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| 1 | Helicobacter pylori may be an initiating factor in newly diagnosed ulcerative colitis patients: A pilot study显示文摘AIM To directly visualize Helicobacter pylori(H. pylori) by the highly sensitive and specific technique of immunohistochemical staining in colonic tissue from patients newly diagnosed with ulcerative colitis(UC).METHODS Colonoscopic biopsies from thirty patients with newly diagnosed UC and thirty controls were stained with Giemsa stain and immunohistochemical stain for detection of H. pylori in the colonic tissue. Results were confirmed by testing H. pylori Ag in the stool then infected patients were randomized to receive either anti H. pylori treatment or placebo.RESULTS Twelve/30(40%) of the UC patients were positive for H. pylori by Giemsa, and 17/30(56.6%) by immunohistochemistry stain. Among the control group 4/30(13.3%) and 6/30(20 %) were positive for H. pylori by Giemsa and immunohistochemistry staining respectively. H. pylori was significantly higher in UC than in controls(P = 0.04 and 0.007). All Giemsa positive patients and controls were positive by immunohistochemical stain. Four cases of the control group positive for H. pylori also showed microscopic features consistent with early UC.CONCLUSION H. pylori can be detected in colonic mucosa of patients with UC and patients with histological superficial ulcerations and mild infiltration consistent with early UC. There seems to be an association between UC and presence of H. pylori in the colonic tissue. Whether this is a causal relationship or not remains to be discovered. | Loai Mansour Ferial El-Kalla Abdelrahman Kobtan Sherief Abd-Elsalam Mohamed Yousef Samah Soliman Lobna Abo Ali Walaa Elkhalawany Ibrahim Amer Heba Harras Maha M Hagras Mohamed Elhendawy | 2018 | World Journal of Clinical Cases2018，6，13： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion,in vivo study显示文摘BACKGROUND Cyanidin-3-O-glucoside(cyan)exhibits antioxidant and anticancer properties.The cell cycle proteins and antimitotic drugs might be promising therapeutic targets in hepatocellular carcinoma.AIM To investigate the effect of cyan administration on cell cycle in hepatic precancerous lesion(PCL)induced by diethylnitrosamine/2-acetylaminofluorene(DEN/2-AAF)in Wistar rats.METHODS In vivo,DEN/2-AAF-induced hepatic PCL,rats were treated with three doses of cyan(10,15,and 20 mg/kg/d,for four consecutive days per week for 16 wk).Blood and liver tissue samples were collected for measurement of the followings;alpha fetoprotein(AFP)liver function and RNA panel differential expression was evaluated via real time polymerase chain reaction.Histopathological examination of liver sections stained with H&E and immunohistochemical study using glutathione S-transferase placental(GSTP)and proliferating cell nuclear antigen(PCNA)antibodies were assessed.RESULTS Cyan administration mitigated the effect of DEN/2-AFF induced PCL,decreased AFP levels,and improved liver function.Remarkably,treatment with cyan dose dependently decreased the long non-coding RNA MALAT1 and tubulin gamma 1 mRNA expressions and increased the levels of miR-125b,all of which are involved in cell cycle and mitotic spindle assembly.Of note,cyan decreased GSTP foci percent area and PCNA positively stained nuclei.CONCLUSION Our results indicated that cyan could be used as a potential therapeutic agent to inhibit liver carcinogenesis in rat model via modulation of cell cycle. | Marwa Matboli Amany H Hasanin Reham Hussein Sarah El-Nakeep Eman K Habib Rawan Ellackany Lobna A Saleh | 2021 | World Journal of Gastroenterology2021，27，14： | 1 |
