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| 1 | 健脾益肾方对非小细胞肺癌细胞体外增殖凋亡作用的实验研究显示文摘目的:探讨健脾益肾方对非小细胞肺癌(NSCLC)细胞体外增殖凋亡的作用。方法:人NSCLC细胞系A549分为四组:空白对照组(仅加入细胞培养液)、阴性对照组(加入细胞,不进行中药处理)、实验组(加细胞加中药处理)。荧光定量PCR和Western blot分别检测Survivin、Bcl-2和Caspase-3的mRNA和蛋白表达。MTT检测细胞增殖;流式细胞术检测细胞凋亡。结果:与空白对照组相比,阴性对照组细胞在24、48、72 h的吸光度值明显升高,细胞凋亡率下降,Survivin和Bcl-2 mRNA和蛋白相对表达量上调,Caspase-3 mRNA和蛋白相对表达量下调,组间比较差异有统计学意义(P<0.05);而健脾益肾方处理的实验组24、48、72 h的吸光度值均显著降低,细胞凋亡率显著上升,Survivin和Bcl-2 mRNA和蛋白相对表达量下调,Caspase-3 mRNA和蛋白相对表达量上调,与空白对照组相比差异有统计学意义(P<0.05)。结论:健脾益肾方可通过下调Survivin和Bcl-2、上调Caspase-3表达诱导NSCLC细胞凋亡,并抑制肿瘤细胞的增殖,进而抑制NSCLC的发展。 | 梁应凤 郭姗姗 张丹 卢敬钗 叶奇 高燕 李倩 Latimer N | 2020 | 陕西中医2020，41，5： | 7 |
| 2 | The current status of nitrogen fertiliser use efficiency and future research directions for the Australian cotton industry显示文摘Fifty years of sustained investment in research and development has left the Australian cotton industry well placed to manage nitrogen(N) fertiliser. The average production in the Australian cotton industry today is greater than two tonnes of lint per hectare due to improved plant genetics and crop management. However, this average yield is well below the yield that would be expected from the amount of N fertiliser used. It is clear from the recent studies that across all growing regions, conversion of fertiliser N into lint is not uniformly occurring at application rates greater than 200-240 kg·hm^(-2) of N. This indicates that factors other than N availability are limiting yield, and that the observed nitrogen fertiliser use efficiency(NFUE) values may be caused by subsoil constraints such as sodicity and compaction. There is a need to investigate the impact of subsoil constraints on yield and NFUE.Gains in NFUE will be made through improved N fertiliser application timing, better targeting the amount of fertiliser applied for the expected yield, and improved soil N management. There is also a need to improve the ability and confidence of growers to estimate the contribution of soil N mineralisation to the crop N budget. Many Australian studies including data that could theoretically be collated in a meta-analysis suggest relative NFUE values as a function of irrigation technique; however, with the extensive list of uncontrolled variables and few studies using non-furrow irrigation, this would be a poor substitute for a single field-based study directly measuring their efficacies. In irrigated cotton, a re-examination of optimal NFUE is due because of the availability of new varieties and the potential management and long-term soil resilience implications of the continued removal of mineralised soil N suggested by high NFUE values. NFUE critical limits still need to be derived for dryland systems. | MACDONALD Ben C.T. LATIMER James O. SCHWENKE Graeme D. NACHIMUTHU Gunasekhar BAIRD Jonathan C. | 2018 | Journal of Cotton Research2018，1，3： | 5 |
| 3 | Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure显示文摘 | Rusty L. Montgomery Thomas G. Hullinger Hillary M. Semus Brent A. Dickinson Anita G. Seto Joshua M. Lynch Christianna Stack Paul A. Latimer Eric N. Olson Eva van Rooij | 2011 | Circulation2011，，14： | 4 |
| 4 | The N-terminal domain of IkappaB alphamasks the nuclear localization signal(s) of p50 and c-Rel homodimers显示文摘 | Latimer M Ernst MK Dunn LL | 1998 | Mol Cell Biol1998，18，5： | 1 |
| 5 | Can optimal primary cytoreduction be predicted in advanced stage epithelial ovarian cancer? Role of preoperative serum CA-125 level显示文摘 | Obeidat B Latimer J Crawford R | 2004 | Gynecol Obstet Invest2004，57，3： | 1 |
| 6 | Can optimal primary cytoreduction be predicted in advanced stage epithelial ovarian cancer? Role of preoperative serum CA125 level显示文摘 | Obeidat B Latimer J Crawford R | 2004 | Gynecol Obstet Invest2004，57，： | 1 |
| 7 | Combining prehension and propulsion: the foot of Ardipithecus ramidus 显示文摘 | LOVEJOY C O LATIMER S SUWA G | 2009 | Science2009，326，： | 1 |
| 8 | In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development显示文摘 | Kirby BB Takada N Latimer AJ | 2006 | Nature Neuroscience2006，9，12： | 1 |
| 9 | Sleep disturbances and falls in older people显示文摘 | Latimer HE Cumming RG Lewis R | 2007 | J Gerontol A Biol Sci Med Sci2007，62，1： | 1 |
| 10 | Spectra and linear polarizations of extragalactic variable sources at centimeter wavelengths显示文摘 | Aller H D Aller M F Latimer G E | 1985 | ApJS1985，59，： | 1 |
| 11 | Reversal of Glial and Neurovascular Markers of Unhealthy Brain Aging by Exercise in Middle - Aged Female Mice 显示文摘 | Latimer C Searcy J Porter N | 2011 | Plos ONE2011，6，10： | 1 |
| 12 | Choosing BLAST options for better detection of orthologs as reciprocal best hits显示文摘 | MORENO - HAGELSIEB G LATIMER K | 2008 | Bioinformatics2008，24，3： | 1 |
| 13 | Endotoxin - induced organ injury显示文摘 | Ghosh S Latimer RD Gray BM | 1993 | Crit Care med1993，21，： | 1 |
| 14 | Association of official analytical chemists official methods of analysis显示文摘 | LATIMER G W | 2012 | Arlington:Aoac Intl2012，，： | 1 |
| 15 | Ectxx~e hnpacts d assertive e~anamity tre~a~:a review of the literature显示文摘 | Latime~ EA | 1999 | Can J Psychiatry1999，44，5： | 1 |
| 16 | Diethylstilboestrol induced alopecia in a dog显示文摘 | Barsanti JA Medleau L Latimer K | 1983 | J Am Vet Med Assoc1983，182，： | 1 |
| 17 | Ischemic pre-conditioning: helping or hindering the natural protection 显示文摘 | Latimer R Murali B | 2003 | Middle East J Anesthesiol2003，17，1： | 1 |
| 18 | The application accuracy of stereotactic frames显示文摘 | Maciumas R Galloway R Latimer J | 1994 | Neurosurg1994，35，： | 1 |
| 19 | Circovirus-like infection in a pigeon 显示文摘 | Woods L W Latimer K S Barr B C | 1993 | J Vet Diagn Invest1993，5，： | 1 |
| 20 | Investigating the role of melanin in UVA/UVB- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cells显示文摘 | Helen Swalwell Jennifer Latimer Rachel M. Haywood Mark A. Birch-Machin | 2011 | Free Radical Biology and Medicine2011，，3： | 1 |
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