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| 1 | Inhibiting collagen Ⅰ production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles显示文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells. | Yan Yan Cancan Du Xixi Duan Xiaohan Yao Jiajia Wan Ziming Jiang Zhongyu Qin Wenqing Li Longze Pan Zhuoyu Gu Fazhan Wang Ming Wang Zhihai Qin | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 7 |
| 2 | Tentative identification, quantitation, and principal component analysis of green pu-erh, green, and white teas using UPLC/DAD/MS显示文摘 | Yang Zhao Pei Chen Longze Lin J.M. Harnly Liangli (Lucy) Yu Zhangwan Li | 2010 | Food Chemistry2010，，3： | 3 |
| 3 | Free radicals scavenging and protective effect of Pu-erh tea extracts on the oxidative damage in the HPF-1 cell显示文摘 | Guoliang Jie Zhi Lin Longze Zhang | 2006 | J Agric Food Chem2006，54，21： | 1 |
| 4 | Free radical scavenging effect of pu-erh tea extracts and their protective effect on oxidative damage in human fibroblast cells显示文摘 | JIE Guoliang LIN Zhi ZHANG Longze | 2006 | Journal of Agricultural and Food Chemistry2006，54，21： | 1 |
| 5 | Detection and quantification and glycosylated flavonoid malonates in celery, Chinese celery,and celery seed by LC-DAD-ESI/MS显示文摘 | LIN Longze LU Shengmin HARNLY J M | 2007 | Journal of Agricultural and Food Chemistry2007，55，4： | 1 |
| 6 | Identification of the phenolic components of Chrysanthemum flower (Chrysanthemum morifolium Ramat)显示文摘 | LIN Longze HARNLY J M | 2010 | Food Chemistry2010，120，1： | 1 |
| 7 | Comparison ofβ-Amyloid Plaque Labeling Methods:Antibody Staining,Gallyas Silver Staining,and Thioflavin-S Staining显示文摘Objective To evaluate senile plaque formation and compare the sensitivity of three differentβ-amyloid(Aβ)labeling methods(antibody staining,Gallyas silver staining,and thioflavin-S staining)to detect Aβdeposition.Methods APPswe/PSEN1dE9 transgenic mice(APP/PS1)of different ages were used to examine spatiotemporal changes in Aβplaque deposition.Antibody staining,Gallyas silver staining,and thioflavin-S staining were used to detect Aβplaque deposition in the same brain region of adjacent slices from model mice,and the results were compared.Results With aging,Aβplaques first appeared in the cortex and then the deposition increased throughout the whole brain.Significantly greater plaque deposition was detected by 6E10 antibody than that analyzed with Gallyas silver staining or thioflavin-S staining(P<0.05).Plaque deposition did not show significant difference between the APP/PS1 mice brains assayed with Gallyas silver staining and ones with thioflavin-S staining(P=0.0033).Conclusions The APP/PS1 mouse model of Alzheimer’s disease could mimick the progress of Aβplaques occurred in patients with Alzheimer’s disease.Antibody detection of Aβdeposition may be more sensitive than chemical staining methods. | Xinze Shi Xuan Wei Longze Sha Qi Xu | 2018 | Chinese Medical Sciences Journal2018，33，3： | 1 |
| 8 | Free radical scavengingeffect of pu-erh tea extracts and their protective effect on oxidative damagein human fibroblast cells显示文摘 | JIE Guoliang LIN Zhi ZHANG Longze | 2006 | J Agric Food Chem2006，54，21： | 1 |
| 9 | Detection andquantification of glycosylated flavonoid malonates in celery,Chinese celery,and celery seed by LC-DAD-ESI/MS 显示文摘 | LIN Longze LU Shengmin HARNLY J M | 2007 | Journal ofAgricultural and Food Chemistry2007，55，4： | 1 |
| 10 | Identification of hydroxycinnamoylquinic acids of arnica flowers and burdock roots using a standardized LC- DAD-ESI/MS profiling method显示文摘 | LIN Longze HARNLY J M | 2008 | Journal of Agricultural and Food Chemistry2008，56，10： | 1 |
| 11 | Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy显示文摘 | Longze Sha Xiaofeng Wu Yuan Yao Bo Wen Jing Feng Zhiqiang Sha Xueqin Wang Xiaoliang Xing Wanchen Dou Liri Jin Wenting Li Naili Wang Yan Shen Jinhui Wang Liwen Wu Qi Xu | 2014 | Molecular Neurobiology2014，，2： | 1 |
| 12 | Detection and quantification and glycosylated flavonoid malonates in celery, Chinese celery, and celery seed by LC-DAD-ESI/MS显示文摘 | LIN Longze LU Shengmin HARNLY J M | 2007 | Journal of Agricultural and Food Chemistry2007，55，4： | 1 |
| 13 | Electrospray high performance liquid chromatography mass spectrometry in phytochemical ananlysis of Kava (Piper methysticum) extract显示文摘 | Xianguo H Longze L Lizhi L | 1997 | Planta Med1997，63，： | 1 |
| 14 | Recovery of rare earth from wet-process phosphoric acid 显示文摘 | Wang L S LongZ Q Huang X W Ying Y Cui D L Guo C Z | 2010 | Hydrometallurgy2010，101，： | 1 |
| 15 | Quinoline alka loids from camptotheca acuminate显示文摘 | LONGZE LIN GEOFFREY A CORDELLA | 1989 | Phytochemistry1989，28，4： | 1 |
| 16 | Detection and quantifica-tion and glycosylated flavonoid malonates in celery, Chinese celery,andcelery seed by LC-DAD-ESI/MS显示文摘 | LIN Longze LU Shengmin HARNLY J M | 2007 | Journal of Agricultural andFood Chemistry2007，55，4： | 1 |
| 17 | Free radicalsscavenging and protective effect of Pu-erh tea extracts on theoxidative damage in the HPF-1 cell显示文摘 | Guoliang Jie Zhi Lin Longze Zhang | 2006 | J Agric Food Chem2006，54，21： | 1 |
| 18 | Analysis of Lignan Constituents from Schisandra Chinensis by Liquid Chromatographyelectrospray Mass Spectrometry显示文摘 | Xia guo He Lizhi Lian Longze Lin | 1997 | Journal of Chromatography1997，757，： | 1 |
| 19 | Densification and microstructural evolution of a high niobium containing TiAl alloy consolidated by spark plasma sintering显示文摘 | Jiawen Wang Yan Wang Yong Liu Jianbo Li Longze He Chi Zhang | 2015 | Intermetallics2015，，： | 1 |
| 20 | Triterpene saponins from Aster yunnanensis 显示文摘 | Shao Yu Zhou Bingnan Lin Longze | 1995 | Phytochemistry1995，38，6： | 1 |
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