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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | Component analysis of Chinese medicine and advances in fuming-washing therapy for knee osteoarthritis via unsupervised data mining methods显示文摘OBJECTIVE: To analyze the component law of Chinese medicines in fuming-washing therapy for knee osteoarthritis(KOA), and develop new fuming-washing prescriptions for KOA through unsupervised data mining methods.METHODS: Chinese medicine recipes for fuming-washing therapy for KOA were collected and recorded in a database. The correlation coefficient among herbs, core combinations of herbs, andnew prescriptions were analyzed using modified mutual information, complex system entropy cluster, and unsupervised hierarchical clustering, respectively.RESULTS: Based on analysis of 345 Chinese medicine recipes for fuming-washing therapy, 68 herbs occurred frequently, 33 herb pairs occurred frequently, and 12 core combinations were found.Five new fuming-washing recipes for KOA were developed.CONCLUSION: Chinese medicines for fuming-washing therapy of KOA mainly consist of wind-dampness-dispelling and cold-dispersing herbs, blood-activating and stasis-resolving herbs,and wind-dampness-dispelling and heat-clearing herbs. The treatment of fuming-washing therapy for KOA also includes dispelling wind-dampness and dispersing cold, activating blood and resolving stasis, and dispelling wind-dampness and clearing heat. Zhenzhutougucao(Herba Speranskiae Tuberculatae), Honghua(Flos Carthami), Niuxi(Radix Achyranthis Bidentatae), Shenjincao(Herba Lycopodii Japonici), Weilingxian(Radix et Rhizoma Clematidis Chinensis), Chuanwu(Radix Aconiti), Haitongpi(Cortex Erythrinae Variegatae), Ruxiang(Olibanum),Danggui(Radix Angelicae Sinensis), Caowu(Radix Aconiti Kusnezoffii), Moyao(Myrrha), and Aiye(Folium Artemisiae Argyi) are the main herbs used in the fuming-washing treatment for KOA. | Jun Liu Jianke Pan Yanping Wang Dingkun Lin Dan Shen Hongjun Yang Xiang Li Minghui Luo Xuewei Cao | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 32 |
| 3 | Active catalysts based on cobalt oxide@cobalt/N-C nanocomposites for oxygen reduction reaction in alkaline solutions显示文摘 | Dekang Huang Yanping Luo Shaohui Li Bingyan Zhang Yan Shen Mingkui Wang | 2014 | Nano Research2014，7，7： | 8 |
| 4 | Microwave-Assisted Synthesis of NiCo_2O_4 Double-Shelled Hollow Spheres for High-Performance Sodium Ion Batteries显示文摘The ternary transitional metal oxide NiCo_2O_4 is a promising anode material for sodium ion batteries due to its high theoretical capacity and superior electrical conductivity. However, its sodium storage capability is severely limited by the sluggish sodiation/desodiation reaction kinetics. Herein, NiCo_2O_4 double-shelled hollow spheres were synthesized via a microwave-assisted, fast solvothermal synthetic procedure in a mixture of isopropanol and glycerol, followed by annealing. Isopropanol played a vital role in the precipitation of nickel and cobalt,and the shrinkage of the glycerol quasi-emulsion under heat treatment was responsible for the formation of the double-shelled nanostructure. The as-synthesized productwas tested as an anode material in a sodium ion battery,was found to exhibit a high reversible specific capacity of 511 m Ahg^(-1) at 100 m Ag^(-1), and deliver high capacity retention after 100 cycles. | Xiong Zhang Yanping Zhou Bin Luo Huacheng Zhu Wei Chu Kama Huang | 2018 | Nano-Micro Letters2018，10，1： | 5 |
