|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of probiotics on pro-inflammatory cytokines and NF-κB activation in ulcerative colitis显示文摘AIM:To demonstrate the therapeutic effect of probiotics in patients with ulcerative colitis(UC),and their effect on inflammatory mediators and nuclear factor(NF)κB activation in these patients.METHODS:Thirty patients with mild to moderate UC were randomly classified into two groups:sulfasalazine group,who received sulfasalazine 2400 mg/d;and probiotic group,who received sulfasalazine 2400 mg/d with probiotic.The patients were investigated before and after 8 wk of treatment with probiotic(Lactobacillus delbruekii and Lactobacillus fermentum).Colonic activity of myeloperoxidase(MPO)was assayed with UV spectrophotometry,the colonic content of interleukin(IL)-6 was determined by enzyme-linked immunosorbent assay(ELISA),fecal calprotectin was determined by ELISA,and expression of NF-κB p65 and tumor necrosis factor (TNF)-αproteins in colonic tissue was identified by immunohistochemistry and reverse transcription polymerase chain reaction,respectively.RESULTS:At the start of the study,colonic mucosal injury and inflammation were demonstrated in UC patients by hematoxylin and eosin staining,and an increase in colonic MPO activity,fecal calprotectin,and expression of colonic TNF-αand NF-κB p65 proteins.The use of probiotic for 8 wk significantly ameliorated the inflammation by decreasing the colonic concentration of IL-6,expression of TNF-αand NF-κB p65,leukocyte recruitment,as demonstrated by a decrease in colonic MPO activity,and the level of fecal calprotectin compared to sulfasalazine group and the control group(P<0.05).CONCLUSION:Oral supplementation with probiotics could be helpful in maintaining remission and preventing relapse of UC. | Sahar K Hegazy Mohamed M El-Bedewy | 2010 | World Journal of Gastroenterology2010，16，33： | 44 |
| 2 | Human umbilical cord mesenchymal stem cells as treatment of adjuvant rheumatoid arthritis in a rat model显示文摘AIM:To investigate the effect of human umbilical cord stem cells,both mesenchymal and hematopoietic(CD34+),in the treatment of arthritis.METHODS:Mesenchymal stem cells(MSCs) and hematopoietic(CD34+) stem cells(HSC) were isolated from human umbilical cord blood obtained from the umbilical cord of healthy pregnant donors undergoing fullterm normal vaginal delivery.MSC,HSC,methotrexate(MTX) and sterile saline were injected intra-articularly into the rat hindpaw with complete freunds adjuvant(CFA) induced arthritis after the onset of disease(day 34),when arthritis had become well established(arthritis score ≥ 2).Arthritic indices were evaluated and the levels of interleukin(IL)-1,tumor necrosis factor(TNF)-α and interferon(IFN)-γ and anti-inflammatory cytokine IL-10 in serum were determined using enzyme-linked immunosorbent assay.Animals of all groups were sacrificed 34 d after beginning treatment,except positive control(PC) which was sacrificed at 10,21 and 34 d for microscopic observation of disease progression.We used hematoxylin,eosin and Masson's trichrome stains for histopathological examination of cartilage and synovium.RESULTS:The mean arthritis scores were similar in all groups at 12 and 34 d post immunization,with no statistical significant difference.Upon the injection of stem cells(hematopoietic and mesenchymal),the overall arthritis signs were significantly improved around 21 d after receiving the injection and totally disappeared at day 34 post treatment in MSC group.Mean hindpaw diameter(mm) in the MSC rats was about half that of the PC and MTX groups(P = 0.007 and P = 0.021,respectively) and 0.6 mm less than the HSC group(P = 0.047),as indicated by paw swelling.Associated with these findings,serum levels of TNF-α,IFN-γ and IL-1 decreased significantly in HSC and MSC groups compared to PC and MTX groups(P < 0.05),while the expression of IL-10 was increased.Histopathological examination with H and E stain revealed that the MTX treated group showed significant reduction of leucocytic infiltrate and hypertrophy of the synovial tissue with moderate obliteration of the joint cavity.Stem cells treated groups(both hematopoietic CD34+ and mesenchymal),showed significant reduction in leucocytic infiltrate and hypertrophy of the synovial tissue with mild obliteration of the joint cavity.With Masson's trichrome,stain sections from the PC group