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| 1 | Heme oxygenase system in hepatic ischemia-reperfusion injury显示文摘Hepatic ischemia-reperfusion injury (IRI) limits access to transplantation. Heme oxygenase-1 (HO-1) is a powerful antioxidant enzyme which degrades free heme into biliverdin,free iron and carbon monoxide. HO-1 and its metabolites have the ability to modulate a wide variety of inflammatory disorders including hepatic IRI. Mechanisms of this protective effect include reduction of oxygen free radicals,alteration of macrophage and T cell phenotype. Further work is required to understand the physiological importance of the many actions of HO-1 identified experimentally,and to harness the protective effect of HO-1 for therapeutic potential. | James A Richards Stephen J Wigmore Luke R Devey | 2010 | World Journal of Gastroenterology2010，16，48： | 14 |
| 2 | Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning显示文摘AIM:To assess the relationship between preoperative computed tomography(CT)and postoperative pathological measurements of esophageal tumor length and the prognostic significance of CT tumor length data.METHODS:A retrospective study was carried out in 56 patients who underwent curative esophagogastrectomy.Tumor lengths were measured on the immediate preoperative CT and on the post-operative resection specimens.Inter-and intra-observer variations in CT measurements were assessed.Survival data were collected.RESULTS:There was a weak correlation between CT and pathological tumor length(r=0.30,P=0.025).CT lengths were longer than pathological lengths in 68%(38/56)of patients with a mean difference of 1.67 cm(95%CI:1.18-2.97).The mean difference in measurements by two radiologists was 0.39 cm(95% CI:-0.59-1.44).The mean difference between repeat CT measured tumor length(intra-observer variation) were 0.04 cm(95%CI:-0.59-0.66)and 0.47 cm (95%CI:-0.53-1.47).When stratified,patients not receiving neoadjuvant chemotherapy showed a strong correlation between CT and pathological tumor length(r =0.69,P=0.0014,n=37)than patients that did(r= 0.13,P=0.43,n=19).Median survival with CT tumor length>5.6 cm was poorer than with smaller tumors,but the difference was not statistically significant.CONCLUSION:Esophageal tumor length assessed using CT does not reflect pathological tumor extent and should not be the only modality used for management decisions,particularly for planning radiotherapy. | Karim Sillah Luke R Williams Hans-Ulrich Laasch Azeem Saleem Gillian Watkins Susan A Pritchard Patricia M Price Catharine M West Ian M Welch | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 10 |
| 3 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 4 | Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier显示文摘 | Nicola F. Fletcher Garrick K. Wilson Jacinta Murray Ke Hu Andrew Lewis Gary M. Reynolds Zania Stamataki Luke W. Meredith Ian A. Rowe Guangxiang Luo Miguel A. Lopez–Ramirez Thomas F. Baumert Babette Weksler Pierre–Olivier Couraud Kwang Sik Kim Ignacio A. R | 2012 | Gastroenterology2012，，3： | 2 |
| 5 | Simulation of the performance of electrical capacitance tomography for muasurement of dense phase pneumatic conveying显示文摘 | K L Ostrowski S P Luke R A Williams | 1997 | Chemical Engineering Journal1997，，6： | 1 |
| 6 | Enhancement of strength and stability of nanostructured Ni by small amounts of solutes显示文摘 | ZHANG Hong-wen LUKe PIPPAN R HUANG Xiao-xu HANSEN N | 2011 | Scr Mater2011，65，： | 1 |
| 7 | Effects of antiagglomerants on the interactions between hydrate particles显示文摘 | Mark R A J Dalton Y Luke H | 2007 | American Institute of Chemical Engineers2007，54，2： | 1 |
| 8 | Ownership and organizational performance: a comparison of technical efficiency across hospital types 显示文摘 | Ozcan Y A Luke R D Haksever G | 1992 | Medical Care1992，30，9： | 1 |
| 9 | Oral administration of protease inhibits enterotoxigenic Escheriehia coli receptor activity in piglet small intestine显示文摘 | Mynott T L Luke R K Chandler D S | 1996 | Gut1996，38，： | 1 |
| 10 | Industrial applications of electrical tomography to solid conveying显示文摘 | LUKE S P WILLIAMS R A | 1997 | Measurement & Control1997，，30： | 1 |
| 11 | Declining rates of physical activity in the United States: What are the contribu- tors? 显示文摘 | BROWNSON R C BOEHMER T K LUKE D A | 2005 | Annu Rev Public Health2005，26，： | 1 |
| 12 | Biasing coevolutionary search for optimal multiagent behaviors显示文摘 | PANAIT L LUKE S WIEGAND R P | 2007 | IEEE Transactions on Evolutionary Computation2007，10，6： | 1 |
| 13 | Low dose secondary prophylaxis reduces joint bleeding in severe and moderate haernophilic children : a pilot study in China 显示文摘 | WU R LUKE KH POON MC | 2011 | Haemophilia2011，17，1： | 1 |
| 14 | Market contestability in the presence ot sunk costs 显示文摘 | Coursey Don R Mark Isaac Margaret luke and Veron I Smith | 1984 | Rand Journal of Economics1984，15，： | 1 |
| 15 | Computational and experimental characterization of physically clustered simple sequence repeats in plants 显示文摘 | Linda C Luke R Dan M | 2000 | Genetics2000，156，2： | 1 |
| 16 | Molecular dyanmics investigation of thickness effect on liquid films 显示文摘 | WENG J G PARK S LUKES J R | 2000 | J Chem Phys2000，10，： | 1 |
| 17 | Effects of antiagglomerants on the interactions between hydrate particles显示文摘 | Anklam Mark R Dalton York J Helmerich Luke | 2007 | American Institute of Chemical Engineers2007，54，2： | 1 |
| 18 | A genome - wide scan for body mass index among Nigerian families 显示文摘 | Adeyemo A Luke A Cooper R | 2003 | Obes Res2003，11，2： | 1 |
| 19 | Prevalence of mutations within the quinolone resistance-determining region of gyrA,gyrB,parC,and pare and association with antibiotic resistance in quinolone-resistant Salmonella enterica显示文摘 | Deborah J E Luke R | 2004 | Antimicrobial Agents and Chemotherapy2004，48，10： | 1 |
| 20 | Subcritical Solvent Extraction of Anthocyanins from Dried Red Grape Pomace显示文摘 | Jeana K Monrad Luke R Howard Jerry W King | | 0，，07： | 1 |
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