology2005，71，12： | 1 |
| 12 | Measuring financial risks with copulas显示文摘 | Beatriz V M M Rafael M | 2004 | International Review of Financial Analysis2004，13，1： | 1 |
| 13 | Authentication of atlantic salmon(Salmo salar)using real-time PCR显示文摘 | Beatriz Herrero Juan M Vieites Montserrat Espieira | 2011 | Food Chemistry2011，127，3： | 1 |
| 14 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 15 | Self-Complementary Catenanes and Their Related Catenanes显示文摘 | Beatriz Cabezon Cao Jianguo Francisco M R | 2000 | Chem Eur J2000，6，12： | 1 |
| 16 | Imaging local estrogen production in single living cells with recombinant fluorescent indicators 显示文摘 | FERNANDO P BEATRIZ D JOSE M P | 2011 | Biosensors & Bioelectronics2011，26，5： | 1 |
| 17 | Peripheral Blood Mononuclear Cells Immunophenotyping in Pulmonary Tuberculosis Patients before and after Treatment显示文摘 | Warly Barcelos Olindo Assis Martins‐Filho Tania Mara Pinto Dabés Guimar?es Márcio Hamilton Prostzner Oliveira Silvana Spíndola‐de‐Miranda Beatriz Nascimento Carvalho Vicente de Paulo Coelho Peixoto Toledo | 2006 | Microbiology and Immunology2006，，： | 1 |
| 18 | Authentication of atlantic cod(Gadus morhua)using real time PCR显示文摘 | Beatriz Herrero Maria Madrinn Juan M Vieites | 2010 | Agric Food Chemistry2010，58，8： | 1 |
| 19 | Quantification of free and esterified sterols in Portuguese olive oils by solid-phase extraction and gas chromatography-mass spectrometry显示文摘 | CUNHA S S FEMANDES J O BEATRIZ M | 2006 | Journal of Chromatography A2006，1128，2： | 1 |
| 20 | Optimisation of extraction procedures for analysis of benzoic and sorbic acids in foodstuffs显示文摘 | Mota F J M Cunha S C Beatriz M | 2003 | Food Chemistry2003，82，： | 1 |
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