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| 1 | A new cell death program regulated by toll-like receptor 9 through p38 mitogen-activated protein kinase signaling pathway in a neonatal rat model with sepsis associated encephalopathy显示文摘Background:Sepsis,a serious condition with high mortality,usually causes sepsis associated encephalopathy(SAE)that involves neuronal cell death.However,the cell death programs involved and their underlying mechanisms are not clear.This study aimed to explore the regulatory mechanisms of different cell death programs in SAE.Methods:A neonatal rat model of SAE was established by cecal ligation and perforation.Survival rate and vital signs(mean arterial pressure and heart rate)were monitored,nerve reflexes were evaluated,and cortical pathological changes were observed by hematoxylin and eosin staining.The expression of pyroptosis,apoptosis,and necroptosis(PANoptosis)-related proteins,mitogen-activated protein kinase(MAPK),and its upstream regulator toll-like receptor 9(TLR9)were detected.The expression of TLR9 in neurons was observed by immunofluorescence staining.The ultrastructure of neurons was observed by transmission electron microscope.Results:First,PANoptosis was found in cortical nerve cells of the SAE rats.Meanwhile,the subunits of MAPKs,p38 MAPK,Jun N-terminal kinase,and extracellular signal-regulated kinase(ERK)were activated.After pharmacologically inhibiting each of the subunits,only p38 MAPK was found to be associated with PANoptosis.Furthermore,blocking the p38 MAPK signaling pathway activated necroptosis but inhibited apoptosis and pyroptosis.When necroptosis was pharmacologically inhibited,apoptosis and pyroptosis were reactivated.Finally,we found that the expression of TLR9,a regulator of MAPKs,was significantly increased in this model.After down-regulation of TLR9,p38 MAPK,and ERK signaling pathways were inhibited,which led to the inhibition of PANoptosis.Further analysis found that down-regulation of TLR9 improved the survival rate and reduced the pathological changes in SAE rats.Conclusions:Our study showed that the programs comprising PANoptosis are activated simultaneously in SAE rats.TLR9 activated PANoptosis through the p38 MAPK signaling pathway.TLR9 may work as a potential target for SAE treatment. | Ruixi Zhou Junjie Ying Xia Qiu Luting Yu Yan Yue Qian Liu Jing Shi Xihong Li Yi Qu Dezhi Mu | 2022 | Chinese Medical Journal2022，，12： | 3 |
| 2 | Multimodal bioimaging based on gold nanorod and carbon dot nanohybrids as a novel tool for atherosclerosis detection显示文摘与多样的性质装备的先进 biocompatible 和柔韧的平台高度为动脉粥样硬化患者的早察觉在生物医学的成像应用程序被要求脉管的疾病和癌症。设计 nanohybrids 高贵金属镇静、荧光灯材料是执行多模式的成像克服单个形式的对应物的限制的一个新方法。此处,我们建议一个多模式的对比代理人的新奇设计;也就是,包括金 nanorods (GNR ) 的提高的 nanohybrid 和碳点(CD ) 与硅石(SiO 2) 作为一座桥。nanohybrid (GNR@SiO 2@CD) 建设基于在 SiO 2 和 silane-functionalized CD 之间结合的共有原子价,它与 CD 连接 GNR 形成典型核心壳单位。新奇结构不仅保留并且甚至高度改进 GNR 和 CD 的光性质,而且与赤裸的 GNR 或荧光染料和 CD 相比在散开思考(医生) 和荧光一生成像显微镜学(FLIM ) 大小拥有优异成像性能。GNR@SiO 2@CD nanohybrids 的优异 bioimaging 性质成功地被利用为,铺平向 vitro 医生和在像织物的幽灵以内的巨噬细胞的 FLIM 大小对比的 theranostic 的道路在为动脉粥样硬化和癌症的代理人。 | Xiaojing Liu Luting Liu Xiujie Hu Shuyun Zhou Rinat Ankri Dror Fixler Zheng Xie | 2018 | Nano Research2018，11，3： | 3 |
| 3 | A study of nonocrystalline TiO2 preparation with inorganotitanates and gelatin dispersant: thermal analysis of complex gel显示文摘 | Xiaoheng Liu Xin Wang Jiangrun Zhang Xi Hu Lute Lu | 1999 | Thermochimica Acta1999，，324： | 1 |
| 4 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 5 | Genetic Polymorphism of Nine Non-CODIS STR Loci in Hu- nan Province-based Chinese Han Population显示文摘 | GUO Juan-juan LIU Ying GUO Ya-dong YAN Jie CHANG Yun-feng CAI Ji-feng LUTing ZHA Lagabaiyila | 2014 | 法医学杂志2014，30，6： | 1 |