showed evidence of vascular edema of almost all vessels within the synovium in nearly all arthritic rats.Vacuoles were also visible in the outer vessel wall.The vessel became hemorrhagic and finally necrotic.In addition,there was extensive fibrosis completely obliterating the joint cavity.The mean color area percentage of collagen in this group was 0.324 ± 0.096,which was significantly increased when compared to the negative control group.The mean color area percentage of collagen in hematopoietic CD34+ and mesenchymal groups was 0.176 ± 0.0137 and 0.174 ± 0.0197 respectively,which showed a marked decrement compared to the PC group,denoting a mild increase in synovial tissue collagen fibers.CONCLUSION:MSC enhance the efficacy of CFAinduced arthritis treatment,most likely through the modulation of the expression of cytokines and amelioration of pathological changes in joints. | Sahar Greish Noha Abogresha Zeinab Abdel-Hady Eman Zakaria Mona Ghaly Mohamed Hefny | 2012 | World Journal of Stem Cells2012，4，10： | 17 |
| 3 | Impact of topical nonsteroidal anti-inflammatory drugs in prevention of macular edema following cataract surgery in diabetic patients显示文摘AIM: To evaluate the efficacy of prophylactic administration of topical non-steroidal anti-inflammatory drugs(NSAIDs) on macular edema following cataract surgery in diabetic patients, and to compare between types of NSAIDs(ketorolac tromethamine 0.4% and nepafenac 0.1%). METHODS: Group 1(control) received artificial tears substitute as a placebo group, group 2(nepafenac) received topical nepafenac 0.1%, and group 3(ketorolac) received topical ketorolac tromethamine 0.4%. Patients were examined postoperatively after completing one week, one month, two months and three months' intervals for evaluating cystoid macular edema(CME) development. The main study outcomes were achieving the best corrected visual acuity(BCVA) and change in the central macular thickness(CMT) measured with optical coherence topography(OCT).RESULTS: Eighty eyes of 76 patients were included in this study. BCVA showed a statistically significant difference at the third month postoperative follow up between the control group and the NSAIDs groups(P=0.04). There was an increase in the CMT in all cases starting from postoperative first week until third month. CMT showed a statistically significant difference between control group and NSAIDs groups from postoperative first month until third month(P=0.008, 0.027, 0.004). There was no statistically significant difference between nepafenac and ketorolac groups in BCVA and OCT CMT. CONCLUSION: Prophylactic preoperative and postoperative NSAIDs may have a role in reducing the frequency and severity of CME in diabetic eyes following cataract surgery. | Ahmed A.Alnagdy Hossam Y.Abouelkheir Sherief E.El-Khouly Sahar M.Tarshouby | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 13 |
| 4 | 过渡金属阳离子预处理对活性炭催化性能的提高显示文摘首先将商用活性炭样品在1%的稀硝酸中处理,然后等体积浸渍在含有5%和10%(质量分数)硝酸钴、硝酸镍或硝酸铜的水溶液中,并在100 ℃干燥至恒重,最后将样品在Ar气氛中于400 ℃焙烧 3 h. 采用X射线衍射、N2吸附和红外光谱等分析手段对不同固体样品进行了表征,并考察了其对异丙醇催化转化和25~45 ℃时过氧化氢催化分解的活性. 结果表明,掺杂5%或10%的过渡金属氧化物后,活性炭样品中含有结晶度很差的CoO, Co3O4, NiO, Cu2O和CuO相的纳米晶. 金属氧化物预处理使活性炭的BET比表面积略有增加. 这些固体样品主要用作脱氢催化剂,其选择性均高于90%. 在225 ℃时,经5%氧化钴、氧化镍和氧化铜处理的活性炭的催化活性比硝酸处理的活性炭分别提高了6%, 24.6%和40.6%. 少量CoO处理后的商用活性炭对H2O2催化分解活性的提高是由参与该催化反应的活性位浓度的显著增加而引起的,该处理过程并没有改变H2O2催化分解的机理. | Sahar A. EL-MOLLA Gamil A. EL-SHOBAKY Sohair A. SAYED AHMED | 2007 | 催化学报2007，28，7： | 13 |
| 5 | Orbital inflammatory disease:Pictorial review and differential diagnosis显示文摘Orbital inflammatory disease(OID) represents a collec tion of inflammatory conditions affecting the orbit. OID is a diagnosis of exclusion, with the differential diagno sis including infection, systemic inflammatory conditions and neoplasms, among other conditions. Inflammatory conditions in OID include dacryoadenitis, myositis, cel lulitis, optic perineuritis, periscleritis, orbital apicitis, and a focal mass. Sclerosing orbital inflammation is a rare condition with a chronic, indolent course involving dense fibrosis and lymphocytic infiltrate. Previously though to be along the spectrum of OID, it is now considered a distinct pathologic entity. Imaging plays an importan role in elucidating any underlying etiology behind orbita inflammation and is critical for ruling out other condi tions prior to a definitive diagnosis of OID. In this re view, we will explore the common sites of involvemen by OID and discuss differential diagnosis by site and key imaging findings for each condition. | Michael N Pakdaman Ali R Sepahdari Sahar M Elkhamary | 2014 | World Journal of Radiology2014，6，4： | 12 |
