|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 2 | Antidepressant-like effect of active fraction of Polyrhachisvicina Roger in a rat depression model显示文摘OBJECTIVE: To investigate the antidepressant-likeeffect of active fraction of Polyrhachis vicina Roger(AFPR) in a rat depression model, and to elucidate the underlying mechanism.METHODS: AFPR was extracted with ethanol followed by petroleum ether. Its antidepressant-like effect was investigated in mice by tail suspension test(TST), forced swimming test(FST) and open field test(OPT). A repeated dose of reserpine(0.5 mg/kg, daily for 14 d) was used to establish a rat depression model. Fluoxetine was used as positive control agent. The effect of AFPR on reserpine-induced ptosis, hypothermia and akinesia, the levels of monoamines and their metabolites, and the activity of monoamine oxidase(MAO) in hippocampus and prefrontal cortex were determined.RESULTS: Administration of AFPR by gavage at 160 and 320 mg/kg significantly reduced the duration of immobility in the FST and TST, and did not affect locomotor activity in the OPT. In the reserpine-induced depression model, AFPR attenuated anhedonia, demonstrated by reversing hypothermia, akinesia and sucrose consumption. AFPR significantly increased the concentration of monoamines, including dopamine, serotonin, noradrenaline and acetylcholine.CONCLUSION: AFPR normalized the metabolism rates of noradrenaline, serotonin and dopamine,and the activity of MAO, which were altered by chronic reserpine exposure. The findings suggest that modulation of the monoaminergic neurotransmitter system likely underlies the antidepressant-like effect of AFPR. | Wei Guining Chu Shifeng Su Qibiao Su Hua Lin Meiyu He Fei Lu Wenjie Lu Guoshou Huang Zhoufeng Tan Xiao Lin Xiao Zeng Xianbiao Wei Baowei Chen Naihong | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 4 |
| 3 | Degradation of 2,2′,4,4′-tetrabromodiphenyl ether by Pycnoporus sanguineus in the presence of copper ions显示文摘The degradation of 2,2′,4,4′-tetrabromodiphenyl ether(BDE-47) by Pycnoporus sanguineus was investigated in order to explore the impact of the heavy metal Cu2+ on BDE-47 decomposition and the subsequent formation of metabolites, as well as to further elucidate the degradation mechanism of BDE-47. An increase in degradation rate from 18.63% to49.76% in the first four days and its stabilization at(51.26 ± 0.08)% in the following days of BDE-47 incubation were observed. The presence of Cu2+ at 1 and 2 mg/L was found to promote the degradation rate to 56.41% and 60.79%, respectively, whereas higher level of Cu2+(≥ 5 mg/L) inhibited the removal of BDE-47. The similar concentration effects of Cu2+ was also found on contents of fungal protein and amounts of metabolites. Both intracellular and extracellular enzymes played certain roles in BDE-47 transportation with the best degradation rate at 27.90% and 27.67% on the fourth and third day, individually. During the degradation of BDE-47, four types of hydroxylated polybrominated diphenyl ethers(OH-PBDEs), i.e., 6′-OH-BDE-47, 5′-OH-BDE-47, 4′-OH-BDE-17, 2′-OH-BDE-28, and two bromophenols, i.e., 2,4-DBP and 4-BP were detected and considered as degradation products. These metabolites were further removed by P. sanguineus at rates of 22.42%,23.01%, 27.04%, 27.96%, 64.21%, and 40.62%, respectively. | Meiqian Wang Hua Yin Hui Peng Mi Feng Guining Lu Zhi Dang | 2019 | Journal of Environmental Sciences2019，31，9： | 4 |
| 4 | Co-metabolic and biochar-promoted biodegradation of mixed PAHs by highly efficient microbial consortium QY1显示文摘Polycyclic aromatic hydrocarbons(PAHs), typical representatives of the persistent organic pollutants(POPs), have become ubiquitous in the environment.In this study, a novel microbial consortium QY1 that performed outstanding PAHs-degrading capacity has been enriched.The degradation characteristics of single and mixed PAHs treated with QY1 were studied, and the effect of biochar on biodegradation of mixed PAHs and the potential of biochar in PAHs-heavy metal combined pollution bioremediation were also investigated.Results showed that, in single substrate system, QY1 degraded 94.5% of 500 mg/L phenanthrene(PHE) and 17.8% of 10 mg/L pyrene(PYR) after 7 days, while in