| 4 | Characterization of a novel Vip3-type from Bacillus thuringiensis and evidence of its presence on a large plasmid显示文摘 | Lobna A M Slim To | 2005 | FEMS Microbiology Letters2005，，24： | 1 |
| 5 | The value of troponin-I measurement in assessment of an thracycline induced cardiotoxicity among breast cancer patients显示文摘 | Lobna S Emad H Hanan S | 2000 | Cancer Inst2000，12，1： | 1 |
| 6 | Effect of adenotonsillectomy on nocturnal enuresis in children with OSA显示文摘 | Heba HA Lobna ME Ahmed EMB | | 0，，2： | 1 |
| 7 | Correlation of HER-2 over- expression with clinic-pathological parameters in Tunisian breast carci- noma显示文摘 | Lobna A Abdelmajid K Habib A | 2008 | World Journal of Surgical Oneology2008，6，112： | 1 |
| 8 | Response to hepatitis B vaccination by liver transplant candidates显示文摘 | Dr. David H. Thiel MD Lobna El-Ashmawy MD Kristin Love BS Judith S. Gavaler PhD Thomas E. Starzl MD PhD | 1992 | Digestive Diseases and Sciences1992，，8： | 1 |
| 9 | Anatomic Variations of the Sphenoid Sinus and Their Impact on Trans-sphenoid Pituitary Surgery 显示文摘 | Ossama H Lobna EF Ossama H | 2008 | Skull Base2008，18，1： | 1 |
| 10 | Improving algorithms for struc- ture learning in Bayesian networks using a new implicit score显示文摘 | Lobna B Afif M Faiez G | 2010 | Expert Systems with Applications2010，37，7： | 1 |
| 11 | Improving algorithms forstructure learning in Bayesian networks using a new implicitseore显示文摘 | Lobna B Afif M Faiez G | 2010 | Expert Systems with Applications2010，37，7： | 1 |
| 12 | Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt显示文摘 | Samer S. El-Kamary Mohamed Hashem Doa’a A. Saleh Mohamed Ehab Sahar A. Sharaf Fatma El-Mougy Lobna Abdelsalam Ravi Jhaveri Ahmed Aboulnasr Hesham El-Ghazaly | 2015 | Journal of Infection2015，，5： | 1 |
| 13 | Antiproliferative, Antioxidant, and Antimutagenic Activities of Flavonoid-Enriched Extracts from (Tunisian) Rhamnus alaternus L.: Combination with the Phytochemical Composition显示文摘 | Rebai Ben Ammar Soumaya Kilani Ines Bouhlel Lobna Ezzi Ines Skandrani Jihed Boubaker Mohamed Ben Sghaier Aicha Naffeti Amor Mahmoud Leila Chekir-Ghedira Kamel Ghedira | 2008 | Drug and Chemical Toxicology2008，，1： | 1 |
| 14 | Histopatholog- ieal effects and determination of the putative receptor of Bacil- lus thuringieris CrylDa toxin in Spodoptera littoralis midgut显示文摘 | DALEL B T MARWA S LOBNA A M | 2013 | Journal of Invertebrate Pathology2013，112，： | 1 |
| 15 | Expression of COX-2 and E-cadherin in Tunisian patients with colorectal adenocarcinoma显示文摘 | Imen Miladi-Abdennadher Rania Abdelmaksoud-Dammak Dorra Ben Ayed-Guerfali Lobna Ayadi Abdelmajid Khabir Ali Amouri Foued Frikha Nabil Tahri Sameh Ellouz Mounir Frikha Tahia Sellami-Boudawara Raja Mokdad-Gargouri | 2011 | Acta Histochemica2011，，6： | 1 |
| 16 | Improving algorithms for structure learning in Bayesian networks using a new implicit score显示文摘 | Lobna B Afif M Faiez G | 2010 | Expert Systems with Applications2010，37，7： | 1 |
| 17 | Personalized information retrieval in specialized virtual libraries 显示文摘 | Lobna Jeribi Beatrice Rumpler Jean Marie Pinon | 2000 | New Library World2000，101，1153： | 1 |
| 18 | Improving algorithms for structure learning in Bayesian Networks u- sing a new implicit score显示文摘 | Bouchaala Lobna Masmoudi Afif Gargouri Faiez | 2010 | Expert Systems with Applications2010，37，： | 1 |
| 19 | Therapeutic management of uterine fibroid tumors:updated French guidelines显示文摘 | Henri M Xavier F Lobna O | 2012 | European Journal of Obstetrics&Gynecology and Reproductive Biology2012，165，2： | 1 |
| 20 | Anatomic variations of the sphenoid sinus and Their impact on Trans-sphenoid Pituitary Surgery显示文摘 | Ossama Hamid Lobna E1 Fiky Ossama Hassan | | 0，，01： | 1 |
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