| 6 | Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children:a randomized controlled trial显示文摘Background Constipation is a common problem in children with spastic cerebral palsy(sCP)with a prevalence that reaches 75%.We hypothesized that treating constipation in those children will improve their health and shorten time spent in daily care.Our aim was to evaluate the efficacy and safety of oral magnesium sulfate for treating chronic constipation in children with sCP.Methods A prospective,double-blinded randomized control trial was carried out involving 100 children aged 2-12 years with sCP(level Ⅲ-Ⅴ of the Gross Motor Functional Classification system)and chronic constipation.They were followed up in the Pediatric neurology clinic,Children's hospital,Ain Shams University,May 2017-January 2019.The intervention group(O-Mg)received oral magnesium sulfate 1 mL/kg/day daily for 1 month compared to the placebo.Outcome measures were constipation improvement and decrease in bowel evacuation time after 1 month.Results Initially,weekly bowel movements,constipation scores and stool consistency were comparable in both groups.After 1 month of regular administration of oral magnesium sulfate,the constipation score,stool frequency and consistency improved compared to the placebo group(P<0.001).Effective safe treatment was achieved in 31(68%)and 4(9.5%)patients in the O-Mg and placebo groups,respectively(RR,2.95;95%CI 2.0-4.5)(P<0.001).Painful bowel evacuation attempts spent by mothers decreased from 25(55.6%)of the cases initially to 10(22%)cases after one month in the O-Mg group(P=0.001).In contrast,in the placebo group,the decrease went from 21(50%)cases initially to 18(42.9%)after 1 month and was not significant(P=0.5).Conclusions Oral magnesium sulfate seems effective in alleviating chronic constipation and pain experience in children with sCP.Consequently,saving maternal time spent in daily bowel evacuation attempts. | Sahar M.A.Hassanein Shaymaa M.Deifallah Hend A.Bastawy | 2021 | World Journal of Pediatrics2021，17，1： | 9 |
| 7 | Fe_3O_4/g-C_3N_4复合催化剂增强芬顿/光-芬顿和类过氧化酶反应的活性及稳定性(英文)显示文摘石墨相的氮化碳(g-C_3N_4)已被广泛用于光催化、水分解、光子检测器、电池、以及光电阴极.与其他光催化材料相比,g-C_3N_4具有价格低廉,易制备,无毒无污染等优点.此外,C_3N_4具有适宜的带隙(2.7 eV),能有效地吸收可见光.有关C_3N_4的光催化研究很多,但是其降解效率受限于电子空穴对的快速复合.因此,为了提高C_3N_4光催化反应效率,需要对其进行改性.磁铁矿(Fe_3O_4)广泛用于光催化和芬顿/光-芬顿反应.Fe_3O_4晶体具有反式尖晶石结构,其中Fe^(2+)和Fe^(3+)同时存在.研究表明,磁铁矿在酸性条件下催化效果显著,然而,它的比表面积小,随着反应时间的推移,铁离子会溶出,不利于有机物降解反应.因此,近来许多研究着重于磁铁矿复合物的制备,以提高磁铁矿的稳定性及催化性能.本文通过惰性氛围高温焙烧三聚氰胺制备了g-C_3N_4,再通过氯化铁和乙酸钠在乙醇中于180°C溶剂热反应,制备Fe_3O_4纳米粒子,最后通过静电自组装过程制备出Fe_3O_4/g-C_3N_4纳米复合材料.利用X射线衍射(XRD),扫描电子显微镜(SEM)及X射线光电子光谱(XPS)等手段验证其组成和结构.XRD结果表明,Fe_3O_4/g-C_3N_4复合材料中可以清晰看到Fe_3O_4和g-C_3N_4的衍射峰,说明这两种材料的晶相得以保持.SEM和TEM结果表明,Fe_3O_4纳米颗粒很好地附着在g-C_3N_4薄片上.XPS结果表明,氮化碳中存在典型的三种N峰;此外还存在铁的两种价态.光-芬顿活性测试中,相同条件下,Fe_3O_4/g-C_3N_4在60 min内将罗丹明B(RhB)几乎降解完全,而单组份的Fe_3O_4或g-C_3N_4对RhB的降解小于50%.可见,复合后的Fe_3O_4/g-C_3N_4光催化性能得到很大提升.单g-C_3N_4本身由于快速的电子空穴复合以及对双氧水的弱亲和力,因而对Rh B降解效果差.单独的Fe_3O_4由于在中性或者碱性条件下反而会抑制光催化芬顿活性.对于制备的Fe_3O_4/g-C_3N_4复合材料,具有以下优点:(1)电子在Fe^(3+)和g-C_3N_4的LUMO轨道上的转移降低了电子-空穴对的复合;(2)Fe_3O_4均匀分布在g-C_3N_4上,对于H_2O_2的吸附提供了有利的高比表面积;(3)Fe_3O_4和g-C_3N_4之间的界面相互作用使得Fe_3O_4的稳定性提高.通过降解RhB的动力学研究,得到反应速率为0.02 min^(–1),属准一级反应.分析检测结果表明,光-芬顿反应后,RhB分子被彻底矿化降解,没有中间产物生成,最终降解为CO_2和水.同时,通过对辣根过氧化物酶(HRP)模拟催化进行测试,以3,3',5,5'-四甲基联苯胺盐酸盐(TMB)作为基质,同时添加双氧水和Fe_3O_4/g-C_3N_4,在pH值为4.5条件下,TMB可以被有效氧化.实验表明,Fe_3O_4/g-C_3N_4添加量为25 mg/ml时,对TMB氧化性能最佳.复合催化剂还用于多巴胺的催化氧化反应.结果表明,多巴胺的氧化反应速率常数为1.21 min^(–1),属一级动力学反应.总之,复合材料提高了Rh B的光催化降解活性和稳定性;对TMB和HRP亲和性好,表现出高的类过氧化酶反应活性;有效的多巴胺氧化反应表明其有望用于生物基氧化反应中.实验结果表明,本文发展的Fe_3O_4/g-C_3N_4复合材料为其他类型复合材料的制备与应用提供了新的思路. | Shafaq Sahar Akif Zeb 刘亚男 Naseeb Ullah 徐安武 | 2017 | Chinese Journal of Catalysis2017，38，12： | 8 |