PHE-PYR mixture system, the biodegradation efficiencies of PHE(500 mg/L) and PYR(10 mg/L) reached 94.0%and 96.2%, respectively, since PHE served as co-metabolic substrate to have significantly improved PYR biodegradation.Notably, with the cooperation of biochar, the biodegradations of PHE and PYR were greatly accelerated.Further, biochar could reduce the adverse impact of heavy metals(Cd^(2+), Cu^(2+), Cr_(2)O_(7)^(2-)) on PYR biodegradation remarkably.The sequencing analysis revealed that Methylobacterium, Burkholderia and Stenotrophomonas were the dominant genera of QY1 in almost all treatments, indicating that these genera might play key roles in PAHs biodegradation.Overall, this study provided new insights into the efficient bioremediation of PAHs-contaminated site. | Min Li Hua Yin Minghan Zhu Yuanyuan Yu Guining Lu Zhi Dang | 2021 | Journal of Environmental Sciences2021，33，9： | 4 |
| 5 | Thiocyanate-induced labilization of schwertmannite: Impacts and mechanisms显示文摘Schwertmannite is an amorphous iron(III)-oxyhydroxysulfate that forms in acid mine drainage(AMD) environments. The characteristic of high heavy metal adsorption capability makes schwertmannite a potentially useful, environmentally friendly material in wastewater treatment. Unstable schwertmannite is prone to recrystallization.Understanding the mechanisms that induce schwertmannite labilization and affect its capacity to remove heavy metals are of great environmental and geochemical significance.Thiocyanate(SCNˉ) is a hazardous pseudohalide that is also normally found in AMD.However, little is known about the impact of Fe(III)-binding ligand SCNˉ on schwertmannite stability and its subsequent capacity to bind trace elements. Here, we investigated the adsorption of SCNˉ on schwertmannite and subsequent mineral transformation to characterize this little-known process. The appearance of Fe2+indicated that the interactions between schwertmannite and SCNˉ may involve complexation and reduction reactions. Results showed that the majority of the adsorbed-SCNˉ was immobilized on schwertmannite during the 60-days transformation. The transformation rates of schwertmannite increased with increasing concentrations of SCNˉ. Goethite was detected as the dominant transformation product with or without SCNˉ. The mechanisms of SCNˉ-promoted dissolution of schwertmannite can be described as follows:(1) formation of Fe(III)–NCS complexes on the schwertmannite surface and in solution, a process which increases the reactivity of solid phase Fe(III);(2) the extraction of Fe(III) from schwertmannite by SCNˉ and subsequent schwertmannite dissolution; and(3) the formation of secondary minerals from extracted Fe(III). These findings may improve AMD treatment strategies and provide insight into the use and potential reuse of schwertmannite as a trace element sorbent. | Cong Fan Chuling Guo Junhui Zhang Cui Ding Xiaofei Li John R.Reinfelder Guining Lu Zhenqing Shi Zhi Dang | 2019 | Journal of Environmental Sciences2019，31，6： | 3 |
| 6 | A fusant of Sphingomonas sp. GY2B and Pseudomonas sp. GP3A with high capacity of degrading phenanthrene显示文摘 | Jing Lu Chuling Guo Jing Li Hui Zhang Guining Lu Zhi Dang Renren Wu | 2013 | World Journal of Microbiology and Biotechnology2013，，9： | 1 |
| 7 | Effects of eggshell addition on calcium-deficient acid soils contaminated with heavy metals显示文摘在这研究,水条件完成(泛滥,湿,或干燥)并且蛋壳剂量( 0 , 0.1 , 1.0 ,和 10.0 g/kg 土壤,分别地)在 pH 变化上,内容无法获得重金属的状态,重金属的形式,并且在与重金属污染的酸土壤的可得到的滋养的元素钙( Ca )分别地被调查。土壤样品连续地在室内被栽培并且由毒性分析了特征的沥滤参考(BCR ) 的过程和社区局顺序的抽取过程。结果证明蛋壳的增加能有效地改进酸土壤的 pH 并且增加它到中立水平。而且,内容无法获得重金属 Cu, Zn,和 Cd 的状态显著地增加了。而且,当土壤与 1.0 g/kg 蛋壳在充满的条件下面被栽培时,无法获得 Cu, Zn,和 Cd 的状态增加了大多数,并且这些重金属被转变成剩余状态。在另一方面, Ca 的可得到的状态的数量与 1.0 g/kg 蛋壳的增加从 73.34 mg/kg 增加了到 432.19,它显示蛋壳的增加戏剧性地改进了 Ca 的可得到的状态。因此,蛋壳能改善它有效地导致了授精的可得到的重金属和改进的减少的土壤环境。简言之,这研究显示蛋壳的增加将是为与重金属污染的酸地土壤的补习的一个新潜在的方法。 | Weiqi Luo Yanping Ji Lu Qu Zhi Dang Yingying Xie Chengfang Yang Xueqin Tao Jianmin Zhou Guining Lu | 2018 | Frontiers of Environmental Science & Engineering2018，12，3： | 1 |
| 8 | Role of ALDP(ABCD1)and mitochondria in X-linked adrenoleukodystrophy显示文摘 | Mc guinness MC Lu JF Zhang HP | 2003 | Mol Cell Biol2003，23，2： | 1 |