| 6 | Hybrid CuO-Co_(3)O_(4)nanosphere/RGO sandwiched composites as anode materials for lithium-ion batteries显示文摘Hybrid CuO-Co_(3)O_(4)nanosphere building blocks have been embedded between the layered nanosheets of reduced graphene oxides with a three dimensional(3D)hybrid architecture(CuO-Co_(3)O_(4)-RGO),which are successfully applied as enhanced anodes for lithium-ion batteries(LIBs).The CuO-Co_(3)O_(4)-RGO sandwiched nanostructures exhibit a reversible capacity of~847 mA·h·g^(-1)after 200 cycles’cycling at 100 mA·g^(-1)with a capacity retention of 79%.The CuO-Co_(3)O_(4)-RGO compounds show superior electrochemical properties than the comparative CuO-Co_(3)O_(4),Co_(3)O_(4)and CuO anodes,which may be ascribed to the following reasons:the hybridizing multicomponent can probably give the complementary advantages;the mutual benefit of uniformly distributing nanospheres across the layered RGO nanosheets can avoid the agglomeration of both the RGO nanosheets and the CuO-Co_(3)O_(4) nanospheres;the 3D storage structure as well as the graphene wrapped composite could enhance the electrical conductivity and reduce volume expansion effect associated with the discharge-charge process. | Yingmeng Zhang Luting Liu Qingwei Deng Wanlin Wu Yongliang Li Xiangzhong Ren Peixin Zhang Lingna Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，7： | 1 |
| 7 | High performance streaked X-ray spectrometer for research of laser-produced plasmas显示文摘In order to mitigate the effect of the strong electromagnetic pulse, which produces laser-plasma interactions, we designed a new streaked X-ray spectrometer (SXS) enclosed within a well-sealed, electromag- netic interference-free cavity. The SXS can cover a wide selection of spectral windows using interchangeable Bragg crystals and by appropriate adjustment of the Bragg angle. The SXS has been used to observe time-re- solved X-ray spectrum in the 2.5 keV to 3.5 keV photon-energy range, resulting in a demonstrated spectral res- olution of about 13 at 2960 eV with a time resolution of 10 ps. The observed time and spectral resolutions dem- onstrate the applicability of the SXS for studies of laser-produced plasmas. | Guo Luting Wei Minxi Hu Xin Deng Keli Chen Tao Deng Bo Zhang Lu Zhao Yang Li Jin Xiao Shaoqiu Liu Shenye | 2016 | 强激光与粒子束2016，28，2： | 0 |
| 8 | Integrated hetero-nanoelectrodes for plasmon-enhanced electrocatalysis of hydrogen evolution显示文摘Hetero-nanostructures of plasmonic metals and semiconductors have attracted increasing attention in the field of photocatalysis.However,most of the hetero-nanostructured catalysts are randomly arranged and therefore require comprehensive structural design for optimizing their properties.Herein,we report the robust construction of hierarchical hetero-nanostructures where gold(Au)nanorods and molybdenum disulfide(Mo S_(2))quantum sheets(QSs)are integrated in highly ordered arrays.Such construction is achieved through porous anodic alumina(PAA)template-assisted electrodeposition.The as-fabricated hetero-nanostructures demonstrate exciting electrocatalysis towards hydrogen evolution reaction(HER).Both plasmon-induced hot-electron injection and plasmonic scattering/reabsorption mechanisms are determinative to the enhanced electrocatalytic performances.Notably,broadband photoresponses of HER activity in the visible range are observed,indicating their superiority compared with random systems.Such integrated hetero-nanoelectrodes could provide a powerful platform for conversion and utilization of solar energy,meanwhile would greatly prompt the production and exploration of ordered nanoelectrodes. | Wenyu Jiang Xianxin Wu Jinquan Chang Yanhong Ma Luting Song Zhexue Chen Cheng Liang Xinfeng Liu Yong Zhang | 2021 | Nano Research2021，14，4： | 0 |