| 8 | Incidence and characteristics of HBV reactivation in hematological malignant patients in south Egypt显示文摘AIM:To investigate characteristics of hepatitis B virus(HBV)implicated in HBV reactivation in patients with hematological malignancies receiving immunosuppressive therapy.METHODS:Serum samples were collected from 53 patients with hematological malignancies negative for hepatitis B surface antigen(HBsAg)before the start of and throughout the chemotherapy course.HBV reactivation was diagnosed when the HBsAg status changed from negative to positive after the initiation of chemotherapy and/or when HBV DNA was detected by realtime detection polymerase chain reaction(RTD-PCR).For detecting the serological markers of HBV infection,HBsAg as well as antibodies to the core antigen(antiHBc)and to the surface antigen were measured in the sera by CEIA.Nucleic acids were extracted from sera,and HBV DNA sequences spanning the S gene were amplified by RTD-PCR.The extracted DNA was further subjected to PCR to amplify the complete genome as well as the specific genomic sequences bearing the enhancerⅡ/core promoter/pre-core/core regions(nt1628-2364).Amplicons were sequenced directly.RESULTS:Thirty-five(66%)of the 53 HBsAg-negative patients were found to be negative serologically for antiHBc,and the remaining 18(34%)patients were positive for anti-HBc.Five of the 53(9.4%)patients with hematologic malignancies experienced HBV reactivation.Genotype D1 was detected in all five patients.Four types of mutant strains were detected in the S gene product of HBV strains and were isolated from 3 patients with HBV reactivation:T/S120,L143,and I126.HBV DNA was detected in the pretreatment HBsAg-negative samples in one of the five patients with HBV reactivation.In this patient,sequences encompassing the HBV full genome obtained from sera before the start of chemotherapy and at the time of de novo HBV hepatitis were detected and it showed 100%homology.Furthermore,in the phylogenetic tree,the sequences were clustered together,thereby indicating that this patient developed reactivation from an occult HBV infection.CONCLUSION:Past infection with HBV is a risk factor for HBV reactivation in Egypt.Mandatory anti-HBc screening prior to chemotherapy in patients with hematological malignancies is recommended. | Abeer Elkady Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Sayuki Iijima Yasuhito Tanaka | 2013 | World Journal of Gastroenterology2013，19，37： | 7 |
| 9 | Corrosion behavior of Ni-P/nano-TiC composite coating prepared in electroless baths containing different types of surfactant | Sahar Afroukhteh Changiz Dehghanian Massood Emamy | 2012 | Progress in Natural Science:Materials International2012，22，5： | 7 |
| 10 | Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis显示文摘AIM:To investigate the anti-oxidative and anti-fibrotic effects of aloe vera in patients with liver fibrosis.METHODS:Aloe vera high molecular weight fractions(AHM) were processed by patented hyper-dry system in combination of freeze-dry technique with microwave and far infrared-ray radiation.Fifteen healthy volunteers as the control group and 40 patients were included.The patients were randomly subdivided into two equal groups:the conventional group was treated with placebo(starch),and AHM group was treated with 0.15 gm/d AHM,both for 12 consecutive weeks.The patients were investigated before and after treatment.Serum activity of aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkaline phosphatase(ALP),hyaluronic acid(HA),transforming growth factor-β(TGF-β) and matrixmetalloproteinase-2(MMP-2) were determined.The reduced glutathione(GSH) and malondialdehyde(MDA) levels in liver were assayed and the expression of hepatic α-smooth muscle actin(α-SMA) was identified by immunohistochemistry.RESULTS:At the start of the study,the hematoxylin and eosin staining revealed fibro-proliferated bile ductules,thick fibrous septa and dense inflammatory cellular infiltration in the patients before treatment.The use of AHM for 12 wk significantly ameliorated the fibrosis,inhibited the inflammation,and resulted in minimal infiltration and minimal fibrosis compared to the conventional group.The enzyme activities of the liver(ALT,AST and ALP) were attenuated after treatment in both groups,and the decrease in the AHM group was more significant as compared with the conventional group.Similar to the AST,the MDA levels were significantly higher before treatment,and were attenuated after treatment in both groups.In contrast,the hepatic glutathione content in the patients were decreased significantly in the AHM group compared to the controls.The serum levels of the fibrosis markers(HA,TGF-β and MMP-2) were also reduced significantly after treatment.The expression of α-SMA was modified in patients before and after treatment as compared with the normal controls.In the conventional group,there was only thin and incomplete parenchymal α-SMA positive septum joining the thickened centrilobular veins,while in the AHM group,few α-SMA positive cells were present in sinusoid and lobule after treatment.CONCLUSION:Oral supplementation with AHM could be helpful in alleviating the fibrosis and inflammation of hepatic fibrosis patients. | Sahar K Hegazy Mohamed El-Bedewy Akira Yagi | 2012 | World Journal of Gastroenterology2012，18，17： | 7 |