| 9 | Fe(Ⅱ)-mediated transformation of schwertmannite associated with calcium from acid mine drainage treatment显示文摘Schwertmannite is an important Fe(Ⅲ)-oxyhydroxysulfate in acid mine drainage (AMD) polluted areas and its stability depends on surrounding environmental factors and previously bound elements.The treatment and neutralization of AMD normally involve the use of lime,which leads to the discharge of abundant Ca in the mining area.Such an environmental disturbance brings up an important and less considered problem of how the reductive transformation of schwertmannite associated with coexisting Ca occurred.Here,the Fe(Ⅱ)-mediated transformation of Ca-adsorbed schwertmannite and subsequent Ca repartitioning behaviors were investigated.Results showed that adsorbed Ca had a weak inhibitory effect on Fe(Ⅱ)-mediated schwertmannite transformation.Release of SO_(4)2-and SEM images both indicated that transformation rates of schwertmannite decreased under the influence of adsorbed Ca.XRD patterns indicated that adsorbed Ca altered schwertmannite transformation pathways and product compositions upon treatment with 0.4 mmol/L Fe(Ⅱ).The end products of Sch notably contained both goethite and lepidocrocite;however,transformation products of SchCa only contained goethite all along.Approximately 33.5%of the surface adsorbed-Ca was released into solution within 6 hr after Fe(Ⅱ) injection.Aqueous Ca behaved in a“first release and then im-mobilization”manner,which indicated dissolution and secondary mineralization drove Ca migration during the Fe(Ⅱ)-mediated transformation of SchCa.Adsorbed Ca blocked the surface sites for subsequent Fe(Ⅱ) adsorption,limited the Fe(Ⅱ)-Fe(Ⅲ) ETAE,and decreased the transformation rates.This work sheds light on the complex geochemical behavior of schwertmannite under the influences of environmental perturbations in AMD environments. | Cong Fan Chuling Guo Wei Chen Guining Lu Yu Shen Zhi Dang | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 10 | Modeling and prediction of soil sorption coefficients of polycyclic aromatic hydrocarbons using quantum chemical descriptors显示文摘 | Guining LU Zhi DANG Xueqin TAO Chen YANG Xiaoyun YI | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 11 | Efficient removal of polybrominated diphenyl ethers from soil washing effluent by dummy molecular imprinted adsorbents: Selectivity and mechanisms显示文摘Surfactant enhanced elution is an effective method for removing hydrophobic organic pollutants from soils.The key to the development of leaching technology is selective removal of targeted pollutants in soil washing effluent and recycling of surfactant solutions.In this study,a molecular imprinting technique was applied to selectively sorb polybrominated diphenyl ethers(PBDEs)in soil washing effluent.The novel molecular imprinted polymers(MIPs)using different template molecules were synthesized by precipitation polymerization.Adsorption behaviors andmechanisms ofMIPs were studied through experiments and theoretical calculations.The results show that 4-bromo-4'-hydroxybiphenyl and toluene can be effective imprinting molecule for MIPs synthesis.The maximal adsorption capacity of selected dummy molecular imprinted polymer(D1-MIP)was 1032.36μmol/g,and that of part molecular imprinted polymer(P-MIP)was 981.13μmol/g.Their imprinting factors in 5 PBDEs adsorption ranged from 2.13 to 5.88,the recovery percentage of Triton X-100 can reach 99.09%,confirming the feasibility of reusing surfactant.Various PBDEs could be removed by MIPs,and Quantitative Structure Property Relationship analysis revealed that PBDEs’molecular volume,planarity,polarity,and hydrophobicity have major influences on their adsorption performance.DFT calculation revealed that Van derWaals force and hydrogen bonding played important roles during selective adsorption.These results can provide effective theoretical guidance for surfactant enhanced soil elution in practical engineering applications. | Yao Ma Jinfan Chen Xiaodong Du Chunsheng Xie Jiangmin Zhou Xueqin Tao Zhi Dang Guining Lu | 2023 | Journal of Environmental Sciences2023，，7： | 0 |
| 12 | Isolation and characterization of phenanthrene-degrading strain Sphingomonas sp. GY2B显示文摘 | Xueqin TAO Guining LU Zhi DANG Chen YANG Xiaoyun YI | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员