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| 1 | Comment on “Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics”显示文摘Attaran et al[1] have recently shown that decreased susceptibility of established Helicobacter pylori(H. pylori) biofilms to specific antibiotics,was associated with the overtly enhanced transcription of two efflux pump genes,hp1165 and hef A,involved in specific resistance to tetracycline and multiple antibiotics,respectively. Apart from antibiotic exposure,secretion of multiple antimicrobial peptides,such as human β-defensins(hβDs),by the gastric epithelium upon Hp challenge,may act as early triggering events that positively impact biofilm formation and thus,antibiotic resistance. In this regard,we undertook genomic transcriptional studies using Hp 26695 strain following exposure to sublethal,similar to those present in the gastric niche,concentrations of hβDs in an attempt to provide preliminary data regarding possible mechanisms of immune evasion and selective sensitivity of Hp. Our preliminary results indicate that hβD exposure ignites a rapid response that is largely due to the activation of several,possibly interconnected transcriptional regulatory networks – origons-that ultimately coordinate cellular processes needed to maintain homeostasis and successful adaptation of the bacterium in the gastric environment. In addition,we have shown that both antibiotic and hβD resistance are mediated by dedicated periplasmic transporters,including the aforementioned efflux pump genes hp1165 and hef A,involved in active export of antibiotics from the cell membrane and/or,as recently suggested,substrate sensing and signalling. Furthermore,itappears that sublethal doses of hβDs may enhance biofilm formation by the sustained expression of,mainly,quorum sensing-related genes. In conclusion,we provide additional data regarding the role of specific innate immune molecules in antibiotic cross-resistance mechanisms that may deepen our understanding in the context of the development of novel eradication regimens. | Evangelos I Kazakos Nick Dorrell Stergios A Polyzos Georgia Deretzi Jannis Kountouras | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 2 | Analysis of air gap flux current and vibration signals as a function of the combination of static and dynamic air-gap eccentricity in 3-phase induction motors显示文摘 | David G Dorrell William T Thomson Steven Roach | 1997 | IEEE Transactions on Industry Applications1997，33，1： | 1 |
| 3 | Analysis of airgap flux,current, vibration signals as a function of the combination of static and dynamic airgap eccentricity in 3-p-hase induction motors 显示文摘 | Dorrell D G Thomson W T Roach S | 1997 | IEEE Transactions on Industry Applications1997，33，1： | 1 |
| 4 | Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis显示文摘 | Dorrell MI Aquilar E Scheppke L | 2007 | Proc Natl Acad sic U S A2007，140，3： | 1 |
| 5 | Regulation of angiogenesis by tissue factor cytoplasmic dimain signaling显示文摘 | Belting M Dorrell MI Sandgren S | 2004 | Nat Med2004，10，5： | 1 |
| 6 | Progenitor cells and retinal angiogenesis显示文摘 | Friedlander M Dorrell MI Ritter MR | 2007 | Angiogenesis2007，10，2： | 1 |
| 7 | Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina显示文摘 | Dorrell MI Otani A Aguilar E | 2004 | Blood2004，103，9： | 1 |
| 8 | Liver repair by intra-and extrahepatic progenitors显示文摘 | Dorrell C Grompe M | 2005 | Stem cell Bey2005，1，1： | 1 |
| 9 | Vulvovaginitis due to fluconazole resistant Candida albicans following self treatment with non-prescribed triazoles显示文摘 | Dorrell L Edwards A | 2002 | Sex Transm Infect2002，78，4： | 1 |
| 10 | Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis 显示文摘 | Ritter MR Dorrell MI Edmonds J | 2002 | Proc Natl Acad Sci USA2002，99，11： | 1 |
| 11 | Regulation of angiogenesis by tissue factor cytoplasmic domain signaling显示文摘 | Belting M Dorrell MI Sandgren S | 2004 | Nat Med2004，10，5： | 1 |
| 12 | A bioassay for rapid determine- nation of amino acid availability values 显示文摘 | Likuski H J A Dorrell H G | 1978 | Poultry Sci1978，571，： | 1 |
| 13 | Analysis of airgap flux, current and vibration signals as a function of the combination of static and dynamic airgap eccentricity in 3-phase induction motors显示文摘 | DORRELL D G THOMSON W T ROACH S | 1997 | IEEE Transaction on In- dustry Engineering1997，33，1： | 1 |
| 14 | In-depth study of direct power control strategies for power converters显示文摘 | Hu J Zhu J Dorrell D G | 2014 | IET Power Electronics2014，7，7： | 1 |
| 15 | Stem Cells and Liver Regeneration 显示文摘 | Duncan AW Dorrell C Grompe M | 2009 | Gastroenterology2009，137，11： | 1 |
| 16 | A major role for intestinal epithelial nueleotide oligomerization domain l(NOD1)ineliciting host bactericidal immune responses to Campylobacter jejuni显示文摘 | Zilbauer M Dorrell N Elmi A | 2007 | Cell Micrebiol2007，9，10： | 1 |
| 17 | Distinct classes ofhuman stem cells that differ in proliferative and self- renewalpotential 显示文摘 | Guenechea G Gan 01 Dorrell C | 2001 | Nat Immunol2001，2，1： | 1 |
| 18 | Unbalancedmagnetic pull due to asymmetry and low-level staticrotor eccentricity in fractional-slot brushlesspermanent-magnet motors with surface-magnet andconsequent-pole rotors显示文摘 | Dorrell D G Popescu M lonel D M | 2010 | IEEE Transactions onMagnetics2010，46，7： | 1 |
| 19 | The structure of the deposit produced by sedimentation of polydisperse suspensions显示文摘 | DORRELL R M HOGG A J SUMNER E J | 2011 | Journal of Geophysical Research2011，116，： | 1 |
| 20 | A bioassay for rapid determinenation of amino acid availability values显示文摘 | Likuski H J A Dorrell H G | 1978 | Poultry Sci1978，571，： | 1 |
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