| 11 | Influence of bioactive sulphated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities显示文摘Objective:To explore the in vivo anticancer,anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens(JCEM) and Pterocladia capillacea(PCEM) as well as hot aqueous extract of Enteromorpha intestinalis(EHEM) against hepatocellular carcinoma rat model(HCC) and to study their chemical composition.Methods:The sugars and amino acids composition of the bioactive polysaccharides of JCEM,PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer,respectively.These polysaccharide extracts(20 mg/kg b.wt.for 5 weeks) were assessed on hepatocarcinogenesis in rats and α-fetoprotein(AFP),carcinoembryonic antigen(CEA),glypican-3(GPC-3),hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) and Ig G levels were evaluated.Results:The GLC analysis of JCEM,PCEM and EHEM polysaccharide revealed the presence of 10,9 and10 sugars,in addition the amino acid analyser enable identification of 16,15 and 15 amino acids,respectively.These polysaccharide extracts of JCEM,PCEM and EHEM produced significant decrease in serum AFP,CEA,GPC-3,HGF and VEGF compared with untreated HCC group.JCEM,PCEM and EHEM had an immunostimulatory responses by increasing the IgG levels as compared by naive value(1.23,1.53 and 1.17 folds),respectively.The bioactive polysaccharides in HCC induced rats improved the humoral immune response.The photomicrographs of liver tissue sections of the groups of HCC treated with polysaccharide extracts of Jania rubens and Enteromorpha intestinalis showed intact histological structure.Moreover,fractions HE1,HE4,HE7 obtained from polysaccharide of EHEM showed moderate cytotoxic activity against Hep G2 in vitro with IC_(50) 73.1,42.6,76.2 μg/mL.However,fractions of PCEM and JCEM show no or weak cytotoxicity against Hep G2 in vitro where the cytotoxic activity of their crude polysaccharide extract proved synergetic effect.Conclusions:The pronounced antitumor activity of sulphated polysaccharide-protein complexes of JCEM and EHEM is due to direct cytotoxic activity,anti-hepatocarcinogensis,and anti-angiogenesis.In addition,JCEM,PCEM and EHEM had an immunostimulatory response and improved the humoral immune response in HCC induced rats. | Azza A.Matloub Hadeer A.Aglan Sahar Salah Mohamed El Souda Mona Elsayed Aboutabl Amany Sayed Maghraby Hanaa H.Ahmed | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 7 |
| 12 | Synthesis and Characterization of Heterocyclic Functionalized Polymers by Click Reaction: Preparation of Magnetic Nanocomposites and Studies on Their Thermal, Mechanical, Photophysical and Metal Ions Removal Properties显示文摘This work reports synthesis and characterization of heterocyclic functionalized polymers, poly(triazole-etherimidazole)s(PTAEI), from a dialkyne-terminated compound, 3-(4,5-bis(4-(propargyloxy)phenyl)-1H-imidazol-2-yl)-9-ethyl-9H-carbazole, by using click reaction. PTAEIs were characterized and their properties such as solubility, thermal, mechanical, photophysical and metal ions adsorption were investigated. These polymers had weight average molar masses(Mw) in the range of 19100-26700 g/mol, exhibited excellent solubility in polar aprotic solvents and formed low-colored flexible thin films by solution casting method. They exhibited good thermal stability with glass transition temperatures(Tg) between 160 °C and 211 °C and 10% weight loss temperatures(T10%) in the range of 308-426 °C. Nanocomposites of PTAEIs with epoxide-terminated Fe3O4 showed that strong interfacial interaction between inorganic particles and the polymer matrix contributed to the enhanced thermal and mechanical properties. The photoluminescence intensity of the PTAEIs increased and the spectra red shifted with increasing Fe3O4 content. The PTAEIs and nanocomposites were tested for their extraction capability of metal ions from aqueous solutions either individually or in the mixture. | Mousa Ghaemy Sahar Shabzendedar Mehdi Taghavi | 2015 | Chinese Journal of Polymer Science2015，33，2： | 5 |