| 5 | A priori error estimates of finite volume element method for hyperbolic optimal control problems显示文摘In this paper,optimize-then-discretize,variational discretization and the finite volume method are applied to solve the distributed optimal control problems governed by a second order hyperbolic equation.A semi-discrete optimal system is obtained.We prove the existence and uniqueness of the solution to the semidiscrete optimal system and obtain the optimal order error estimates in L ∞(J;L 2)-and L ∞(J;H 1)-norm.Numerical experiments are presented to test these theoretical results. | LUO XianBing CHEN YanPing HUANG YunQing | 2013 | Science China Mathematics2013，56，5： | 5 |
| 6 | Selective recovery of Cu^2+ and Ni^2+ from wastewater using bioelectrochemical system显示文摘作为 bioelectrochemical 系统,微生物引起的燃料房间(MFC ) 和微生物引起的电解房间(MEC ) 被开发有选择地恢复 Cu < 啜 class= “ a-plus-plus ” >2+ 和 Ni < 啜 class= “ a-plus-plus ” > 从废水的 2+ 个 离子。废水在系统的阴极房间被对待,在哪个 Cu < 啜 class= “ a-plus-plus ” >2+ 和 Ni < 啜 class= “ a-plus-plus ” >2+ 个 离子被分别地使用 MFC 和 MEC 移开。在起始的 Cu < 啜 class= “ a-plus-plus ” > 500 mg 瀠牥散瑮条 ? 景漠瑵異 ? 慶畬 ? 景椠摮獵牴 ? 湩敶瑳摥戠 ? 的 2+ 集中潈杮? 湯 ?? 捡潡 ? 慔睩湡愠摮愠牢慯? 攠敮杲 ? 牰捩 ? 湡 ? 湩敶瑳敭瑮漠 ? 諗棔娹驺硴超 _ 捥湨汯杯捩污愠瑣癩瑩敩 ? 潦 ? 湩畤瑳祲挠畯摬戠 ? 潰獳扩敬挠湯牴扩瑵牯 ? 湡 ? 牤癩牥 ? 潴琠敨椠摮獵牴慩? 湥牥祧攠晦捩敩据? | Haiping LUO Bangyu QIN Guangli LIU Renduo ZHANG Yabo TANG Yanping HOU | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 4 |
| 7 | Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing显示文摘The naturally occurring prokaryotic CRISPR-Cas systems provide valuable resources for the development of new genome-editing tools.However,the majority of prokaryotic Cas nucleases exhibit poor editing efficiency in mammalian cells,which significantly limits their utility.Here,we have developed a method termed Improving Editing Activity by Synergistic Engineering(MIDAS).This method exerts a synergistic effect to improve mammalian genome-editing efficiency of a wide range of CRISPR-Cas systems by enhancing the interactions of Cas nuclease with the protospacer adjacent motif(PAM)and the single-stranded DNA(ssDNA)substrate in the catalytic pocket simultaneously.MIDAS robustly and significantly increased the gene-editing efficiency of Cas12i,Cas12b,and CasX in human cells.Notably,a Cas12i variant,Cas12iMax,exhibited robust activity with a very broad PAM range(NTNN,NNTN,NAAN,and NCAN)and higher efficiency than the current widely used Cas nucleases.A high-fidelity version of Cas12iMax(Cas12iHiFi)has been further engineered to minimize off-target effects.Our work provides an expandable and efficacious method for engineering Cas nucleases for robust mammalian genome editing. | Yangcan Chen Yanping Hu Xinge Wang Shengqiu Luo Ning Yang Yi Chen Zhikun Li Qi Zhou Wei Li | 2022 | The Innovation2022，3，4： | 3 |
| 8 | Identification of ssDNA aptamers specific to clinical isolates of Streptococcus mutans strains with different cariogenicity显示文摘链球菌 mutans,一个克积极的容许的厌氧的细菌,被认为是为牙齿的龋的一个主要 etiological 因素。在 thisstudy,从龋活跃、没有龋的个人的牙齿的瓷釉表面的匾为 S 被获得并且栽培。mutans 隔离。形态学检查,生物化学的描述,和聚合酶链反应被执行到识别。mutans。S 的 cariogenicity。从临床的标本孤立的 mutans 种类被测试细菌的 acidogenicity, aciduricity,细胞外的 polysaccharideproduction,和粘附能力评估。最后,减少性的 SELEX (由 exponentialenrichment 的 ligands 的系统的进化) 指向整个未经触动的房间的技术与 highcariogenicity 为对种类特定的 ssDNA aptamers 习惯于屏幕。在九轮减少性的 SELEX 以后,足够的水池丰富是由放射性的 isotopeanalysis 出现被完成。充实的水池随机被克隆并且定序,由联机的 MEME 和 RNA 结构软件 analysisof 列在后面序列。从流动 cytometry 的结果显示了那 aptamers H1, H16, H4, L1, L10,和 H19 能 discriminatehighly cariogenic S。mutans 紧张从糟糕, cariogenic 拉紧。在这些之中, Aptamer H19 与 cariogenic S 有最强壮的有约束力的能力。有 69.45 的一个分离常数的 mutans 紧张 ? 畣慬? 敭档湡獩獭漠 ??? 湡 ? 桴 ? 潰整瑮慩? 敮 ? 桴牥灡略楴? 瑳慲整楧獥潦 ? 桴 ? 牴慥浴湥 ? 景琠楨?湩敦瑣潩 | Wei Cui Jiaojiao Liu Donghua Su Danyang Hu Shuai Hou Tongnan Hu Jiyong Yang Yanping Luo Qing Xi Bingfeng Chu Chenglong Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 3 |