| 9 | Transcriptome-wide association analysis identified candidate susceptibility genes for nasopharyngeal carcinoma显示文摘Dear Editor,Nasopharyngeal carcinoma(NPC)is a common malignancy in East and Southeast Asia,especially in South China.The etiology of NPC has been linked to genetic susceptibility,Epstein-Barr virus(EBV)infection,and environmental factors.Accumulated evidence including multiple genome-wide association studies(GWASs)has revealed robust genetic predisposition of NPC.However,GWAS-identified genetic variants collectively account for only 8.2%of NPC heritability[1].The underlying inherited predisposition is largely undetermined.The strongest genetic signal for NPC consistently hits the human leukocyte antigen(HLA)region on 6p21[2].However,the highly polymorphic nature and complicated long-range linkage disequilibrium(LD)in the HLA region particularly obscure the causal variants driving the association.In addition,most genetic variants located in introns or intergenic regions.The causal genes mediating genetic effects on NPC risk have rarely been ascertained by GWAS alone. | Yong-Qiao He Wen-Qiong Xue Dan-Hua Li Tong-Min Wang Zhi-Ming Mai Da-Wei Yang Chang-Mi Deng Ying Liao Wen-Li Zhang Ruo-Wen Xiao Luting Luo Hua Diao Xiating Tong Yanxia Wu Jiang-Bo Zhang Ting Zhou Xi-Zhao Li Pei-Fen Zhang Xiao-Hui Zheng Shao-Dan Zhang Ye-Zhu Hu Minzhong Tang Yuming Zheng Yonglin Cai Ellen T.Chang Zhe Zhang Guangwu Huang Su-Mei Cao Qing Liu Lin Feng Ying Sun Maria Li Lung Hans-Olov Adami Weimin Ye Tai-Hing Lam Wei-Hua Jia | 2022 | Cancer Communications2022，42，9： | 0 |
| 10 | The effect of urbanization and exposure to multiple environmental factors on life-history traits and breeding success of Barn Swallows(Hirundo rustica)across China显示文摘In addition to landscape changes,urbanization also brings about changes in environmental factors that can affect wildlife.Despite the common referral in the published literature to multiple environmental factors such as light and noise pollution,there is a gap in knowledge about their combined impact.We developed a multidimensional environmental framework to assess the effect of urbanization and multiple environmental factors(light,noise,and temperature)on life-history traits and breeding success of Barn Swallows(Hirundo rustica)across rural to urban gradients in four locations spanning over 2500 km from North to South China.Over a single breeding season,we measured these environmental factors nearby nests and quantified landscape urbanization over a 1km~2radius.We then analysed the relationships between these multiple environmental factors through a principal component analysis and conducted spatially explicit linear-mixed effects models to assess their effect on lifehistory traits and breeding success.We were particularly interested in understanding whether and how Barn Swallows were able to adapt to such environmental conditions associated with urbanization.The results show that there is significant variation in the exposure to environmental conditions experienced by Barn Swallows breeding across urbanization gradients in China.These changes and their effects are complex due to the behavioural responses ameliorating potential negative effects by selecting nesting sites that minimize exposure to environmental factors.However,significant relationships between landscape urbanization,exposure to environmental factors,and life-history traits such as laying date and clutch size were pervasive.Still,the impact on breeding success was,at least in our sample,negligible,suggesting that Barn Swallows are extremely adaptable to a wide range of environmental features. | Yanyan Zhao Emilio Pagani-Nú~nez Yu Liu Xiaoying Xing Zhiqiang Zhang Guangji Pan Luting Song Xiang Li Zhuoya Zhou Yanqiu Chen Donglai Li Yang Liu Rebecca J.Safran | 2022 | Avian Research2022，13，3： | 0 |
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