| 13 | prevention of renal dysfunction by nutraceuticals prepared from oil rich plant foods显示文摘Objective:To investigate the protective effect of extracts prepared from avocado,walnut,flaxseed and Eruca sativa seeds in a rat model of kidney dysfunction induced by intraperitoneal cisplatin.Methods:Ethanol and petroleum ether extracts mixture was prepared from each plant.Six groups of rats were conducted:control healthy,cisplatin group and four test groups where rats were given daily oral dose of each extract mixture before cisplatin injection.Different biochemical and cytogenetic parameters and kidney histopathology were determined.Acute toxicity was tested for the nutraceuticals.Total phenolic contents,faity acids(FA) and unsaponifiable matter were assessed in the extracts.Results:Walnut ethanol extract showed the highest content of total phenolic.FA analysis revealed that all the studied plants were rich in unsaturated FA.Gas-liquid chromatographic investigation of the unsaponifiable matter showed the presence of campeslerol.stigmaslerol and β—sitosterol in all the studied plants.Cisplatin treatment induced significant increase in plasma urea,creatinine and malondialdehyde along with significant reduction of plasma albumin,total protein,calalase and total antioxidant as well as reduction in creatinine clearance.Histopathological examination proved the induction of kidney dysfunction.Some sorts of chromosomal aberration and spermshape abnormalities were noticed after cisplatin treatment.Administration of extracts mixtures produced improvements in biochemical,histopathological and cytogenetic parameters.Conclusions:Administration of the studied nutraceuticals proved to possess protective role against cisplatin—induced nephrotoxicity,chromosomal aberration and abnormal sperms.All studied uutraceuticals showed complete safety. | Sahar Y.Al-Okbi Doha A.Mohamed Thanaa E.Hamed Reham SH.Esmail Souria M.Donya | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，8： | 5 |
| 14 | Reciprocal impact of host factors and Helicobacter pylori genotypes on gastric diseases显示文摘AIM: To assess the impact of Helicobacter pylori(H. pylori) genotypes and patient age and sex on the development of gastric diseases.METHODS: H. pylori-infected patients(n = 233) referred to the endoscopy unit at Tehran University of Medical Sciences(Tehran,Iran) were diagnosed with chronic gastritis(CG),gastric ulcer(GU),or duodenal ulcer(DU). Brucella blood agar was used for biopsy cultures and H. pylori isolation under microaerobic conditions. H. pylori isolates were confirmed with biochemical tests and through amplification of the 16 S r RNA gene. DNA was extracted from fresh cultures of the H. pylori isolates and used for amplification of vac A alleles and the cag A gene. Statistical analysis was performed to determine the association between H. pylori genotypes,age(< 40 years vs > 40 years) and sex of the patient,and gastric diseases.RESULTS: CG was the most prevalent gastric disease(113/233; 48.5%),compared to GU(64/233; 27.5%)and DU(56/233; 24%). More patients were male,and gastric diseases were more frequent in patients > 40 years(P < 0.05). The percentage of CG and GU patients that were male and female did not show a significant difference; however DU was more common in males(P < 0.05). Interestingly,a diagnosis of CG in patients > 40 years was more common in females(18.5%) than males(11.6%)(P = 0.05),whereas a diagnosis of GU or DU in patients > 40 years was more frequent in males(14.6% vs 10.7% and 12.4% vs 4.3%,respectively). Overall,genotyping of the H. pylori isolates revealed that the vac A s1(82%),vac A m2(70%),and cag A+(72.5%) alleles were more frequent than vac A s2(18%),vac A m1(29.2%),and cag A-(all P < 0.05). The vac A s1m2 cag A+ genotype was the most prevalent within the three disease groups. vac A s1m2 frequency was 56.2% with a similar occurrence in all diagnoses,while vac A s1m1 appeared more often in DU patients(33.9%). A genotype of vac A s2m2 occurred in 15% of isolates and was more common in CG patients(21.2%); vac A s2m1 was the least common genotype(3%). The vac A s1 allele was found to be a risk factor for DU,vac A s2 for CG,and vac A s1 and vac A s2 for GU(all P < 0.05). The vac A s2m2 genotype was associated with the development of CG and GU compared to DU(P < 0.05). No correlation was found between vac A m or cag A and gastric diseases.CONCLUSION: The outcome of H. pylori infection is the result of interaction between bacterial genotypes and the age and sex of infected individuals. | Sahar Honarmand-Jahromy Farideh Siavoshi Reza Malekzadeh Taher Nejad Sattari Saeid Latifi-Navid | 2015 | World Journal of Gastroenterology2015，21，31： | 5 |