| 9 | Effects of exogenous ABA application on post-anthesis dry matter redistribution and grain starch accumulation of winter wheat with different staygreen characteristics显示文摘The objective of this study was to investigate whether and how exogenous abscisic acid(ABA)is involved in mediating starch accumulation in the grain and redistribution of carbohydrates during grain filling of two wheat cultivars with different staygreen characteristics.At blooming stage,plants of Wennong 6(a staygreen cultivar)and Jimai 20(control)were sprayed with10 mg L-1abscisic acid(ABA)for 3 days.The application of ABA significantly(P<0.05)increased grain filling rate,starch accumulation rate and content,remobilization of dry matters to kernels,and 1000-grain weight of the two cultivars.Exogenous ABA markedly(P<0.05)increased grain yield at maturity,and Wennong 6 and Jiami 20 showed 14.14%and 4.86%higher compared yield than the control.Dry matter accumulation after anthesis of Wennong 6 was also significantly(P<0.05)influenced by exogenous ABA,whereas that of Jimai 20 was unchanged.Application of ABA increased endogenous zeatin riboside(ZR)content 7 days after anthesis(DAA),and spraying ABA significantly increased endogenous indole-3-acetic acid(IAA)and ABA contents from 7 to 21 DAA and decreased gibberellin(GA3)content at 14 DAA,but increased GA3content from 21 to 35 DAA.The results suggested that increased yield of staygreen was due to greater starch assimilation owing to a higher filling rate and longer grain-filling duration. | Dongqing Yang Yongli Luo Yingli Ni Yanping Yin Weibing Yang Dianliang Peng Zhengyong Cui Zhenlin Wang | 2014 | The Crop Journal2014，2，Z1： | 3 |
| 10 | The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages显示文摘The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies;however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis contributed to the psychological stressevoked tumor susceptibility, and the stress hormone glucocorticoid(GC) was identified as a principal detrimental factor. Mechanistically, GC disturbed the balance of the 'eat me' signal receptor(low-density lipoprotein receptor-related protein-1, LRP1) and the 'don’t eat me' signal receptor(signal regulatory protein alpha, SIRPa). Further analysis revealed that GC led to a direct, glucocorticoid receptor(GR)-dependent trans-repression of LRP1 expression, and the repressed LRP1, in turn, resulted in the elevatedgene level of SIRPa by down-regulating mi RNA-4695-3 p. These data collectively demonstrate that stress induces the imbalance of the LRP1/SIRPa axis and entails the disturbance of tumor cell clearance by macrophages. Our findings provide the mechanistic insight into psychological stress-evoked tumor susceptibility and indicate that the balance of LRP1/SIRPa axis may serve as a potential therapeutic strategy for tumor treatment. | Yanping Wu Xiang Luo Qingqing Zhou Haibiao Gong Huaying Gao Tongzheng Liu Jiaxu Chen Lei Liang Hiroshi Kurihara Yi-Fang Li Rong-Rong He | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 11 | Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis显示文摘The plant aluminum(Al)-activated malate transporter ALMT1 mediates the efflux of malate to chelate the Al in acidic soils and underlies the plant Al resistance.Here we present