| 15 | Is toxoplasmosis a potential risk factor for liver cirrhosis?显示文摘Objective:To document Toxoplasma gondii(T.gondii) antibody status in patients with liver disease,blood samples were taken from 180 hepatic patients and 180 healthy controls.Methods:Toxoplasma IgG antibody was detected using enzyme-linked immunosorbent assay and histopathological assessment of liver biopsy METAVIR score was applied.Results:Anti-T.gondii IgG antibodies were found in 32.8%of patients and in 22.2%of controls(P=0.02).Toxoplasma seropositivity was significantly associated with lymphadenopathy,history of blood transfusion and reflex impairment in patients.Chronic hepatitis C virus(HCV)and chronic HCV-related cirrhosis groups compared to chronic HBV and chronic HBV-related cirrhosis groups expressed significantly higher prevalence of T.gondii seropositivity(odds ratio(OR) =4;95%confidence interval(CI):1.3-12.6;P=0.013,OR=4.8;95%CI:1.5-14.9;P=0.006,respectively).Within the chronic HCV group,T.gondii seropositivity significantly associated disease evolution as regards to METAVIR histopathological system for fibrosis and inflammation(OR=19.4;95%CI:2.3-165.2;P=0.0008,OR=0.29;95%CI:0.1-0.8;P=0.01,respectively).Albumin,international normalized ratio(INR) and platelets count were the laboratory parameters significantly altered in Toxoplasma-positrvc chronic HCV patients(P=0.00 l,0.03,0.04,respectively).Child-Pugh scoring for cirrhosis in chronic HCV group placed the majority of seropositive patient in class C with significant statistical difference compared to Child A reference group(OR= 0.08;95%67:0.01-0.5;P=0.003).Conclusions:Toxoplasma seropositivity was high in patients with cirrhosis and associated higher grades of inflammation and necrosis signifying disease evolution,suggesting that cirrhotic patients may thus form a risk group for toxoplasmosis. | Abeer Abd El-Rehim El-Henawy Ahmed Abdel-Razik Sahar Zakaria Dina Elhammady Niveen Saudy Manar Sobh Azab | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，10： | 4 |
| 16 | Incremental value of magnetic resonance neurography of Lumbosacral plexus over non-contributory lumbar spine magnetic resonance imaging in radiculopathy: A prospective study显示文摘AIM: To test the incremental value of 3T magnetic resonance neurography(MRN) in a series of unilateral radiculopathy patients with non-contributory magnetic resonance imaging(MRI).METHODS: Ten subjects(3 men,7 women; mean age54 year and range 22-74 year) with unilateral lumbar radiculopathy and with previous non-contributory lumbar spine MRI underwent lumbosacral(LS) plexus MRN over a period of one year. Lumbar spine MRI performed as part of the MRN LS protocol as well as bilateral L4-S1 nerves,sciatic,femoral and lateral femoral cutaneous nerves were evaluated in each subject for neuropathy findings on both anatomic(nerve signal,course and caliber alterations) and diffusion tensor imaging(DTI)tensor maps(nerve signal and caliber alterations).Minimum fractional anisotropy(FA) and mean apparent diffusion coeffcient(ADC) of L4-S2 nerve roots,sciatic and femoral nerves were recorded.RESULTS: All anatomic studies and 80% of DTI imaging received a good-excellent imaging quality grading. In a blinded evaluation,all 10 examinations demonstrated neural and/or neuromuscular abnormality corresponding to the site of radiculopathy. A number of contributory neuropathy findings including double crush syndrome were observed. On DTI tensor maps,nerve signal and caliber alterations were more conspicuous. Although individual differences were observed among neuropathic appearing nerve(lower FA and increased ADC) as compared to its contralateral counterpart,there were no significant mean differences on statistical comparison of LS plexus nerves,femoral and sciatic nerves(P > 0.05).CONCLUSION: MRN of LS plexus is useful modality for the evaluation of patients with non-contributory MRI of lumbar spine as it can incrementally delineate the etiology and provide direct objective and non-invasive evidence of neuromuscular pathology. | Avneesh Chhabra Sahar J Farahani Gaurav K Thawait Vibhor Wadhwa Allan J Belzberg John A Carrino | 2016 | World Journal of Radiology2016，8，1： | 4 |