cryo-electron microscopy(cryo-EM)structures of Arabidopsis thaliana ALMT1(AtALMT1)in the apo,malate-bound,and Al-bound states at neutral and/or acidic pH at up to 3.0Åresolution.The AtALMT1 dimer assembles an anion channel and each subunit contains six transmembrane helices(TMs)and six cytosolicα-helices.Two pairs of Arg residues are located in the center of the channel pore and contribute to malate recognition.Al binds at the extracellular side of AtALMT1 and induces conformational changes of the TM1-2 loop and the TM5-6 loop,resulting in the opening of the extracellular gate.These structures,along with electrophysiological measurements,molecular dynamic simulations,and mutagenesis study in Arabidopsis,elucidate the structural basis for Al-activated malate transport by ALMT1. | Jiangqin Wang Xiafei Yu Zhong Jie Ding Xiaokang Zhang Yanping Luo Ximing Xu Yuan Xie Xiaoxiao Li Tian Yuan Shao Jian Zheng Wei Yang Jiangtao Guo | 2022 | Cell Research2022，32，1： | 3 |
| 12 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 13 | Temperature control for extractive dividing-wall column with an adjustable vapor split:methylal/methanol azeotrope separation显示文摘 | XIA Ming XIN Yanping LUO Junwen | 2013 | Ind Eng Chem Res2013，52，17： | 1 |
| 14 | Epigenomic plasticity enables human pancreatic [alpha] to [Beta] cell reprogramming显示文摘 | Bramswig Nuria C Everett Logan J Schug Jonathan Dorrell Craig Liu Chengyang Luo Yanping Streeter Philip R Naji Ali Grompe Markus Kaestner Klaus H | 2013 | Journal of Clinical Investigation2013，，3： | 1 |
| 15 | Axonal and Dendritic Changes are Associated with Diabetic Encephalopathy in Rats: An Important Risk Factor for Alzheimer's Disease显示文摘 | Yanping Zhou Yi Luo Jiapei Dai | 2012 | Journal of Alzheimer's Disease2012，，4： | 1 |
| 16 | Design and syntheses of novel phthalazin-1 (2H)-one derivatives as acetohydroxyacid synthase inhibitors 显示文摘 | LI Yuanxiang LUO Yanping XI Zhen | 2006 | J Agirc Food Chem2006，54，24： | 1 |
| 17 | Prognostic evaluation of Nanog, Oct4, Sox2, PCNA, Ki67 and E-cadherin expression in gastric cancer显示文摘 | Ning Li Wenying Deng Jie Ma Bing Wei Kang Guo Wei Shen Yanping Zhang Suxia Luo | 2015 | Medical Oncology2015，，： | 1 |
| 18 | Effects of eggshell addition on calcium-deficient acid soils contaminated with heavy metals显示文摘在这研究,水条件完成(泛滥,湿,或干燥)并且蛋壳剂量( 0 , 0.1 , 1.0 ,和 10.0 g/kg 土壤,分别地)在 pH 变化上,内容无法获得重金属的状态,重金属的形式,并且在与重金属污染的酸土壤的可得到的滋养的元素钙( Ca )分别地被调查。土壤样品连续地在室内被栽培并且由毒性分析了特征的沥滤参考(BCR ) 的过程和社区局顺序的抽取过程。结果证明蛋壳的增加能有效地改进酸土壤的 pH 并且增加它到中立水平。而且,内容无法获得重金属 Cu, Zn,和 Cd 的状态显著地增加了。而且,当土壤与 1.0 g/kg 蛋壳在充满的条件下面被栽培时,无法获得 Cu, Zn,和 Cd 的状态增加了大多数,并且这些重金属被转变成剩余状态。在另一方面, Ca 的可得到的状态的数量与 1.0 g/kg 蛋壳的增加从 73.34 mg/kg 增加了到 432.19,它显示蛋壳的增加戏剧性地改进了 Ca 的可得到的状态。因此,蛋壳能改善它有效地导致了授精的可得到的重金属和改进的减少的土壤环境。简言之,这研究显示蛋壳的增加将是为与重金属污染的酸地土壤的补习的一个新潜在的方法。 | Weiqi Luo Yanping Ji Lu Qu Zhi Dang Yingying Xie Chengfang Yang Xueqin Tao Jianmin Zhou Guining Lu | 2018 | Frontiers of Environmental Science & Engineering2018，12，3： | 1 |
| 19 | Distribution of IgM, IgD and IgZ in mandarin fish, Siniperca chuatsi lymphoid tissues and their transcriptional changes after Flavobacterium columnare stimulation 显示文摘 | Tian Jingyun Sun Baojian Luo Yanping | 2009 | Aquaculture2009，288，12： | 1 |
| 20 | Distribution of IgM, IgD and IgZ in mandarin fish, Siniperca chuatsi lymphoid tissues and their transcriptional changes after Flavobacterium columnare stimulation显示文摘 | Jingyun Tian Baojian Sun Yanping Luo Yongan Zhang Pin Nie | 2008 | Aquaculture2008，，1： | 1 |
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