| 17 | Traditional and modern aspects of hemorrhoid treatment in Iran:a review显示文摘Hemorrhoidal disease is a prevalent anorectal condition which is generally not managed well with current pharmacologic interventions. However, in Iranian traditional medicine(ITM) there are numerous plants with hemorrhoid-healing properties. The present research assembled plants with hemorrhoidhealing properties in ITM; their related pharmacological effects, phytochemical constituents and mechanisms of action in the modern medicine were also gathered. For this purpose, leading ITM textbooks were searched for plants with hemorrhoid-healing effects. Further, in vitro, in vivo and clinical studies on the most cited species were considered using scientific databases. Studying ITM textbooks revealed37 medicinal plants with hemorrhoid-healing effects. Among the mentioned herbal medicines, six species, including Allium ampeloprasum, Phyllanthus emblica, Aloe vera, Terminalia chebula, Vitis vinifera and Commiphora mukul, had the largest number of related pharmacological effects documented in scientific databases. These herbs from ITM should be considered as important resources for producing novel drugs for hemorrhoid treatment. | Sahar Dehdari Homa Hajimehdipoor Somayeh Esmaeili Rasool Choopani Seyed Alireza Mortazavi | 2018 | Journal of Integrative Medicine2018，16，2： | 3 |
| 18 | Nd-doped ZnO as a multifunctional nanomaterial显示文摘Chemically synthesised ZnO and Nd-doped ZnO nanoparticles were investigated for structural, optical, magnetic properties along with photocatalytic activity. Transmission electron microscopy measurement was performed on the undoped and doped ZnO nanoparticles. Compared to the undoped ZnO, Nd-doped ZnO nanoparticles showed enhanced photoluminescent and ferromagnetic properties. The Nd-doped ZnO nanoparticles also showed improved photocatalytic properties compared with the undoped ZnO nanoparticles. Furthermore, the effect of UV light irradiation was studied with thermoluminescence (TL) and photoluminescence (PL) measurement techniques. It was found that in case of Nd-doped ZnO nanoparticles TL intensity increased while the green emission in PL spectra decreased with UV-light irradiation. This was attributed to the production of more surface defects on UV irradiation on Nd-doping. | Surender Kumar P.D. Sahare | 2012 | Journal of Rare Earths2012，30，8： | 3 |
| 19 | Effect of pyrite content of feed and configuration of locked particles on rougher flotation of copper in low and high pyritic ore types显示文摘Misreported pyrite into copper concentrates dramatically declines copper grade and recovery. Copper flotation can be also more complicated if flotation feed comes from an elevated-pyritic copper ore. In this investigation, the effect of two different ore types(high pyritic and low pyritic feeds) was studied on rougher stage of industrial copper flotation circuit. Samples were taken from different streams and the structure of chalcopyrite within the pyrite and non-sulfide gangue minerals was examined in various size fractions for mentioned ore types. Results indicated that 72% and 56% of the total floated pyrite was transferred to concentrate in first four cells in the low and high pyritic feeds, respectively. Whereas, this proportion for floated SiO_2 in last ten cells was detected as 72% and 71%, respectively. A detailed interpretation of the effect of locked particles in different size fractions on rougher flotation cells is studied from industrial point of view. | Sahar Agheli Ahmad Hassanzadeh Behzad Vaziri Hassas Mohammad Hasanzadeh | 2018 | International Journal of Mining Science and Technology2018，28，2： | 3 |
| 20 | 小剂量瑞芬太尼对全麻苏醒拔管期不良反应的作用显示文摘背景瑞芬太尼可以减轻全麻苏醒期时的咳嗽、躁动和血流动力学变化等不良反应。方法在一项前瞻性、随机、双盲临床试验中,60例接受鼻部手术的成人患者采用以瑞芬太尼为基础的麻醉方案。在苏醒期,瑞芬太尼组患者将瑞芬太尼用量减至维持量的1/10,而对照组患者则停止使用。结果两组患者的苏醒时间和气管拔管时间无明显区别。与对照组相比,瑞芬太尼组在苏醒期(输注速率:0.014±0.011μg·kg·min^-1)的咳嗽发生率(40%vs80%,P=0.002)和严重程度均明显减轻,不自主运动发生率降低(3.3%vs30%,P=0.006),心率较慢。结论在苏醒期使用小剂量瑞芬太尼不会延长苏醒时间,且降低气管插管所致咳嗽的发生率和严重程度。 | Marie T. Aouad Achir A. Al-Alami Viviane G. Nasr Fouad G. Souki Reine A. Zbeidy Sahar M. Siddik-Sayyid 韩柳(译) 李成辉(校) | 2010 | 麻醉与镇痛2010，，6： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员